T Cell Engagers 1

• 1609 · PDF 为肿瘤学和自身免疫领域下一代T细胞衔接器解锁pMHC靶点空间 Unlocking pMHC target space for next generation T cell engagers in oncology and autoimmunity Roberto Magliozzi, Haydn Prosser, Hanif Ali, Amy Li, Luca Pellegrinet, Ni Huang, Petra Mlcochova, Wei Wang, Ruben Cabanillas, E-Chiang Lee, Allan Bradley
• 1610 · PDF 一种新颖多功能的前药T细胞衔接器平台及展现强效且肿瘤限制性活性的新候选分子 A novel and versatile Prodrug T cell engager platform with a novel candidate demonstrating potent and tumor-restricted activity Zhou Lv, Yinhui Ding, Jingjing Mao, Huifeng Lv, Yang Yang, Yi Ren, Yu Zhang, Lijun Wang, Danqing Wu, Xuan Wu, Shiyong Gong
• 1611 · PDF 针对IGFBPL1的T细胞衔接器的开发：小细胞肺癌及其他神经内分泌癌的新靶点 Development of a T cell engager against IGFBPL1: A novel target for small cell lung cancer and other neuroendocrine cancers Lauren A. Pitt, Eleanor Leung, Ruban Kannan, Shereen Jabar, Nicole Church, Zariah Rosenes, Ben Kiefel, Matthew Beasley
• 1612 · PDF 新型CD3结合物助力T细胞衔接器实现强效肿瘤控制、有限的细胞因子释放及与共刺激的安全配对 Novel CD3 binders enable T cell engagers with potent tumor control, limited cytokine release, and safe pairing with co-stimulation Sinduja Marx, Ian Blumenthal, Kristina Pilat, Shelli M. Morris, Emily J. Girard, Kenneth Brasel, Ray Ruff, Alison M. Williams, Hailey Hentschel, Steven Chen, Chunfeng Yin, James M. Olson, Jason Price
• 1613 · PDF 使用新型同类最佳CD3结合物扩展强效双特异性PD-L1:CD3 T细胞衔接器的治疗窗口 Expanded therapeutic window of potent bispecific PD-L1:CD3 T cell engager using a novel best-in-class CD3 binder Andrew J. Mhyre, Emily J. Girard, Sinduja Marx, Shelli M. Morris, Kristina Pilat, Alison M. Williams, Parvathi Muthuraman, Ray Ruff, Hailey Hentschel, Steven Chen, Chunfeng Yin, Zachary Crook, Jason Price, James M. Olson
• 1614 · PDF 用于开发T细胞衔接器的新型抗CD3单域抗体 Novel anti-CD3 single domain antibodies for the development of T cell engager Jieying Liu, Yongqing Cheng, Mengmeng Sun, Xiaoqian Zhang, Hui Cong, Rumeng Bao, Changchang Zhang, Yu Dan, Shuang Wang, Jie Yang, Donghui Wu, Lei Wu, Jijie Gu
• 1615 · PDF 发现靶向CD28的单域抗体以促进共刺激性T细胞衔接器的开发 Discovery of CD28 targeting single domain antibodies to facilitate the development of costimulatory T cell engager Siwei Nie, Yali Wan, Hang Zhou, Xinyan Ji, Jianqing Xu, Lei Wu, Jijie Gu
• 1616 · PDF CLSP-5282：一种同类首创的T细胞衔接器，靶向HLA-A*03:01呈递的KRas G12V突变肽 CLSP-5282, a first-in-class T cell engager targeting KRas G12V mutant peptide presented on HLA-A*03:01 Amanda Ford, Lenore Cullen, Alec R. Andrews, Justina X. Caushi, Catherine Souza, Veselin S. Dobrev, Raffaello Verardi, Hayden Jones, Brena Williams, Kai Li Tan, Michael Alloway, Anthony S. Gizzi, James Bingham, Gillian A. Kingsbury, Jessica Kohler
• 1617 · PDF AI辅助开发靶向MAGE-A4的TCR样T细胞衔接器用于黑色素瘤治疗 AI-assisted development of a TCR-like T cell engager targeting MAGE-A4 against melanoma Yang Liu, Qi Zhao
• 1618 · PDF 一种用于新一代癌症治疗的新型pan-γδ T细胞衔接器平台 A novel pan-gamma-delta T cell engager platform for next-generation cancer therapeutics Baotian Yang, Yuan Wu, Tengfei Yu, Sha Cheng, Qun Sun, Siwei Nie, Lei Wu, Jijie Gu
• 1619 · PDF XTX601的发现与优化：一种被遮蔽的靶向claudin 18.2的T细胞衔接器 Discovery and optimization of XTX601, a masked claudin 18.2-targeting T cell engager Jason Hedges, Pyae Hein, David Crowe, Aaron Bogle, Jing Ying Eng, Manoussa Fanny, Wilson Guzman, Sami Kahloun, Bernard Lanter, Janice Lee, Natalia Malkova, Haley Saxton, Kyle Smith, Sallyann Vu, Yihong Zhang, Kurt Jenkins, Elsie DiBella, Benjamin Nicholson, Scott Coleman, Carl Uli Bialucha
