Genomic Dissection to Define Novel Therapeutic Strategies

• 489 489 gRNA、表位和转录组的多组学单细胞组合索引揭示K562细胞中药物敏感性的调节因子 Multi-omic single-cell combinatorial indexing of gRNA, epitopes, and transcriptome uncovers modulators of drug sensitivity in K562 cells Sangwon Kang, Su-Hyeon Lee, Byungjin Hwang
• 490 490 使用双重可诱导Cas9系统对蛋白激酶组进行高通量混合CRISPR筛选与高容量单细胞分析 High-throughput pooled CRISPR screening with high-capacity single cell analysis of the protein kinome using a dual inducible Cas9 system Clarence Mills, Anna Sheydina, Jesse Stombaugh, Emily Feldman, Josien Levenga, Kevin Taylor
• 491 · PDF 一个包含1亿个细胞的单细胞图谱，助力机制性和基因型特异性药物反应的发现 A 100 million cell single cell atlas enabling mechanistic and genotype-specific drug response discovery Aisling Sinclair, Joey Pangallo, Vuong Tran, Efthymia Papalexi, Simone Marrujo, Bryan Hariadi, Crina Curca, Olivia Kaplan, Sarah Schroeder, Ajay Sapre, Guillermo Gallareta Olivares, Maria Nigos, Oliver Sanderson, Hoai Hguyen, Alec Salvino, John Thompson, Ryan Koehler, Sam You, Gokhan Demirkan, Charles Roco, Alexander Rosenberg
• 492 · PDF 从癌症基因组图谱（TCGA）全基因组数据集中发掘具有治疗靶向性的突变 Uncovering therapeutically targetable mutations from The Cancer Genome Atlas (TCGA) whole-genome datasets Ryul Kim, Chunyang Bao, Hansol Park, Gang-Hee Lee, Won-Chul Lee, Jonghoon Lee, Yoonsuh Lee, Beomki Lee, David Lehotzky, Ron Solan, Antonia Kowalewski, Xavi Loinaz, Vasuki Narasimha Swamy, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Andrew D. Cherniack, Luis Antonio Corchete Sanchez, Brian P Danysh, Zachary Everton, Chip Stewart, Haruna Tomono, Gengchao Wang, Esther Rheinbay, Gad Getz, Young Seok Ju
• 493 · PDF 肺癌中可靶向驱动因素的基因组图景 Genomic landscape of targetable drivers in lung cancer Olivia Lee, Soo-Ryum Yang, Wei Zhao, Huu Phuc Hoang, Tongwu Zhang, Maria Teresa Landi
• 494 · PDF 多组学患者来源类器官嵌入可预测靶向治疗反应和KRAS抑制剂敏感性 Multi-omics patient-derived organoid embeddings predict targeted therapy response and KRAS inhibitor sensitivity Lelia Polit, Nico Trummer, Rafal Pietrzak, Mateo Longarini, Alexis Finkbeiner, Anna-Rose Gryspeert, Jean Bouteiller, Jérome Caron, Fanny Jaulin, Gustave Ronteix
• 495 · PDF 使用SBX测序的PRISM多重化癌症细胞系单细胞多组学药物反应分析 Single-cell multiomic drug response profiling of PRISM-multiplexed cancer cell lines sequenced with SBX Houlin Yu, Guoping Wang, Stephanie Yaung, Heejo Choi, Megan Rogers-Peckham, Michael Kartje, Matthew Rees, Paul Lund, Brian Haas, Charlotte Yang, Laura Doherty, Lacey McGee, Kendall Berg, Cynthia Cech, Salka Barrett, Anasha Arryman, Joanne Leadbetter, Taylor Lehmann, John Mannion, Chen Zhao, Marc Prindle, Melud Nabavi, Carolyn Morrison, Peter Smibert, Kit Nazor, Todd Golub, Catarina D. Campbell, Jennifer Roth, Niall Lennon, Victoria Popic, Dean Procter, Kokoris Mark, Aziz M. Al'Khafaji
• 496 · PDF Oncolinkage：发现用于癌症治疗的肿瘤选择性表面靶点 Oncolinkage: Discovery of tumor-selective surface targets for cancer therapy McKensie A. Collins, Benjamin T. Hallisey, Andrew Astley, Rick Nicoletti, Murray O. Robinson
