PO.CL05.13 · 临床研究
Vaccines and Other Immunomodulatory Agents
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6690 · PDF 膀胱癌中免疫治疗相比化疗的早期无进展生存不利:一项随机试验的荟萃分析 Unfavorable early progression-free survival of immunotherapy compared to chemotherapy in bladder cancer: A meta-analysis of randomized trials Donghwi Choi, Hangyul Lee, Jinha Kim, Young Kwang Chae
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6691 · PDF 头颈癌中免疫治疗相比化疗的早期无进展生存较差的模式:一项随机试验的荟萃分析 Pattern of inferior early progression-free survival with immunotherapy versus chemotherapy in head and neck cancer: A meta-analysis of randomized trials Donghwi Choi, Hangyul Lee, Jinha Kim, Young Kwang Chae
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6692 · PDF 自佐剂α-螺旋多肽同时递送新抗原mRNA并激活树突状细胞以根除肿瘤 Self-adjuvanting alpha-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors Jiadiao Zhou
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6693 · PDF KLRG1+PD-1+CD8+T细胞驱动由全身性STING纳米疫苗诱导的强效抗肿瘤免疫 KLRG1 + PD-1 + CD8 + T cells drive potent antitumor immunity induced by a systemic STING nanovaccine Shuang Chen, Shuyue Ye, Qiang Feng, Gang Huang, Animesha Krishnamurthy, Baran Devrim Sumer, Jinming Gao
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6694 · PDF 用于抗原特异性T细胞激活的单核细胞来源树突状细胞 Monocyte-derived dendritic cells for antigen-specific T cell activation Kaitlin Hsu, Jessica Voce, Amy Zhao, Jessie Ni
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6695 · PDF NSCLC中仅免疫治疗相较于化疗的早期进展劣势:一项随机对照试验的荟萃分析 Early progression disadvantage of immunotherapy-only treatment versus chemotherapy in NSCLC: A meta-analysis of randomized controlled trials Jinha Kim, Hangyul Lee, Donghwi Choi, Young Kwang Chae
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6696 · PDF 一种源自条件重编程原代肿瘤细胞的衰老全细胞疫苗平台,可启动强效T细胞免疫并在小鼠乳腺癌模型中克服ICI耐药 A senescent whole-cell vaccine platform derived from conditionally reprogrammed primary tumor cells primes potent T-cell immunity and overcomes ICI resistance in murine breast cancer models Sara Rasouli, Chongwen Cao, Weiyi Gong, Haichang Li, Bei Liu, Anna Vilgelm, Jenny Li, Xuefeng Liu
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6697 · PDF Pelareorep联合atezolizumab和化疗在晚期胰腺癌中显示免疫转化活性:GOBLET试验队列1的生物标志物结果 Pelareorep combined with atezolizumab and chemotherapy shows immune conversion activity in advanced pancreatic cancer: Biomarker results of cohort 1 of the GOBLET trial Hendrik Schürmann, Sven-Thorsten Liffers, Richard Trauger, Thomas Heineman, Dirk Arnold, Jens T. Siveke
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6698 · PDF EpitopeMiner:用于证据驱动的个性化癌症疫苗设计的可扩展知识挖掘 EpitopeMiner: Scalable knowledge mining for evidence-driven personalized cancer vaccine design Agamjyot Singh Chadha, Isaac Jiasheng Cheong, Marcia Zhang, Wei Kit Tan, Wei Lin Tang, Jing Quan Lim, Solomonraj Wilson, Choon Kiat Ong, Bernett Lee, Chwee Ming Lim, Olaf Rotzschke, Mai Chan Lau