• 1620 · PDF ATG-112：一种新型ALPP/G x CD3双特异性T细胞衔接器，用于治疗ALPP/G+实体瘤 ATG-112, a novel ALPP/G x CD3 bispecific T cell engager, for the treatment of ALPP/G + solid tumors Jishun Chen, Yu Bai, Suya Bai, Huiling Liu, Zaoshun Hu, Jay Mei, Peng Chen, Bing Hou
• 1621 · PDF ATG-106：一种新型"2+1"格式的靶向CDH6的T细胞衔接器（TCE），显示出强效的T细胞依赖性细胞毒性和体内抗肿瘤疗效 ATG-106, a novel “2+1”format CDH6-targeted T-cell Engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy Tengteng Li, Peng Chen, Huiling Liu, Zaoshun Hu, jiaqi yan, jie huang, Jay Mei, Bing Hou
• 1622 · PDF 亲和力优化的双特异性T细胞衔接器W308051选择性杀伤表达PSMA的肿瘤细胞且细胞因子分泌有限 The affinity-optimized bispecific T cell engager W308051 selectively kills PSMA-expressing tumor cells with limited cytokine secretion Johannes Breuning, Yi Qin, Yunying Chen, Xia Wang, Jijie Gu
• 1623 · PDF 一种用于新一代癌症治疗的新型pH依赖性T细胞衔接器平台 A novel pH dependent T cell engager platform for next generation cancer therapeutics Jie Li, Wenqian Fang, Nan Feng, Tengfei Yu, Siwei Nie, Lei Wu, Jijie Gu
• 1624 · PDF 逻辑门控的switch-DARPin T细胞衔接器联合CD2共刺激，可提高对MSLN和EpCAM共表达卵巢癌的安全性和疗效 Logic-gated switch-DARPin T cell engager with CD2 co-stimulation for improved safety and efficacy in MSLN and EpCAM co-expressing ovarian cancer Matteo Bianchi, Sarah Jetzer, Simon Häberle, Aline Eggenschwiler, Albulena Toska, Anja Schlegel, Justin D. Walter, Stephan Wullschleger, Tamara Lekishvili, Yvonne Kaufmann, Rocio Evangelista Vaz, Marcela Guzman Ayala, Alexander Link
• 1625 · PDF 用于结直肠癌的VHH纳米抗体掩蔽的条件性激活CDH17 T细胞衔接器 VHH nanobody-masked conditionally active CDH17 T cell engager for colorectal cancer Lei Wu, Guoxin Ni, Xiaoyue Liu, Sha Cheng, Senfeng Xiang, Yi Liu, Xia Wang, Donghui Wu, Tengfei Yu, Jijie Gu
• 1626 · PDF 一种新型机器学习衍生的nectin-4 x CD3双特异性T细胞衔接器LGTX-101表现出高度的肿瘤选择性并在体内强效诱导肿瘤消退 A novel machine-learning derived nectin-4 x CD3 bispecific T-cell engager, LGTX-101, demonstrates high degrees of tumor selectivity and potently induces tumor regression in vivo Lucrecia Alberdi, Sabrina Bouhafs, Dan Foxler, Justin Grace, Winston Haynes, Catherine Howsham, Leo Kassimatis, Sylwia Marshall, Lida Mavrogonatou, James McClory, Portia McGhan, Rebecca Mighell, Michael Mullin, Sandra Pasternakiewicz, Sujata Ravi, Nush Sarvaria, Gino Van Heeke, Angus Sinclair
• 1627 · PDF DS-2243a是一种HLA-A*02/NY-ESO导向的双特异性T细胞衔接器，在实体瘤临床前模型中显示出强效抗肿瘤活性 DS-2243a, an HLA-A*02/NY-ESO-directed bispecific T‑cell engager, shows potent anti-tumor activity in preclinical models of solid tumors Junya Ichikawa, Ayaka Yatsu, Ryuichi Nakamura, Akemi Kita, Shingo Noguchi, Yoko Ishimoto, Chikako Maru, Kento Tanaka, Kensuke Nakamura, Shinji Furuzono, Makiko Nakayama, Toshiaki Ohtsuka, Reimi Kawaida
• 1628 · PDF 一种双特异性PDL1:CD3 T细胞衔接器可强效杀伤难治性原发性和转移性颅内肿瘤 A bispecific PDL1:CD3 T-cell engager potently kills intractable primary and metastatic intracranial tumors Emily J. Girard, Shelli M. Morris, Kristina Pilat, Alison M. Williams, Kenneth Brasel, Heather Conti, Parvathi Muthuraman, Ray Ruff, Hailey Hentschel, Steven Chen, Chunfeng Yin, Zachary Crook, Jason Price, Andrew J. Mhyre, James M. Olson
• 1629 · PDF 一种改进用于实体瘤治疗的双特异性T细胞衔接器的创新方法 An innovative approach to improve bispecific T-cell engagers for solid tumor therapy Hing C. Wong, Xiaoyun Zhu, Varghese George, Hamidreza Farzaneh, Crystal Gilkes, Natalia Valderrama, Alyssa Thompson, Lijing You, Lucas Gomez, Christian Echeverri, Niraj Shrestha, Peter R. Rhode, Jack Egan
