Integrative Computational Approaches 1

• 1462 · PDF 从单细胞RNA测序中捕获的细胞类型特异性体细胞变异是恶变前血液转录程序的基础 Cell type-specific somatic variants captured from single-cell RNA sequencing underlie transcriptional programs in pre-malignant blood Jasmine Ryu Won Kang, Mawusse Agbessi, June Kim, Ido Nofech-Mozes, Marie-Julie Fave, Philip Awadalla
• 1463 1463 DNA甲基化驱动的克隆性剪接新抗原可预测肺癌免疫治疗应答 DNA methylation driven clonal splicing neoantigens predict immunotherapy response in lung cancer Sadegh Saghafinia, Carla Castignani, Amirhossein Ghorbanpour, Carlos Marínez-Ruiz, Francisco Gimeno-Valiente, Ariana Huebner, Cristina Naceur-Lombardelli, Raju Veeriah, Mariam Jamal-Hanjani, Alan Hackshaw, Nnennaya Kanu, Charles Swanton, Crispin Hiley
• 1464 · PDF CELLama-Perturb：一种用于绘制肿瘤空间异质性中药物敏感性图谱的虚拟细胞建模方法 CELLama-Perturb: A virtual cell modeling approach for mapping drug sensitivity across spatial tumor heterogeneity Haenara Shin, Jeongbin Park, Dongjoo Lee, Hongyoon Choi
• 1465 · PDF 基于表达的免疫表型ML模型可预测肺腺癌的ICI应答和长期临床获益 Expression-based immune-phenotyping ML model predict ICI response and long-term clinic benefit in lung adenocarcinoma Ki Wook Lee, Hyun Woo Park, Han-En Lo, Sehhoon Park, Balachandran Manavalan, Young-Jun Jeon
• 1466 · PDF CellNeighbor：患者肿瘤与细胞系模型的转录图谱，用于指导临床前模型选择 CellNeighbor: A transcriptional atlas of patient tumors and cell line models to inform preclinical model selection Caitlin M. A. Simopoulos, Gabrielle Persad, Otto Morris, Carlos A. Origel Marmolejo, Laura M. Richards, Kelly M. Biette
• 1467 · PDF 在多模态肿瘤学基础模型上采用组相对策略优化进行机制感知的癌症治疗规划 Mechanism-aware cancer therapy planning with group-relative policy optimization on a multimodal oncology foundation model Eric E. Schadt, Jackson Stokes, Lihua Zhao, Jason Chin, Jonathan Tyler, Lijia Sun, Lauren Beck, Duo Xu, Aviva G. Beckmann, Iker Huerga
• 1468 · PDF 种系全外显子组测序提示同源重组修复通路基因是无镰状血红蛋白病的SMARCB1缺陷型肾髓质表型的风险因素 Germline whole exome sequencing implicates homologous recombination repair pathway genes as risk factors in SMARCB1 deficient renal medullary phenotypes without sickle hemoglobinopathies Pankaj Kumar Chauhan, Panayiotis Kontoyiannis, Evan von Eschenbach, Jessica P. Cheng, Susan S. Thomas, Luigi Perelli, Christopher J. Logothetis, Daria Melikhova, Lev Bedniagin, Michael Hensley, Nizar M. Tannir, Pavlos Msaouel
• 1469 · PDF 神经母细胞瘤的多组学分析鉴定出与较高复发风险相关的免疫学生物标志物：MICCHADO研究结果 Multi-omics profiling of neuroblastoma identifies immunological biomarkers associated with higher risk of relapse: Results from the MICCHADO study Antonio Colaprico, Alexandra Saint-Charles, Stelly Ballet, Charles Bobin, Joffrey Alves-Gasnier, Valery Attignon, Nathalie Droin, Ana Lalanne, Doriane Gorret, Lydie Cassard, Imene Hezam, Yasmine Iddir, Anthony Ferrari, Elnaz Saberi Ansari, Gaëlle Pierron, Julien Masliah-Planchon, Angela Bellini, Nathalie Chaput, Charlotte Butterworth, Benoit Dumont, Olivier Lantz, Olivier Delattre, Nadège Corradini, Claudia Pasqualini, Gudrun Schleiermacher
