AACR Project GENIE: Predictive Models and AI

• 1 · PDF Synapse.org作为支持多中心癌症数据协调、基准测试和广泛社区复用的基础平台 Synapse.org as a foundational platform supporting multicenter cancer data coordination, benchmarking, and broad community reuse Adam Taylor, Gaia Andreoletti, Robert Allaway, Jineta Banerjee, Orion Banks, Angie Bowen, Kevin Boske, Aditi Gopalan, Ashley Clayton, Xindi Guo, Savitha Sangameswaran, Amber Nelson, Aditya Nath, Milen Nikolov, Anh Nguyet Vu, Ziwei Pan, Alex Paynter, Chelsea Nayan, Thomas Yu, Bishoy Kamel, Serghei Mangul, Alberto Pepe, Luca Foschini, Susheel Varma
• 2 · PDF 用于精准肿瘤学的变异解读网络服务：Genome Nexus 与 reVUE Variant interpretation web services for precision oncology: Genome Nexus and reVUE Xiang Li, Alexandria Dymun, Benjamin Preiser, Reshma Ramaiah, Allison Richards, Walid Chatila, Moriah Nissan, Amanda Dhaneshwar, Sara E. DiNapoli, Erika Gedvilaite, Thomas Y. Cong, Hongxin Zhang, Bryan Lai, Selcuk Onur Sumer, Aditi Gopalan, Tonatiuh Gonzalez, Madelaine Rangel, Trevor J. Pugh, Rose Brannon, Michael Berger, Debyani Chakravarty, Nikolaus Schultz, Jianjiong Gao, Ino de Bruijn
• 3 · PDF 评估一款用于 AACR GENIE BPC 数据临床基因组分析的智能体式 LLM 聊天机器人 Evaluation of an agentic LLM chatbot for clinico-genomic analysis of AACR GENIE BPC data Likhita Thiriveedi, Kenneth L. Kehl
• 4 · PDF 用于结直肠癌精准肿瘤学中临床、基因组及健康社会决定因素数据实时整合的多智能体对话式人工智能生态系统 A multi-agent conversational artificial intelligence ecosystem for real-time integration of clinical, genomic, and social determinants of health data in colorectal cancer precision oncology Enrique Velazquez-Villarreal, Brigette Waldrup
• 5 · PDF 人工智能驱动的精准医疗在接受 FOLFOX 治疗的非裔美国结直肠癌患者中识别具有预后意义的 WNT 通路改变 Artificial intelligence-driven precision medicine identifies prognostic WNT pathway alterations in African American colorectal cancer patients treated with FOLFOX Tsion Z. Minas, Brigette Waldrup, Francisco G. Carranza, Sophia Manjarrez, Enrique Velazquez-Villarreal
• 6 · PDF 通过对话式人工智能赋能高危人群：一个用于患者倡导和精准肿瘤学的框架 Empowering populations at risk through conversational artificial intelligence: a framework for patient advocacy and precision oncology Araceli Estrada, Brigette Waldrup, Francisco G. Carranza, Sophia Manjarrez, Enrique Velazquez-Villarreal
• 7 · PDF 利用计算推理对 GENIE BPC NSCLC 队列进行分子信息驱动的治疗疗效预测 Molecularly-informed prediction of treatment efficacy in the GENIE BPC NSCLC cohort using computational reasoning Barbara Vodicska, Eniko Kispeter, Dora Lakatos, Gabor Gy Kalmar, Robert Doczi, Dora Gorog-Tihanyi, Anna Dirner, Reka Szalkai-Denes, William T. Beck, Arkadiusz Z. Dudek, Christophe Le Tourneau, Istvan Petak
• 8 · PDF 利用体外模型预测 PDGFRA 突变型胃肠道间质瘤对 imatinib 的反应 Using in vitro models to predict imatinib responses in PDGFRA-mutant gastrointestinal stromal tumor Homma M. Khosroyani, Alina Teuber, Ajia Town, Lillian Klug, Denisse Evans, Jerry Call, Sara Rothschild, Neeta Somaiah, Prapassorn Thirasastr, Ping Chi, Marion Liu, Peter Hohenberger, Piotr Rutkowski, Patrick Schoffski, Abbas Agaimy, Mehdi Brahmi, Carol Beadling, Sebastian Bauer, Johanna Falkenhorst, Michael C. Heinrich
• 9 · PDF ShinyEvents：协调真实世界纵向数据以获得临床洞见和生存分析 ShinyEvents: Harmonizing real-world longitudinal data for clinical insights and survival analytics Alyssa Obermayer, Joshua Davis, Roger Li, Rodrigo Rodrigues Pessoa, Brandon J. Manley, G. Daniel Grass, Aik Choon Tan, Dung-Tsa Chen, Timothy Shaw
• 10 · PDF 一种针对黑色素瘤驱动突变年龄依赖性选择的连续建模框架 A continuous modeling framework for age-dependent selection on melanoma driver mutations Yihan Liu, Moein Rajaei, Jeffrey D. Mandell, Jorge Alfaro-Murillo, Jeffrey P. Townsend
• 11 · PDF 基于人工智能的局部肿瘤微环境空间分析与非小细胞肺癌中c-MET表达的关系 Artificial intelligence-based spatial analysis of the local tumor microenvironment in relation to c-MET expression in non-small cell lung cancer Ji-Hyang Lee, Joshua Littrell, Chiyoon Oum, Taebum Lee, Sanghoon Song, Yoojoo Lim, Chang Ho Ahn, Jim Christian, Seokwhi Kim, Siraj M. Ali
• 12 · PDF 由人工智能增强的整合空间多组学分析揭示南加州患者早发性结直肠癌中与祖先相关的分子特征 Integrative spatial multi-omics profiling enhanced by artificial intelligence reveals ancestry-associated molecular features in early-onset colorectal cancer among Southern California patients Francisco G. Carranza, Brigette Waldrup, Yuxin Jin, Yonatan Amzaleg, David Craig, John Carpten, PE-CGS Network, Enrique I. Velazquez Villarreal
• 13 · PDF 整合转录组数据以改进多组学肿瘤起源分类 Integrating transcriptomic data to improve multi-omic tumor-of-origin classification Pranav Gadde, Naga Mudda, Pratayanch Sav, Krithik Senthilkumar, Aadarsh Sivaraman, Krithik Mudda
• 14 · PDF 跨多中心队列的软骨肉瘤突变分析 Mutational profiling of chondrosarcoma across multicenter cohorts Luyuan Li, Wensi Tao, Robert L. Walker, Manish KC, Darshan Gundala, Josiane E. Eid, Zhenfeng Duan, Jonathan C. Trent

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