Antibody-Drug Conjugates and Linker Engineering 1

• 1672 · PDF Enhanced delivery and activity of a novel antibody-drug conjugate, PF-08052667, for treatment of non-muscle invasive bladder cancer Christopher M. Carosino, Devra Olson, David Ortiz, Steven Duniho, Maddy Burcher, Eliana Moskovitz, Rebecca Mazahreh, Iliyana Mikell, Matthew R. Levengood, Sharsti Sandall, Joeseph D. Dekker
• 1673 · PDF PF-08046033 (GPS): A novel first in class auristatin S antibody-drug conjugate for treatment of GPNMB-expressing solid tumors Parul Katoch, Gabriele Blahnik-Fagan, Xiao Di Yang, Marlena Gray, KC Crowder, Vineet Kumar, Midori Clarke, Kaveh Alizadeh, Samantha Sarrett, Serena Wo, Gardenia Zaki, Andrea Lim, Elizabeth Gray, Philip Moquist, Michael Flister, Sharsti Sandall
• 1674 · PDF Diversity-oriented dpADC discovery with high throughput dual-conjugation platform and predictive resistant disease models Meijun Xiong, Yanchun Li, Qingsong Wu, Chong Liu, Shanshan Xie, Zhongsheng Hu, Yajun Sun, Zengyan Mu, Haibo He, Yanwen Feng, Xinju Gao, Paul H. Song, Gang Qin
• 1675 · PDF Payload-recycling ADCs (PR-ADCs): A novel ADC platform for reducing free-payload toxicity and enhancing therapeutic index Jianmin Fang, Dong Li, Jing Jiang, Yuanhao Li, Wei Zhang, Xiaoshan Min, Zhulun Wang
• 1676 HA-00495: A development candidate ADC featuring a novel protein translation inhibitor payload with broad efficacy and a favorable non human primate safety profile Tara L. Arvedson, Victor Cee, Corey Reeves, Madhura Deshpande, Natacha Le Moan, Kyle Dunbar, Amandeep Gakhal, Chris Kimberlin, Cynthia Bailey, Edres Babacarkhial, Nolan Carney, Xufeng Cao, Yi-Ming Chiang, Amber Cornelius, Natalie Duong, Colin Harvey, Yingxia Hu, Dimitri Kharakovsky, Jose Leighton, Dennis Liu, Luca Lizzardo, Octovia Monteiro, Samuel Oteng-Pabi, Bruno Perlatti, Rajani Marthappa Shenoy, Joseph Spraker, Mélanie Uguen, Jakub Vaith, Sandeep Venkataram, Kendra Wheeler, Shiyan Xu, Danielle Yee, Clarence Yeung, Eva Yuan
• 1677 · PDF NL019: A next-generation TROP2/NECTIN4 dual-target nanobody-based ADC developed from the NanoOne™ Platform Meiguang Xiong, Binbin Wang, Jie Ni, Chenchen Lu, Fang Yu, Yu Zhang
• 1678 · PDF Integrated ADC platform: From discovery to functional evaluation Meimei Yin, Xiaoming Miao, Yang Zheng, Jingbo Ding, Jun Liu, Fang Zhang, Zhongyao Ma, Letian Kuai, Wenji Su
• 1679 · PDF Plate-based conjugation for antibody and payload optimization in ADC development Zeinab Fereshteh, Madhavi Latha S. Chalasani, Rupa Sarkar, Julien Dugal-Tessier, Nareshkumar Jain
• 1681 RenLite ® transgenic mice provide a high-quality platform for accelerating the development of fully human bispecific antibodies or ADCs worldwide Jade Hsu, Wenjiao Zhang, Jun Du, Zhuolin Li, Yifu Zhang, Yanfei Han, Chengzhang Shang, Yi Yang
• 1682 Potency-Attenuated analogues of PNU-159,682 in conjugation with GlycoConnect ® and HydraSpace ® technologies provide ADCs with improved tolerability and efficacy Marcel Scheepstra, Remon van Geel, Jorin Hoogenboom, Lianne Lelieveldt, Sorraya Popal, Mick Verhagen, Oleksandr Zagorodko, Finn McSorley, Çağla Koç, Margarida Espadinha, Floris van Delft, Anette Sommer, Sander van Berkel
• 1683 · PDF Enhancing therapeutic efficacy and overcoming resistance with a novel dual-payload antibody-drug conjugate technology Antoine Attinger, Léo Marx, Diana Bianca Rocha Gomes, Vincent Gerusz, Min Ma, Viktoriia Postupalenko, Alain Monjardet, Nicolas Quesnot, Christophe Chardonnens, René Wuttke, Noémie Luong
• 1684 · PDF ALM-502: A highly effective ADC for solid tumor therapy - enhancing payload delivery through molecular design Graham Cotton, Estelle McLean, Paul Trumper, Mark Wappett, Stephanie Gatdula, Stacey Dodd, Greg Papadakos, Stephanie Burton, Georgiana Parau, Aidan McCann, Chiara Saladino, Jennifer Thom, Aaron N. Cranston, Tim Harrison
• 1685 The HER2-targeting dual-payload antibody-drug conjugate combining a topoisomerase I inhibitor and a microtubule inhibitor demonstrates superior efficacy and overcomes resistance to single-payload ADCs in xenograft models Angela Matcham, Robert Yuan, Brian Vuillemenot, Rhoneil Pena, Young Park, Abigail Yu, Jeffrey Hanson, Cuong Tran, Xiaofan Li, Miao Wen, Daniel Calarese, Werner Rubas, Krishna Bajjuri, Guifen Xu, Alice Yam, Hanspeter Gerber
