PO.ET08.03 · 实验与分子治疗
Targeted Radiopharmaceuticals and Combination Strategies in Cancer Therapy
- 7182 7182 用于前列腺癌的新型高亲和力PSMA靶向放射性配体177Lu-PSMA-3D1015的开发与评价 Development and evaluation of a novel high affinity PSMA-targeted radioligand 177 Lu-PSMA-3D1015 for prostate cancer Lu Hou, Quanpeng Wang, Haitian Fu, Chuang Xi, Wanggui Yang, Fangqiang Tang, Qing Gao, Lan Qin, Wenhua Huang, Henry Ho, Chunjing Yu, John Gong
- 7183 7183 SCN-PYTA:一种用于三价放射性金属的新型双功能螯合剂(BFC),用于开发靶向特异性的显像与治疗放射性药物 SCN-PYTA: A new bifunctional chelator (BFC) for trivalent radiometals to develop target-specific radiopharmaceuticals for imaging and therapy Shankar Vallabhajosula, Nikki A. Thiele, Kyu J. Son, Vicente Navarro, Md Faizul Islam, Alex Brown, Neil H. Bander, Phillip W. Kantoff
- 7184 7184 GT-008:一种可实现对CD24肿瘤相关糖基化形式选择性放射性核素递送的单克隆抗体——临床前概念验证研究 GT-008: A monoclonal antibody enabling selective radionuclide delivery to a tumor-associated glycosylation form of CD24 - Preclinical proof-of-concept study Johanna Gellert, Andreas Franz, Manon Weis, Evelyn Hartung, Stephanie Gurka, Lydia Verlaat, Sophie Marinoff, Antje Danielczyk, Patrik Kehler, Dirk Pleimes
- 7185 7185 ²²⁵Ac-RAX104:一种针对锕-225优化的新型PSMA靶向放射性配体,展现出增强的肿瘤滞留和更优的疗效 ²²⁵Ac-RAX104: A novel PSMA-targeted radioligand optimized for actinium-225 demonstrates enhanced tumor retention and superior efficacy Xupeng Hu, Yang Cao, Min Hong, Shuanglong Liu, Guangzhou Han, Gang Chen
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- 7187 7187 BRP-020063的临床前评价——一种用于治疗nectin4阳性癌症的首创基于肽的放射性药物 Preclinical evaluation of BRP-020063, a first-in-class peptide based radiopharmaceutical for the treatment of nectin4-positive cancers Maoyi Lei, Lei Peng, Bo Shan
- 7188 7188 靶向降钙素基因相关肽受体(CGRPR)的诊疗一体化策略在人类癌症临床前小鼠模型中显示出疗效 Theranostics targeting the calcitonin gene-related peptide receptor (CGRPR) demonstrate efficacy in a preclinical mouse model of human cancer Prabhakar Eeka, Darpan N. Pandya, Andrew F. Russo, Yusuke Shiozawa, Thaddeus J. Wadas
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- 7191 7191 6-thio-dG通过重塑肿瘤微环境增强多形性胶质母细胞瘤的标准放射治疗 6-thio-dG enhances standard-of-care radiation therapy by reprogramming the tumor microenvironment in glioblastoma multiforme Anthony Alexander Grichuk, Merve Yilmaz, Summer Barron, Priya Darbha, Shannon M. McCabe, Jerry W. Shay, Kristin Huntoon
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- 7193 7193 短暂暴露于TTFields通过下调DNA修复通路增强胶质母细胞瘤的放射应答 Short exposure to TTFields potentiates radiation response in glioblastoma via downregulation of DNA repair pathways Anat Klein-Goldberg, Tali Voloshin, Aviv Meir, Efrat Zemer-Tov, Hila Ene, Lena Lifshitz, Kerem Wainer-Katsir, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti
- 7194 7194 抑制谷氨酰胺代谢联合放射破坏线粒体功能并损害同源重组 Inhibiting glutamine metabolism in combination with radiation disrupts mitochondrial function and impairs homologous recombination Scott Bright, Yogesh Rai, Rishab Kolachina, Hadil Elldakli, Mark D. Wasley, Gabriel O. Sawakuchi