• 497 · PDF 阿曼乳腺癌队列中跨年龄组治疗反应的转录组预测因子 Transcriptomic predictors of therapy response across age groups in an omani breast cancer cohort Muna Al Dlali, Habiba El Keraby, Hamza Zaidom, Radiya Al ajmi, Cheryl Crozier, Jane Bayani, Sirin A. Adham
• 498 · PDF 扰动数据缺口：用CRISPR筛选加速发现 The perturbation data gap: Accelerating discovery with CRISPR screening Elena Vialetto, Ronay Cetin, Sebastian Süsser, Simran Rastogi, Angela Hinchie, Jessica Martyn, Martin Wegner, Manuel Kaulich
• 499 · PDF 整合基因组与空间分析揭示脐尿管癌的起源及其可攻击的脆弱性 Integrated genomic and spatial analyses elucidate the origins and vulnerabilities of urachal carcinoma Toru Imai, Tatsunori Shimoi, Akiko Maeshima, Jumpei Kashima, Ibuki Tsuru, Hisashi Hashimoto, Jun Takahashi, Eijiro Nakamura, Yoshiyuki Matsui, Hiroyuki Mano, Kan Yonemori, Yosuke Tanaka
• 500 · PDF 基因融合与微卫星不稳定性（MSI）的共存定义了结直肠癌一个临床上独特的亚型 Co-occurrence of gene fusions and microsatellite instability (MSI) defines a clinically distinct subtype of colorectal cancer Scott Kulm, Sebastià Franch-Expósito, Paul Fields, Catherine Igartua
• 501 · PDF 整合多组学分析揭示 SWI/SNF 亚基特异性通路改变及可攻击的脆弱性 Integrated multiomic profiling reveals SWI-SNF subunit-specific pathway alterations and targetable vulnerabilities Clemence Astier, Jorge Bretones Santamarina, Marlène Garrido, Léo Colmet-Daage, Thibault Delobel, Marcos Bolanos, Marianne Chasseriaud, Elodie Anthony, Daphné Morel, Roman M. Chabanon, Theo Roumeliotis, Mercedes Pardo, Elaine Del Nery, Jyoti Choudhary, Annabelle Ballesta, Sophie Postel-Vinay
• 502 502 通过免疫组化（IHC）检测的 MTAP 缺失与通过二代测序（NGS）和 DNA 荧光原位杂交（FISH）检测的 MTAP 纯合缺失的比较 Comparison of MTAP loss by immunohistochemistry (IHC) and MTAP homozygous deletion by next-generation sequencing (NGS) and DNA fluorescence in-situ hybridization (FISH) Lisa Huang, Lauren Giampapa, Paige Montanaro, Ishwarya Krishna, Shannon Chilewski, Haeun Hwangbo, Wen-Chi Chou, Sarah Jamerson, Lynn Dong, Olufemi Adelakun, Juliana Coculo, John Rassa, Jonathan Baden, Travis Hollmann, Igor Katsyv
• 503 · PDF 评估卵巢癌中的旁系同源基因依赖性以推动靶点发现 Assessing paralog dependency in ovarian cancer to drive target discovery Amy R. Lowe, Siobhan O'Brien, Marissa Fujimoto, Alice H. Berger
• 504 · PDF 干扰素富集的基因表达特征与口腔鳞状细胞癌中的 ADAR1 依赖性相关 Interferon enriched gene expression signatures are associated with ADAR1 dependency in oral squamous cell carcinoma Pei San Yee, Jie Ying Teo, Shi Mun Yee, Shiyin Ooi, Yee Hua Tan, Mathew J Garnett, Siew Kit Ng, Annie Wai Yeeng Chai, Sok Ching Cheong
• 505 · PDF 分子标准诊疗 Molecular Standard of Care Sam Phillips, Eric Collisson
• 506 506 高内涵 CRISPR 激活筛选鉴定出基于 RNA 的合成致死机制，使癌细胞对靶向性 T 细胞细胞毒性敏感 High content CRISPR activation screens identified synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity Jeehyun Yoe, Reece V. Akana, Olivia Laveroni, Chang Sun, Young-Min Kim, Livnat Jerby

在会议检索中浏览本分会场