PO.ET03.07 · 实验与分子治疗
Targeting Drug Resistance 1: Apoptosis and Autophagy
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1841 · PDF Venetoclax重塑Notch信号通路以驱动北美成人T细胞白血病/淋巴瘤的耐药 Venetoclax rewires Notch signaling to drive resistance in North American adult T-cell leukemia/lymphoma Ankit Tanwar, Salman Sadullah Usmani, Sovira Chaudhry, Aditi Shastri, Marina Konopleva, Murali Janakiram, Ali Bazarbachi, B. Hilda Ye, Xingxing Zang, Amit Verma, R. Alejandro Sica
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1843 · PDF Venetoclax耐药的AML细胞模型作为探索针对BCL2抑制剂耐药的新一代药物的平台 Venetoclax-resistant AML cell models as a platform for exploring new generation drug for BCL2 inhibitor resistance Jinjin Wang, John Liu, Lin Teng
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1844 · PDF BCL6的表观遗传重编程驱动大B细胞淋巴瘤的治疗应答并揭示合成依赖性 Epigenetic rewiring of BCL6 drives responses and unveils synthetic dependencies in large B cell lymphoma Haopeng Yang, Kevin Bowman, Wenzhi Ji, Sai Gourisankar, Ashley L. Wilson, Zihan Yang, Ethan Marszalek, Stephen M. Hinshaw, Tinghu Zhang, Xiaofan Liu, Andrey Krokhotin, Sabin Nettles, Suprateek Kundu, Gerald R. Crabtree, Nathanael S. Gray, Michael R. Green
- 1845 1845 靶向线粒体和谷胱甘肽代谢使白血病细胞对DNA低甲基化药物与venetoclax联合治疗敏感 Targeting mitochondrial and glutathione metabolism sensitizes leukemia cells to DNA-hypomethylating agents and venetoclax combination therapy Pony Yu-Ling Lee, Joy Khag, Marvin A. Aberin, Ta-Yu Liu, Ya-Ting Lu, Kun-Yuan Lin, Chao-Di Chang, Shan-Yun Cheng, Ya-Wen Hung, Chih-Chieh Yang, Yu-Hsien Chang, Chien-Chang Shen, Yao-Ming Chang, Hsing-Chen Tsai, Shih-Yu Chen, Shu-Ping Wang
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1847 · PDF 通过靶向NHE6介导的内体-自噬机制改善多发性骨髓瘤对蛋白酶体抑制剂的应答 Improve proteasome inhibitor response by targeting NHE6-mediated endosomal-autophagic machaniery in multiple myeloma Yutong Wang, Liuting Chen, Winston Huang, Jin He, Li Bao, Yihui Fan, Pei Lin, Qing Yi, Jing Yang
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1848 · PDF IL-1驱动的信号传导促进B细胞淋巴瘤临床前模型对PI3K和BCL2抑制剂的耐药 IL-1-driven signaling promotes resistance to PI3K and BCL2 inhibitors in B-cell lymphoma preclinical models Alberto J. Arribas, Federica Fuzio, Eleonora Cannas, Michela Chiappa, Luciano Cascione, Giulio Sartori, FIlippo Spriano, Andrea Rinaldi, Georg Stussi, Emanuele Zucca, Davide Rossi, Anastasios Stathis, Andrea Alimonti, Giovanna Damia, Massimo Broggini, Francesco Bertoni
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1849 · PDF 双重抑制AURKA和ERBB克服边缘区淋巴瘤模型对PI3K/BTK/BCL2抑制剂的耐药 Dual inhibition of AURKA and ERBB overcomes resistance to PI3K/BTK/BCL2 inhibitors in marginal zone lymphoma models Emma Pesenti, Alberto J. Arribas, Maidel Carpio, Eleonora Cannas, Georg Bischof, Francesco Bertoni
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1850 · PDF 共靶向EZH2和TEAD通过肿瘤内在固有免疫信号在Hippo通路突变癌症中引发凋亡 Co-targeting EZH2 and TEAD elicits apoptosis through tumor-intrinsic innate immune signaling in Hippo pathway-mutated cancers Antja-Voy Hartley, Mustafa Al-Dulaimi, Navin R. Mahadevan, Pinar Eser, William W. Feng, Tran Thai, Jeanelle A. Tsai, Caitlyn Weston, Nicholas Tourtillot, Matthew Booker, Joseph Kulesza, Zhaorong Li, Elizabeth Cohen, Sean Lenahan, Choudhury Fabliha Yusuf, Abeba Teshager, Prafulla C. Gokhale, Shweta Kukreja, Sonsoles Liria Veiga, Rong Li, Xintao Qiu, Henry W. Long, Michael Y. Tolstorukov, Matthew G. Oser, Nathanael S. Gray, David A. Barbie, Pasi A. Janne
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1851 · PDF 通过抑制蛋白磷酸酶5(PP5)克服ccRCC中的药物耐药 Overcoming drug resistance in ccRCC through inhibition of protein phosphatase 5 (PP5) Sarah J. Backe, Rebecca Sager, Jennifer Heritz, John Chisholm, Mark Woodford, Dimitra Bourboulia, Gennady Bratslavsky, Mehdi Mollapour
