Targeted Antigen Therapies and Immunity

• 2649 · PDF 靶向肿瘤内皮细胞和癌细胞的抗PRND抗体药物偶联物用于治疗胶质母细胞瘤和肉瘤等富血管肿瘤 Tumor endothelial cell and cancer cell targeting anti-PRND antibody-drug conjugate to treat hypervascular tumors such as glioblastoma and sarcomas Byoungmo Kim, Ha Kyeong Lee, So-Young Choi, Sera Lee, Sang Yoon Kim, Youngro Byun, Seong Who Kim
• 2650 · PDF 打破免疫沉默：肿瘤靶向分子治疗重塑进展性神经母细胞瘤中的肿瘤-免疫界面 Breaking immune silence: Tumor-targeted molecular therapy reprograms the tumor-immune interface in progressive neuroblastoma Loganayaki Periyasamy, Sreenidhi Mohanvelu, Sheeja Aravindan, Poorvi Subramanian, Natarajan Aravindan
• 2652 · PDF MGT-1142，一种靶向新型聚糖用于小细胞肺癌的抗体药物偶联物 MGT-1142, an antibody-drug conjugate targeting a novel glycan for small-cell lung cancer Su-Yu Tsai, Maomao He, Ju-Mei Li, Ping Chao, Ting-Chun Hung, Mei-Hsuan Tsai, Charng-Sheng Tsai
• 2653 · PDF 晚期黑色素瘤中免疫检查点抑制剂与BRAF/MEK抑制剂的序贯用药：基于Kaplan-Meier重建个体水平数据的荟萃分析 Sequencing immune checkpoint inhibitors and BRAF/MEK inhibitors in advanced melanoma: A meta-analysis of Kaplan-Meier-reconstructed individual level data Anderson Ruiz Simoes, Isabella Michelon, Wellington Neto, Metamia Ciampricotti, Ludimila Cavalcante
• 2654 · PDF DB-1421是一种经优化的EGFR/MUC1双特异性ADC，在临床前研究中表现出更佳的肿瘤选择性以及令人期待的疗效和安全性 DB-1421, an optimized EGFR/MUC1 bispecific ADC, exhibits improved tumor selectivity, promising efficacy and safety in preclinical studies Chenggang Li, Jun Yao, Yongsheng Nie, YANG QIU, Haiqing Hua
• 2655 · PDF DB-1323是一种新一代靶向间皮素的抗体药物偶联物，在临床前模型中展现出抗肿瘤活性和良好的安全性特征 DB-1323, a next-generation mesothelin targeting antibody-drug conjugate, demonstrated anti-tumor activity and favorable safety profile in pre-clinical models Haiqing Hua, Xi Li, Jun Yao, Tao Cheng, Junjie Yang, Xinyue Chen, Sang Pil Lee, Jiyoung Shin, Yunseon Choi, Gisun Baek, Alexandre Joyeux, Jung Chae Lim
• 2656 · PDF DB-1329：一种靶向CDCP1的新型抗体药物偶联物在多种实体瘤中展现出强效的临床前抗肿瘤活性 DB-1329: A novel antibody-drug conjugate targeting CDCP1 demonstrates potent preclinical anti-tumor activity across multiple solid tumors Hui Yang, Yujie Liu, YANG QIU, Haiqing Hua
• 2657 · PDF DB-1326是一种新型双载荷TA-MUC1靶向抗体药物偶联物，在临床前肿瘤模型中显示出强效的抗肿瘤疗效 DB-1326, a novel dual-payload TA-MUC1-directed antibody-drug conjugate, shows potent antitumor efficacy in pre-clinical tumor model Chenggang Li, Lei Yi, Jun Yao, Yang Qiu, Haiqing Hua
• 2658 2658 MSI-H BRAF V600E结直肠癌独特的生物学和免疫微环境特征：PD-1、BRAF和EGFR联合抑制的潜力 Distinct biological and immune microenvironment features of MSI-H BRAF V600E colorectal cancer: Potential for combined PD‑1, BRAF, and EGFR inhibition Lulu He, Feng Guo
• 2659 · PDF 靶向CD44v9的抗体药物偶联物作为晚期乳腺癌的新型疗法 CD44v9-targeted antibody-drug conjugate as a novel therapy for advanced breast cancer Dileep R. Reddy, McKenna E. Flynn, Yasuaki Anami, Zhaoxuan Yang, Jayden Aleman, Minji Seo, Kyoji Tsuchikama, Jennifer A. Maynard, Naoto T. Ueno, Jangsoon Lee
• 2660 · PDF AV-P138-ADC（ARR-002）是一种新型MUC16/NaPi2b双靶点四价ADC，用于治疗卵巢癌和子宫内膜癌 AV-P138-ADC (ARR-002), a novel MUC16/NaPi2b dual-target tetravalent ADC, for the treatment of ovarian and endometrial cancers Sunil Bhakta, Levi Blazer, Cristina Abrahams, Jiang Liu, Coen Kuijl, Jarrett Adams, Marcin Kowanetz, Luna Musib, Amy Kim, Wanda Kwan, Viswanatham Katta, Vidya S. Jonnalagadda, Reva Raghupathi, Paul Polakis, Stuart Lutzker, Sachdev S. Sidhu, Jagath Reddy Junutula
