Mechanisms and Targets in DNA Damage Repair

• 510 · PDF 单细胞多组学揭示BRCA1/2高风险输卵管上皮的早期代谢与分化重塑 Early metabolic and differentiation remodeling in BRCA1/2 high-risk fallopian tube epithelium revealed by single-cell multi-omics Quentin Chartreux, Marcela Haro, Josh Brand, Andrew Li, Bobbie J. Rimel, Patrick Sung, Simon Gayther, Huy Dinh, Fabiola Medeiros, Kate Lawrenson
• 512 512 抑制野生型IDH1诱导同源重组缺陷并增强胰腺癌对PARP抑制剂的敏感性 Wild-type IDH1 inhibition induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in pancreatic cancer Mehrdad Zarei, Priyashree Sunita, Alexander Loftus, Faith Nakazzi, Semmer Ali, Om Prajapati, Soubhi Tahhan, Hallie J Graor, Shakti Prasad Pattanayak, Sami Abul-Khoudoud, Luke D. Rothermel, Rui Wang, Jonathan R. Brody, Jordan M. Winter
• 513 · PDF PARP1选择性抑制剂AZD5305在同源重组（HR）缺陷型胃癌细胞中表现出抗肿瘤作用并激发免疫反应 AZD5305, a PARP1 selective inhibitor, exhibits antitumor effects and stimulates immune response in homologous recombination (HR)-deficient gastric cancer cells Sujin Ham, Hae Min Hwang, Youlim Noh, Jiwon Koh, Chaeyoung Lee, Seohyeon Lim, Minyoung Jeong, Yu-Jin Kim, Minyoung Lee, Changhee Park, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im
• 514 · PDF 2-羟基黄烷酮增强PARP抑制剂在BRCA野生型乳腺癌细胞系中的活性 Potentiation ofPARP inhibitor activity in BRCA -wildtype breast cancer cell lines by 2-hydroxyflavanone Harshit Khosla, Sharda P. Singh, Chhanda Bose, Sharad S. Singhal, Sanjay Awasthi
• 515 · PDF Topoisomerase3-Rmi1解联体的底物选择性及RPA介导的调控 Substrate selectivity and RPA-mediated regulation of Topoisomerase3-Rmi1 decatenation Minyong Kim, Quan Wang, Hengyao Niu
• 516 · PDF 患者来源卵巢癌的整合基因组与转录分析揭示HRD相关特征及体内对PARP抑制的反应 Integrated genomic and transcriptional profiling of patient-derived ovarian cancers reveals HRD-associated features and in vivo response to PARP inhibition Kyle C. Strickland, Sheri Barnes, Zachary D. Wallen, Michelle F. Green, Laine V. Morris, Paul DePietro, Kobina A. Amoah, Jennifer B. Jackson, Pratheesh Sathyan, Taylor J. Jensen, Brian Caveney, Eric A. Severson, Rebecca A. Previs, Shakti Ramkissoon, Scott C. Wise
• 517 · PDF 通过单一检测实现全面且精确的结构变异检测 Comprehensive & precise structural variant detection with a single assay J. Zachary Sanborn, James Durbin, Mital Bhakta, Lisa Munding
• 518 · PDF Caspase-4缺失损害核肌动蛋白介导的DNA双链断裂修复并增加癌细胞的放射敏感性 Caspase-4 deficiency impairs nuclear actin-mediated DNA double-strand break repair and increases radiosensitivity in cancer cells Shohei Nagasaka, Tomomitsu Doi, Kunie Obayashi, Masaoki Kohzaki, Kazuhiro Sumida, Yosuke Chiba, Junkoh Yamamoto, Motoyoshi Endo
• 519 · PDF 从视网膜母细胞瘤房水cfDNA解码致癌基因扩增结构，作为染色体碎裂和ecDNA生物学的模型 Decoding oncogene amplification structures from retinoblastoma aqueous humor cfDNA as a model for chromothripsis and ecDNA biology Yilin Chen, Liya Xu
