Molecular Classification and Tumor Biology in Cancer

• 3868 · PDF Distinct tumor microenvironmental landscapes define molecular subtypes in non-muscle-invasive bladder cancer Songjun Xu, Matthew H. V. Byrne, Jiarui Zhang, Ahmad Alalti, Devika Agarwal, Neil Beeharry, Olesya Chornoguz, Kyla Dooley, Kin Cheung Lee, Shuwei Li, Guneet Walia, Tommaso Mansi, Joel Greshock, Calliope Dendrou, Freddie Hamdy, Lisa Browning, Dan J. Woodcock, Patrick Wilkinson, Shibu Thomas
• 3869 · PDF Leveraging CpG methylation signatures for robust multi-class cancer classification across platforms Marco A. De Velasco, Kazuko Sakai, Daiki Nakatsu, Seiichiro Mitani, Shuji Minamoto, Takahiro Haeno, Hidetoshi Hayashi, Kazuto Nishio
• 3870 · PDF Deep learning-powered morphological analysis of acute myeloid leukemia Ezgi June Olgac, Meghan Burr, Minna Suvela, Daniela Mendoza-Ortiz, Ella Sinervuori, Heikki Kuusanmäki, Mika Kontro, Caroline Heckman
• 3871 Molecular correlates of response and survival in a phase II trial of weekly carboplatin/paclitaxel plus cemiplimab (wCP+C) in advanced/metastatic mucosal head and neck squamous cell carcinoma (a/mHNSCC) Mateus Trinconi Cunha, Fahad Rind, Priyanka Bhateja, Esmerina Tili, David Konieczkowski, Darrion Mitchell, Sujith Baliga, Sung Jun Ma, Simeng Zhu, Gogineni Emile, John Grecula, Nolan Seim, Catherine Harring, Lauren Miller, Abberly Lott Limbach, Kang Stephen, James W. Rocco, Christian Rolfo, Dukagjin Blakaj, Marcelo Bonomi
• 3873 Molecular heterogeneity in non-muscle invasive bladder cancer reveals clinically divergent subtypes with contrasting Bacillus Calmette-Guérin response and clinical outcomes Jee-Woo Seo, Il-San Jeong, Yeo-Gyeong Yoon, Jae-Yoon Kim, Seon-Young Kim, Seung-Woo Baek, Seon-Kyu Kim
• 3874 Phosphoproteomic subtyping and characterization of colorectal cancer by comprehensive phosphoproteomics of fresh frozen endoscopic biopsy specimens Jun Adachi, Hirokazu Shoji, Hidekazu Hirano, Yosui Nojima, Satoshi Muraoka, Yutaka Saito, Ken Kato, Narikazu Boku, Yukihide Kanemitsu
• 3875 · PDF Identifying the tumor site of origin using molecular profiling with an AI-based classifier Carlos E. Zuazo, Michael J. Demeure, David R. Braxton, Sourat Darabi
• 3876 Prognostic and predictive value of the Clearseq1-4 tumor microenvironment classification in localized and metastatic clear-cell renal cell carcinoma Benoit Beuselinck, Lisa Kinget, Edward Mctaggart, Octavie Demeulenaere, Edouard Roussel, Bram Boeckx, Jessica Zucman-Rossi, Gabrielle Couchy, Henri Vandermeulen, Liesbeth De Wever, Marcella Baldewijns, Agnieszka Wozniak, Diether Lambrechts, Stefan Naulaerts, Abhishek D. Garg, Annelies Verbiest, Maarten Albersen
• 3877 · PDF Integrative application of Lymphly reveals shared molecular landscape across B-cell lymphomas Dmitrii Snitkin, Pavel Zemskiy, Andrey Suponin, Mark Meerson, Ekaterina Nesterenko, Alexander Bagaev, Alexander Nesmelov, Konstantin Chernyshov, Nikita Kotlov
• 3878 ZEB1 expression in NEUROD1-positive and combined YAP1-dominant pulmonary neuroendocrine carcinomas is associated with a locally immunosuppressive microenvironment Noriko Takemura-Kobayashi, Kei Asayama, Rawya Mohamed Salih Ibrahim, Masahiro Maki, Ryota Matsuoka, Aya Shiba-Ishii, Ayako Suzuki, Yutaka Suzuki, Daisuke Matsubara
