Integration of Clinical and Research Data

• 2708 · PDF 通过空间解析的药物响应预测揭示成纤维细胞介导的对肺癌治疗响应的影响 Revealing fibroblast-mediated impacts to therapy response through spatially resolved drug response prediction in lung cancer Robert F. Gruener, Weijie Zhang, Lilin Wang, Adam M. Lee, R. Stephanie Huang
• 2709 · PDF PRECISE：一种用于甲状腺乳头状癌的预后性甲状腺滤泡细胞来源基因特征 PRECISE: A prognostic thyroid follicular cell-derived gene signature for papillary thyroid carcinoma Sophie Li, Chia C. Wu, Vicente R. Marczyk, Matthew A. Loberg, Aatish Thennavan, Maxime Tarabichi, Li Xu, Ying C. Henderson, Tuan M. Tran, Quanhu Sheng, George J. Xu, Eric C. Huang, Marie-Claude Hofmann, Xiao Zhao, Stephen Y. Lai, Michelle D. Williams, Wenyi Wang, Sarah Hamidi, Mark E. Zafereo, Maria E. Cabanillas, Nicholas E. Navin, Vivian L. Weiss, Jennifer R. Wang
• 2710 · PDF 单核多组学分析揭示EGFR和ALK突变型肺腺癌中保守的适应性状态 Single-nuclei multiomic profiling reveals conserved adaptive states in EGFR- and ALK-mutant lung adenocarcinoma Naomi Kaste Mfonfu, Floriane Brayé, Galina Boldina, Matteo Cesaroni, Luc Friboulet, Sergey Nikolaev, Andrey Yurchenko
• 2711 · PDF 来自ETOP BEAT-meso试验的单核与空间转录组学大规模整合揭示恶性胸膜间皮瘤中具有临床相关性的异质性 Large-scale integration of single-nuclei and spatial transcriptomics from the ETOP BEAT-meso trial reveals clinically relevant heterogeneity in malignant pleural mesothelioma Daria Buszta, Jonathan Bac, Maxim Norkin, Arsh Shaikh, Bernd Illing, Adriano Martinelli, Isinsu Katircioglu, Melissa Ensmenger, Sylvie Andre, Marina Alexandre-Gaveta, Sanjay Popat, Anthony Pope, Riyaz Shah, Toby Talbot, Julia Giner, Janthur Wold-Dieter, Ernst Nadal, Annamaria Catino, David Gilligan, Amy Roy, Georgia Dimopoulou, Rosita Kammler, Stephen P. Finn, Zoi Tsourti, Enriqueta Felip, Patrick Vagenknecht, Solange Peters, Rolf A. Stahel, Marianna Rapsomaniki, Raphael Gottardo, Krisztian Homicsko
• 2712 · PDF MPACT-DPD:一种用于预测DPYD错义变异功能影响的可解释机器学习分类器 MPACT-DPD: An interpretable machine learning classifier for predicting the functional impact of DPYD missense variants Lulu Jiang, Ryan Jonathan Swartz, Lauryn Allyn Hahn, Brianna Bembenek, Hannah Marie Krause, Kelly Bouchonville, Steven M. Offer
• 2713 · PDF 使用非匹配的预处理多组学数据进行集成机器学习可对非小细胞肺癌免疫检查点抑制的反应进行分类 Ensemble machine learning using unmatched pre-treated multi-omic data can classify response to immune checkpoint inhibition in non-small cell lung cancer Alexander Azizi, Arvind Ravi, Natalie Vokes, Stephen-John Sammut, Petar Stojanov, Justin Gainor, Gad Getz
• 2714 · PDF 一种新型Ikaros/Aiolos转录特征的开发及其与接受CELMoDs治疗的多发性骨髓瘤患者反应的相关性 Development of a novel Ikaros/Aiolos transcriptional signature and correlation with patient response in multiple myeloma patients treated with CELMoDs Saleh Tamim, Nicholas Stong, Yan Kai, Diana Jankeel, Bonny Gaffney, Antonina Kurtova, Alberto R. Perez, Celia Fontanillo, Tracy T. Chow, Patrick R. Hagner, Danny Jeyaraju, Chad C. Bjorklund, Michael Amatangelo, Kai Wang, Anita Gandhi, Maria Ortiz-Estevez
