PO.ET06.05 · 实验与分子治疗
Molecular Targets 2
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5712 · PDF 通过虚拟筛选鉴定阻断肿瘤特异性调幅射频电磁场治疗作用的FDA批准药物 Virtual screening identification of FDA approved drugs blocking the therapeutic action of tumor-specific amplitude-modulated radiofrequency electromagnetic fields Hugo Jimenez, Ping Dou, Aaban A. Azmi, Elyas Khan, Alhussein Elshebiny, Yusuf Fateh, Nathan Elias, Cameron Osenkowski, Liyue Zhang, Grayson Barker, Allan M. Johansen, Ravi Paluri, Janaka S. S. Liyanage, Mohammed N. Al Hallak, Anthony F. Shields, Muhammad W. Saif, Husain Y. Khan, Amro Aboukameel, Md Hafiz Uddin, Sahar F. Bannoura, Ramzi M. Mohammad, Alexandre Barbault, Boris C. Pasche
- 5713 5713 基于扩增子的DNA与RNA NGS联合检测相较于杂交捕获DNA-NGS在中国NSCLC驱动基因SNV/INDEL分析中的性能比较 Comparative performance of amplicon-based DNA and RNA NGS co-detection versus hybrid-capture DNA-NGS for SNV/INDEL profiling in Chinese NSCLC driver genes Zefeng Xie, Yuze Zhao, Haitao Li, Yu Li, Yulan Chen, Meilian Liu, Xuyuan Li
- 5714 5714 基于扩增子的DNA与RNA联合检测相较于杂交捕获DNA-NGS改善中国实体瘤中ROS1融合的识别 Amplicon-based DNA and RNA co-detection improves ROS1 fusion identification across Chinese solid tumors compared with hybrid capture DNA-NGS Meiyi Li
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5715 · PDF 雄激素剥夺前列腺癌中的组蛋白修饰酶:EZH1作为协同治疗靶点 Histone-modifying enzymes in androgen-deprived prostate cancer: EZH1 as a synergistic therapeutic target Tanaya Purohit, Emily Schmitt, Zachary Schultz, Marcelo Bigarella, Kayla Bahr, Mohammad Rizvi, Diana Garcia, Sean Sardeson, Erika Heninger, Shannon Reese, Jacob Popp, Joshua M. Lang, Karla Esbona, Wei Huang, Peter W. Lewis, John M. Denu, Bing Yang, David F. Jarrard
- 5716 5716 在骨转移性前列腺癌中建立doxycycline/methacycline与乙酰化KLF5之间的药物-靶点关系 Establishing a drug-target relationship between doxycycline/methacycline and acetylated KLF5 in bone-metastatic prostate cancer Duo Zhang, Xinyuan Jiang, Yutian Ren, Yujing Qin, Shiqi Deng, Qifan Zhou, Yuanguang Chen, Zhiqian Zhang, Xumu Zhang, Jin-Tang Dong
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5717 · PDF 鉴定负责SCLC抗原ELAVL4异天冬氨酰化与聚集的区域 Identifying the regions responsible for isoaspartylation and aggregation of SCLC antigen ELAVL4 Shiori Fukutome, Diego Alejandro Velarde, Chunli Yan, Whitaker Cohn, Nazarius Lamango, Ite A. Offringa
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5718 · PDF Cbx5作为增强小细胞肺癌免疫治疗的潜在靶点 Cbx5 as a potential target to enhance immunotherapy in small cell lung cancer Hong Cao, Yiting Li, Jiajia Gu, Yuan Hao, Ziyang Wang, Benjamin A. Nacev, Kwok-Kin Wong, Hua Zhang
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5719 · PDF MSH2与MLH1在基底样乳腺癌中的对立作用 Contrasting roles of MSH2 and MLH1 in basal-like breast cancer Tanzia Islam Tithi, Jiao Mo, Nicholas Borcherding, Sung Jo, Heather R Kates, Chandra Maharjan, Seyedehalaleh Anvar, Richard L. Bennett, Jixiu Shan, Rohan A. Desai, Kailey E Cash, Masayoshi Honda, Lei Wang, Kawther K. Ahmed, Kalyanee Shirlekar, Li Chen, Katherine N. Gibson-Corley, Ronald Weigel, Jonathan D. Licht, Maria Spies, Ryan Kolb, Weizhou Zhang