• 1470 · PDF 选取代表性组织学切片以实现经济高效的3D空间转录组学与肿瘤微环境重建 Selecting representative histologic sections for cost-efficient 3D spatial transcriptomics and tumor microenvironment reconstruction Minh-Khang Le, James Evans, Harsimran Kaur, Sojung Lee, Vivek Pujara, Alan Joey Simmons, Seungwoo Kang, Jai Mehta, Louis J. Vaickus, Ken Lau, Joshua Jay Levy
• 1471 · PDF 基于MORPHAEUS的无监督学习增强传统组织空间表型分析 Unsupervised learning with MORPHAEUS enhances conventional tissue spatial phenotyping Elias Pavlatos, Benjamin Tate, Gregory Joseph Baker, Joanna Pucilowska
• 1472 · PDF AI衍生的细胞核形态测量学作为肺腺癌新型预后指标 AI-derived nuclear morphometrics as a novel prognostic indicator in lung adenocarcinoma Bokyung Ahn, Hee Sang Hwang, Hyun-Jung Sung, Se Jin Jang, Pil-Jong Kim, Heounjeong Go
• 1473 · PDF 空间关联局部指标生物信息学分析识别出肝肿瘤边缘的免疫抑制区 Local indicators of spatial association bioinformatics analysis identifies animmunosuppressive zone at the liver tumor margin Yoshiki Nonaka, Kanae Echizen, Tomonori Kamiya, Maho Tsuda, Yoshimi Yukawa-Muto, Hideki Fujii, Ryo Takahashi, Takahiro Kodama, Naoko Ohtani
• 1475 · PDF 一款用于系统识别潜在不良药物-药物相互作用的循证工具 An evidence-based tool to systematically identify potential adverse drug-drug interactions Meetali Sinha, Ansu Kumar, Rajeev K, Vandana Nair, Liptimayee Behura, Deepak Lala, James Wingrove
• 1476 · PDF 通过整合的混合Transformer与图卷积网络改进空间转录组数据 Improve spatial transcriptomic data with integrated hybrid transformer and graph convolutional networks Steven Yan, Limin Jiang, Yan Guo
• 1477 · PDF 溶酶体转运几何驱动三阴性乳腺癌中的免疫抑制性分泌 Lysosomal routing geometry drives immunosuppressive secretion in triple negative breast cancer Sudhanshu Sharma, Manoj K. Mishra
• 1478 · PDF 统一分子结构与细胞形态以增强癌症中的药物-靶点相互作用建模 Unifying molecular structure and cellular morphology to enhance drug-target interaction modeling in cancer Ying-Ju Lai, Yu-Chiao Chiu
• 1479 1479 CAB：一种置信度感知的序列模型，用于高通量预测抗体类抗癌治疗药物中突变驱动的结合亲和力变化 CAB: A confidence-aware sequence model enabling high-throughput prediction of mutation-driven binding affinity change in antibody-based cancer therapeutics Yuanfei Sun, Bing Jiang, Huiping Liu
• 1480 · PDF 超级增强子处的转录凝聚体介导先天免疫中pH依赖的转录调控 Transcriptional condensates at super-enhancers mediate pH-dependent transcriptional control in innate immunity Shengyuan Wang, Zhongyang Wu, Zhe Zhong, Zhenjia Wang, Xu Zhou, Chongzhi Zang
• 1481 · PDF 整合分析识别与肾细胞癌及其风险因素相关的潜在蛋白质组中介物 Integrative analysis identifies potential proteomic intermediates associated with renal cell carcinoma and its risk factors Ibrahim Hossain Sajal, Andrew J. Song, Kevin M. Brown, Mitchell J. Machiela, Peter Kraft, Stephen J. Chanock, Mark P. Purdue, Diptavo Dutta
