LBPO.ET02 · 实验与分子治疗 · Late-Breaking
Late-Breaking Research: Experimental and Molecular Therapeutics 2
- LB180 LB180 异柠檬酸脱氢酶(IDH)亚型转换赋予骨髓增生异常肿瘤对ivosidenib的耐药性 Isocitrate dehydrogenase (IDH) isoform switch confers resistance to ivosidenib in myelodysplastic neoplasm Nicole Lux, Patrick R. Gonzales, Stephen D. Hyter, Shivani Golem, Wei Cui, Ramesh Balusu, Abdulraheem Yacoub
- LB182 LB182 以CTC/cfDNA生物标志物为指导的精准医学克服肝细胞癌免疫检查点抑制剂耐药 CTC/cfDNA biomarker-guided precision medicine to overcome immune checkpoint inhibitor resistance in hepatocellular carcinoma Yang Cui, Alexandria Borges, Meng Li, Linda Sher, Bangyan Stiles, Dan G. Duda, Anthony El-Khoueiry, Keigo Machida
- LB183 LB183 KRAS G12D ON/OFF抑制剂VS-7375联合PRMT5抑制在MTAP缺失/KRAS G12D突变型胰腺癌中带来强效持久的肿瘤消退 Strong durable tumor regressions with the KRAS G12D ON/OFF inhibitor VS-7375 in combination with PRMT5 inhibition in MTAP-deleted/KRAS G12D -mutant pancreatic cancer Ryan D. Mouery, Kristina Drizyte-Miller, Clint A. Stalnecker, Adrienne D. Cox, Silvia Coma, Jonathan A. Pachter, Channing J. Der
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- LB185 LB185 靶向线粒体二氢硫辛酰胺转乙酰基酶驱动的氧化还原信号的新型肽诱饵以改善癌症化疗结局 Novel peptide decoy targeting mitochondrial dihydrolipoyl transacetylase-driven redox signaling to improve cancer chemotherapy outcomes Jung Seok Hwang, Jaehyun Kim, Kiyoung Eun, Vanessa Avalos, Sydney Shuff, Margaret Stephens, Sumin Kang
- LB186 LB186 致癌性KRAS突变驱动雌激素非依赖性并在治疗耐药的ER+乳腺癌中诱导可靶向的易感性 Oncogenic KRAS mutations drive estrogen independence and induce targetable vulnerabilities in treatment-resistant ER+ breast cancer Priya S. Hibshman, Dan Ye, Rosario Chica-Parrado, Saurabh Mendiratta, Albert Lin, Ariella B. Hanker, Carlos L. Arteaga
- LB187 LB187 KRAS-MAPK信号通路适应性改变是胰腺导管腺癌对野生型IDH1抑制产生获得性耐药的基础 KRAS-MAPK signaling adaptation underlies acquired resistance to wild-type IDH1 inhibition in pancreatic ductal adenocarcinoma Sami O. Abul-Khoudoud, Mehrdad Zarei, Priyashree Sunita, Goutam Dey, Semmer Ali, Faith Nakazzi, Hallie J. Graor, Jordan M. Winter
- LB188 LB188 诱变驱动的基因组不稳定性将ecDNA扩增与前列腺癌的耐药性和免疫调节联系起来 Mutagenesis-driven genome instability links ecDNA amplification to drug resistance and immune modulation in prostate cancer Xiaoling Li
- LB189 LB189 靶向剪接体蛋白hnRNPH1/H2的治疗在BRAF抑制剂耐药性黑色素瘤中展现出强效抗黑色素瘤活性并增强肿瘤免疫应答 Therapeutic Targeting of Spliceosomal Proteins hnRNPH1/H2 Demonstrates Potent Anti-Melanoma Activity In BRAF Inhibitor Resistant Melanoma, and Enhances Tumor Immune Response Sadeeshkumar Velayutham, Maab Sultan, Tulsi Desai, Shweta Shah, Nhut Minh Nguyen, Eli Rome, Ryan Seerattan, Aveta Singh, Keiran Smalley, Jun Yong Choi, Vladimir Beljanski, Dmitriy Minond
- LB190 LB190 单细胞DNA测序揭示芳香化酶抑制新辅助临床试验中的克隆选择、激素适应和治疗耐药 Single cell DNA sequencing reveals clonal selection, hormonal adaptation and treatment resistance in neoadjuvant clinical trial of Aromatase inhibition Vessela N. Kristensen, Denise G. O`Mahony, Tom Lesluyes, Ina S. Brorson, Patrik H. Vernhoff, Ksenia Sokolova, Miriam R. Aure, Grethe G. Alnæs, Rebecca M. Hoøen, Arvind Y. M. Sundaram, Chandra Theesfeld, Stephanie B. Geisler, Torill Sauer Sauer, Nazli Bahrami, Andliena Tahiri, Torben Lüders, Olga Troyanskaya, Charles Vaske, Peter Van Loo, Jürgen Geisler
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- LB197 LB197 VS-7375，一种非共价的ON/OFF双重KRAS G12D抑制剂，在胰腺癌临床前模型中表现出优于仅ON型KRAS G12D抑制剂的活性 VS-7375, a non-covalent dual ON/OFF KRAS G12D inhibitor, displays superior activity to ON-only KRAS G12D inhibitors in preclinical models of pancreatic cancer Brandon L. Mouery, Clint A. Stalnecker, Adrienne D. Cox, Silvia Coma, Jonathan A. Pachter, Channing J. Der
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- LB199 LB199 高通量空间转录组学揭示triplatin诱导的DNA损伤信号传导及胰腺癌PDX模型中肿瘤-成纤维细胞微环境的重编程 High-plex spatial transcriptomics reveals triplatin-induced DNA damage signaling and tumor-fibroblast niche reprogramming in pancreatic cancer PDX models Praveen Bhoopathi, Khoa L. A. Huynh, Erica J. Peterson, Vashti Bandy, Anna Gibson, Vignesh Vudatha, Arunima Punjala, Dongyu Zhang, Jinze Liu, J Chuck Harrell, Nicholas P. Farrell, Jose G. Trevino
- LB475 LB475 GPER作为内分泌耐药乳腺癌中可靶向治疗的靶点 GPER as an actionable target in endocrine resistant breast cancer Sierra Vidaurri, Shweta Singh, Valerie Ledezma, Emma Garza, Francisco Flores, Alexander Lim, Muhammad Noorani, Shubhank Goyal, Aura Calderon, Anupam Dhasmana, Swati Dhasmana, Murali Mohan Yallapu, Subhash C. Chauhan, Diane Nguyen, Sheema Khan