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5720 · PDF 高TROP2表达在头颈癌中常见并与淋巴结转移相关 High TROP2 expression is frequent and linked to nodal metastasis in head and neck cancer David Dum, Juliana Knief, Christoph Thorns, Morton Freytag, Florian Lutz, Waldemar Wilczak, Katharina Möller, Florian Viehweger, Fiete Gehrisch, Nina Schraps, Claudia Hube-Magg, Martina Kluth, Maria Christina Tsourlakis, Ronald Simon, Guido Sauter, Natalia Gorbokon, Munir Hamad, Nikolaus Möckelmann, Till Clauditz, Adrian Münscher, Viktoria Chirico
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5721 · PDF 抑制醛脱氢酶作为克服耐药性多发性骨髓瘤的策略 Aldehyde dehydrogenase inhibition as a strategy to overcome drug-refractory multiple myeloma Michael J. Ingling, Robert Chitren, Krishne Gowda, Shantu Amin, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj Pandey
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5722 · PDF 胞质分裂蛋白调节因子1(PRC1)通过协调肿瘤-基质互作促进Wilms瘤进展 Protein regulator of cytokinesis 1 (PRC1) promotes Wilms tumor progression by orchestrating tumor-stromal crosstalk Qiushi Wang, Tianshun Zhang
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5723 · PDF TMEM165-CLOCK融合蛋白通过增强溶酶体胞吐作用驱动转移 TMEM165-CLOCK fusion protein drives metastasis through enhanced lysosomal exocytosis Youngkeun Lee, Ji-yoon Choi, Min-jeong Kim, Sung Wook Seo
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5724 · PDF HMGB1过表达是ERG阴性前列腺癌中一项强有力且独立的预后特征 HMGB1 overexpression is a strong and independent prognostic feature in ERG negative prostate cancer Neele Heckmann, Nicolas Hertzsprung, Christian Bernreuther, Eike Burandt, Florian Lutz, Clara Lühr, Clara von Bargen, Martina Kluth, Maria Tsourlakis, Nina Schraps, Fiete Gehrisch, Ronald Simon, Hans Heinzer, Alexander Haese, Henning Plage, Sarah Minner, Guido Sauter, Thorsten Schlomm, Markus Graefen, Cosima Völkl
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5725 · PDF 靶向Rac1作为T细胞淋巴瘤的治疗易感靶点 Targeting Rac1 as a therapeutic vulnerability in T-cell lymphomas Lucero Alvarado, María M. Debernardi, Gonzalo Gonzalez, Helena Andrea Sterle, Valeria G. Sanchez, Silvina Palmer, Sofia Rivarola, Jorgelia Real, Barrozo Julio, Goergina A. Cardama, Florencia Cayrol
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5726 · PDF 用印楝(Azadirachta indica)柠檬苦素类化合物Nimbolide靶向治疗犬膀胱癌 Targeting canine bladder cancer with Nimbolide, a Neem ( Azadirachta indica ) limonoid Conner Suen, Eashan Sharma, Gabriel Gilchrist, Neelu Batra, Christopher A. Lucchesi, Kenneth A. Iczkowski, Robert B. Rebhun, Paramita M. Ghosh
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5727 · PDF MTAP缺失在头颈部肿瘤中常见但取决于肿瘤原发部位 MTAP deficiency is common in head and neck tumors but dependent on the site of tumor origin Juliana Knief, Christoph Thorns, Morton Freytag, Florian Lutz, Viktoria Chirico, David Dum, Waldemar Wilczak, Katharina Möller, Florian Viehweger, Fiete Gehrisch, Nina Schraps, Claudia Hube-Magg, Martina Kluth, Maria C. Tsourlakis, Ronald Simon, Guido Sauter, Natalia Gorbokon, Munir Hamad, Nikolaus Möckelmann, Till Clauditz, Adrian Münscher
- 5728 5728 在中国NSCLC中,基于扩增子的DNA和RNA NGS联合检测相比杂交捕获DNA-NGS可增强ROS1融合检出并提高伴侣多样性 Amplicon-based DNA and RNA NGS co-detection enhances ROS1 fusion detection and partner diversity compared with hybrid-capture DNA-NGS in Chinese NSCLC Yang Zebo
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5729 · PDF 通过整合蛋白基因组学分析在黑色素瘤组织活检中发现肿瘤特异性抗原 Discovery of tumor-specific antigens in melanoma tissue biopsies via integrated proteogenomic analysis Arthur Viodé, Daniel Gautheret, Anamarija Pfeiffer, Hughes Hermann, Sharane Muralli, Séverine Roy, Antoine Meant, Amaury Lachaud, Yuehan Feng, Caroline Robert