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- 7196 7196 通过成像质谱流式细胞术检测放射性药物及其冷替代物可实现单细胞功能应答、治疗性生物分布及免疫微环境调控的评估 Detection of radiopharmaceuticals and their cold surrogates by Imaging Mass Cytometry enables assessment of single-cell functional response, therapeutic biodistribution, and modulation of the immune microenvironment Jennifer L. Gorman, Felix B. Salazar, Kevin Wyszatko, Michael J. Geuenich, Smriti Kala, Thom G. A. Reuvers, Matthew Watson, Daniel Majonis, Hang Zhou, Bao Ying Chen, Christopher Heskett, Marjolijn Hameetman, Qanber Raza, Sheila Singh, Christina Loh, James Mansfield, Julie Nonnekens, Erik de Blois, Kieran R. Campbell, Saman Sadeghi, Anna M. Wu, Hartland W. Jackson
- 7197 7197 MP0712的分子特征——一种处于临床阶段、基于²¹²Pb的Radio-DARPin候选药物,用于小细胞肺癌(SCLC)的靶向抗DLL3放射治疗 Molecular characteristics of MP0712, a clinical stage ²¹²Pb-based Radio-DARPin candidate for targeted anti-DLL3 radiotherapy of small cell lung cancer (SCLC) Stefanie Riesenberg, Amal Saidi, Francesca Malvezzi, Aaron Schatzmann, Christian Reichen, Tania Stallons, Nicole Pina, Aline Eggenschwiler, Amy Wong, Madlaina Mettier, Jitka Rantanen, Marcela Guzman-Ayala, Julien Torgue, Daniel Steiner
- 7198 7198 新一代肿瘤治疗电场技术与肉桂醛/肉桂油对三阴性乳腺癌细胞凋亡、细胞周期阻滞及生长抑制的协同作用 Synergistic effects of next-generation Tumor-Treating Fields technology and cinnamaldehyde/cinnamon oil on apoptosis, cell cycle arrest and growth suppression in triple-negative breast cancer cells Saqib N. Peracha, Joseph M. Rohde, Margaux A. Santos, Emma C. Higgins, Lexa M. Campbell, Wageesha T. Mallehevidana, Juliana R. Seide, Aidan Hollister, Therese M. Annulis, Abdu Mohammed, Kiran Khurshid, Noor U. Huda, Aaron P. Provenzano, Jason R. Henderson, Daniel Kuebler, Joseph A. Pathakamuri, John J. O'Connell
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- 7201 7201 用于增强放射免疫治疗疗效的可点击裂解放射免疫偶联物的临床前评估 Preclinical evaluation of click-cleavable radioimmunoconjugates for enhanced treatment efficacy in radioimmunotherapy Marleen H. M. E. van Stevendaal, Kim E. de Roode, Luc H. M. Zijlmans, Jenne T. Meinema, Hendrina M. de Wert-Wattimury, Renate C. van Daalen-Bruens, Bianca Matthee, Mark W. Konijnenberg, James Nagarajah, Raffaella Rossin, Marc S. Robillard
- 7202 7202 在临床前前列腺癌异种移植模型中对²²⁵Ac-PSMA-Trillium与其他²²⁵Ac-PSMA-SMOL资产的比较评估 Comparative evaluation of 225 Ac-PSMA-Trillium with other 225 Ac-PSMA-SMOL assets in a preclinical prostate cancer xenograft model Urs B. Hagemann, Maria Spelling, Shankari Nair, Martin Kohs, Meike Fehder, Stefan Stargard, Sabine Zitzmann-Kolbe, Dmitry Zubov, Ming Xu
- 7203 7203 基于²¹²Pb的CEA预靶向放射免疫治疗在免疫缺陷和人源化小鼠模型中展现出肿瘤靶向和强效TGI,为mCRC的FIH研究提供依据 212 Pb-based CEA pretargeted radioimmunotherapy demonstrates tumor targeting and potent TGI in immunodeficient and humanized mouse models, informing a FIH study in mCRC Sofia H. L. Frost, Alexandre Pichard, Annabelle Mouchotte, Agnès Colmont, Sara Colombetti, Alexander Haas, Hans Peter Grimm, Birgit Kittel, Stephen Fowler, Bernhard Reis, Vincent Wolowski, Uta Sweere, Michael Hettich, Wolfgang Jacob, Frederic Prince, Christian Klein, Pablo Umana, Julien Torgue, Axel Boehnke
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