PO.CL06.03 · 临床研究
Targeted Therapies, Predispositions, and Survivorship in Pediatric Cancers
- 7870 7870 用TAK-981靶向MYC-SUMO轴逆转免疫抑制并恢复骨肉瘤中的抗原呈递 Targeting the MYC-SUMO axis with TAK-981 reverses immune suppression and restores antigen presentation in osteosarcoma Bikesh Kumar Nirala, Jeffrey Ritzenthaler, Tajhal Patel, Taku Yamamichi, Ryo Tsukada, Lyazat Kurenbekova, Juan Dou, Heath Bradley, Atreyi Dasgupta, Jason T. Yustein
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- 7873 7873 一种靶向IGF-1R的新型"载荷型"多肽LX-101在尤因肉瘤中的体内临床前疗效 In vivo preclinical efficacy of a novel “payload-bearing” peptide LX-101 targeting IGF-1R in Ewing sarcoma Roberto Cardenas-Zuniga, Jiaqian Fan, Asmaa G. Ahmed, Marcus Thurm, Kien Ryan Cao, Clement Agyemang, Danh Truong, Joseph A. Ludwig
- 7874 7874 细胞黏附分子1(CADM1)-GGFG-Exatecan与CADM1-PEG3-VC-Exatecan在骨肉瘤临床前模型中的剂量反应疗效对比 Dose-response efficacy of cell adhesion molecule 1 (CADM1)-GGFG-Exatecan vs CADM1-PEG3-VC-Exatecan in preclinical osteosarcoma models Zhongting Zhang, Caterina Longo, Wendong Zhang, Yifei Wang, Yanhua Yi, Zhaohui Xu, Xin Zhou, Adil Bahadir, Michael Roth, Jonathan Gill, Richard Gorlick
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- 7876 7876 褪黑素在儿童癌症幸存者的临床前模型中防护长期多柔比星诱导的心脏毒性 Melatonin protects against long-term doxorubicin-induced cardiotoxicity in a preclinical model of childhood cancer survivors Marisol Fernandez Ortiz, Logan Davis, Joseph Schell, Erik Marchant, Blake Rasmussen, David Gius, Gregory Aune
- 7877 7877 AVA-NP-695与DDRi联用展现出强烈协同作用,在罕见儿童癌症中产生强效抗肿瘤活性 Combination of AVA-NP-695 and DDRi demonstrates strong synergy resulting in potent anti-tumor activity in rare pediatric cancers Aditya Kulkarni, Borja Ruiz-Fernandez de Cordoba, Avijit Goswami, Sandeep Goyal, Kawaljit Singh, Princy Khurana, Alejandro Sweet-Cordero
- 7878 7878 破坏脂质-ETV6轴:尤因肉瘤中的一个治疗易感性 Disrupting the lipid-ETV6 axis: A therapeutic vulnerability in Ewing sarcoma Yuan Gao, Hang Zhao
- 7879 7879 Opaganib与奥沙利铂和多柔比星联用作为复发/难治性高危神经母细胞瘤的新型挽救治疗 Opaganib in combination with oxaliplatin and doxorubicin as a novel salvage therapy for relapsed/refractory high-risk neuroblastoma Jeremy Hengst, Mohammad Haque, Muhammad Younis, Thussenthan Walter Angelo, Anna Bourne, Katherine McClain, Meenakshi Shukla, Jonathan Lerch, Tarlan Arjmandi, Eric Cochran, Lynn Maines, Charles D. Smith, Vladimir S. Spiegelman, Jacqueline M. Kraveka, Giselle L. Saulnier Sholler
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- 7883 7883 表面CADM1（细胞黏附分子1）丰度可预测CADM1-GGFG-Exatecan ADC在骨肉瘤中的载荷递送及体外疗效，有助于优选候选药物 Surface CADM1 (Cell Adhesion Molecule 1) abundance predicts payload delivery and in-vitro efficacy of CADM1-GGFG-Exatecan ADC in osteosarcoma, aiding optimal candidate selection Caterina Longo, Zhongting Zhang, Wendong Zhang, Yifei Wang, Adil Bahadir, Yi Yanhua, Zhaohui Xu, Xin Zhou, Michael Roth, Jonathan Gill, Richard Gorlick
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- 7885 7885 界定儿科及青少年和年轻成人（AYA）骨与软组织肉瘤的全基因组cfDNA甲基化图谱 Defining genome-wide cfDNA methylation landscapes in pediatric and adolescent and young adult (AYA) bone and soft-tissue sarcomas Lilli J. Greiner, Roman O. Kowalchuk, Jeff Szymanski, Pradeep S. Chauhan, Adam Amundson, Peter J. Schoettler, Wendy Allen-Rhoades, Stephanie F. Polites, Peter S. Rose, Kelly Bailey, Linda McAllister-Lucas, Anita Mahajan, Nadia Laack, Aadel Chaudhuri
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- 7887 7887 儿童癌症幸存者中免疫失调多基因风险评分与霍奇金淋巴瘤之间的关联 Associations between polygenic risk scores for immune dysregulation and Hodgkin lymphoma in childhood cancer survivors Ji Yun Tark, Sharon M. Castellino, Philip J. Lupo, Austin L. Brown
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- 7891 7891 儿童精准癌症医学时代分子匹配靶向治疗的真实世界治疗：取得进展还是缓慢前行？ Real world treatment with molecularly matched targeted therapies in the era of pediatric precision cancer medicine: Gaining ground or inching forward? Jennifer A. Oberg, Jack Boublik-Whiteley
- 7892 7892 儿童急性髓系白血病（AML）风险的多祖源全基因组关联研究（GWAS）识别出四个风险位点 Multi-ancestry genome-wide association study (GWAS) of pediatric acute myeloid leukemia (AML) risk identifies four risk loci Cindy Im, Lauren J. Mills, Peggy Meng, Marijana Vujkovic, Jenny N. Poynter, Melissa Maria Hudson, Kirsten K. Ness, Joseph L. Wiemels, Logan G. Spector, Saonli Basu, Zhaoming Wang, Richard Aplenc
