Biomarkers Predictive of Therapeutic Benefit 5

• 5235 · PDF Real world prediction and biological characterization of sotorasib sensitivity using multimodal AI and liquid biopsy genomic inputs Maayan Baron, Felicia Kuperwaser, Sepideh Foroutan, Sunil Kumar, Dillon Tracy, Kevin Freisen, Brandon Funkhouser, Zong Miao, Nathaniel Tann, Fahad Khan, Sean Klei, Jordan Wolinsky, Taylor Wood, Jean Michel Rouly, Nick Lee, Ripple Khera, Anshu Jain, Jeff Sherman, Emily A. Vucic
• 5236 · PDF Updated exploratory biomarker analysis of cadonilimab plus regorafenib as second-line or later therapy in advanced hepatocellular carcinoma: Identification of Bola3 as a potential predictive biomarker Yang Liu, Jin Zhang, Qi Qi, Dandan Wu, Linze Xu, Yueguo Li, Huikai Li
• 5237 · PDF The significant co-expression of claudin-3(CLDN3) and B7-H3(CD276) as a potential biomarker for targeted therapy in neuroendocrine carcinomas Ji-Hye Nam, Ju-Yeon Kim, Jae Choi, Minjung Sung, Jae Hwan Kang, Hobin Yang, Yoon-la Choi, Young Kee Shin
• 5238 · PDF Retrospective study for clinical biomarkers to guide post-EGFR-TKI treatment strategies in EGFR-mutant NSCLC Tadaaki Yamada, Kenji Morimoto, Naoki Furuya, Hisashi Tanaka, Akihiro Yoshimura, Tomohiro Oba, Makoto Hibino, Takahito Fukuda, Yasuhiro Goto, Akira Nakao, Shinsuke Ogusu, Yuta Okazaki, Taishi Harada, Takayo Ota, Ken Masubuchi, Tae Hata, Koji Mikami, Shoki Matsumoto, Ryoichi Honda, Koji Date, Yusuke Chihara, Koichi Takayama
• 5239 · PDF Biomarker dynamics in the completed phase I study of DT-9081: An analysis of ex vivo cytokine stimulation, urinary PGEM, and tumoral biomarkers in advanced solid tumors Thomas Maurin, Lola Lecru, Antoine Mousson, Orphée Blanchard, Malaury Schappler, Christophe Le Tourneau, Zahra Castel-Ajgal, Jean-Pascal Machiels, Rachel Galot, Nuria Kotecki, Christiane Jungels, Jean-Pierre Delord, Iphigenie Korakis, Camille Dietsch, Luc Baron, Maria Jesus Garcia Léon, Edith Steinberg, Katia Saulnier, Samira El-Farouk, Calire Jouffroy-Zeller, Anne Quesnel, Carolina Duarte, Abdelkrim Taamma, Anne-Laure Blayo, Thibaut Brugat, Nathalie Lenne, Jean-Marie Cuillerot, Stephan Schann
• 5240 · PDF A CXCL10/11 and CCL19 duplex chromogenic assay complements PD-L1 immunohistochemistry in non-small cell lung cancer Alexander L. Tang, Liad Elmelech, William L. Tang, Maxwell Spurrell, Maria Ganci, Yiwen He, Catherine B. Meador, Christopher S. Nabel, Jessica J. Lin, Mari Mino-Kenudson, Nir Hacohen, Justin F. Gainor, Jonathan H. Chen
• 5241 · PDF Personalized fusion measurable residual disease detection in acute myeloid leukemia using droplet digital PCR Asra Noor, Xiaojuan Cao, Maggie J. Cox, Francesca Ferraro, David H. Spencer, Stephen T. Oh, Grant A. Challen, Andrew L. Young
• 5242 · PDF Down regulation of HPV 16 and NF-ΚB and upregulation of gigaxonin and immune markers in APG-157 treated head and neck cancer: A phase 2A clinical investigation Saroj K. Basak, Bhavani Shankara Gowda, Manasvini Kala, Jin Zhong, Trent Su, Daniel Sanghoon Shin, Marilene B. Wang, Eri S. Srivatsan
• 5243 · PDF Profiling of peripheral LAG-3+CD8+ T cells: An immune cell population associated with immunotherapy resistance Ariel Kogan Zajdman, Cory A. Brennick, Kayla J. Foster, Sydney A. Riddick, Tatiana Shcheglova, Matthew Adamow, Jasme Lee, Ronglai Shen, Katherine S. Panageas, Xiyu Peng, Margaret K. Callahan
• 5244 Genomic HLA class I allelic imbalance undermines enduring immunotherapy response in advanced non small cell lung cancer Yiting Dong#, Shun Wang#, Wenbin Li*, Zhijie Wang*, Jie Wang*
• 5246 · PDF Immune profiling and targetable biomarkers in NSCLC: Toward rational design of CKI-based combinations Rania Gaspo, Alexandra Jean, Renaud Burrer, Jérôme Sallette, Amanda Finan-Marchi, Marie Gérus-Durand
• 5247 · PDF Integrating immunohistochemistry for biomarker detection in NSCLC: A step toward precision therapy Rania Gaspo, Renaud Burrer, Jérôme Sallette, Amanda Finan-Marchi, Marie Gérus-Durand
