T Cell Engagers 2 / Antibody-Drug Conjugates 1

• 5582 · PDF 携带第二信号的三特异性TCE可提升实体瘤应答的疗效、持久性与安全性 Trispecific TCE with second signal boosts solid tumor response efficacy, durability and safety Yuanyuan Wang, Huijuan Lu, Hanmian Cai, Chun Liu, Liang Xiao, Peipei Hu, Chang Zhou, Yongting Huo, Di Lu
• 5584 · PDF TCX-101:一种共靶向肿瘤相关碳水化合物(TACA)抗原与肿瘤相关蛋白抗原(TAA)的三特异性T细胞衔接器(TcE),用于治疗实体瘤并具有增强的临床前活性 TCX-101, a trispecific T-cell engager (TcE) co-targeting a tumor-associated carbohydrate (TACA) antigen and a tumor-associated protein antigen (TAA) for the treatment of solid tumors with enhanced preclinical activity Karla E. G. Soto, Francesco Muraca, Stephan Grunwald, Wiebke Winkler, Carolin Lange, Jean Engela, Peter Sondermann, Matthias Ocker
• 5585 · PDF ARK102:一种靶向TROP2、HER2和CD3的新型三特异性T细胞衔接器,用于治疗实体瘤 ARK102, a novel tri-specific T cell engager targeting TROP2, HER2, and CD3 for treatment of solid tumors Kyeongsik Min, Deukjoo Ahn, Sangwoo Park, Jaejin Jeon, Heeyeon Kim, Yongwon Jung, Yong-Boo Kuk, Jeongmin An, Taehwan Jeong, Seungwon Lee
• 5586 · PDF 一种靶向CDH17的下一代CD8选择性三特异性T细胞衔接器,具有增强的疗效和降低的毒性 A next-generation CD8-selective tri-specific T cell engager targeting CDH17 with enhanced efficacy and reduced toxicity Jian Guo, Jiaojiao Ding, Tian Wang, Hanmian Cai, Liang Xiao, Peipei Hu, Chang Zhou, Yongting Huo, Di Lu
• 5587 · PDF VTS208:一种用于治疗胃肠道(GI)癌症的首创CD3/CLDN18.2/CDH17三特异性T细胞衔接器(TCE) VTS208: A first-in-class CD3/CLDN18.2/CDH17 Tri-specific T cell engager (TCE) for the treatment of gastrointestinal (GI) cancer Wei (Vivian) Wang, Xuekun Zhang, Man Xu, Yingchun Wang, Mei Yuan, Yanwei Wang, Liping Chen, Yanling Gong, Jing Li
• 5588 · PDF 一种靶向CDH17并具有4-1BB共刺激的下一代三特异性T细胞衔接器,用于治疗胃肠道癌症 A next-generation tri-specific T cell engager targeting CDH17 with 4-1BB co-stimulation for the treatment of gastrointestinal cancers Shan Gao, Xiaoli Zhang, Yuanyuan Yang, Zhijian Cai, Feifei Cui, Liu Yang, Lei Fang
• 5589 · PDF 一种由mRNA-LNP递送的双互补位DLL3靶向三特异性T细胞衔接器在体外和体内驱动强效抗肿瘤活性 A biparatopic DLL3-targeting trispecific T-cell engager delivered by mRNA-LNP drives potent anti-tumor activity in vitro and in vivo Xue Qiao, Qiang Zhang, Lushuai Jin, Yao Lv, Shaoli Liu, Xiaoju Zhang, Xiaoyun Ma, Hongya Han, Wei Xu
• 5590 · PDF BCG024:一种新型DLL3×CD3×4-1BB三特异性T细胞衔接器,在临床前模型中增强T细胞持久性和功能 BCG024: A novel DLL3×CD3×4-1BB trispecific T cell engager enhances T cell persistence and functionality in preclinical models Guan Wang, Baihong Liu, Liu Yang, Xue Li, Shuangshi Liu, Yu Qi, Jinhua Zhao, Yang Chen, Frank An, Yi Yang
• 5591 · PDF 开发一种新型抗CD19 x BCMA双靶向T细胞衔接器,用于治疗自身免疫性疾病和B细胞恶性肿瘤 Development of a novel anti-CD19 x BCMA dual targeted T cell engager for the treatment of autoimmune diseases and B cell malignancies Lin Huan, Hao Ran, Shiyi Wang, Xiaoping Zhang, Bing Yang, Yang He, Dandan Liu, Chenpeng Su, Chuan Chen, Xiaoqian Chen, Kezhen Ye, Liang Tian, Jian Peng, Zhenping Zhu
• 5592 · PDF QL535:一种新型CD2共刺激的PSMA靶向T细胞衔接器,在PDX模型中具有剂量反应性疗效,并在NHP中呈现良好的GLP毒理学特征 QL535: A novel CD2-costimulating PSMA-targeted T-cell engager with dose-responsive efficacy in PDX models and a favorable GLP toxicology profile in NHP Xiao Liu
• 5593 · PDF 一种采用新型CD3结合物的CD19/BCMA双靶向VHH格式T细胞衔接器,具有增强的效力和安全性特征 A CD19/BCMA dual-targeting VHH format T-cell engager with novel CD3 binder for enhanced potency and safety profile Fan Wu, Yongfeng Li, Liang Xiao, Chang Zhou, Peipei Hu, Jiya Shi, Tingchu Wu, Yue Huang, Mengying Liang, Chun Liu, Yuanyuan Wang, Yongting Huo, Di Lu