• 1482 · PDF 一种基于深度学习的多模态整合框架用于临床结局预测 A deep learning-based multimodal integration framework for clinical outcome prediction Baoyi Zhang, Helen Tian, Thanh Bui, Yookyung Christy Choi, Mona H. Cai, Peter Ansell, Aditee Shrotre, Steven Chirieleison, Kevin Kolahi, Xi Zhao, Josue Samayoa, Weilong Zhao
• 1483 · PDF 切割的ATP5A1在氧化应激下介导一个poly(ADP-核糖)依赖的R-loop稳态调控轴 Cleaved ATP5A1 mediates a poly(ADP-ribose)-dependent regulatory axis for R-Loop homeostasis under oxidative stress Aniruddha Mukherjee, Kaveri Goel, Weiqi Lei, Nicholas Hill, Rory Greer, Yuhua Song, Neil Pfister
• 1484 · PDF p-EMT过渡枢纽及其DC2-巨噬细胞生态位定义口腔鳞状细胞癌的复发 p-EMT transitional hub and its DC2-macrophage niche define recurrence in oral squamous cell carcinoma Yongjoon Jin, Jeong-Yeon Ji, Hyojung Lee, Na-yeon Kim, Eun-Jae Chung, Jong-Il Kim
• 1485 · PDF 利用真实世界数据的多模态AI用于LUSC患者亚型发现 Multimodal AI for patient subtype discovery in LUSC using real-world data Swati Kaushik, Mark Carty, Akul Singhania, Justin Guinney, Radia Johnson
• 1486 · PDF 从动物到计算肿瘤学：数字孪生作为下一代骨转移研究的伦理推动者 From animals to computational oncology: Digital twins as ethical enablers of next-generation bone metastasis research Luca Marsilio, Stefan Maksimovic, Elisa Serafini, Alice Maccarini, Sergio Barrios, Pietro Cerveri, Stefano Casarin, Eleonora Dondossola
• 1487 1487 源自组织学的空间微域揭示用于增强特发性肺纤维化诊断的多组学生物标志物 Spatial microdomains from histology reveal multi-omic biomarkers for enhanced idiopathic pulmonary fibrosis diagnosis Raymond Yan, Brian Falkenstein, A. Burak Tosun, Filippo Pullara, S. Chakra Chennubhotla
• 1488 · PDF 结构导向的EZH2与多巴胺D1受体双重靶向可抑制TNBC生长和转移 Structure-guided dual targeting of EZH2 and dopamine D1 receptor suppresses TNBC growth and metastasis Francesco Drago, Libere Ndacayisaba, Xilal Y. Rima, Gautam Sarathy, Deborah Ramsey, Gwen Fewell, Senthil Saravanamuthu, Sanjay Gupta, Giovanni Nigita, Eduardo Reátegu, Pierre Giglio, Christian Rolfo, Eswar Shankar
• 1489 · PDF STniche：一种从空间转录组学识别肿瘤微环境中功能性微环境的方法 STniche: An approach to identify functional niches in the tumor microenvironment from spatial transcriptomics Sasi Arunachalam, Oscar Ospina, Alex C. Soupir, Xiaoqing Yu, Brooke L. Fridley
• 1490 · PDF 基于单细胞的人类小细胞肺癌蛋白活性图谱 A single cell-based protein activity landscape for human small cell lung cancer Lucas ZhongMing Hu, Anish Thomas, Andrea Califano
• 4875 · PDF 在芯片上模拟GBM与血管的相互作用 Modeling GBM-vasculature interaction on chip Promise Emeh, Alan Fetah, Jade Admiraal, Marleen Bokkers, Kevin Jimenez-Cowell, Will Allen, Nienke Wevers, Martine Lamfers, Clemens M. Dirven, Todd Burton, Karla Queiroz

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