Mechanisms and Targets in DNA Damage Repair

• 510 · PDF Early metabolic and differentiation remodeling in BRCA1/2 high-risk fallopian tube epithelium revealed by single-cell multi-omics Quentin Chartreux, Marcela Haro, Josh Brand, Andrew Li, Bobbie J. Rimel, Patrick Sung, Simon Gayther, Huy Dinh, Fabiola Medeiros, Kate Lawrenson
• 512 512 Wild-type IDH1 inhibition induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in pancreatic cancer Mehrdad Zarei, Priyashree Sunita, Alexander Loftus, Faith Nakazzi, Semmer Ali, Om Prajapati, Soubhi Tahhan, Hallie J Graor, Shakti Prasad Pattanayak, Sami Abul-Khoudoud, Luke D. Rothermel, Rui Wang, Jonathan R. Brody, Jordan M. Winter
• 513 · PDF AZD5305, a PARP1 selective inhibitor, exhibits antitumor effects and stimulates immune response in homologous recombination (HR)-deficient gastric cancer cells Sujin Ham, Hae Min Hwang, Youlim Noh, Jiwon Koh, Chaeyoung Lee, Seohyeon Lim, Minyoung Jeong, Yu-Jin Kim, Minyoung Lee, Changhee Park, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im
• 514 · PDF Potentiation ofPARP inhibitor activity in BRCA -wildtype breast cancer cell lines by 2-hydroxyflavanone Harshit Khosla, Sharda P. Singh, Chhanda Bose, Sharad S. Singhal, Sanjay Awasthi
• 515 · PDF Substrate selectivity and RPA-mediated regulation of Topoisomerase3-Rmi1 decatenation Minyong Kim, Quan Wang, Hengyao Niu
• 516 · PDF Integrated genomic and transcriptional profiling of patient-derived ovarian cancers reveals HRD-associated features and in vivo response to PARP inhibition Kyle C. Strickland, Sheri Barnes, Zachary D. Wallen, Michelle F. Green, Laine V. Morris, Paul DePietro, Kobina A. Amoah, Jennifer B. Jackson, Pratheesh Sathyan, Taylor J. Jensen, Brian Caveney, Eric A. Severson, Rebecca A. Previs, Shakti Ramkissoon, Scott C. Wise
• 517 · PDF Comprehensive & precise structural variant detection with a single assay J. Zachary Sanborn, James Durbin, Mital Bhakta, Lisa Munding
• 518 · PDF Caspase-4 deficiency impairs nuclear actin-mediated DNA double-strand break repair and increases radiosensitivity in cancer cells Shohei Nagasaka, Tomomitsu Doi, Kunie Obayashi, Masaoki Kohzaki, Kazuhiro Sumida, Yosuke Chiba, Junkoh Yamamoto, Motoyoshi Endo
• 519 · PDF Decoding oncogene amplification structures from retinoblastoma aqueous humor cfDNA as a model for chromothripsis and ecDNA biology Yilin Chen, Liya Xu
• 520 · PDF Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes Liis Uuskula-Reimand, Christian A. Lee, Robin H. Oh, Zoe P. Klein, Nina Adler, Sana Akhtar Alvi, Ellen Langille, Elisa Pasini, Kevin C. Cheng, Evgenija Serafimova, Diala Abd Rabbo, Huayun Hou, Ricky Tsai, Mamatha Bhat, Daniel Schramek, Michael Wilson, Juri Reimand
• 521 · PDF Impression of AKT inhibitor in chromatin accessibility in mCRPC Sasikumar Ponnusamy, Surendra Gulla, Tej Sharma, Ephraim Jeremiah Gardner, Abbas Jawadala, Adaora Amobi, Maddie Aust, Tobi Ogunbowale, Roberto Pili, Remi M. Adelaiye-Ogala
• 522 522 Oncometabolite D-2-hydroxyglutarate impairs homologous recombination by disrupting chromatin topology Fengchao Lang, Karambir Kaur, Chunzhang Yang
• 523 · PDF Pan-cancer assessment of an RNA-based signature of HRD Stephanie N. Thiede, Hannah J. Glover, Matthew E. Berginski, Joshuah Kapilivsky, Andrew Sedgewick, Kyle A. Beauchamp, Chithra Sangli, Michelle M. Stein, Justin Guinney, Timothy Taxter
• 524 · PDF Characterizing PTEN:Ki67 interactions and contribution to radioresistance in glioblastoma Brandon Marshall Jones, Sejal Patel, Brett Taylor, Nidhi Nathwani, Takayuki Morimoto, Yashpreet Kaur, Frank Furnari
• 526 · PDF The role of ssDNA in alternative DNA DSB repair and the opportunity for therapeutic intervention Jessica Lynn Kersey, John J. Turchi
• 527 · PDF Development of novel Ku-targeted DNA-PK inhibitors for cancer therapy Katherine Pawelczak, Pamela S. VanderVere-Carozza, Maria Casiano, Lacey Dobrolecki, John J. Turchi
• 528 · PDF Sun exposure shapes distinct mutational profiles in human skin cells Neda Bahrani, Aravind K. Bandari, Bishal Tandukar, Delahny Deivendran, Harsh Sharma, Alan Hunter Shain
• 529 · PDF Interplay of circadian cryptochrome 1 (CRY1) and DNA repair in prostate cancer (PCa) Arwa Fallatah, Stefan DiFazio, Lakshmi Ravindranath, Orly Richter, Christopher McNair, Ayesha Shafi
• 531 · PDF Germline HRR alterations and ancestry-related outcomes in Brazilian triple-negative breast cancer patients: A comprehensive genomic and clinical study Rafael C. Brianese, Karina M. Santiago, Gabriel Bandeira do Carmo, Leticia S. Pimentel, Diego Ortunes, Rafaella Ormond, Marcos L. Santoro, Giovana T. Torrezan, Marcelo Moreno, Ândrea R. dos Santos, Marina de Brot, Fabiana B. A. Makdissi, Solange M. Sanches, Jose C. C. Rocha, Dirce Maria Carraro
• 5134 · PDF In vitro and in vivo biology characterization of two novel inhibitors targeting the different domains of DNA polymerase theta (Polθ) Omar Loss, Michael Bestwick, Tammy Ladduwahetty, Mark Andrews, Ju Wang, Jiangchuan He, Linli Ding, Tan Pang, Rui Yang, Hing Sham, Kui Lin

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