LBPO.BCS02 · 生物信息与计算 · Late-Breaking
Late-Breaking Research: Bioinformatics, Computational Biology, Systems Biology, and Convergent Science 2
- LB433 LB433 从快速尸检对转移性前列腺癌演进进行多组学重建揭示多克隆播散及对液体活检的意义 Multi-omic reconstruction of metastatic prostate cancer evolution from rapid autopsy reveals polyclonal seeding and implications for liquid biopsy Azhar Khandekar, Manasvita Vashisth, Pushpa Itagi, Robert Patton, Mohamed Adil, Patricia Galipeau, Michael Haffner, Colm Morrisey, Peter Nelson, Gavin Ha
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- LB436 LB436 缺氧驱动的磷脂酰丝氨酸重塑促进头颈部鳞状细胞癌中ADAM17的构象可塑性 Hypoxia-driven phosphatidylserine remodeling promotes conformational plasticity of ADAM17 in head and neck squamous cell carcinoma James Waters, Jonah Wannebo, Alicja Gluszko
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- LB438 LB438 通过多尺度机制性通路串扰分析解码治疗诱导的肿瘤微环境网络重连以克服耐药 Decoding therapy-induced rewiring of the tumor microenvironment networks to overcome drug resistance through multiscale mechanistic pathway crosstalk analysis Minsoo Choi
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- LB440 LB440 定量系统药理学（QSP）助力AMP01的研究与转化，AMP01是一种新型次世代抗PD1双特异性药物，可放大并将内源性IL15重定向至PD1高表达T细胞，从而最大化疗效和治疗指数 Quantitative Systems Pharmacology (QSP) enables research and translation of AMP01, a novel next generation anti PD1 bispecific that amplifies and redirects endogenous IL15 to PD1 high expressing T Cells, maximizing efficacy and therapeutic index John M. Burke, Abhishek Mukhopadhyay, Mark Fogg, Stacey Tom-Yew, Harsh Pratap, David Flowers, Diana Marcantonio, Sarah Minucci, Diana Hausman, David de Graaf, Surjit Dixit
- LB441 LB441 面向平台化PBPK-QSP模型用于GenSci139的首次人体剂量选择——GenSci139是一种潜在同类最佳的EGFR×HER2双特异性ADC，用于癌症患者 Towards a platform PBPK-QSP model for first-in-human dose selection of GenSci139, a potential best-in-class EGFR×HER2 bispecific ADC, in patients with cancer Fan Zhang, Yehua Xie, Guangli Ma, Xiao Liang, Xumin Zhao, Yihui Lin, Xuan Ye, Peng Qi, Xiaozhen Wang, Haizhou Zhang, Shu Zhang, Siqin Wang, Lei Jin
- LB442 LB442 全身PBPK/PD建模以支持GenSci140（一种潜在同类最佳FRalpha双互补位ADC）在癌症患者中的首次人体剂量选择 Whole body PBPK/PD modeling to support first-in-human dose selection for GenSci140, a potential best-in-class FRalpha biparatopic ADC, in patients with cancer Fan Zhang, Yehua Xie, Guangli Ma, Xiao Liang, Xumin Zhao, Yihui Lin, Xuan Ye, Peng Qi, Xiaozhen Wang, Haizhou Zhang, Shu Zhang, Siqin Wang, Lei Jin
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- LB447 LB447 Somatic DiagAI：对药物-变异关联进行自动评分以支持癌症基因组学中的临床决策 Somatic DiagAI: Automated scoring of drug-variant associations to support clinical decision-making in cancer genomics Nicolas Duforet Frebourg, Daiana Ganiewich, Mitchell Nemcek
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- LB449 LB449 追踪人类结肠从发育经衰老的克隆演化以理解结直肠癌的起始 Tracing clonal evolution of the human colon from development through aging to understand colorectal cancer initiation Jinsil Jeong, Jeong Mo Bae, Seung-Yong Jeong, Ji Won Park, Hyun Jung Lee, Min Jung Kim, Young Seok Ju
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