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6699 · PDF 用于评估靶向cGAS-STING轴的免疫疗法的新型临床前免疫功能健全小鼠模型 Novel preclinical immunocompetent mouse model for assessment of immunotherapies targeting cGAS-STING axis Angela Pappalardo, Philippe De La Rochere, Patricia Isnard-Petit, Gaëlle H. Martin, Fabiane Sonego, Kader Thiam
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6700 · PDF 一套完全整合的体外和体内工具,用于将微生物用作对抗癌症的新型治疗武器 A fully integrated set of in vitro and in vivo tools for utilization of micro-organisms as new therapeutic weapons against cancer Guillaume Serin, Lucie Demontoux, Elizabeth Bertrand, Marie Leblanc, Sylvie Maubant, Ismahene Benzaid, Marc Hillairet De Boisferon
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6701 · PDF 重新设计癌症疫苗:Bria-OTS+ 整合固有免疫与适应性免疫,实现广泛而持久的抗肿瘤应答 Re-engineering cancer vaccines: Bria-OTS+ integrates innate and adaptive immunity for broad and persistent anti-tumor responses Miguel A. Lopez-Lago, Pravin Kesarwani, Vikas Bhardwaj, Xiaoyi Zheng, Ying Liu, Sagarika Pachhal, Patience cournoo, Renee Cortez, George Woodfield, Charles Wiseman, William V. Williams
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6702 · PDF 一种 Cxcl10 mRNA-LNP 佐剂在黑色素瘤模型中增强免疫检查点抑制剂应答 A Cxcl10 mRNA-LNP adjuvant enhances immune checkpoint inhibitor responses in melanoma models Kaitlyn M. Landreth, Katherine Lee, Emel Sen Kilic, Joshua Chapman, Mary Garland-Kledzik, F. Heath Damron, Tracy W. Liu
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6703 · PDF Rg002:一种基于 mRNA-LNP、靶向 HPV-16/18 相关恶性肿瘤的免疫疗法 Rg002: An mRNA-LNP-based immunotherapy targeting HPV-16/18-related malignancies Shan Cen, Lan Zhu, Fei Chen, Wei Wang, Lihua Qiu, Hua Yang, Yijie Dong, Weiguo Zhang, Huizhen Zhang, Jing Wang
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6704 · PDF 运动减轻老年荷黑色素瘤小鼠主动脉中抗 PD-1 诱导的外膜巨噬细胞炎症 Exercise attenuates anti-PD-1-induced adventitial macrophage inflammation in the aorta of aged melanoma-bearing mice Jonghae Lee, Sumedha Pareek, Truong Lam, Fei Wang, Guanshu Liu, Jared K Burks, Jun-ichi Abe, Keri Schadler
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6705 · PDF 一种用于克服免疫细胞工程改造障碍的多功能凝聚层递送系统 A versatile coacervate based delivery system to overcome engineering barriers in immune cells Renxia Zhang, Peipei Zhu, Manman Lu, Qing Zhang, Lihong Jiang, Xiaowen Fei, Xiaofei Gao
- 6707 6707 开发表达 MG53 的溶瘤麻疹病毒用于肺癌治疗 Developing oncolytic measles virus expressing MG53 for the treatment of lung cancer Zhongguang Li, Cheng Chih Hsu, Fei Jiang, Matthew Bu, Ellica Leong, Umme Lubaba, Xuefeng Liu, Jianrong Li, Haichang Li
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6708 · PDF 新辅助 pembrolizumab 联合治疗性 DNA 疫苗在一项 HPV 阳性 HNSCC 的 2 期试验中重塑瘤内免疫 Neoadjuvant pembrolizumab with therapeutic DNA vaccine reshape intratumoral immunity in a phase 2 trial of HPV-positive HNSCC Hye Ryun Kim, June-Young Koh, Chang Gon Kim, Min Hee Hong, Hyun Jun Hong, Dahee Kim, Nam Suk Sim, Sun Och Yoon, Gamin Kim, Wonrak Son, Yeju Kim, Chang Geol Lee, Kyung Hwan Kim, Jeong Seok Lee, Chan-Young Ock, Yoon Woo Koh
