PO.TB09.03 · 肿瘤生物学
Methods to Measure Tumor Evolution and Heterogeneity
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685 · PDF eTRACER揭示EGFR突变型肺腺癌免疫逃逸的时空图景 eTRACER illuminates the spatiotemporal landscape of immune escape in EGFR-mutant lung adenocarcinoma Hongbin Ji, Zheng Hu, Jinhua Yang, Liangzhen Hou, Xue Wang
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686 · PDF 利用小鼠和患者来源类器官解析结直肠癌异质性及其与微生物群的相互作用 Dissecting colorectal cancer heterogeneity and microbiota interactions using murine and patient-derived organoids Markus Tschurtschenthaler, Valentina Brunner, Nicholas Bodenstein, Expedito M. Diógenes, Lisa Niedermeier, Nicole A. Schmid, Miguel G. Silva, Moritz Jesinghaus, Roland Rad, Bärbel Stecher, Julius Fischer, Dieter Saur
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687 · PDF 肺癌前病变中KRAS的原位定位与空间组学特征分析 In situ KRAS -mapping and spatial -omics characterization in lung premalignancy Amanda Lindberg, Bartosz Sobocki, Patrick Micke, Carina Strell
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688 · PDF 遗传性免疫逃逸演化轨迹的泛癌种图谱绘制 Pan-cancer mapping of genetic immune escape evolutionary trajectories Shengqing Gu, Wenjie Chen, Toby Baker, Zhihui Zhang, Huw A. Ogilvie, Peter Van Loo
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689 · PDF 前列腺素E₂信号在溃疡性结肠炎癌变中的意义 Significance of prostaglandin E₂ signaling in the carcinogenesis of ulcerative colitis Tatsunari Fukuoka, Masakazu Yashiro, Hiroaki Kasashima, Nobuhiro Naito, Iguru Omori, Yasuhiro Fukui, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Kiyoshi Maeda
- 690 690 基于甲基化的肿瘤分数动态的分层混合效应三次样条建模,用于免疫治疗患者治疗反应和结局的泛癌种评估 Hierarchical mixed effects cubic spline modeling of methylation-based tumor fraction dynamics for pan-cancer assessment of treatment response and outcomes in immunotherapy patients Christopher Pretz, Amar Das, Carin Espenschied, Sara Wienke, Samantha I. Liang, Christopher Cabanski
- 691 691 可视化主动监测患者纵向MRI中前列腺癌病灶的差异性生长:通过Habitat风险评分和数字病理进行定量映射 Visualizing differential prostate cancer lesion growth in longitudinal MRIs of patients on active surveillance: Quantitative mapping by Habitat Risk Score and digital pathology Sandra M. Gaston, Yuwei Zhang, Veronica M. Wallaengen, Amanda Galvez, Leonard Salcedo, Adrian L. Breto, Ahmad Algohary, Noah C. Lowry, Jakub Karczmarzyk, Gupta R. Rajarsi, Erich Bremer, Tahsin Kurc, Benjamin O. Spieler, Oleksandr N. Kryvenko, Alan Pollack, Sanoj Punnen, Joel Saltz, Radka Stoyanova
- 692 692 用于改进急性髓系白血病(AML)中MRD(可测量残留病)评估和克隆动态的新型单细胞和bulk NGS检测方法 Novel single cell and bulk NGS assays for improved assessment of MRD (measurable residual disease) and clonal dynamics in acute myeloid leukemia (AML) Crystal Zhou, Ruwan Gunaratne, Emily Yang, Rachel Agoglia, Diwash Jangam, Charu Tiwari, Kailee Tanaka, Tsoyu Chiang, Chandler Ho, Sydney Lu, James L. Zehnder, Bing Melody Zhang, Henning Stehr, Tian Yi Zhang
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693 · PDF ER阳性乳腺癌中的ET耐药细胞群体:从图谱分析到治疗靶向 ET-resistant cell populations in ER positive breast cancer: From profiling to therapeutic targeting Svetlana Semina, Rosemary Huggins J. Huggins, Huiping Zhao, Virgilia Macias, Leo Feferman, Andre A. Kajdacsy-Balla, Debra A. Tonetti, Kent F. Hoskins, Geoffrey L. Greene, Jonna M. Frasor, Jonathan Coloff
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694 · PDF 空间解析基因组学揭示胶质母细胞瘤的演化模式及影像学相关性 Spatially resolved genomics reveals evolutionary modes and imaging correlates in glioblastoma You Jin Song, Yelyzaveta Miller-Michlits, Karl-Heinz Nenning, Christoph Bock, Ji Yoon Lee, Jiwon Kim, Jisoo Hong, Dayoung Lee, Namsung Moon, Harim Koo, Jason K. Sa, Adelheid Woehrer
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696 · PDF 利用原钙黏蛋白基因簇甲基化条形码进行体内克隆谱系追踪 In vivo clonal lineage tracing using methylation barcodes in the protocadherin gene cluster Christopher T. Boniface, Samuel Hackett, Adriana V. A. Fonseca, Akemi Ramos-Yamasaki, Caroline Watson, Joanna Baxter, Jyoti Nangalia, Sadik Esener, Hisham Mohammed, Jamie Blundell