• 3879 SPP1-driven immunometabolic reprogramming of tumor-associated neutrophils in glioblastoma Matthew Alexander Abikenari, John Hyunkuk Choi, Ravi Medikonda, Lily Kim, Rohit Verma, Justin Liu, Adam Sjoholm, George Nageeb, Brandon Hwa-Lin Bergsneider, Caren Yu-Ju Wu, Kwang Bog Cho, Andrew Tran, David Bakalov, Matei Banu, Michael Lim
• 3880 · PDF Functional high risk multiple myeloma is unified by a highly proliferative signature on gene expression profiling Hashini Thilakaratne, Jessie Zhao, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Nicholas E. Bingham, Andrew Spencer
• 3881 · PDF Heterogeneity in tumor microenvironment across MMR subtypes of endometrial cancer: Analysis from the ENGOT-EN6-NSGO/GOG-3031/RUBY trial Lucy Gilbert, Annika Auranen, Mitchell I. Edelson, Mikalai Pishchyk, Joseph Buscema, Tamar Safra, Nicole S. Nevadunsky, Christine Gennigens, Kari Ring, Line Bjørge, Bhavana Pothuri, Helen D. Eshed, Iwona Podzielinski, Noelle G. Cloven, Tashanna K. Myers, Kathryn P. Pennington, Claire Rooney, Rumen Kostadinov, Robert W. Holloway, Trine Nøttrup
• 3883 Integrated morphometric and molecular classification of central nervous system cancers in 10 seconds using a unified platform with picosecond infrared laser mass spectrometry Alexa Nina Fiorante, Michael Woolman, David Munoz, Farshad Nassiri, Gelareh Zadeh, Sunit Das, Howard Ginsberg, Arash Zarrine-Afsar
• 3884 Multiplex immunofluorescence based spatial analysis of HER2 positive breast cancer patients treated with bintrafusp alfa: A translational pathology study Maria Gabriela Raso, Elizve N. Barrientos-Toro, June Li, Renganayaki K. Pandurengan, Harsh Batra, Ximing Tang, Diego Oliva Rico, Julia Mendoza Perez, Jill Schwartz Gomez, Senthil Damodaran, Alastair Thompson, Andreas W. Machl, Natalia Jacob, Jennifer Keating Litton, Rashmi Krishna Murthy, Cara L. Haymaker
• 3885 Application of transcriptomic bladder-cancer subtypes to upper-tract urothelial carcinoma (UTUC) across international cohorts reveals racial differences and translational limitations Joshua M. Scurll, Henning Bahlburg, Tran Anh Thu (Wendy) Phung, John Heard, Mamoru Hashimoto, Kazutoshi Fujita, Daniel Luthringer, Toru Sakatani, Kaoru Murakami, Charles J. Rosser, Ewan A. Gibb, Peter C. Black, Hideki Furuya
• 3886 A novel glioblastoma subtype classification using hallmark gene set signatures: Association between poor prognosis and TP53 downstream pathway Yu Jin Kim, Jeongman Park, Woo Young Kwon, Jaejoon Lim, Sung Hwan Lee
• 3887 Multiple myeloma risk classification of CoMMpass using Consensus Genomic Staging identifies differences between patients with high and low African genetic ancestry Steven M. Foltz, Chaitanya R. Acharya, Alexander Gout, Yuxin Jin, David E. Avigan, Ravi Vij, Shaji Kunnathu Kumar, Sagar Lonial, Hearn Cho, Katie Wozniak, Jonathan J. Keats, Craig Cole, John D. Carpten, George J. Mulligan
• 3889 Genomic-immunophenotypic landscape of early-stage pulmonary carcinoid tumors and their prognostic implications Song Xu, Lingling Zu, Ning Zhou, Jingya Wang, Xiongfei Li, Haixiang Yu, Sibo Peng, Chunxia Su, Dingzhi Huang
• 3890 HDAC6 as a convergent oncogenic and immunoregulatory hub across multiple cancer types Chia-Wei Wu, Chia-Yi Hsu, Eing-Mei Tsai, Tsung-Hua Hsieh
• 3891 · PDF Morphologic spectrum of bladder cancer variants and incidental prostate pathology in cystoprostatectomy specimens Shannon Carskadon, Aryan Joshi, Nilesh S. Gupta, Nallasivam Palanisamy

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