• 5594 · PDF CD3和CD2信号的药理学整合触发CD2花冠的形成,从而增强T细胞活化 Pharmacological integration of CD3 and CD2 signaling triggers formation of a CD2 corolla that boosts T cell activation Sergio Trombetta, Shengpan Zhang, Tanmay Mitra, Salvatore Valvo, Colleen Brown, Oksana Segreeva, Stella Martomo, Martin Preyer, Jay Fine, Jeremy Myers, Michael Dustin
• 5595 · PDF 开发EDP001,一种靶向CD19和BCMA的四价T细胞衔接器,用于治疗B细胞淋巴瘤 Development of EDP001, a tetravalent T Cell engager targeting CD19 and BCMA for B Cell lymphoma Qinglin Du, Zongjun Xia, Pan Du, Xing Wang, Xiaoman Wang, Feng Wang, Xueyan Yang, Yi Wu, Shuhua Han
• 5597 · PDF Plinabulin在有或无免疫检查点抑制剂的情况下增强基于拓扑异构酶抑制剂的抗体药物偶联物的抗肿瘤疗效 Plinabulin boosts antitumor efficacy of topoisomerase inhibitor-based antibody-drug conjugates without or with immune checkpoint inhibitor Yingjuan June Lu, Xiaoyan He, Weiwei Cheng, Zhengyan Zhang, James Tonra, Lan Huang
• 5598 · PDF 利用电子传递链动力学使OXPHOS依赖性癌症对免疫疗法敏感 Exploiting electron transport chain dynamics to sensitize OXPHOS-dependent cancers to immunotherapy Haojie Dong, Guoyun Kao, Umesh P. Yadav, Lei Zhang, Arshad J. Ansari, Srinivasarao Singireddi, Bei Jia, Jianai Sun, Guohua Wu, Yini Wang, Xin He, Lei Zhang, Zheng Li, Ruiheng Wang, Wei Chen, Meng Liu, Shuaishuai Ge, Yang Li, Whitaker Cohn, Amandeep Salhotra, David B. Sykes, Jie Jin, Jianjun Chen, Guido Marcucci, Shoubao Ma, Hong Zheng, Yong Zhang, Ling Li
• 5599 · PDF ATG-125,一种新型B7H3 × PD-L1双特异性抗体药物偶联物,通过双靶向免疫逃逸和直接肿瘤杀伤展现出强效抗肿瘤疗效 ATG-125, a novel B7H3 × PD-L1 bispecific antibody-drug conjugate, demonstrates potent antitumor efficacy by dual targeting of immune evasion and direct tumor killing Jishun Chen, Suya Bai, Yu Bai, Huiling Liu, Zaoshun Hu, Jay Mei, Peng Chen, Bing Hou
• 5601 · PDF LBL-061：一种用于治疗多种实体瘤的新型EGFR×PD-L1靶向药物偶联物 LBL-061: A novel EGFR×PD-L1 targeted drug conjugate for the treatment of multiple solid tumors Yurong Qin, Yang Ye, Yujia Dang, Juan Tang, Peng Zhang, Yan Zhu, Shuijun Hu, Mi Ye, Xiaoxiao Liu, Xu Bao, Huan Lin, Wanting Wang, Guojin Wu, Jianming Sun, Hui Yuwen, Yuanzhi Lv, Jing Guan, Min Chen, Yue Zhao, Jordan Zhu, Charles Cai, Xiao Huang, Xiaoqiang Kang, Hong Ling
• 5602 · PDF 用于靶向PD-L1的抗体药物偶联物的新型ATR抑制剂载荷 Novel ATR inhibitor payloads for antibody-drug conjugates targeting PD-L1 Anne Roulston, Martin Duplessis, Francois Denis, Hugo Poirier, Shou Yun Yin, Sara Fournier, Roselyn Kryczka, Jessica Desjardins, Nancy Laterreur, Abira Rajah, Alexanne Bonneau-Fortin, Bingcan Liu, Alejandro Alvarez-Quilon, Philipe Mochirian, Ismael Samudio
• 5603 · PDF 靶向小细胞肺癌（SCLC）肿瘤-免疫微环境（TIME）中的B7-H3 Targeting B7-H3 in the small cell lung carcinoma (SCLC) tumor-immune microenvironment (TIME) Marco Campisi, Carla Stornante, Ian D. Dryg, Harrison Olszewski, Alan E. Bers, Ian Gillanders, Kathleen Pfaff, Robert Gentleman, Scott Rodig, Navin R. Mahadevan, David A. Barbie
• 5604 · PDF TAK-188，一种具有新型鹅膏蕈碱载荷的抗体药物偶联物，通过选择性清除CCR8+瘤内调节性T细胞破坏免疫抑制并产生强效抗肿瘤免疫 TAK-188, an antibody-drug conjugate with a novel amanitin payload, disrupts immune suppression and leads to potent anti-tumor immunity through selective depletion of CCR8 + intratumoral regulatory T-cells Cierra N. Casson, Eun-Ah Bae, Sarah B. Hesse, Carla Guarino, Rohan Diwanji, Tiquella Hatten, Adam Hinthorne, Jian Huang, Ajeeth K. Pingili, Judy Qiuju Shi, Natasha Iartchouk, Brandon Wilkinson, Jessica Riceberg, Anikó Palfi, Natalie Roy D’Amore, Torsten Hechler, Adnan O. Abu-Yousif
• 5605 · PDF 用于靶向化学免疫治疗的先进双载荷抗体药物偶联物 Advanced dual payload antibody-drug conjugates for targeted chemoimmunotherapy X. Margaret Liu, Zhuoxin “Zora” Zhou

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