Spatial Proteomics and Transcriptomics 1

• 1200 · PDF 空间解析的肿瘤细胞MHC II类分子塑造三阴性乳腺癌的适应性免疫与治疗应答 Spatially resolved tumor-cell MHC class II shapes adaptive immunity and therapeutic response in triple-negative breast cancer Yi Liu, Sachin Kumar Deshmukh, Thiti Susiriwatananont, Panuch Eiamprapaporn, Bogang Wu, Heikki Joensuu, Roberto A. Leon-Ferre, David Zahrieh, Judy C. Boughey, James Newell Ingle, Fergus J. Couch, Sharon Wu, Shipra Gandhi, Maryam Lustberg, George W. Sledge, Matthew P. Goetz, Keith L. Knutson, E Aubrey Thompson, Jodi Carter, Saranya Chumsri
• 1201 · PDF CDH1突变携带者中弥漫型胃癌从癌前病变到浸润性病变演进的空间三维与多组学图谱 Spatial 3D and multi-omics mapping of diffuse gastric cancer evolution from preinvasive to invasive lesions in CDH1 mutation carriers Yunhe Liu, Idania Carolina Lubo Julio, Wei Lu, Alejandra G. Serrano, Jean R. Clemenceau, Amber Famiglietti, Karen Colbert, Yibo Dai, Yang Liu, Jun Wang, Jeremy L. Davis, Mingyao Li, Paul F. Mansfield, Tae Hyun Hwang, Luisa M. Solis-Soto, Linghua Wang
• 1202 · PDF 伴肉瘤样/横纹肌样去分化肾肿瘤的空间解析转录组分析揭示潜在生物学机制及相关新生物标志物 Spatially-resolved transcriptome analysis of renal tumors with sarcomatoid/rhabdoid dedifferentiation uncovers underlying biology and new biomarkers relevant to these tumors Minjun Kim, Mustafa Soytas, Burge Ulukan, Tamiko Nishimura, Senthilkumar Kailasam, Ariel Madrigal, Zohreh Mehrjoo, Kate Glennon, Eleonora Scarlata, Madeleine Arseneault, Morag Park, Hamed Najafabadi, Fadi Brimo, Ozgur Sahin, Simon Tanguay, Yasser Riazalhosseini
• 1203 · PDF 保守性及癌症特异性免疫-基质生态位的空间原型 Spatial archetypes of conserved and cancer-specific immune-stromal niches Tian Chu, Jimin Min, Yunhe Liu, Yang Liu, Yibo Dai, Kyung Serk Cho, Xueshuai Han, Kai Yu, Fuduan Peng, Anirban Maitra, Humam Kadara, Linghua Wang
• 1204 · PDF 老龄小鼠自发性肺肿瘤的空间多组学表征 Spatial multiomic characterization of spontaneous lung tumors in aged mice Adam Thiesen, Sema Akkurt, Javad Noorbakhsh, Te-Chia Wu, Andrew Salner, Peter Yu, Susan Airhart, Olga Anczukow, Ron Korstanje, Karolina Palucka, Jeffrey H. Chuang
• 1205 1205 通过RNA-seq数据图像表征实现轨迹感知的空间转录组学解卷积 Trajectory-aware spatial transcriptomics deconvolution via image representation of RNA-seq data Junyan Liu, Md Tauhidul Islam, Lei Xing
• 1207 · PDF STIC病变的多模态分析识别出具有高级别浆液性卵巢癌基因组特征的前驱状态 Multimodal profiling of STIC lesions identifies precursor states with genomic features of high grade serous ovarian cancer Duaa Hassan Al-Rawi, Nataly Naser Al Deen, Cristina Sotomayor-Vivas, Kerstin Thol, Herman Chui, Aveline Filliol, Areej Alsaafin, Hunter Green, Danguole Norkunaite, Mercedes Duran, Nicholas Ceglia, Kara Long-Roche, Britta Weigelt, Andrew McPherson, Scott W. Lowe, Sohrab Shah
