PO.TB07.02 · 肿瘤生物学
Metabolic and Transcriptional Control of Cancer Stem Cell Plasticity
- 2182 2182 线粒体sirtuins在前列腺癌干样细胞中的上调 Upregulation of mitochondrial sirtuins in prostate cancer stem-like cells Shiv Verma, Leah Tharian, Jason A. Mears, Sanjay Gupta
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2183 · PDF FABP4作为三阴性乳腺癌中一种新型癌干细胞标志物发挥功能 FABP4 functions as a novel cancer stem cell marker in triple-negative breast cancer Huiyi Feng, Jinquan Xia, Fuhua Zhong, Yinghuan Cen, Lu Jiang, Pan Zhao, Lin Gao, Chang Zou
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2184 · PDF 界定肾细胞癌中的癌起始细胞及其脆弱性 Defining cancer initiating cells and their vulnerabilities in renal cell carcinoma Zohreh Mehrjoo, Hellen Kuasne, Ariel M. Aguirre, Ozge Saatci, Ali Shahini, Matthew G. Annis, Anne-Marie N. Fortier, Tianyuan Lu, Larisa M. Soto, Hong Zhao, Dongmei Zuo, Virginie Pilon, Matthew Dankner, Tamiko Nishimura, Kevin Petrecca, Jonathan D. Spicer, Peter Siegel, Simon Tanguay, Hamed S. Najafabadi, Sahin Ozgur, Morag Park, Yasser Riazalhosseini
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2185 · PDF Trem1维持肝细胞癌中的肝癌干性 Trem1 sustains liver cancer stemness in hepatocellular carcinoma Ashwin Ajith, Arsha Sreekumar, Kanza Mamouni, Anatolij Horuzsko
- 2186 2186 高良姜素通过敲低TINCR表达有效抑制肝癌干细胞的增殖和干性特征 Galangin effectively inhibits the proliferation and stemness characteristics of liver cancer stem cells by knocking down the expression of TINCR. Amira S. Fyala, Mohamed M. H Elkewedi, Ahmed S. Sultan
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2187 · PDF eIF4A1在三阴性乳腺癌中对癌症干性的直接调控 Direct regulation of the cancer stemness by eIF4A1 in triple-negative breast cancer Azeezat Oluwatobiloba Osikoya, Shobhit Srivastava, David Terrero, Dayanidhi Raman
- 2188 2188 对AML PDX模型的整合转录组分析和流式细胞术分析鉴定出LSCs与原始细胞共有的嘌呤-嘧啶代谢依赖性 Integrative transcriptomic profiling and flow cytometry analysis of AML PDX models identify purine-pyrimidine metabolic dependency shared in LSCs and blasts Kangsan Kim, Haiming Xu, Geoff Nelson, Tim Nieuwenhuis, Huiyun Liu, Justine Roderick-Richardson, Jessie Hao-ru Hsu, Brandon Willis, Lisa Drew, Omid Tavana
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2189 · PDF 通过PDK3依赖性的SOX2乳酸化对胰腺癌干性的代谢控制 Metabolic control of pancreatic cancer stemness through PDK3 dependent SOX2 lactylation Neelanjana Gayen, Nivedeta Krishna Kumar, Ayoola O. Ogunleye, Palanisamy Nallasamy, Venkatesh Varadharaj, Saravanakumar Marimuthu, Surinder K. Batra, Moorthy P. Ponnusamy
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2190 · PDF Trib3被鉴定为胰腺癌干细胞的关键治疗靶点 Trib3 identified as a key therapeutic target for pancreatic cancer stem cells Nirjhar M. Aloy, Kyle McAndrews, Adam Zulli, Kathryn Baldwin, Kristine Von Maltzan, Sarah Thayer
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2191 · PDF NQO1抑制FBXL14依赖的SNAIL降解,从而在结直肠癌细胞中促进EMT介导的干性 NQO1 inhibits FBXL14-dependent SNAIL degradation to promote EMT-mediated stemness in colorectal cancer cells Ha Gyeong Kim, Yunmi Cho, Eun-Taex Oh
