LBPO.MCB01 · 分子与细胞生物学 · Late-Breaking
Late-Breaking Research: Molecular/Cellular Biology and Genetics 1
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- LB094 LB094 染色质区室的表观遗传去稳定化定义了头颈部鳞状细胞癌中富含驱动突变的染色体薄弱环节 Epigenetic destabilization of chromatin compartments defines chromosomal weak links enriched for driver mutations in head and neck squamous cell carcinoma Ashley Ramos-López, Sebastián Rodríguez-Torres, Laura Palmieri, Yanira González-Rodríguez, Amanda García-Negrón, Guie Beeu Guerrero-Hunt, Adhi Guerrero-Thillet, Mariana Brait, David Sidransky, Rafael Guerrero-Preston
- LB095 LB095 癌症中的染色体薄弱环节:胃肿瘤发生中与全局DNA甲基化改变耦合的A/B区室重连 Chromosomal weak links in cancer: A/B compartment rewiring coupled to global DNA methylation alterations in gastric tumorigenesis Ashley Ramos-López, Sebastián Rodríguez-Torres, Laura Palmieri, Yanira González-Rodríguez, Robert Gilman, Martha H. Jahuira-Arias, Jaime Cok, Juan Combe, Gloria Vargas, William Prado, Mariana Brait, David Sidransky, Rafael Guerrero-Preston
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- LB097 LB097 HDAC抑制通过全基因组转录机器的重新分布使胰腺癌对DNA损伤性疗法敏感 HDAC inhibition sensitizes pancreatic cancer to DNA-damaging therapies via genome-wide redistribution of transcriptional machinery Gaoyang Liang, Hung V. T. Nguyen, Jonathan Zhu, Hervé Tiriac, Hadiqa Zafar, Daniel Y. Cao, Gabriela Estepa, Dylan C. Nelson, Yang Dai, Tae Gyu Oh, Christopher Liddle, Ruth T. Yu, Andrew M. Lowy, Weiwei Fan, Morgan L. Truitt, Annette R. Atkins, Jeremiah A. Johnson, Michael Downes, Ronald M. Evans
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- LB102 LB102 评估临床全基因组测序与癌症基因panel检测相比的治疗和诊断效用 Evaluating the therapeutic and diagnostic utility of clinical whole-genome sequencing in comparison with cancer gene panel testing Norio Tanaka, Osamu Gotoh, Ippei Fukada, Arisa Ueki, Takayuki Ueno, Shunji Takahashi, Seiichi Mori, Tetuso Noda
- LB103 LB103 对具有非洲血统的驱动基因阴性肾细胞癌进行全基因组测序，发现了靶向panel测序遗漏的MET结构变异 Whole-genome sequencing of driver-negative renal cell carcinoma with African ancestry identifies MET structural variations missed by targeted panel sequencing Setor Amuzu, Sean A. Fletcher, Srinivas R. Viswanathan, Jie-Fu Chen, Jian Carrot-Zhang
- LB104 LB104 基于标记的肿瘤-正常单倍型匹配揭示全基因组重组，并利用GIAB从头组装的胰腺肿瘤-正常样本发现单倍型特异性体细胞结构变异 Marker-based tumor-normal haplotypes matching reveals genome-wide recombination and haplotype specific somatic structural variation discovery using GIAB de novo pancreatic tumor-normal assemblies Chunlin Xiao, Justin Wagner, Jennifer McDaniel, Francoise Thibaud-Nissen, Justin Zook
- LB105 LB105 随机3期DREAM3R试验的转化研究分析：度伐利尤单抗联合化疗作为晚期胸膜间皮瘤一线治疗 Translational analyses from the randomized phase 3 DREAM3R trial: DuRvalumab with chEmotherapy as first line treAtment in advanced pleural Mesothelioma Valsamo (Elsa) Anagnostou, Anna K. Nowak, Chris Brown, Brett G. M. Hughes, Noushin Niknafs, Tracy Hoang, Jaime Wehr, Connull Leslie, Qiong Meng, Asimina Zoitou, Kennet J. O’Byrne, Wee L. Chin, Thomas John, Peter Illei, Sonia Yip, Nick Pavlakis, Julie Brahmer, Martin R. Stockler, Patrick M. Forde, Alistair Cook
- LB107 LB107 黏附型GPCR BAI3的一种新型短亚型源自替代启动子，可逆转EMT过程并在多形性胶质母细胞瘤（GBM）中带来生存获益 A novel short isoform of adhesion GPCR BAI3, originated from an alternative promoter, reverses the EMT process, and confers survival benefit in glioblastoma multiforme (GBM) Rashed Rezwan Parag, Virginea De Araujo Farias, Haifa A. Alsharif, Md Simul Bhuiya, Jesse Stillwell, Yuki Kuranaga, Maryam Ahmadian Elmi, Naoki Hama, Masakazu Kamata, Sushant Bhatnagar, Erwin G. Van Meir
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