Tumor Models and Assays: In Vitro, In Vivo

• 7520 · PDF 开发用于卵巢癌临床前评估的患者来源类器官和异种移植模型 Developing patient-derived organoid and xenograft models for preclinical assessment in ovarian cancer Choong-Jae Lee, Jubi Heo, Joo Hang Jeong, Ha-eun Lee, Jinyoung Park, Wonyoung Choi, Sang Yoon Park, Yo Han Woo, Myong Cheol Lim, Sun-Young Kong
• 7521 · PDF 优化肿瘤组织酶解离以快速生成有活力的类肿瘤体 Optimization of tumor tissue enzymatic dissociation for rapid and viable tumoroid generation Colin D. Paul, Anthony Chatman, Logan Wilson, Chris Yankaskas, Pradip Shahi Thakuri, Matt Dallas, David Kuninger
• 7522 · PDF 妇科肿瘤中植物化学物质的离体药物敏感性与计算机模拟评估 Ex vivo drug sensitivity and in silico evaluation of phytochemicals in gynaecological cancers Maria Nomusa Sikhakhane, Deepak Govindaraj, Mutsa Monica Takundwa, Xavier Siwe Noundou
• 7523 7523 用于研究肿瘤侵袭和治疗反应的血管化胶质母细胞瘤肿瘤球模型 A vascularized glioblastoma tumor spheroid model for studying tumor invasion and therapeutic response Anagha Shreesha, Sheridan Ke-Wing Fok, Brendan Harley
• 7524 · PDF 基因定义的类器官系统揭示早期鳞状肿瘤演变过程中PIK3CA介导的口腔-免疫程序抑制 Genetically defined organoid systems uncover PIK3CA-mediated suppression of an oral-immune program during early squamous neoplastic evolution Hua Zhao, Young Min Park, Yueyuan Zheng, Qiong Mao, Hao Wu, Fanyi Mo, Uttam K. Sinha, Parish Sedghizadeh, De-Chen Lin
• 7525 · PDF 利用携带多种突变的患者来源肿瘤类器官进行药物筛查，以识别针对转移性癌症患者的有效治疗药物 Drug screening using patient-derived tumoroids harboring diverse mutations to identify effective therapeutics for metastatic cancer patients Seyoum Ayehunie, Dylan Bryda, Alex armento, Groves Megan, Anthony Tolcher
• 7526 · PDF 乳腺癌类器官作为PDX的互补临床前模型，实现免疫治疗评估 Breast cancer organoids as a complementary preclinical model to PDX, enabling immunotherapy evaluation Olivier Déas, Emilie Indersie, Amandine Prioux-Quartier, Philippe Lluel, Emilie Decaup
• 7527 · PDF 序贯3D功能分析显示一例卵巢癌患者在新辅助治疗后药物耐药和敏感性特征得以保留 Sequential 3D functional profiling shows preserved drug resistance and sensitivity profiles after neoadjuvant treatment in an ovarian cancer patient Chiara Maestri, Ivan Trus, Rajeshwar Nitiyanandan, Ricardo J. Parker, Chris Apfel
• 7528 · PDF 利用共聚焦活细胞成像评估复杂肿瘤学模型中的治疗疗效和毒性 Utilizing confocal live-cell imaging for evaluating therapeutic efficacy and toxicity in complex oncology models John Rauch, Jasmine Trigg, Kirsty McBain, Jonathan Bezenah, Libuse Oupicka, Richard Lister, Laura Skerlos
• 7529 7529 患者来源肿瘤的可重复3D生物打印实现高保真临床前药物测试 Reproducible 3D bioprinting of patient-derived tumors enables high-fidelity preclinical drug testing H. Nikki March, Ben Kennedy, Olivia Matthews, Andrew McCormack, Abby McSorley, Laura Nixon, Lorna Ewart
• 7530 · PDF 利用成像、细胞毒性检测和流式细胞术，对胶质母细胞瘤神经球与单层培养中的治疗反应及干细胞标志物表达进行比较分析 Comparative analysis of therapy responses and stem cell marker expression in glioblastoma neurospheres verus monolayer cultures using imaging, cytotoxicity assays, and flow cytometry Daniel S. Costa, Joseph P. Kolb, Olivia Mankos, Karsten E. Fynboe, Stephanie M. Fogerson, William D. Culp, Kathryn R. Meshaw
• 7532 · PDF 用于转化癌症研究的多癌种患者来源类器官平台 Multi-cancer patient-derived organoid platform for translational cancer research JUBI HEO, Choong-Jae LEE, Eun Joo LEE, Sung Weon Choi, Sang-Jae Park, Sang Myung Woo, Sang Yoon Park, Myong Cheol Lim, So-Youn Jung, Bo Hyun Kim, Jung Won Chun, Joohyun Hong, Wonyoung Choi, Sun-Young Kong