- 2192 2192 SLFN5介导NOTCH1的液-固相变,以抑制非小细胞肺癌的干性和放疗耐药 SLFN5 mediates liquid-to-solid phase transition of NOTCH1 to suppress stemness and radioresistance of non-small cell lung cancer Mi Tang, Lu Zhang, Jiaxin Zhao, Hongji Dai, Zhiyong Yuan, Zeyun Mi, Zhiqiang Wu
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2193 · PDF UPP1通过代谢重编程促进顺铂诱导的卵巢癌干细胞富集 UPP1 promotes cisplatin-induced cancer stem cell enrichment in ovarian cancer via metabolic reprogramming Jessica J. Miao, Linzhou Wang, Ananya Banerjee, Na Li, Yajing Yang, Aidan Li, Kevin Wang, Patrick Stevens, Xiaoli Zhang, Qi-En Wang
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2194 · PDF PLK1-OCT4调控轴控制前列腺癌的谱系可塑性和神经内分泌分化 A PLK1-OCT4 regulatory axis controls lineage plasticity and neuroendocrine differentiation in prostate cancer Mohammad Esfini Farahani, Yanquan Zhang, Meng Wu, Ruixin Wang, Fatemeh Seilani, Xinyi Wang, Xiaoqi Liu
- 2195 2195 自然杀伤细胞的形态学发现及利用胶束化营养保健品增强其活性 The morphological discovery of the natural killer cells and enhancement of their activity using micellized nutraceuticals Jerry T. Thornthwaite, Olufemi Emmanuel Akanni, Daniel Strasser, Kyle A. Thornthwaite
- 2196 2196 基质柔软度和流体剪切力通过TRPV4促进卵巢癌干性、致瘤性和转移 Matrix softness and fluid shear forceact through TRPV4 to promote ovarian cancer stemness, tumorigenicity and metastasis Zhenchuan LEI
- 2197 2197 帕比司他、维奈克拉和抗CD40联合治疗在免疫清除癌症干细胞中的机制基础 Mechanistic basis of panobinostat, venetoclax, and anti-CD40 combination therapy in the immune elimination of cancer stem cells Yishu Xu, Juraj Jakubik, Leoni Moldaner, Gautami Atul Gaidhani, Zuzana Tatarova
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2198 · PDF 靶向Bmi-1可抑制黏液表皮样癌的癌症干性和肿瘤生长 Targeting Bmi-1 suppresses cancer stemness and tumor growth in mucoepidermoid carcinoma Satoshi Yamada, Kristy Warner, Jaqueline Vaz Vanini, Zhaocheng Zhang, Ririko Tsuboi, Jacques Eduardo Nör
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2199 · PDF 剖析ROBO4在调控乳腺癌细胞可塑性中的功能 Dissecting ROBO4 function in regulating breast cancer cell plasticity Isobel J. Fetter, Veronica Haro Acosta, Paloma Medina, Shaheen S. Sikandar
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2200 · PDF 间充质状态驱动胶质母细胞瘤的干性并限制其分化 The mesenchymal state drives stemness and limits differentiation in glioblastoma Emanuele Filiberto Rosatti, Denise Sighel, Anna Veronese, Toma Tebaldi, Alessandro Quattrone
- 2201 2201 复发性子宫平滑肌肉瘤的多维转录组图谱揭示了具有高药物敏感性和更佳患者预后的干细胞样激素细胞 Multidimensional transcriptomic alas of recurrent uterine leiomyosarcomas uncovers stem-like hormonal cells with high drug sensitivity and improved patient outcomes Maria Moozhiyil Korah, James P. Agolia, Biren Reddy, Renceh A. B. Flojo, Amanda Gonçalves, Lilin Wang, Rosyli F. Reveron-Thornton, Chuner Guo, Beatrice Sun, Amanda R. Kirane, George Poultsides, Deshka Foster, R. Stephanie Huang, Gregory W. Charville, Michael T. Longaker, Daniel Delitto
