Tumor Heterogeneity

• 7499 7499 肾癌中肉瘤样/横纹肌样去分化的遗传演化 Genetic evolution of sarcomatoid/rhabdoid de differentiation in renal cancers. Natalie R. Abuelsamen, Kate I. Glennon, Mustafa Soytas, Madeleine Arseneault, Peixi Liu, eleonora scarlata, fadi brimo, Simon Tanguay, Yasser Riazalhosseini
• 7500 · PDF 通过对患者样本进行深度单细胞多组学分析揭示TP53突变型急性髓系白血病中的谱系依赖性调控程序 Dependent lineage regulatory programs in TP53-mutated acute myeloid leukemia revealed through deep single-cell multi-omic profiling of patient samples Felix A. Radtke, Bijay S. Jaiswal, Gonzalo Lopez, Junfei Zhao, Sagnik Banerjee, Daiane Hemerich Brennan, Yilin Zhao, Verena Körber, Marlen Metzner, Rachel Moore, Bilyana Stoilova, Batchimeg Usukhbayar, David Cruz Hernandez, Maria Ortiz Estevez, Aimee O’Donohue, Daniel Lopes de Menezes, Rajasekhar NVS Suragani, Anita K. Gandhi, Paresh Vyas
• 7502 · PDF 纺锤体组装检查点完整性决定小细胞肺癌对KIF18A抑制的敏感性 Spindle assembly checkpoint integrity determines sensitivity to KIF18A inhibition in small-cell lung cancer Chiori Tabe, Rajesh Kumar, Yang Zhang, Yue Huang, Ajit Kumar Sharma, Roshan L. Shrestha, Anish Thomas
• 7503 · PDF EGFR抑制剂耐药肿瘤上皮细胞簇的时空分析 Spatio-temporal analysis of EGFR inhibitor resistant tumor epithelial clusters Shuichi Watanabe, Yoshiyuki Suehara, Masachika Ikegami, Soohwan Park, Yo Kimura, Toshihide Ueno, Takuo Hayashi, Hiroyuki Mano, Kazuya Takamochi, Shinji Kohsaka
• 7504 · PDF 继发性MSH3/MSH6改变是否定义了MSI胃癌的一种免疫调节性亚型？ Do secondary MSH3/MSH6 alterations define an immune-modulatory subtype of MSI gastric cancer? Marika Milan, Daniela Conticelli, Marco Volante, Claudia Orrù, Emanuela Boccuni, Simona Corso, Silvia Giordano
• 7505 · PDF 单细胞转录组学在激素受体阳性乳腺癌中鉴定出具有侵袭性表型的EPCAM-low和EPCAM-negative上皮细胞群 Single-cell transcriptomics identifies distinct EPCAM-low and EPCAM-negative epithelial populations with aggressive phenotypes in hormone-receptor positive breast cancer Élise Di Lena, Alyssa Victoria Francis, Atilla Omeroglu, Sarkis Meterissian, Luke McCaffrey
• 7506 · PDF CEACAM1主导的分子程序驱动EGFR突变型肺腺癌的免疫逃逸 CEACAM1-dominant molecular program drives immune escape in EGFR-mutant lung adenocarcinoma Jianyu Li, Qinglin Wang, Tongyan Liu, Siwei Wang, Rong Yin
• 7507 · PDF 多区域全基因组测序揭示von Hippel-Lindau（VHL）相关透明细胞肾细胞癌的基因组演化和异质性 Genomic evolution and heterogeneity of von Hippel-Lindau (VHL)-associated clear cell renal cell carcinoma revealed by multi-region whole-genome sequencing Francesca Corea, Husayn A. Pallikonda, Scott T. C. Shepherd, Isaline Rowe, Alessandro Larcher, Andrea Salonia, Samra Turajlic, Thomas J. Mitchell, Rosa Bernardi, Umberto Capitanio
• 7509 · PDF 时空性癌细胞轨迹构成胶质母细胞瘤异质性的基础 A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity Grant De Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Richard Mair, Sam Behjati, Oliver Stegle, Omer Bayraktar
• 7510 · PDF 口腔鳞状细胞癌中染色体外DNA的分子和临床相关性 Molecular and clinical correlates of extrachromosomal DNA in oral squamous cell carcinoma Lucas Penny, Hugh Kim, Jeffrey Bruce, Matthew Waas, Meinusha Govindarajan, Christopher Yao, Thomas Kislinger, Laurie Ailles, Scott V. Bratman
• 7511 · PDF 染色体外MDM2扩增定义了一种ecDNA允许性肿瘤细胞状态，该状态影响跨癌种的细胞间肿瘤异质性和治疗反应 Extrachromosomal MDM2 amplifications define an ecDNA-permissive tumor cell state that impacts intercellular tumor heterogeneity and treatment response across cancers Rachel Schmargon, Giulia Montuori, Elias Rodriguez-Fos, Lotte Brückner, Dennis Gürgen, Anton George Henssen, Jan-Rafael Dörr
• 7513 · PDF 整合克隆和单细胞分析揭示早期子宫内膜样子宫内膜癌中祖细胞驱动的肿瘤多样化 Integrated clonal and single-cell analyses uncover progenitor-driven tumor diversification in early-stage endometrioid endometrial carcinoma Suguru Miyata, Hiroshi Yoshida, Toyoyuki Hanazawa, Masahito Kawazu
• 7514 · PDF 空间多模态和功能解析揭示透明细胞肾细胞癌中UCHL1驱动的恶性程序 Spatial multimodal and functional dissection reveal a UCHL1-driven malignant program in clear cell renal cell carcinoma Yize Li, Wagma Caravan, Xiyi Wei, Kapur B. Dhami, Kazuhito Sato, Xiangwei Fang, Preet Lal, Hongyi Liu, Lijun Chen, Cody Weimholt, Hui Zhang, Li Ding, Feng Chen
• 7515 · PDF 揭示神经母细胞瘤异质性背后的转分化机制 Uncovering transdifferentiation mechanisms underlying heterogeneity in neuroblastoma Michele Tomanelli, Jennifer Hoti, Ilaria Medici, Chaimae Sellak, Tullio Florio, Aldo Pagano

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