PO.ET07.02 · 实验与分子治疗
Pharmacogenomics and Translational Biomarkers for Precision Cancer Therapy
- 3133 3133 转移性结直肠癌患者贝伐珠单抗二线化疗的药物遗传学交互作用分析：随机BEBYP试验结果 A pharmacogenetic interaction analysis of second-line chemotherapy with bevacizumab in metastatic colorectal cancer patients: Results from the randomized BEBYP trial Arianna Bandini, Paola Orlandi, Marco Scalese, Gianluca Masi, Federica Marmorino, Chiara Cremolini, Guido Bocci
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- 3137 3137 DPYD rs75017182携带者中的部分选择性剪接解释了其与严重5-FU毒性的中等程度关联 Partial alternative splicing in carriers of DPYD rs75017182 explains modest association with severe 5-FU toxicity to 5-FU Lauryn Allyn Hahn, Ryan Schwartz, Hannah Marie Krause, Lulu Jiang, Brianna Bembenek, Kelly Bouchonville, Steven M. Offer
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- 3142 3142 胃癌PDX模型中对Wnt/β-catenin凝聚物调节剂DPTX3186反应的基因组决定因素及其临床开发意义 Genomic determinants of response to the Wnt/Beta-catenin condensate modulator DPTX3186 in gastric cancer PDX models and implications for clinical development Francis Carpenter, Kip West, Doug Baumann, Adam Talbot, Thomas Durand-Reville, Karl Hsu, Ann Boija, Isaac Klein
- 3143 3143 共同靶向两条不同的雄激素受体调控信号通路作为前列腺癌的治疗策略 Co-targeting of two distinct androgen receptor-regulated signaling pathways as a therapeutic approach in prostate cancer Min-Yu Ko, Rachid Safi, Suzanne E. Wardell, Paige Watkinson, Isabel Jones, Brianna Richardson, John D. Norris, Donald P. McDonnell
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- 3148 3148 人血微核网织红细胞：作为肿瘤药物开发中DNA双链断裂药效学生物标志物的应用 Human blood micronucleated reticulocytes: Application as a pharmacodynamic biomarker for DNA double strand breaks in oncology drug development Jeffrey C. Bemis, Colette Baxter, Gillian Langford, Timothy A. Yap, Susanna Varkey Ulahannan, Nehal Lakhani, Babar Bashir, Kathleen N. Moore, Payal Shah, Svetlana Avlasevich, Dorothea Torous, Stephen Dertinger
- 3149 3149 微核（MN）动力学在临床前模型及患者网织红细胞中作为首创DNA聚合酶theta（PolΘ）抑制剂ART6043的药效学生物标志物 Micronuclei (MN) dynamics in preclinical models and in patient reticulocytes as a pharmacodynamic biomarker for the first in class DNA polymerase theta (PolΘ) inhibitor ART6043 Colette L. Baxter, Timothy A. Yap, Susanna V. Ulahannan, Nehal Lakhani, Minal Barve, Erika P. Hamilton, Babar Bashir, Helen M. R. Robinson, Jayesh B. Majithiya, Paula Costales, Sarah V. Holt, Samantha C. Skelton, Marina Roy-Luzarraga, Jeff C. Bemis, Dorothea Torous, Svetlana Avlasevich, Susana Barriga, Bryony Harrop, Gillian A. Langford, Ian Smith, Graeme C. M. Smith
- 3150 3150 InVEST44™是一种具有成本效益的体外安全性检测组合，可在早期药物发现中识别脱靶效应 InVEST44™ is a cost-effective in vitro safety panel that identifies off-target effects in early-stage drug discovery Julian R. Wooltorton, Afsara Ahona, Nicole Barbacane, Alex D'Andrea, Justin Lansberry, Cindy Lay, Paige Miller, John Ries, Jamin Steffen, Patricia Valentine
- 3151 3151 肝细胞对肿瘤学药物化合物毒性的高通量高多重蛋白质组学分析：一个用于毒性评估、免疫风险预测和加速药物开发的平台 High-throughput high-plex proteomic profiling of hepatocyte toxicity to oncologic drug compounds: A platform for toxicity assessment, immune risk prediction, and drug development acceleration Nicole Paul, Alyssa Rosenbloom, Nathaniel Robichaud, Kiran Edwardson, Nathan Chang, Narges Rashidi, Milad Dagher
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- 3153 3153 一个用于同时评估抗癌疗效和多器官毒性的整合式体外分析平台 An integrated in vitro profiling platform for the simultaneous assessment of anti cancer efficacy and multi organ toxicity Xia Tu, Hao Wen, Dawei Yan, Jingna Ren, Qin Guo, Peichuan Zhang, Haiheng Dong
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- 3155 3155 在等摩尔静脉给药后，Re(CO)3-phenformin与phenformin在小鼠PDAC模型中的药代动力学/药效学相关性及生物分布比较 Pharmacokinetic/pharmacodynamic correlation and biodistribution of Re (CO)3-phenformin compared with phenformin in murine PDAC model following equimolar intravenous dosing Amir Mohammad Gholizadeh, Fatima Dagher, Mikayla Skillman, Airong Li, Chun Li, Diana S-L Chow
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- 3157 3157 多次给药后 HCC 小鼠体内 M-CPA/PTX 中紫杉醇与环巴胺的药代动力学/药效学相关性及生物分布 Pharmacokinetic/pharmacodynamic correlation and biodistribution of paclitaxel and cyclopamine from M-CPA/PTX in HCC mice following multiple dosing Emanuel R. Baltrip, Lu Dai, Qiu-Xu Teng, Defeng Deng, Guodong Zhang, Chun Li, Diana S.-L. Chow
- 3158 3158 奈必洛尔与达沙替尼在 4T1 三阴性乳腺癌模型中的药代动力学与生物分布评价：对药物-药物相互作用的意义 Pharmacokinetic and biodistribution evaluation of nebivolol and dasatinib in the 4T1 triple-negative breast cancer model: Implications for drug-drug interaction Airong Li, Mikayla Skillman, Junhyoung Park, Fatima Dagher, Amir M. Gholizadeh, Emanuel Baltrip, Meghana Trivedi, Benny A. Kaipparettu, Diana S.-L. Chow
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