• 520 · PDF 拓扑异构酶IIb结合勾勒出癌症基因组中局部化的突变过程和驱动突变 Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes Liis Uuskula-Reimand, Christian A. Lee, Robin H. Oh, Zoe P. Klein, Nina Adler, Sana Akhtar Alvi, Ellen Langille, Elisa Pasini, Kevin C. Cheng, Evgenija Serafimova, Diala Abd Rabbo, Huayun Hou, Ricky Tsai, Mamatha Bhat, Daniel Schramek, Michael Wilson, Juri Reimand
• 521 · PDF AKT抑制剂对mCRPC中染色质可及性的影响 Impression of AKT inhibitor in chromatin accessibility in mCRPC Sasikumar Ponnusamy, Surendra Gulla, Tej Sharma, Ephraim Jeremiah Gardner, Abbas Jawadala, Adaora Amobi, Maddie Aust, Tobi Ogunbowale, Roberto Pili, Remi M. Adelaiye-Ogala
• 522 522 致癌代谢物D-2-羟基戊二酸通过破坏染色质拓扑结构损害同源重组 Oncometabolite D-2-hydroxyglutarate impairs homologous recombination by disrupting chromatin topology Fengchao Lang, Karambir Kaur, Chunzhang Yang
• 523 · PDF 基于RNA的HRD特征的泛癌评估 Pan-cancer assessment of an RNA-based signature of HRD Stephanie N. Thiede, Hannah J. Glover, Matthew E. Berginski, Joshuah Kapilivsky, Andrew Sedgewick, Kyle A. Beauchamp, Chithra Sangli, Michelle M. Stein, Justin Guinney, Timothy Taxter
• 524 · PDF 表征PTEN:Ki67相互作用及其对胶质母细胞瘤放射抵抗性的贡献 Characterizing PTEN:Ki67 interactions and contribution to radioresistance in glioblastoma Brandon Marshall Jones, Sejal Patel, Brett Taylor, Nidhi Nathwani, Takayuki Morimoto, Yashpreet Kaur, Frank Furnari
• 526 · PDF ssDNA在替代性DNA DSB修复中的作用及其治疗干预机会 The role of ssDNA in alternative DNA DSB repair and the opportunity for therapeutic intervention Jessica Lynn Kersey, John J. Turchi
• 527 · PDF 用于癌症治疗的新型Ku靶向DNA-PK抑制剂的开发 Development of novel Ku-targeted DNA-PK inhibitors for cancer therapy Katherine Pawelczak, Pamela S. VanderVere-Carozza, Maria Casiano, Lacey Dobrolecki, John J. Turchi
• 528 · PDF 日晒在人类皮肤细胞中塑造出不同的突变谱 Sun exposure shapes distinct mutational profiles in human skin cells Neda Bahrani, Aravind K. Bandari, Bishal Tandukar, Delahny Deivendran, Harsh Sharma, Alan Hunter Shain
• 529 · PDF 昼夜节律隐花色素1（CRY1）与前列腺癌（PCa）中DNA修复的相互作用 Interplay of circadian cryptochrome 1 (CRY1) and DNA repair in prostate cancer (PCa) Arwa Fallatah, Stefan DiFazio, Lakshmi Ravindranath, Orly Richter, Christopher McNair, Ayesha Shafi
• 531 · PDF 巴西三阴性乳腺癌患者中的种系HRR改变与祖源相关结局：一项全面的基因组和临床研究 Germline HRR alterations and ancestry-related outcomes in Brazilian triple-negative breast cancer patients: A comprehensive genomic and clinical study Rafael C. Brianese, Karina M. Santiago, Gabriel Bandeira do Carmo, Leticia S. Pimentel, Diego Ortunes, Rafaella Ormond, Marcos L. Santoro, Giovana T. Torrezan, Marcelo Moreno, Ândrea R. dos Santos, Marina de Brot, Fabiana B. A. Makdissi, Solange M. Sanches, Jose C. C. Rocha, Dirce Maria Carraro
• 5134 · PDF 两种靶向DNA聚合酶theta（Polθ）不同结构域的新型抑制剂的体外和体内生物学表征 In vitro and in vivo biology characterization of two novel inhibitors targeting the different domains of DNA polymerase theta (Polθ) Omar Loss, Michael Bestwick, Tammy Ladduwahetty, Mark Andrews, Ju Wang, Jiangchuan He, Linli Ding, Tan Pang, Rui Yang, Hing Sham, Kui Lin

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