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6709 · PDF 24,000 多项免疫肿瘤学试验中生物标志物应用的时间趋势 Temporal trends in biomarker utilization across 24,000+ immuno-oncology trials Fahad Benthani, Samik Upadhaya, Cynthia L. Neben, Kellie R. McDonald, Alicia Y. Zhou
- 6710 6710 开发激活T细胞的核酸融合疫苗以预防转移性葡萄膜黑色素瘤的建立 Development of T cell activating nucleic acid fusion vaccine to prevent metastatic uveal melanoma establishment Vitali Alexeev, Mizue Terai, Sergei Koshkin, Takami Sato
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6711 · PDF 在卵巢癌小鼠模型中研究TLR4和TLR9驱动的免疫治疗对MyD88和NLRP3通路的调节 Investigating MyD88 and NLRP3 pathway modulation in a TLR4 and TLR9 driven immunotherapy in a murine model of ovarian cancer Ania V. Klas, Rita E. Serda
- 6712 6712 利用表达双特异性巨噬细胞接合器的溶瘤腺病毒促进肿瘤抗原的非特异性交叉呈递 Promoting improved agnostic cross presentation of tumor antigens with an oncolytic adenovirus expressing bispecific macrophage engagers Ahmet Hazini, Margarida Rei, Natanya Cartwright, Ricardo A. Fernandes, Kerry Fisher, Len Seymour
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6713 · PDF 设计基于水凝胶的疫苗以预防胰腺导管腺癌的复发 Engineering a hydrogel-based vaccine to prevent recurrence in pancreatic ductal adenocarcinoma Peter Yuxin Xie, James P. Agolia, Rosyli F. Reveron-Thornton, Chuner Guo, Maria Moozhiyil Korah, Andrea Delitto, Deshka Foster, Ovijit Chaudhuri, Daniel Delitto
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6714 · PDF 用于评估B细胞CAR-T疗法疗效和安全性的人源化SLE小鼠模型 Humanized SLE mouse model for evaluating B-cell CAR-T therapy efficacy and safety Ruowen Zhang, Thi Minh Thi Ho, Bo Peng, Hongjing Qu, Qi Jiang, Benjamin Wei, Qingcong Lin
- 6715 6715 HER2多表位疫苗联合T-DM1治疗残留HER2阳性乳腺癌的安全性导入阶段的安全性、耐受性及早期免疫应答 Safety, tolerability, and early immune responses in the safety run-in of an HER2 multi-epitope vaccine combined with T-DM1 in residual HER2-positive breast cancer Saranya Chumsri, Sharmila Giri, Andy J. Ness, David W. Hillman, Nadine Norton, Davitte Cogen, Brian M. Necela, Aziza Nassar, Donald W. Northfelt, Pooja Advani, Rohit Rao, Alvaro Mareno-Aspitia, Brenda Ernst, Kathryn J. Ruddy, Matthew P. Goetz, Keith L. Knutson
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6716 · PDF ALK-mRNA疫苗作为ALK+癌症的新型免疫疗法 ALK-mRNA vaccine as a new Immunotherapy for ALK+ cancers Gabriele Saccu, Alessandro Gasparetto, Carmen Mecca, Elisa Bergaggio, Simone Piane, Taek-Chin Cheong, Nirmala Tilija Pun, Roberto Chiarle
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6717 · PDF 靶向胃癌的装甲型claudin 18.2纳米抗体CAR NK细胞的临床前研究 Preclinical study of armored claudin 18.2 nanobody CAR NK cells targeting gastric cancer Byeong-Hyeok Choi, Ga-Ram Hwang, Morgan Flaherty, Vincent M. DeStefano, Masayuki Wada, Kevin Pinz, Jennifer E. Chow, Nabil Hagag, Yu Ma, Jing Luo, Yupo Ma
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6718 · PDF 通过单细胞转录组分析鉴定T细胞反应性的新型细胞表面标志物 Identifying new cell surface markers of T-cell reactivity through single cell transcriptomic analysis Abraham A. Hakim, Lisa Kenney, Nivedita Mohan Ratnam, Jared J. Gartner, Ian S. Goldlust, Aarushi Bhasin, Brian Bui, Nicholas D. Klemen, Steven A. Rosenberg, Frank J. Lowery