• 2661 · PDF AZD5335，一种靶向叶酸受体α的ADC，在肺腺癌中发挥抗肿瘤作用 AZD5335, a folate receptor alpha-targeted ADC, exerts anti-tumor responses within lung adenocarcinoma Jason J. Zoeller, Ravinder Tammali, Nancy Lee, Isabella Tilmont, Judith Anderton, Shailesh Metkar, Michael Ophir, Jixin Wang, Claire Myers, Lara McGrath, Alma Andoni, Ina Bisha, Iris Dino, Xhenifer Guza, Simon Christ, Michael Lehmann, Roger Dodd, Neki Patel, Tim Brier, Marc L. Hyer, Marco Gymnopoulos, Sabina Cosulich, Alejandra Negro, Elaine Hurt, Puja Sapra
• 2662 · PDF MGT-1141，一种靶向DLL3阳性癌症的抗体药物偶联物 MGT-1141, an antibody-drug-conjugate targeting DLL3 positive cancers Mei-Hsuan Tsai, Maomao He, Su-Yu Tsai, Ju-Mei Li, Ping Chao, Ting-Chun Hung, Charng-Sheng Tsai
• 2663 · PDF 靶向YAP/TEAD信号通过激活胞质DNA感应通路扰乱RNA聚合酶II活性并增强胃食管癌的免疫治疗应答 Targeting YAP/TEAD signaling disturbs RNA polymerase II activity and enhances immunotherapy response via activated cytosolic DNA sensing pathway in gastroesophageal cancer Yanting Yann Zhang, Ayna Mammedova, Dipti Athavale, Curt Balch, Mikel Ghelfi, Xiaodan Yao, Gennaro Calendo, Songjie Liu, David Pulipati, Yahui Li, Xiaoxin Chen, Francis Spitz, Generosa Grana, Vladimir Khazak, Shumei Song
• 2664 · PDF MGT-1143，一种用于胃肠道癌症的新型CDH17靶向ADC MGT-1143, a novel CDH17-targeting ADC for gastrointestinal cancers Maomao He, Ping Chao, Su-Yu Tsai, Ju-Mei Li, Ting-Chun Hung, Mei-Hsuan Tsai, Charng-Sheng Tsai
• 2665 · PDF 携带双载荷的MET/HER3抗体药物偶联物：一种消除肿瘤逃逸机制的双靶点策略 The MET/HER3 antibody-drug conjugate with dual payload: A dual-target approach to eliminate tumor escape mechanism Yuan-Liang Wang, Chi-Huan Lu, Woan-Eng Chan, Ting-Yu Chang, Hong-Syuan Lin, Cheng-Yen Wei, Shin-Jin Lin, Lu-Tzu Lu, Meng-Hsin Liu, Wei-Jhen Huang, Ya-Chi Chen
• 2666 · PDF CVL006（一种新型PD-L1/VEGF双特异性抗体）治疗晚期实体瘤的开放标签、多中心I期临床研究 An open-label, multicenter Phase I clinical study of CVL006, a novel PD-L1/VEGF bispecific antibody, in advanced solid tumors Jin Li, Ning Li, Shuhang Wang, Ye Guo, Kai Yao, Yanjie Zhu, Feng Ye, Hao Zeng, Steve Shen, Jin Zhang
• 2667 · PDF TM4SF1作为胆道癌中一种可被免疫效应细胞疗法靶向的新型肿瘤相关抗原 TM4SF1 as a novel tumor-associated antigen in biliary tract cancers targetable by immune effector cell therapy Lorraine Nuniz*, Julia Pham, Juliette Jacques, Josephine Hinneh, Jocelin Chen, Corynn Kasap, Jon Akutagawa, Chih-Hao Chang, Robin K. Kelley, Arun Wiita, Jonathan Chou, Kwun Wah Wen, Vipul Kumar*, Franklin Huang
• 2671 · PDF TROP2表达预测患者源性乳腺癌类器官对datopotamab deruxtecan（Dato-DXd）的敏感性 TROP2 expression predicts sensitivity to datopotamab deruxtecan (Dato-DXd) in patient-derived breast cancer organoids Won-Ji Ryu, Min Hwan Kim, Geon-Uk Kim Kim, Joohyuk Sohn, Yumi Hwang, Jeong Dong Lee, Shinyoung Park, Hyun Myoung Yun, Kyoo Hyun Kim, Gun Min Kim, Hyung Seok Park
• 2672 · PDF 针对炎性乳腺癌中Lipocalin-2的小分子抑制剂表征 Characterization of small molecule inhibitors against Lipocalin-2 in inflammatory breast cancer Sthephanie Estrada-Mojica, Fatma Valiyeva, Pablo E. Vivas Mejia

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