PO.TB10.12 · 肿瘤生物学
Physicochemical Modulation of Cancer Ecosystems: Mechanical Forces, Hypoxia, and Acidosis
- 756 756 Matrix stiffness induces Ca²⁺-DCLK1-PIP5K1A mechanotransduction as a biomechanical checkpoint in pancreatic cancer progression and chemotherapy resistance Haoxiang Zhang, Chuanbin Zhao, Jiaoshun Chen, Xiaoqing Hu, Jianwei Bai, Long He, Zanglong Deng, Tao Yin
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- 759 759 Mechanical remodeling of the tumor microenvironment promotes breast cancer and neutrophil-ssociated immunosuppression through ERG3-ALOX5 signaling Lingpeng Tang, Liangyu Wei, Jinpeng Lu, Haoxiang Zhang, Songsong Wu
- 761 761 Collagen turnover is dominated by fibrogenesis in lung adenocarcinoma and fibrolysis in lung squamous cell carcinomas Victoria Batto, Marselina Arshakyan, Rasmus Sund Pedersen, Neel Ingemann Nissen, Enrico Almici, Noemi Reguart, Morten Karsdal, Nicholas Willumsen, Jordi Alcaraz
- 762 762 A tunable 3D organoid model reveals stiffness-dependent stromal activation and cytokine signaling in pancreatic cancer Carolyn M. Ruiz-Rivera, Ba Xuan Hoang, Jamel Ali, Thomas D. Schmittgen, Bo Han
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- 767 767 Tumor stiffness as a functional biomarker of KRAS-mutant NSCLC: Insights from the ARTIDIS prospective clinical cohort Jordi Alcaraz, Elba Marin, Héctor Sanz-Fraile, Marina Querol, Paula Gausa, Keat Neal, Marselina Arshakyan, Marc Rico-Pastó, Marc Boada, David Sanchez, Carolina Ortiz Velez, Reinier Oropesa Nunez, Gitika Srivastava, Ahmed Jizawi, Sara Nizzero, Tobias Appenzeller, Philipp Oertle, Marko Loparic, Marija Plodinec, Noemi Reguart
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- 771 771 ECM stiffness and glutamine availability rewire metabolic and immune phenotypes in 3D Co-culture models of pancreatic cancer and cancer-associated fibroblasts Jonathan Barajas, Carolyn Ruiz, Zhi Yang, Bo Han, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon
- 773 773 Single-cell and spatial transcriptomic profiling reveal fibrosis-related tumor states in lung squamous cell carcinoma associated with idiopathic pulmonary fibrosis KENTA MANABE, Atsushi Matsuoka, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kazuya Hisamatsu, Ryota Fujiwara, Kosei Ishimura, Shunsuke Mori, Ryunosuke Fujii, Asuka Mimata, Kazuhiro Okada, Ryo Yoshichika, Mao Yoshikawa, Yuma Fukumoto, Haruchika Yamamoto, Kumi Nakajima, Shin Tanaka, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
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- 776 776 A cancer cell intrinsic program for matrix remodeling and CAF recruitment in slow growing, poor prognosis colorectal cancers Claudio Isella, Anna Cassisa, Consalvo Petti, Alexandra Ambra Ulla, Jie Zhou, Carlo Leonardi, Roberta Porporato, Daniela Cantarella, Letizia Franco, Cinzia Benetti, Jill Carol Rubinstein, Jessica Erriquez, Mariangela Russo, Francesco Sassi, Elena Grassi, Ymera Pignochino, Alberto Puliafito, Ivan Molineris, Rebecca Senetta, Andrea Bertotti, Livio Trusolino, Jeffrey H. Chuang, Alberto Bardelli, Enzo Medico
- 777 777 An ATP-grasp superfamily enzyme induced under serum starvation and hypoxia as a potential biomarker for pancreatic cancer diagnosis Katsuya Takenaka, Yukako Komori, Yoshiyasu Nakamura, Shiro Koizume, Yohei Miyagi
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