• 2715 · PDF 一个全面的头颈部鳞状细胞癌单细胞图谱定义了恶性细胞状态并使得能够对既往的大宗转录组队列进行去卷积 A comprehensive single-cell atlas of head and neck squamous cell carcinoma defines malignant cell states and enables deconvolution of legacy bulk transcriptomic cohorts Yuanyuan Shen, Tingyi Li, Roger Li, Xuefeng Wang, Xiaoqing Yu
• 2716 · PDF 基于机器学习的筛查工具用于在实验室检测有限的慢性肾脏病患者中检测多发性骨髓瘤 Machine learning-based screening tool for multiple myeloma detection in chronic kidney disease patients with limited laboratory testing Wen-Chi Wu, Muh-Hwa Yang, Chih-Yu Yang
• 2717 · PDF 通过多基因评分对糖尿病和非糖尿病男性进行前列腺癌风险分层 Prostate cancer risk stratification by polygenic score in diabetic and non-diabetic men Gukjin Lee, Sang-Hyuk Jung, Jonghyun Lee, Ki Won Moon, Jae-Seung Yun, Dokyoon Kim
• 2718 · PDF 液体活检cfDNA甲基化在单次检测中预测肺肿瘤大小和转移潜能 Liquid biopsy cfDNA methylation predicts lung tumor size and metastatic potential in a single assay Kade P. Pettie, Shiva Farashahi, Jackson Killian, Andrew Wong, Yifan Wu, Dorna Kashef, Franziska Michor, Jocelyn Charlton, Kieran Chacko
• 2719 · PDF 利用计算推理在GDSC细胞系数据中进行分子指导的治疗疗效预测 Molecularly-informed prediction of treatment efficacy in GDSC cell line data using computational reasoning Robert Doczi, Akos Takacs, Anna Dirner, Dora Lakatos, Barbara Vodicska, Dora Gorog-Tihanyi, Reka Szalkai-Denes, Eniko Kispeter, Andras Makkos, Aniko Gorbe, Peter Ferdinandy, William T. Beck, Christophe Le Tourneau, Petak Istvan
• 2720 · PDF 一个全面的、由LLM赋能的药效学生物标志物资源库，用于加速癌症药物研发 A comprehensive LLM-enabled pharmacodynamic biomarker resource to accelerate cancer drug development Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu, Rebecca Johnson, David Maxwell, Kaitlyn Brickey, Bissan Al-Lazikani
• 2721 2721 对癌前诊断电子健康记录的全表型关联研究在All of Us研究计划中识别出风险因素和保护因素 Phenome-wide association study of pre-cancer diagnosis electronic health records identifies risk and protective factors in the All of Us Research Program Charles C. D. Rich, Alyssa B. Bair, Britton E. Richardson, Katelyn C. Forbes, Blaine A. Bates, Mary F. Davis, Matthew H. Bailey
• 2722 · PDF 整合分析识别出ELF3-CREB1共激活是高危胰腺癌的预后驱动因素 Integrated analysis identifies ELF3-CREB1 co-activation as a prognostic driver of high-risk pancreatic cancer Poorva Poorva, Rimpi Khurana, Varunkumar Krishnamoorthy, Sudhakar Jinka, Yan Guo, Vineet Kumar Gupta, Nagaraj Nagathihalli
• 2723 · PDF 基因组驱动因素和免疫冷微环境与中国儿童B-ALL复发相关 Genomic drivers and an immune-cold microenvironment are associated with relapse in Chinese pediatric B-ALL Dan Yu, Yanni Hu, Xue Tang, Junlin Wang, Junwen Wang, Jianwen Xiao
