Structural and Chemical Biology

• 2412 · PDF 抑制苹果酸酶作为利用癌症代谢重编程的策略：一种基于结构的方法 Malic enzyme inhibition as a strategy to exploit metabolic reprogramming in cancer: A structure-based approach Ben Andrew Krinkel, Yuliana Yosaatmadja, Mark Daniel Slayton, Jin Heon Jeon, Jack Copping, Jack Flanagan, Sofia Merajver, Chris Squire, Kerry Loomes
• 2413 · PDF CYP2E1介导的肝细胞癌铁死亡机制的洞见 Insights in CYP2E1-mediated ferroptosis in hepatocellular carcinoma Kristy L. Thomas, Kylie R. Driggers, Hyland C. Gonzalex, Jessica H. Hartman
• 2414 · PDF 靶向ADAR1的干扰素诱导型异构体p150用于治疗口腔鳞状细胞癌（OSCC） Targeting the interferon-inducible isoform, p150 of ADAR1 for the treatment of oral squamous cell carcinoma (OSCC) Annie Wai Yeeng Chai, Pei San Yee, Xavier Wezen Chee, Stephanie Hao Ling Cheah, Jie Ying Teo, Keng Yoon Yeong, Siew Kit Ng, Siaw San Hwang, Sok Ching Cheong
• 2415 2415 首创的CHD4稳定型抑制剂，可捕获并解离NuRD复合物 First-in-class stabilizing inhibitor of CHD4 that traps and disassembles the NuRD complex Anthony Sanchez, Minkyu Kim, Ivan Babic, Kyle Miller, Elmar Nurmemmedov
• 2416 · PDF 使用新型椭圆二色光谱仪分析非癌性和癌性蛋白结构 Analyzing non-cancerous and cancerous protein structure using a novel Elliptical Dichroism Spectrometer Tommy Gao, Dali Sun
• 2417 · PDF 使用LiP-MS对分子胶进行全蛋白质组范围的靶点结合和三元复合物图谱分析 Proteome-wide target engagement and ternary complex mapping of molecular glues using LiP-MS Martin Soste, Polina Shichkova, Matevz Stefancic, Daniel Redfern, Francesca Cavallo, Lorna Charge, Ka Ying Lee, Ricardo Canavate del Pino, Denise Swift, Roland Hjerpe, Stuart Thomson, Allan Jordan, Yuehan Feng
• 2418 · PDF 针对大型内在无序蛋白的非共价小分子探针发现 Non-covalent small molecule probe discovery of large intrinsically disordered protein Yichen Xiang, Marc Ramos Sala, Jose I. Vergara Panzone, Nancy Jiang, Diya Rana, Eliot Ebert, Angela N. Koehler
• 2419 2419 作为靶向 PI3K/MAPK 和 JAK/STAT 通路的强效抗黑色素瘤药物的新型功能化 β-内酰胺的合成与评价 Synthesis and evaluation of novel functionalized beta-lactams as potent anti-melanoma agents targeting PI3K/MAPK and JAK/STAT pathways Joy Temiloluwa Folahan, Ojasvi Dutta, Tolulope Omole, B. Donji, Konstantin Kousoulas, Timothy Beng, Jean Christopher Chamcheu
• 2421 · PDF 结合深度突变扫描和下一代蛋白质测序，利用显性蛋白变体开发 DNA 修复抑制剂 Combining deep mutational scanning and next-generation protein sequencing to harness dominant protein variants to develop DNA repair inhibitors Nigel O'Neil, Lina Ma, Anthony Oppedisano, Esteban Lenoir, Philip Hieter, Peter C. Stirling
• 2422 · PDF 下一代化学生物学：通过表型筛选绘制嘌呤组可成药空间揭示基因型特异性脆弱性 Next-generation chemical biology: Mapping the Purinome druggable space reveals genotype-specific vulnerabilities via phenotypic screening Ali Khateb, Ritika Gangaraju, Eric Gonzalez, Maizie Lee, Akshat K. Nigam, Jessica San Juan, Agnes Tan, Imran S. Haque, Thilo J. Heckrodt, Jack D. Sadowsky, Stig K. Hansen, Raymond V. Fucini
• 2423 · PDF 作为化学探针的靶向多梳抑制复合物 1 的新型小分子抑制剂的评价 Evaluation of novel small molecule inhibitors targeting Polycomb repressive complex 1 as chemical probes Geoffrey Hewett, Haiqing He, Yiwu Yao, Se Ra Park, Sydney Musser, Trupta Purohit, Jolanta Grembecka, Tomasz Cierpicki
• 2424 · PDF 评价 NSD1 和 NSD3 共价小分子抑制剂在癌细胞系中的生化活性和内源性结合 Evaluating the biochemical activity and endogenous engagement of covalent small molecule inhibitors of NSD1 and NSD3 in cancer cell lines Joshua Ray, Bradley Clegg, Sergei Zari, Kibum Kim, Se Ra Park, Jolanta Grembecka, Tomasz Cierpicki
• 2426 · PDF ADGRL4 的冷冻电镜结构为其激活机制提供了功能性见解 The cryo-EM structure of ADGRL4 provides functional insights into its mechanism of activation David M. Favara, Qingchao Chen, Anastasiia Gusach, Aurora Diamante, Jayesh C. Patel, Patrcia C. Edwards, Christopher G. Tate
• 2427 2427 使用微流控调制光谱法（MMS）优化 pH 低插入肽 pH 依赖性构象变化的检测 Optimizing the detection of pH-dependent conformational changes in pH-low insertion peptides using microfluidic modulation spectroscopy (MMS) Emma Sanderson, Ryan Bynum, Happy Agarwal, Lacey McNally
• 2428 · PDF 结构蛋白质组学与人工智能助力PROTAC理性设计 Structural proteomics and AI powers PROTAC rational design Nitzan Simchi, Michal Ran Shchory, Joseph Rinberg, Alon Shtrikman, Yaron Ben Shoshan-Galeczki, Gali Arad, Katharina Lange, Sagie Brodsky, Anjana Shenoy, Dimitri Kovalerchik, Yonatan Kedem, Iris Alchanati, Galina Otonin, Noam Cohen, Kirill Pevzner, Eran Seger
• 2429 · PDF 纳米制剂实现氯硝柳胺（niclosamide）在胰腺癌治疗中的老药新用：用于增强生物利用度的快速溶解口服制剂 Nanoformulation enabling repurposing of niclosamide for the treatment of pancreatic cancer: Rapidly soluble oral formulation for enhanced bioavailability Bhoomi Mukeshbhai Dholariya, Ketankumar Patel

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