• 5248 · PDF Single-cell multi-omics reveals co-mutation of TP53 and epigenetic gene driving myeloid transformation in B-ALL following CAR-T therapy Shuang Zhao, Yanjing Tang, Meng Su, Bowen Cui, Rongrong Fan, Han Wang, Liu Yang, Lixia Ding, Ronghua Wang, Huiying Sun, Ying Zhong, Qiaoqiao Shi, Yuxuan Guo, Lili Song, Xinyu Wan, Tianyi Wang, Jing Yang, Benshang Li, Yu Liu
• 5249 · PDF Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma Robert Saddawi-Konefka, Binbin Wang, Lauren M. Clubb, Cynthia Tang, Di Wu, Sumit Mukherjee, Sahil Sahni, Saugato Rahman Dhruba, Sumeet Patiyal, Chi-Ping Day, Parth Anil Desai, Clint Tanner Allen, Kun Wang, J. Silvio Gutkind, Eytan Ruppin
• 5250 · PDF Method development and workflow optimization of a CTC-based biomarker assay to predict response to CDK4/6 inhibitors in HR+/HER2- breast cancer Mantasha Tabassum, Shivaani Suresh Kanna, Wangjia Cao, Suneel Kumar, Mothaffar F. Rimawi, George Miles, Meghana Trivedi
• 5251 · PDF Precise description of metabolomic states using NGS uncover new potential biomarkers of response to TKIs in ccRCC Alina Tarasova, Stanislav Kurpe, Andrey Kravets, Nikita Kotlov
• 5252 · PDF Computational modeling of comprehensive genomic profiling to predict chemo-immunotherapy benefit in early stage NSCLC Prashant Nair, Kishor Promod, Ansu Kumar, Swati Khandelwal, Ambreen Ambreen, Susheel George, Mamatha Patil, Deepak Lala, Ashokraja Bala, Veena Balakrishnan, Shweta Kapoor, Drew Watson, James Wingrove, Tejas Patil
• 5253 · PDF Molecular correlates of progression-free survival in recurrent gliomas treated with pembrolizumab Shameel Shafqat, Muhammad Asad Maqbool, Hussam Al Kateb, Terry C. Burns, Jian L. Campian, Shannon P. Fortin Ensign, Evanthia Galanis, Julie E. Hammack, Cristaine M. Ida, Mitch L. Klebig, Timothy J. Kaufmann, Autumn C. Moon, Maciej M. Mrugala, Bryan J. Neth, Alyx B. Porter, Michael W. Ruff, Ugur T. Sener, Wendy J. Sherman, Joon H. Uhm, Rachael A. Vaubel, Sani H. Kizilbash
• 5254 · PDF Copy number amplification of PSG is associated with poor survival in female lung adenocarcinoma patients Jung Hun Oh, Yingjie Zhu, Himangi Srivastava, Leyla Ebrahimpour, Rena Elkin, Larry Norton, Nadeem Riaz, Joseph O. Deasy
• 5255 KRAS subtype may modify the poor immunotherapy response in pancreatic cancer: Evidence from early phase trials Dilsa Mizrak Kaya, Yangruijue Ma, Tarik Demir, Aparna Kalyan, Sheetal Kircher, Mary Mulcahy, Al B. Benson III, Ruohui Chen, Devalingam Mahalingam
• 5256 Association of NME1, CXCL12, VDR, DNMT1, CAV1, IL27, and IL33 polymorphisms with breast cancer susceptibility in Bangladeshi women: A case-control and in silico study Mohammad Safiqul Islam, Md Abdul Barek
• 5257 · PDF Armored TIL GT201 induces potent tumor-specific TCR expansion and durable antitumor responses in advanced solid tumor Pin Wang, Rong Zhou, Yong Han, Zhengxiang Han, Weijia Fang, Kai Chen, Youguo Chen, Liqing Ma, Lili Lu, Derun Shen, Jiahui Jin, Yiyang Tan, Ke Liu, Zhenjiang Liu, Jingman Wang, Zhao Xu, Jingwei Sun, Jun Cui, Jing Yu, Yue He, Yarong Liu
• 5258 · PDF Monitoring of molecular response during immunotherapy by circulating tumor DNA in non-small cell lung cancer Johanna Svensson, Maria Yhr, Per Torstensson, Levent Akyürek, Andreas Hallqvist, Sukanya Raghavan, Anna Rohlin
• 5260 · PDF DNMT3A -mutated tumor-infiltrating clonal hematopoiesis predicts immune checkpoint inhibitor response in advanced non-small cell lung cancer Geun-Ho Park, Cheolyong Joe, Hyemin Kim, Eunjoo Oh, Naeun Lee, Subin Kim, Junsu Choe, Jinyong Kim, Sehhoon Park, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Joo Kyung Park, Se-Hoon Lee
• 5261 · PDF Serial plasma tumor-informed next generation sequencing as a new efficacy metric to guide immunotherapy treatment discontinuation Meghan J. Mooradian, Aleigha Lawless, Julianne Czapla, Amaya Gasco, Patrick Boyle, Merrida Childress, Ryan J. Sullivan

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