Tumor Models and Assays: In Vitro, In Vivo

• 7520 · PDF Developing patient-derived organoid and xenograft models for preclinical assessment in ovarian cancer Choong-Jae Lee, Jubi Heo, Joo Hang Jeong, Ha-eun Lee, Jinyoung Park, Wonyoung Choi, Sang Yoon Park, Yo Han Woo, Myong Cheol Lim, Sun-Young Kong
• 7521 · PDF Optimization of tumor tissue enzymatic dissociation for rapid and viable tumoroid generation Colin D. Paul, Anthony Chatman, Logan Wilson, Chris Yankaskas, Pradip Shahi Thakuri, Matt Dallas, David Kuninger
• 7522 · PDF Ex vivo drug sensitivity and in silico evaluation of phytochemicals in gynaecological cancers Maria Nomusa Sikhakhane, Deepak Govindaraj, Mutsa Monica Takundwa, Xavier Siwe Noundou
• 7523 7523 A vascularized glioblastoma tumor spheroid model for studying tumor invasion and therapeutic response Anagha Shreesha, Sheridan Ke-Wing Fok, Brendan Harley
• 7524 · PDF Genetically defined organoid systems uncover PIK3CA-mediated suppression of an oral-immune program during early squamous neoplastic evolution Hua Zhao, Young Min Park, Yueyuan Zheng, Qiong Mao, Hao Wu, Fanyi Mo, Uttam K. Sinha, Parish Sedghizadeh, De-Chen Lin
• 7525 · PDF Drug screening using patient-derived tumoroids harboring diverse mutations to identify effective therapeutics for metastatic cancer patients Seyoum Ayehunie, Dylan Bryda, Alex armento, Groves Megan, Anthony Tolcher
• 7526 · PDF Breast cancer organoids as a complementary preclinical model to PDX, enabling immunotherapy evaluation Olivier Déas, Emilie Indersie, Amandine Prioux-Quartier, Philippe Lluel, Emilie Decaup
• 7527 · PDF Sequential 3D functional profiling shows preserved drug resistance and sensitivity profiles after neoadjuvant treatment in an ovarian cancer patient Chiara Maestri, Ivan Trus, Rajeshwar Nitiyanandan, Ricardo J. Parker, Chris Apfel
• 7528 · PDF Utilizing confocal live-cell imaging for evaluating therapeutic efficacy and toxicity in complex oncology models John Rauch, Jasmine Trigg, Kirsty McBain, Jonathan Bezenah, Libuse Oupicka, Richard Lister, Laura Skerlos
• 7529 7529 Reproducible 3D bioprinting of patient-derived tumors enables high-fidelity preclinical drug testing H. Nikki March, Ben Kennedy, Olivia Matthews, Andrew McCormack, Abby McSorley, Laura Nixon, Lorna Ewart
• 7530 · PDF Comparative analysis of therapy responses and stem cell marker expression in glioblastoma neurospheres verus monolayer cultures using imaging, cytotoxicity assays, and flow cytometry Daniel S. Costa, Joseph P. Kolb, Olivia Mankos, Karsten E. Fynboe, Stephanie M. Fogerson, William D. Culp, Kathryn R. Meshaw
• 7532 · PDF Multi-cancer patient-derived organoid platform for translational cancer research JUBI HEO, Choong-Jae LEE, Eun Joo LEE, Sung Weon Choi, Sang-Jae Park, Sang Myung Woo, Sang Yoon Park, Myong Cheol Lim, So-Youn Jung, Bo Hyun Kim, Jung Won Chun, Joohyun Hong, Wonyoung Choi, Sun-Young Kong
• 7533 · PDF The protease MALT1 is required for chronic lymphocytic leukemia genesis in Eμ-TCL1 mice Delia Carlino, Julia Boehling, Terri Rasmussen, Van Hoang, Carole Bitar, Matthew Burow, Nakhle Saba
• 7534 · PDF Novel mouse models for cancer research Jason Beckwith, Jen Merriam, Darcy Pomerleau, Crystal Davis, Jennifer Kelmenson, Hiroaki Onda
• 7535 · PDF Over 800! Establishment of an ADC payload efficacy database across diverse tumor cell lines: Foundation for optimized in vitro ADC evaluation and drug development Guoqian Wang, Yao Tang, Jingxiao Xu, Tingduo Lv, jinying ning, Feng Hao
• 7536 · PDF In vitro and in vivo screening platform for discovery of JAK2 inhibitors Na Li, Hao Huang, Xinyu Zhong, Guoqian Wang, Xuyang Duan, Yue Huang, Jinying Ning, Feng Hao
• 7537 · PDF From BTK in-situ mutation (C481S, A428D, etc.) to in vivo screening: A comprehensive platform to address drug resistance in BTK-targeted therapy Yao Tang, Guoqian Wang, Hao Huang, Yue Huang, Jinying Ning, Feng Hao
• 7538 · PDF Establishment of a translational research ecosystem: A globally networked PDX model platform to accelerate oncology drug development Alyssa Simonson, Anna Stackpole, Amy Fredrickson, Johnnie Mitchell, Jennifer Garcia, Natalia Baños Herraiz, Jim Lund, Ashley Jamison, Andrew Cunningham, Kyriakos P. Papadopoulos, Victor Moreno Garcia, Emiliano Calvo, Chris Takimoto, Michael J. Wick
• 7539 · PDF In vivo metastatic prostate tumor model development and follow-up progression using in vivo bioluminescence imaging Vincent Faugeroux, Nicolas Hoffmann, Sarah Belderbos, Maëva Albanese, Kenny Herry, Nicolas Ancellin, Caroline Mignard, Marc Hilairet de Boisferon
• 7540 · PDF Integrated multi-omics analysis reveals conserved tumor-associated antigens (TAAs) profiles in PDX and organoid models for advancing ADC development Xiaolong Tu, Likun Zhang, Jie Lin, Hengyuan Liu, Jun Zhou, Marrit Putker, Ludovic Bourre, Julie Myer
• 7541 · PDF Comprehensive preclinical in vivo oncology platform for rational drug candidate nomination Amandine Alard, Marie Lafitte, Nizar Serhan, Giuseppina Claps, Frédérique Dol-Gleizes, Pascale Lejeune
• 7542 · PDF In vitro and in vivo evaluation of bortezomib using the 5TGM1 cell line and a syngeneic mouse model of multiple myeloma Mari I. Suominen, Katja M. Fagerlund, Justyna Zdrojewska, Jukka P. Rissanen, Jenni H. E. Mäki-Jouppila
• 7544 · PDF Validation of a bone metastasis technology platform against clinically used standard-of-care therapies Tiina E. Kähkönen, Jie Wen, Ru Yang, Jussi M. Halleen
• 7548 · PDF Mechanistic insights into reactive oxygen species (ROS) homeostasis in ovarian cancer chemoresistance Minjun HE, Michelle K.Y. SIU, Mingo M.H. YUNG, Crystal TANG, Ruiqian ZHANG, Cui CAN, Xiaoyan ZHONG, Haonan LU, Kui LIU, Annie N.Y. CHEUNG, Hextan Y.S. NGAN, David W. CHAN, Karen K.L. CHAN
• 7549 · PDF Development of personalized medicine strategies for rectal cancer Kiki Lianos, Kelly Olsen, Aleksandra Edmundson, Danielle Siganto, Matthew Burge, David Clark, Vicki Whitehall

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