• 7533 · PDF 蛋白酶MALT1是Eμ-TCL1小鼠慢性淋巴细胞白血病发生所必需的 The protease MALT1 is required for chronic lymphocytic leukemia genesis in Eμ-TCL1 mice Delia Carlino, Julia Boehling, Terri Rasmussen, Van Hoang, Carole Bitar, Matthew Burow, Nakhle Saba
• 7534 · PDF 用于癌症研究的新型小鼠模型 Novel mouse models for cancer research Jason Beckwith, Jen Merriam, Darcy Pomerleau, Crystal Davis, Jennifer Kelmenson, Hiroaki Onda
• 7535 · PDF 超过800种！建立跨多种肿瘤细胞系的ADC载荷疗效数据库：优化体外ADC评估与药物开发的基础 Over 800! Establishment of an ADC payload efficacy database across diverse tumor cell lines: Foundation for optimized in vitro ADC evaluation and drug development Guoqian Wang, Yao Tang, Jingxiao Xu, Tingduo Lv, jinying ning, Feng Hao
• 7536 · PDF 用于发现JAK2抑制剂的体外和体内筛选平台 In vitro and in vivo screening platform for discovery of JAK2 inhibitors Na Li, Hao Huang, Xinyu Zhong, Guoqian Wang, Xuyang Duan, Yue Huang, Jinying Ning, Feng Hao
• 7537 · PDF 从BTK原位突变（C481S、A428D等）到体内筛选：一个应对BTK靶向治疗耐药性的综合平台 From BTK in-situ mutation (C481S, A428D, etc.) to in vivo screening: A comprehensive platform to address drug resistance in BTK-targeted therapy Yao Tang, Guoqian Wang, Hao Huang, Yue Huang, Jinying Ning, Feng Hao
• 7538 · PDF 建立转化研究生态系统：一个全球联网的PDX模型平台以加速肿瘤药物开发 Establishment of a translational research ecosystem: A globally networked PDX model platform to accelerate oncology drug development Alyssa Simonson, Anna Stackpole, Amy Fredrickson, Johnnie Mitchell, Jennifer Garcia, Natalia Baños Herraiz, Jim Lund, Ashley Jamison, Andrew Cunningham, Kyriakos P. Papadopoulos, Victor Moreno Garcia, Emiliano Calvo, Chris Takimoto, Michael J. Wick
• 7539 · PDF 利用体内生物发光成像建立体内转移性前列腺肿瘤模型并随访进展 In vivo metastatic prostate tumor model development and follow-up progression using in vivo bioluminescence imaging Vincent Faugeroux, Nicolas Hoffmann, Sarah Belderbos, Maëva Albanese, Kenny Herry, Nicolas Ancellin, Caroline Mignard, Marc Hilairet de Boisferon
• 7540 · PDF 整合多组学分析揭示PDX与类器官模型中保守的肿瘤相关抗原（TAAs）谱，助力推进ADC开发 Integrated multi-omics analysis reveals conserved tumor-associated antigens (TAAs) profiles in PDX and organoid models for advancing ADC development Xiaolong Tu, Likun Zhang, Jie Lin, Hengyuan Liu, Jun Zhou, Marrit Putker, Ludovic Bourre, Julie Myer
• 7541 · PDF 用于合理提名候选药物的全面临床前体内肿瘤学平台 Comprehensive preclinical in vivo oncology platform for rational drug candidate nomination Amandine Alard, Marie Lafitte, Nizar Serhan, Giuseppina Claps, Frédérique Dol-Gleizes, Pascale Lejeune
• 7542 · PDF 利用5TGM1细胞系及多发性骨髓瘤同基因小鼠模型对硼替佐米进行体外与体内评价 In vitro and in vivo evaluation of bortezomib using the 5TGM1 cell line and a syngeneic mouse model of multiple myeloma Mari I. Suominen, Katja M. Fagerlund, Justyna Zdrojewska, Jukka P. Rissanen, Jenni H. E. Mäki-Jouppila
• 7544 · PDF 针对临床常用标准治疗方案验证骨转移技术平台 Validation of a bone metastasis technology platform against clinically used standard-of-care therapies Tiina E. Kähkönen, Jie Wen, Ru Yang, Jussi M. Halleen
• 7548 · PDF 卵巢癌化疗耐药中活性氧（ROS）稳态的机制洞察 Mechanistic insights into reactive oxygen species (ROS) homeostasis in ovarian cancer chemoresistance Minjun HE, Michelle K.Y. SIU, Mingo M.H. YUNG, Crystal TANG, Ruiqian ZHANG, Cui CAN, Xiaoyan ZHONG, Haonan LU, Kui LIU, Annie N.Y. CHEUNG, Hextan Y.S. NGAN, David W. CHAN, Karen K.L. CHAN
• 7549 · PDF 直肠癌个体化医疗策略的开发 Development of personalized medicine strategies for rectal cancer Kiki Lianos, Kelly Olsen, Aleksandra Edmundson, Danielle Siganto, Matthew Burge, David Clark, Vicki Whitehall

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