PO.TB10.12 · 肿瘤生物学
Physicochemical Modulation of Cancer Ecosystems: Mechanical Forces, Hypoxia, and Acidosis
- 756 756 基质硬度诱导Ca²⁺-DCLK1-PIP5K1A机械转导，作为胰腺癌进展和化疗耐药中的一个生物力学检查点 Matrix stiffness induces Ca²⁺-DCLK1-PIP5K1A mechanotransduction as a biomechanical checkpoint in pancreatic cancer progression and chemotherapy resistance Haoxiang Zhang, Chuanbin Zhao, Jiaoshun Chen, Xiaoqing Hu, Jianwei Bai, Long He, Zanglong Deng, Tao Yin
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- 759 759 肿瘤微环境的机械重塑通过EGR3-ALOX5信号通路促进乳腺癌及中性粒细胞相关免疫抑制 Mechanical remodeling of the tumor microenvironment promotes breast cancer and neutrophil-ssociated immunosuppression through ERG3-ALOX5 signaling Lingpeng Tang, Liangyu Wei, Jinpeng Lu, Haoxiang Zhang, Songsong Wu
- 761 761 肺腺癌中胶原更新以纤维生成为主，而肺鳞状细胞癌中以纤维溶解为主 Collagen turnover is dominated by fibrogenesis in lung adenocarcinoma and fibrolysis in lung squamous cell carcinomas Victoria Batto, Marselina Arshakyan, Rasmus Sund Pedersen, Neel Ingemann Nissen, Enrico Almici, Noemi Reguart, Morten Karsdal, Nicholas Willumsen, Jordi Alcaraz
- 762 762 可调控三维类器官模型揭示胰腺癌中硬度依赖性的基质激活和细胞因子信号 A tunable 3D organoid model reveals stiffness-dependent stromal activation and cytokine signaling in pancreatic cancer Carolyn M. Ruiz-Rivera, Ba Xuan Hoang, Jamel Ali, Thomas D. Schmittgen, Bo Han
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- 767 767 肿瘤硬度作为KRAS突变型NSCLC的功能性生物标志物：来自ARTIDIS前瞻性临床队列的见解 Tumor stiffness as a functional biomarker of KRAS-mutant NSCLC: Insights from the ARTIDIS prospective clinical cohort Jordi Alcaraz, Elba Marin, Héctor Sanz-Fraile, Marina Querol, Paula Gausa, Keat Neal, Marselina Arshakyan, Marc Rico-Pastó, Marc Boada, David Sanchez, Carolina Ortiz Velez, Reinier Oropesa Nunez, Gitika Srivastava, Ahmed Jizawi, Sara Nizzero, Tobias Appenzeller, Philipp Oertle, Marko Loparic, Marija Plodinec, Noemi Reguart
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- 771 771 ECM硬度和谷氨酰胺可用性在胰腺癌与癌相关成纤维细胞的3D共培养模型中重塑代谢和免疫表型 ECM stiffness and glutamine availability rewire metabolic and immune phenotypes in 3D Co-culture models of pancreatic cancer and cancer-associated fibroblasts Jonathan Barajas, Carolyn Ruiz, Zhi Yang, Bo Han, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon
- 773 773 单细胞和空间转录组分析揭示与特发性肺纤维化相关的肺鳞状细胞癌中的纤维化相关肿瘤状态 Single-cell and spatial transcriptomic profiling reveal fibrosis-related tumor states in lung squamous cell carcinoma associated with idiopathic pulmonary fibrosis KENTA MANABE, Atsushi Matsuoka, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kazuya Hisamatsu, Ryota Fujiwara, Kosei Ishimura, Shunsuke Mori, Ryunosuke Fujii, Asuka Mimata, Kazuhiro Okada, Ryo Yoshichika, Mao Yoshikawa, Yuma Fukumoto, Haruchika Yamamoto, Kumi Nakajima, Shin Tanaka, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
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- 776 776 生长缓慢、预后不良的结直肠癌中一种驱动基质重塑与CAF募集的癌细胞内在程序 A cancer cell intrinsic program for matrix remodeling and CAF recruitment in slow growing, poor prognosis colorectal cancers Claudio Isella, Anna Cassisa, Consalvo Petti, Alexandra Ambra Ulla, Jie Zhou, Carlo Leonardi, Roberta Porporato, Daniela Cantarella, Letizia Franco, Cinzia Benetti, Jill Carol Rubinstein, Jessica Erriquez, Mariangela Russo, Francesco Sassi, Elena Grassi, Ymera Pignochino, Alberto Puliafito, Ivan Molineris, Rebecca Senetta, Andrea Bertotti, Livio Trusolino, Jeffrey H. Chuang, Alberto Bardelli, Enzo Medico
- 777 777 一种在血清饥饿和缺氧条件下被诱导的ATP-grasp超家族酶作为胰腺癌诊断的潜在生物标志物 An ATP-grasp superfamily enzyme induced under serum starvation and hypoxia as a potential biomarker for pancreatic cancer diagnosis Katsuya Takenaka, Yukako Komori, Yoshiyasu Nakamura, Shiro Koizume, Yohei Miyagi
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