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5730 · PDF CDX1与PVT1外显子9相关启动子结合驱动侵袭性前列腺癌中致癌性PVT1外显子9的过表达 CDX1 binding to the PVT1 exon 9-associated promoter drives oncogenic PVT1 exon 9 overexpression in aggressive prostate cancer Chinedum C. Udekwu, Siti K. Nuraziza, Seidu Adams, Rachel E. Bonnaci, E. Oluwabunmi Olapade-Olaopa, Olorunseun O. Ogunwobi
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5731 · PDF ID4在侵袭性三阴性乳腺癌中维持未分化和免疫逃逸状态,代表一种新型可成药易感靶点 ID4 maintains undifferentiated and immune-evasive states in aggressive triple-negative breast cancer and represents a novel druggable vulnerability Lautaro Rivera, Carla Toro, Juan Manuel Fernandez, Jochen Maurer, Maria Teresita Branham
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5732 · PDF 氯离子胞内通道蛋白1结合肽的鉴定与功能分析及其在基于ProTac的癌症治疗中的应用 Identification and functional analysis of chloride intracellular channel protein 1-binding peptide and its uses for ProTac-based cancer therapy Aryeong Lee, Byungheon Lee
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5733 · PDF 利用工程化PCMT1解码SCLC中ELAVL4的异天冬氨酰化:一种揭示免疫触发因素的策略 Decoding ELAVL4 isoaspartylation in SCLC using engineered PCMT1: A strategy for uncovering immune triggers Davin Pan, Shiori Fukutome, Xuhan Zhou, Diego De Luna Moran, Chunli Yan, Diego Alejandro Velarde, Whitaker Cohn, Ite A. Offringa
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5734 · PDF 靶向exportin 1单独及与5-氟尿嘧啶联合使用可减少皮肤鳞状细胞癌的生长 Targeting exportin 1 reduces cutaneous squamous cell carcinoma growth alone and in combination with 5-fluorouracil Moynul Islam, Justin Rudd, Louise Monga, James Grunkemeyer, Laura Hansen
- 5735 5735 咪喹莫特靶向tankyrase 2以抑制Wnt活化的结直肠癌 Imiquimod targets tankyrase 2 to suppress wnt-active colorectal cancer Philemon Ubanako, Ramesh Pandian, Adedapo Adeyinka, Bernice Monchusi, Clement Penny
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5736 · PDF BMAL2通过调节同源重组维持DNA完整性以促进卵巢透明细胞癌的肿瘤发生 BMAL2 maintains DNA integrity via regulating homologous recombination to promote ovarian clear cell carcinoma tumorigenesis Grace Yin Tze Tan, Pei-Yi Lin, Li-Tzu Cheng, Wendy Wenhua Hwang-Verslues
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5737 · PDF 开发靶向IL-8信号的药物以阻断向食管腺癌的进展 Developing agents to target IL-8 signaling and intercept progression to esophageal adenocarcinoma Yun Zhang, Andrew Alt, Nick Santoro, Shari Barnett, Kiran Lagisetty, Jules Lin, Rishindra M. Reddy, Chigozrim Ekeke, Andrew Chang, David Odell, Laura A. Kresty
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5738 · PDF 超越bulk:利用多重空间分析和3D聚类分析解决RNASeq/质谱/IHC不一致,以优化HER3(bs)Ab和(bs)ADC治疗策略 Beyond bulk: Resolving RNASeq/mass spectrometry/IHC discrepancies with multiplexed spatial profiling and 3D cluster analysis to refine HER3 (bs)Ab and (bs)ADC therapeutic strategies Jeannette Fuchs, Christophe Mas, Eric Durandau, Diana Rocha Gomes, Min Ma, Antoine Attinger, Anna Pokorska-Bocci
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5739 · PDF 体外界定口腔鳞状细胞癌中的钠通道亚型 Defining sodium channel isoforms in oral squamous cell carcinoma in vitro Kelly Jean Sherman, Alexis Gray, Dennis Paul