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697 · PDF 利用超表面增强拉曼光谱对黑色素瘤肿瘤微环境进行无标记空间图谱分析 Label-free spatial profiling of the melanoma tumor microenvironment using metasurface-enhanced Raman spectroscopy Kai Chang, Mamatha Serasanambati, Feven Naba, Priyanuj Bordoloi, Antony Georgiadis, Emma Wagner, Hamish Carr Delgado, Chih-Yi Chen, Varun Dolia, Baba Ogunlade, Remi Dado, Ariel Stiber, Jack Hu, Amanda R. Kirane, Jennifer Dionne
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698 · PDF 用于神经母细胞瘤细胞状态可视化的新型报告工具 Novel reporter tool for visualization of neuroblastoma cell state Samantha Turk, Melody Allensworth, Justina McEvoy, Marybeth Lupo, Jackie Norrie, Michael A. Dyer
- 699 699 肿瘤患者来源类器官中的动态适应性与异质性:对癌症演化和耐药性的洞见 Dynamic adaptation and heterogeneity in tumor patient-derived organoids: Insights into cancer evolution and drug resistance Javier Frias Aldeguer, Jasmin Pourfarzad, Alessandro Gregory, Farzin Pourfarzad, Rene Overmeer, Robert G. J. Vries, Sylvia F. Boj
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700 · PDF 结合新型数据分析算法利用One Lambda LABType产品检测HLA等位基因基因组缺失的可行性 Feasibility to detect genomic loss of HLA alleles by One Lambda LABType products combined with novel data analysis algorithm Svetlana Argounova, Bernabe Valdez, Kevin Lam, Hanna Bennett, Anna Chikova
- 701 701 患者来源类器官生物样本库保留肿瘤异质性和分子特征 Patient-derived organoid biobanks preserve tumor heterogeneity and molecular signatures Rene Overmeer, Farzin Pourfarzad, Alejandra Hernandez Segura, Merel Derksen, Carla Verissimo, Robert G. J. Vries, Sylvia F. Boj
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702 · PDF 利用克隆动态克服耐药:结直肠癌中的适应性治疗框架 Harnessing clonal dynamics to overcome resistance: An adaptive therapy framework in colorectal cancer Harley I. Richker, Bailey Sierra Kane, Gissel Marquez Alcaraz, Ellie Pahl, Ryan Carr, Nagarajan Kannan, Carlo C. Maley
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703 · PDF 通过游离DNA分析追踪融合驱动型肉瘤的肿瘤演化和异质性 Tracking tumor evolution and heterogeneity in fusion-driven sarcomas through cell-free DNA analysis Tom T. Fischer, Panna Lajer, Konstantin Okonechnikov, Anke King, Karla Catacora, Katharina Bauer, Iris Oezen, Tanja Jutzi, Katherine Kelly, Calvin Hans Setiadi, Waqar Hussain, Kendra K. Maass, Roland Imle, Anja Speicher, Kamelia Soleiman-Masihi, Nadine Volk, Birgit Besenbeck, Robert Kuechler, Anu Mathews, Editha Gnutzmann, Julia Ketzer, Daniela Richter, Daniel Huebschmann, Ana Banito, Claudia Ball, Kathrin Schramm, David T. W. Jones, Jan-Philipp Mallm, Uta Dirksen, Sabine Stegmaier, Monika Sparber-Sauer, Richard F. Schlenk, Hanno Glimm, Stefan Froehling, Stefan M. Pfister, Supat Thongjuea, Kristian W. Pajtler, Daniel B. Lipka
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704 · PDF 单细胞分辨率的全范围基因组分析揭示黑色素瘤亚克隆的遗传、表观遗传及平行进化 Full-range genomic analysis at single-cell resolution reveals genetic, epigenetic, and parallel evolution of melanoma subclones Chi-Ping Day, Yuelin Liu, Anton Goretsky, Ayse Keskus, Salem Malikic, Eva Perez-Guijarro, Glenn Merlino, Eytan Ruppin, Suleyman Cenk Sahinalp, Mikhail Kolmogorov
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706 · PDF 超越单个核心活检:空间基因组分析提升胶质母细胞瘤中治疗靶点的检出 Beyond a single core biopsy: Spatial genomic profiling improves therapeutic target detection in glioblastoma Enmar Harfoush, Taylor Weiskittel, Mylan Blomquist, Dustin Grief, Aadel A. Chaudhuri, Leland S. Hu, Nhan L. Tran, Shannon Fortin-Ensign
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707 · PDF 对模拟祖先序列的系统发育与机器学习分析揭示ccRCC的异质性进化 Phylogenetic and machine learning analyses of simulated ancestral sequences reveals heterogeneous ccRCC evolution Nic Fisk, Christopher Cross, Brian M. Shuch, Jeffrey Peter Townsend