• 2724 · PDF 一种利用基因组特征对乳腺癌受体亚型进行分类的机器学习方法 A machine learning approach to classify breast cancer receptor subtype using genomic features Sandro Satta, Philip Miller, Samuel Rivero-Hinojosa, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu
• 2725 · PDF TP53突变型胶质瘤中分级依赖的生存和共突变图景：生物学见解与治疗意义 Grade-dependent survival and co-mutation landscapes in TP53-mutant gliomas: Biological insights and therapeutic implications Harpreet Kaur, Kevin Camphausen, Uma Shankavaram
• 2726 · PDF MUC13在HCC中的临床病理学和分子学意义 Clinicopathological and molecular significance of MUC13 in HCC Anupam Dhasmana, Swati Dhasmana, Rajasekhar Baru, Abigail Gomez, Iris A. Perez, Sheema S. Khan, Murali M. Yallapu, Subhash C. Chauhan
• 2727 · PDF 一种设计的活菌治疗剂在预测模型中恢复应答者样微生物组特征并改善免疫检查点抑制剂(ICI)应答 A designed live bacterial therapeutic restores responder-like microbiome profiles and improves immune checkpoint inhibitor (ICI) response in a predictive model Glen J. Weiss, Sonia Timberlake, Kinga Zielinska, Marina Santiago, Johannes Woehrstein, Christopher Weidenmaier
• 2728 · PDF 癌症复杂性知识门户：一个符合FAIR原则的资源发现工具 The Cancer Complexity Knowledge Portal: A FAIR-aligned tool for resource discovery Orion Banks, Ashley Clayton, Aditi Gopalan, Amber Nelson, Verena Chung, Amy Heiser, Jay Hodgson, Aditya Nath, Adam Hindman, Milen Nikolov, Adam Taylor, Angie Bowen, Susheel Varma, Jineta Banerjee
• 2729 · PDF 体细胞突变的选择景观在乳腺癌中编码组织病理学信息 The selective landscape of somatic mutations encodes histopathological information in breast cancer Gift Asefon, Nic Fisk
• 2731 · PDF Sylvester数据门户：对一个多样化临床基因组学队列的群体水平特征描述 Sylvester Data Portal: Population-level characterization of a diverse clinicogenomic cohort Oliver Mazariegos, Jeronimo Pissinis, Pearl Seo, Marcin Pilarczyk, Lukas Rupprecht, Caty Chung, Franklin Sotolongo, Marcin Blicharz, Piotr Smol, Michal Pyrkosz, Mateusz Jura, Vasileios Stathias, Stephan Schürer
• 2732 · PDF 佛罗里达癌症研究(FL CARES)网络与加速协作计算癌症研究平台(PAC3R) Florida Cancer Research (FL CARES) network and the Platform for Accelerating Collaborative Computational Cancer Research (PAC3R) Jeronimo Pissinis, Michael S. Sinclair, Marcin Pilarczyk, Caty Chung, Dusica Vidovic, Lukas Rupprecht, Franklin Sotolongo, Oliver Mazariegos, Kathleen M. Jagodnik, Carlos Obregon, Tingyi Li, Ling Cen, Jiang Bian, Ji-Hyun Lee, Qianqian Song, Bikhyat Adhikari, Till Krenz, Ritik Bhandari, Umamaheswari Natarajan, Gogce C. Crynen, Appu Rathinavelu, Stuart Chalk, Mondal M. Ananda, Xuefeng Wang, Vasileios Stathias, Stephan Schürer
• 2733 · PDF 一个用于多倍体巨型癌细胞药物应答整合分析的交互式网络平台 An interactive web platform for integrative analysis of drug responses in polyploid giant cancer cells Li-Ju Wang, Hsiao-Chun Chen, Chien-Hung Shih, Yuan Zhang, Huikang Ye, Ying-Ju Lai, Yushu Ma, Tiffany Habib, Hsi-Chun Wang, Yu-Chih Chen, Yu-Chiao Chiu

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