• 1686 Development of ZW418, a biparatopic PTK7-targeting antibody-drug conjugate incorporating a novel pan-RAS inhibitor payload for the treatment of non-small cell lung cancer Luying Yang, Alex Wu, Vincent Fung, Kaylee J. Wu, Sara Weeres, Katina Mak, Taixiang Wang, Victoria Harman-McKenna, Allysha Bissessur, Jesse Leblanc, Vidhi Khanna, Matthew Bonderud, Jodi Wong, Rehan Higgins, Linglan Fu, Dunja Urosev, Raffaele Colombo, Graham A. E. Garnett, Jamie R. Rich, Stuart D. Barnscher
• 1687 · PDF Engineering multi-specific and multi-payload ADCs to address tumor heterogeneity and drug resistance Greg Liang, Songyan Huang, Fan Feng, Mingqi Shao, Qikuan Chen, Kaijian Bi, Haixia Chen, Yanjie Chen, Yan Zhu, Hu Liu
• 1688 · PDF Empowering development of next generation ADCs & XDCs through advanced WuXiDARx conjugation technologies Qirui Fan, Hu Chen, Jingjie Huang, Lin Zhang, Zekun Wang, Ding Wei, Guoguang Wei, Yanjie Zhao, Laisen Wang, Cindy Cheng, Marie Zhu
• 1689 Next generation ConjuAll BCMA antibody-drug conjugates (ADCs) LCB14-2524 and LCB14-2516 show increased efficacy in preclinical models of multiple myeloma Matthew Sender, Joe Ponte, Stephen Slocum, Yun-Hee Park, Yunjoo Jung, Chul Woong Chung, Rodrigo Ruiz-Soto, Jeiwook Chae
• 1690 · PDF Preclinical development of XNW27011, an antibody drug conjugate targeting claudin18.2 for treatment of CLDN 18.2-positive solid tumors Yonghan Hu, Yuanbao Li, Zhenwei Wu, Yuzhen Hou, Liang Kong, Shihua Wang, Zhe Zhang, Ka Ruan, Wengui Wang, Hui Zhao, Qifeng Shi, Haiyang Wei, Xiaojun Liu, Meijie Le, Jing Qiang
• 1691 · PDF Site-specific dual-payload antibody conjugation enhances antitumor efficacy Wei-Ting Sun, Shih-Hsien Chuang, Shih-Chong Tsai, Cheng-Chou Yu
• 1692 · PDF STX-1, a first-in-class ADC targeting DPP4 protein, acts as an anticancer and senolytic treatment Benjamin Le Calvé, Delphine Dayde, Grégoire Jouffroy, Omayma Asbai, Virginie Lelarge, Justine Choeur, Thierry Mathieu, Florence Lhospice, Eric Angevin
• 1693 Targeting MET-LGR5 crosstalk using an antibody-drug conjugate combination with diverse payloads to overcome adaptive resistance in colorectal cancer Shraddha Subramanian, Peyton Christian High, Zhengdong Liang, Cara Guernsey-Biddle, Adela Aldana, Kendra S. Carmon
• 1694 Application of tangential flow-filtration (TFF) to enable solvent exchange and precipitation process for the production of payload-linkers of antibody-drug conjugates Sudhir Patil, Feng Xu, Minglin Wang, Jianwei Bian, Xudong Wei
• 1695 · PDF Preclinical characterization of STRO-227: A PTK7-targeting dual-payload ADC with topoisomerase 1 and tubulin inhibitors Daniel Calarese, Kshama Doshi, Garrett Gross, Brian Vuillemenot, Xiaofan Li, Mark Armanini, Guifen Xu, Miao Wen, Krishna Bajjuri, Gang Yin, Werner Rubas, Alice Yam, Hanspeter Gerber
• 1696 · PDF IN30758, an integrin-targeted antibody drug conjugate (ADC) demonstrating strong therapeutic effects in multiple solid tumors Baoyuan Zhang, Shiqiang Lu, Yue Ma, Jiaming Gao, Fengmin Xi, Ran Pang, Leo Liu, Zaiqi Wang
• 1697 NW024-1, a novel ALPP/ALPPL2-targeting antibody drug conjugate with a topoisomerase 1 inhibitor payload, demonstrates potent antitumor efficacy Juanjuan Li, Wenting Luo, Li Liu, Yiran Wu, Gang Liu, Changcheng Li, Yaolan Dai, Jiabao Liu, Zhijian Li, Lixia Wang, Dan Wang, Dan Mi, Jiaoyi Zhong, Bin Liu, Desi Pan, Zhigang Guo
• 1698 A novel synergistic dual-payload FRalpha ADC (CTPH-08) that can potentially offer benefits for low IHC+ ovarian cancer patients by improving MTD and MED Soyeon Lim, Myeong Joo Kim, Junho Ha, Heegoo Jun, Jongchan Lee, So Hee Im, Seo Ha Kim, Young Sang Kim, Seung Chan Kim, Hyo Jin Kang, Chang-Sun Lee
• 1699 · PDF GlycoConnect® ADC toolbox expansion with dual payload ADC (dpADC) technology Remon van Geel, Lieke Kraaijvanger, Mick Verhagen, Nick Burgers, Marie Nassiet, Margarida Espadinha, Elias Post, Sander van Berkel, Floris van Delft, Marcel Scheepstra, Anette Sommer

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