Antibodies, Antibody-Drug Conjugates, and Nucleic Acids

• 2393 DXC016, a novel cMET-targeting dual payload antibody-drug conjugate, demonstrates potent antitumor activity and favorable PK for potential subcutaneous use Yong Du, Jiaojiao Yu, Huihui Guo, Lingli Zhang, Xiaoqiang Xie, Jialei Hu, Xiafen Wu, Yunxia Zheng, Yuanyuan Huang, Junxiang Jia, Wei Liu, Zhouyang Zhou, Qingliang Yang, Robert Y. Zhao
• 2394 A novel 2+2 IgG-like bispecific antibody-drug conjugate targeting EBV GP220/350 and EGFR for selective treatment of nasopharyngeal carcinoma Saihong Yu, Yunxia Zheng, Junxiang Jia, Xiangfei Kong, Juan Wang, Yi Luo, Hangbo Ye, Xueqing Ma, Qingliang Yang, Robert Y. Zhao
• 2395 · PDF DXC011, a novel dual-payload antibody-drug conjugate targeting folate receptor alpha Zhicang Ye, Huihui Guo, Wei Zheng, Junpeng Wang, Yifang Xu, Hui Xia, Yuanyuan Huang, Junxiang Jia, Wei Liu, Xiang Chen, You Zhou, Qingliang Yang, Robert Y. Zhao
• 2396 A novel 2+2 IgG-like bispecific antibody-drug conjugate with dual payloads for targeted therapy of heterogeneous gastrointestinal cancers Wei Zheng, Junxiang Jia, Xiaolei Liu, Gengxiang Zhao, Yongxiang Chen, Xia Zhou, Simin Zhao, Qingliang Yang, Robert Y. Zhao
• 2397 · PDF Cell based payload release highlights design, site, and cell dependent ratio shifts in dual payload ADCs Nan Hsuan Wang, Wei-Han Lee, Evelyn He, Li Chuan Huang, Yu-Chao Huang, David Teng-Yi Huang, Ya-Chi Chen
• 2398 · PDF Dissecting ADC pulmonary toxicity: A murine ADC-associated ILD model to guide and inform ADC discovery Suresh Anaganti, Arti Bhujade, Steven Murkli, Zachary Sparta, Nabin Panth, Alexander Weig, Richa Vartak, Julien Dugal-Tessier, Nareshkumar Jain
• 2399 Discovery of ZL-6201, a novel LRRC15-targeting antibody drug conjugate (ADC) for the treatment of sarcomas and epithelial solid tumors He Xu, Zengxia Li, Jiaqing Yi, Wilson Peng, Qiuping Ye, Xinchao Xia, Lei Wang, Xinchuan Dai, Yue Ge, Donghui Li, Ziruo Wen, Changwei Lv, Joshua Zeng, Qidong Hu, Lina Wang, Jelveh Lameh, Nathan Ihle, Bing Wan, Linda N. Liu
• 2400 · PDF Design and evaluation of mRNA translation inhibitors for use as antibody drug conjugate payloads Mark Petersen, Jodi Wong, Samir Das, Vidhi Khanna, Kurt Stahl, Micheal G. Brant, Truman Hirkala-Schaefer, Jesse Leblanc, Victoria K. Harman-McKenna, Manuel Lasalle, Graham A. E. Garnett, Rehan Higgins, Catalina Suarez, Kaylee J. Wu, Linglan Fu, Germanna Righetto, Devika Sim, Adele Chan, Allysha Bissessur, Ambroise Wu, Araba Sagoe-Wagner, Luying Yang, Andrea Hernandez Rojas, Dunja Urosev, Sam Lawn, Vincent Fung, Stuart D. Barnscher, Raffaele Colombo, Jamie R. Rich
• 2401 Developing a single B cell platform to accelerate antibody discovery and screening Spencer Chiang, Wenlin Ren, An Ouyang, Yu Sun, Xiaoli Li
• 2402 · PDF Rapid lead generation with the Pioneer Antibody Discovery Platform Birthe Jessen-Park, Sarah-Jane Kellmann, Mateusz Putyrski, Manuel Cavada, Hanh Hanuschka, Christian Frisch, Achim Knappik, Francisco Ylera
• 2403 · PDF Advancing precision oncology through innovative bioconjugation and linker architecture strategies Shuhui Chen, Dan Hart, Matt Giese, Erika Leonard, Bowu Luan, Shamali Roy, Michael Fiebig, Catherine Bladen
• 2404 · PDF Selective tumor immune activation by novel nucleic acid drug Akimitsu Okamoto, Kunihiko Morihiro, Makoto Yamamoto
• 2405 · PDF A first-in-class IKZF1/3 degrader antibody conjugate (DAC) as a potential myeloma treatment Shuai Wu, Jinyu Yang, Mo Dan, Xiwu Hui, Bing Yao, Miaomiao Wei, Bin Bao, Qiwen Zhu, Linlin Xiao, Penghui Wen, Xiaodan Zhang, Wei Fang, Xiao Li
• 2406 A novel BRD4 degrader-HER2-targeting antibody-drug conjugate (DAC) overcomes trastuzumab deruxtecan resistance in HER2-positive cancers Xin Yu, Bin Yang, Wendi Ni, Haibo Liu, Jan Willem Theunissen, Jesse Chen, Jin Wang
• 2407 · PDF DAC-1522: A novel Trop2-targeting degrader-antibody conjugate for precision oncology Chuanjie Chen, Qianqian Shen, Xinhui Cai, Yaqi Ding, Xiaoyu Yang, Yanfen Fang, Carlos Chai, Jian Ding, Yi Chen, Xuan Zhang
• 2408 · PDF ADCs in cancer treatment: SPR-driven insights into discovery and characterization ​ Soraya Diez-Posada, Cynthia Shuman, Narashima Murthy Bandaru, Anna Moberg, Bryan Edwards, Sam Ness, Lowri Davies, Anja Pomowski, Laura Bouché, Isabel Perez-Castro, Howard Desmond, Gokhan Yahioglu, Mahendra P. Deonarain

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