PO.CH01.06 · 化学

Rapid lead generation with the Pioneer Antibody Discovery Platform

编号 2402 展板 10 时间 4/20 09:00–12:00 区域 Section 38 主讲 Birthe Jessen-Park

分会场 Antibodies, Antibody-Drug Conjugates, and Nucleic Acids

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作者与单位

Birthe Jessen-Park¹, Sarah-Jane Kellmann², Mateusz Putyrski², Manuel Cavada², Hanh Hanuschka², Christian Frisch², Achim Knappik², Francisco Ylera²

¹Bio-Rad Laboratories, Hercules, CA,²Bio-Rad Laboratories, Munich, Germany

摘要 Abstract

The Pioneer™ Antibody Discovery Platform is Bio-Rad's biotherapeutic antibody generation service, centered around the Pioneer Antibody Library-one of the largest functional Fab libraries (225 billion unique sequences). Informed by over 18 years of phage display expertise, the library is optimized for therapeutic antibody selection. It integrates SpyDisplay, a proprietary SpyTag-based selection system, and TrailBlazer, a modular platform for rapid format assembly. We showcase data on antibody selection against IL-6R, C5aR, and CXCR4, demonstrating that the Pioneer Platform yields diverse, high-affinity, and functional leads for difficult targets. These candidates show comparable or superior performance to clinically developed or marketed antibodies across key parameters.

利益披露 Disclosure

B. Jessen-Park, None.. S. Kellmann, None.. M. Putyrski, None.. M. Cavada, None.. H. Hanuschka, None.. C. Frisch, None.. A. Knappik, None.. F. Ylera, None.

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