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1852 · PDF CRISPR筛选确定BMF缺失是ALK重排肺癌中耐药持留细胞的存活因子 CRISPR screening identifies BMF loss as a drug-tolerant persister cell survival factor in ALK-rearranged lung cancer Ryohei Katayama, Takahiro Utsumi, Ken Uchibori, Makoto Nishio
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1853 · PDF NAT10介导的ac4C RNA修饰通过ATG5依赖性自噬促进结直肠癌干性和5-FU耐药 NAT10-mediated ac 4 C RNA modification promotes colorectal cancer stemness and 5-FU resistance via ATG5-dependent autophagy Xin Kong, Junyong Weng, Zhe Wang, Ajay Goel
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1854 · PDF 用KS18选择性抑制Mcl-1可克服凋亡耐药并增强急性髓系白血病中FLT3靶向治疗 Selective Mcl-1 inhibition with KS18 overcomes apoptotic resistance and enhances FLT3-targeted therapy in acute myeloid leukemia Sahil Jethi, Krishne Gowda, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Manoj K. Pandey
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1855 · PDF PI3K/mTOR双重抑制剂通过凋亡和自噬双重机制克服ALK重排NSCLC中的ceritinib耐药 PI3K/mTOR dual inhibitor overcomes ceritinib resistance in ALK-rearranged NSCLC via both apoptosis and autophagy Hyun-Min Ryu, Joo Young Ha, Shinkyo Yoon, Yunkyung Sung, Deokhoon Kim, Chang Hoon Lee, Wanlim Kim, Seyoung Seo, Sang-We Kim, Kang-Seo Park, Dae Ho Lee
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1856 · PDF ETV4下调通过AMPK-ULK1依赖性保护性自噬介导乳腺癌中的trametinib耐药 Downregulation of ETV4 mediates trametinib resistance via AMPK-ULK1-dependent protective autophagy in breast cancer Xiaodong Liu, Ji Won Kim
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1857 · PDF BTK和BCL2抑制剂获得性耐药机制揭示B细胞淋巴瘤中临床可操作的脆弱性 Mechanisms of acquired resistance to BTK and BCL2 inhibitors reveal clinically actionable vulnerabilities in B-cell lymphoma Alberto J. Arribas, Camilla Scalise, Eleonora Cannas, Maria Elena Carazzolo, Luciano Cascione, Andrea Rinaldi, Carlo Visco, Davide Rossi, Francesco Bertoni
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1858 · PDF APG-2449抑制FAK可增强MAPK通路阻断在BRAF V600E突变肿瘤模型中的抗肿瘤活性 FAK inhibition by APG-2449 enhances the antitumor activity of MAPK pathway blockade in BRAF V600E-mutant tumor models Zhou Yu, Zhiyan Liang, Xinyi Yao, Shujie He, Dajun Yang, Yifan Zhai
- 1859 1859 果糖转运蛋白的过表达增强促存活信号并赋予Ph样B细胞急性淋巴细胞白血病对venetoclax的耐药 Overexpression of fructose transporter increases pro-survival signaling and confers venetoclax resistance in Ph-like B-cell acute lymphoblastic leukemia Serene Xavier, Sonia Rodriguez, Zhaohui Gu, Lucy Ghoda, Stuart Blakemore, Lukas Frenzel, Alexey Danilov, Vinod Pullarkat
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1860 · PDF 确定葡萄膜黑色素瘤中ONC212耐药的机制以开发联合治疗策略 Determining mechanisms of ONC212-resistance in uveal melanoma to develop combination therapy strategies Md Alauddin, Chandrani Chattopadhyay
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1861 · PDF 脂肪酸氧化抑制可抑制胰腺导管腺癌中伴自噬的获得性耐药 Acquired drug resistance with autophagy is suppressed by fatty acid oxidation inhibition in pancreatic ductal adenocarcinoma Soo-Youl Kim, Sang M. Woo, Wonyoung Choi, Joon Hee Kang, Sung Hoon Sim, Jung Won Chun
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1862 · PDF 靶向核仁素可克服急性髓系白血病中MCL-1介导的venetoclax耐药 Targeting nucleolin overcomes MCL-1-mediated venetoclax resistance in acute myeloid leukemia Kyung Jin Kim, Jihyun Um, Eun Jung Shin, Yu Mi Ji, Sung Hwan Moon, Soo Jin Lee
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1863 · PDF venetoclax耐药AML模型的建立与表征以支持临床前药物发现 Development and characterization of the venetoclax-resistant AML model to enable preclinical drug discovery Jifan Yuan, Miaomiao Yu, Gaoxiang Liu, Jian Xiang, Xiangnan Qiang, Zhixiang Zhang
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1864 · PDF G3BP1敲低通过诱导凋亡使急性髓系白血病细胞系HL60对venetoclax敏感 G3BP1 knockdown sensitizes the acute myeloid leukemia cell line HL60 to venetoclax by inducing apoptosis Naoko Hosono, Rie Nishi, Naoko Ida, Chantana Polprasert, Rosesanun Pavaputanont, Takahiro Yamauchi