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2202 · PDF APOBEC3C重塑造血干细胞和祖细胞的RNA剪接与自我更新 APOBEC3C rewires RNA splicing and self-renewal in hematopoietic stem and progenitor cells Inge van der Werf, Jane Isquith, Emma Klacking, Jessica Pham, Wenxue Ma, Shuvro P. Nandi, Rongjie Wu, Claire Engstrom, Neha Katragadda, Anna A. Khachatrian, Thomas Whisenant, Ludmil Alexandrov, Catriona Jamieson
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2203 · PDF PSMD2抑制破坏自噬周转并在ER+乳腺癌中形成自噬依赖性脆弱点 PSMD2 Suppression Disrupts Autophagy Turnover and Creates an Autophagy-Dependent Vulnerability in ER+ Breast Cancer Yejoo Lee, Ju Hee Kim, So-Youn Jung, Wonshik Han
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2204 · PDF ID蛋白调控卵巢癌化疗后的IL-6表达和癌症干细胞样特征 ID proteins regulate IL-6 expression and cancer stem-like cell features following chemotherapy in ovarian cancer Megan A. Keene, Mikella Robinson, Darren Lighter, Carrie D. House
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2205 · PDF 对患者来源卵巢癌细胞系富集的癌症干细胞进行异构体水平转录组分析 Isoform-level transcriptome analysis for enriched cancer stem cells from patient-derived ovarian cancer cell lines Rachel S. Perkins, Jisun Kang, Matthew S. Jung, Sue Chin Lee, Wenjing Zhang, Won-Young Choi
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2206 · PDF 揭示一种具有干性和独特治疗反应的胰腺导管腺癌亚群 Uncovering a pancreatic ductal adenocarcinoma sub-population with stemness and unique therapeutic response SHIFA KHAN, Wen-Cheng Chung, Charles D. Moore, Keli Xu
- 2207 2207 肿瘤电场治疗(TTFields)对从胶质母细胞瘤患者脑室下区分离的癌症干细胞样细胞转录组和分泌组的影响 The impact of tumor treating fields (TTFields) on the transcriptome and the secretome of cancer stem-like cells isolated from the sub-ventricular zone of glioblastoma patients Rachel B. Sidebottom, Antonia E. Sajche Sapon, Yamhilette Licon-Munoz, Christian A. Bowers, Sara G.m. Piccirillo
- 2208 2208 MAP2介导的整合素失调重编程癌细胞可塑性,驱动肝细胞癌中肝癌细胞向间充质和干性状态转变 MAP2-mediated integrin dysregulation reprograms cancer cell plasticity to drive liver cancer cell transition to a mesenchymal and stemness state in hepatocellular carcinoma Ut Kei Lou, Tin-Lok Wong, Huajian Yu, Ki-Fong Man, Ka-Hei Lam, Jia Jian Loh, Lei Zhou, Yuan Gao, Cheng-Han Yu, Stephanie Ma
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2209 · PDF RelB驱动高级别浆液性卵巢癌中整合素介导的应激耐受和复发 RelB drives integrin-mediated stress tolerance and relapse in high-grade serous ovarian cancer Omar Lujano Olazaba, Mikella Robinson, Greg J. Jordan, Sofia Howe, Cassidy Lucht, Anna Platen, Dishant Vandra, Mena Shammas, Katelyn Shelby, Ingrid Niesman, Christina M. Annunziata, Carrie Danielle House
- 2210 2210 哇巴因对脑癌干细胞和肿瘤细胞发挥抗肿瘤和衰老细胞清除双重作用 Ouabain exerts both anti-tumor and senolytic effects in brain cancer stem and tumor cells Alaa Daoud Sarsour, Gila Kazimirsky, Moran Dvela-Levitt, Chaya Brodie, Heidrun Weidemann, Iris Frid
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2211 · PDF STAT1和STAT3协同控制癌症干细胞(CSC)命运及IFNgamma依赖性的CSC维持 STAT1 and STAT3 cooperatively control cancer stem cell (CSC) fate and IFNgamma-dependent CSC maintenance Sophia Hidalgo, Anushka Poola, Yipeng Zhang, Rachel Zhou, Kourosh Kouhmareh, Jack D. Bui, Magalie Dosset