• 1630 · PDF 一种新型肿瘤相关抗原cb02作为双特异性T细胞衔接器在癌症中的临床前研究 Preclinical investigation of a novel tumor associated antigen, cb02, as a bispecific t-cell engager in cancer Mary Mathieu, Daniel Reiton, Kevin Nuno, Egle Jurgaityte, Jason Chen, Nathan Fisher, Prasuna Paluru, Robert Chen, Ralph McAnelly, Colton Bracken, Jen Chew, Javeria Haroon, Maeve O'Huallachain, Maggie Lu, Jeffrey Verboon, Max Mumbach, Alexander Martinko, David Kugler, Dan Rock, Burcu Yigit
• 1631 · PDF 利用现货型T细胞增强双特异性T细胞衔接器治疗在T细胞反应欠佳患者中的疗效 Leveraging off-the-shelf T cells to enhance bispecific T cell engager therapy efficacy in patients with suboptimal T cell responses Saghar Pahlavanneshan, Stephen J. Forman, Xiuli Wang
• 1632 · PDF DBXO-1的临床前特征研究：一种针对主要实体瘤的多pMHC靶向双特异性T细胞衔接器 Preclinical characterization of DBXO-1, a multi-pMHC targeted bispecific T cell engager for major solid tumors Johanna K. Kaufmann, Jason Lajoie, John L. Silberstein
• 1633 · PDF MAIT衔接器：规避Treg抑制以在实体瘤中实现更强的活性 MAIT engagers: Avoiding Treg suppression to deliver stronger activity in solid tumors. Simon E. Plyte, Marie Fraudeau, Dorothee Winterberg, Claire Germain, Camille Rousseau, Maxime Audin, Alexandre Ivagnes, Sothea Touch Dumoitier, Sarah Ducellier, Lise Fenou, Hans Heinrich Oberg, Pierre Emmanuel Gerard, Isabelle Teulon, Daniela Wesch, Matthias Peipp, Julie Prigent
• 1634 · PDF 一种条件性激活的双靶向TCE，具有卓越的肿瘤选择性，用于治疗实体瘤 A conditionally-active, dual-targeting TCE with superior tumor selectivity for the treatment of solid tumors Steffen Dickopf, Jorge A. Lerma Romero, Jessica Seib, Laura Perucho-Aznar, Steffen Runz, Abdul-Habib Maag, Anna Pryszlak, Anja Schreiber, Martha Gschwandtner, Christoph Erkel, Richard J. Austin
• 1635 · PDF CBX-663：一种首创的TCR模拟型T细胞衔接器，靶向TERT肽-HLA复合物，在实体恶性肿瘤的临床前模型中体外介导强效细胞毒性、体内介导肿瘤抑制 CBX-663, a first-in-class TCR-mimetic T-Cell Engager targeting the TERT peptide-HLA complex, mediates potent cytotoxicity in vitro and tumor inhibition in vivo in preclinical models of solid malignancies Yu Huang, Ricard Masia, Bhupal Ban, Qunyan Yu, Jennifer Helble, Jessica Jimenez, Delainey O’Connor, Preethi Sankaran, Christine A. Devlin, Melissa Bikowitz, Emily McNally, Sarah Jaffe, Tanzila Rahman, Alona Kulesha, Andrew Wolpert, Shawn O’Malley, Yue Li, Michael Jennings, Galina Gabriely, Mathilde A. Poussin, Daniel J. Powell, Nga Sze Amanda Mak, Tao Wang, Geraldine L. C. Paulus, Michi Schebesta, Benjamin Lee, Dmitri Wiederschain
• 1636 · PDF TNF驱动的旁分泌杀伤决定了Teclistamab在骨髓瘤中的细胞毒性疗效 TNF-driven paracrine killing determines the cytotoxic efficacy of Teclistamab in Myeloma Allison Carr, Elise Sintim-Aboagye, Adrian Ting
• 1637 · PDF 人-食蟹猴交叉反应性CD3纳米抗体核心的TCE平台增强临床转化 Human-cynomolgus cross-reactive CD3 nanobody-centric TCE platform enhances clinical translation Yuanyuan Wang, Ce Gu, Liang Xiao, Huijuan Lu, Ruhan Lin, Tingchu Wu, Peipei Hu, Chang Zhou, Fan Wu, Jian Guo, Yongting Huo, Di Lu
• 1638 · PDF 一个高通量荧光素酶癌细胞组合推动DLL3靶向TCE的发现 A high-throughput luciferase cancer cell panel driving DLL3-targeted TCE discovery Chen Cai, Yue Zhai, Kejun Mao, Yixiao Zhao, Mingying Li, Qian Wang, Yan Zhang, Lili Chai, Tj (Tiejun) Bing

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