• 1208 · PDF MONSTAR-SCREEN-3空间图谱：泛癌TME原型及临床相关的肿瘤-免疫生态系统 The MONSTAR-SCREEN-3 Spatial Atlas: Pan-cancer TME archetypes and clinically relevant tumor-immune ecosystems Mitsuho Imai, Eun Seop Seo, Jiyeon Hyeon, Shingo Sakashita, Yuka Nakamura, Tadayoshi Hashimoto, Shin Kobayashi, Jun Yuda, Riu Yamashita, Taro Shibuki, Takao Fujisawa, Masataka Amisaki, Kensuke Matsuda, Shun-ichiro Kageyama, Michiko Nagamine, Takeshi Kuwata, Hideaki Bando, Woong-Yang Park, Takayuki Yoshino
• 1209 · PDF FGFR2易位型鼻窦腺癌：一种具有独特且可靶向分子表型的双相性浆液黏液性腺癌 FGFR2 translocated sinonasal adenocarcinoma: A biphasic seromucinous adenocarcinoma with a distinctive and targetable molecular phenotype Diana Bell, Randal S. Weber, Miao Zhang, Michelle Afkhami, Raja R. Seethala
• 1210 · PDF 整合空间与单细胞图谱分析揭示一个预先存在的、治疗耐药的亚克隆驱动管腔型乳腺癌的早期局部复发 Integrated spatial and single-cell profiling uncovers a pre-existing, treatment-resistant subclone that drives early local relapse in luminal breast cancer Kazutaka Otsuji, Tomo Osako, Yoko Takahashi, Chikako Shibata, Sumito Saeki, Asumi Iesato, Tetsuo Noda, Kengo Takeuchi, Takayuki Ueno, Reo Maruyama
• 1211 · PDF 空间转录组学揭示乳腺癌对trastuzumab deruxtecan耐药的药代动力学屏障和肿瘤内在决定因素 Spatial transcriptomics uncovers pharmacokinetic barriers and tumor-intrinsic determinants of resistance to trastuzumab deruxtecan in breast cancer Changhee Park, Minki Choi, Jiwon Koh, Sungwoo Bae, Hongyoon Choi, Kwon Joong Na, Dae-Won Lee, Kyung-Hun Lee, Han Suk Ryu, Seock-Ah Im
• 1212 · PDF 空间转录组学揭示新辅助osimertinib治疗的EGFR突变型非小细胞肺癌中独特的SPP1-CD44信号网络 Spatial transcriptomics reveals distinct SPP1-CD44 signaling networks in neoadjuvant osimertinib treated EGFR mutant non-small cell lung cancer Whitney Tamaki, Daniel L. Kerr, Wei Wu, Grant Eilers, Anatoly Urisman, Yu-Ting Chou, Philippe Gui, Shigeki Nanjo, Johannes Ruediger Kratz, David Jablons, Trever G. Bivona, Collin M. Blakely
• 1213 1213 侵袭性淋巴瘤中与CAR-T治疗临床应答相关的线粒体转录组谱 Mitochondrial transcriptome profiles associated with clinical responses to CAR-T therapy in aggressive lymphoma Jacqueline Turner, Panwen Wang, Patrizia Mondello, Melinda Tan, Christoph Schaefers, Chen Wu, Andre de Menezes Silva Corraes, Kevin Regan, Zuoyi Shao, Ma Audrey, Arushi Khurana, Nora N. Benanni, Yucai Wang, Paul Hampel, Saad J. Kenderian, Jonas Paludo, Urshila Durani, Patrick B. Johnston, Jose Caetano Villasboas, Stephen M. Ansell, Haidong Dong, Ying Li, Zeng Hu, Yi Lin
• 1214 · PDF SPACE：用于三维模型中高通量CRISPR筛选的空间分辨多组学分析 SPACE: Spatially resolved multiomic analysis for high-throughput CRISPR screening in 3D models Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu, Sierra McKinzie, Michael Patrick, Sharanya Iyengar, Maerjianghan Abuduli, Marianne Spatz, Nandita Joshi, Brendan Miller, Shams Vellarikkal, Timothy Riordan, Danny Bitton, Jan Lubojacky, Iya Khalil, Federica Piccioni, Michael Rhodes, Alex Tamburino, Shanshan He, Joseph Beechem, Vanessa Peterson
• 1215 · PDF 具有极端临床结局的原发性黑色素瘤的空间转录组学分析 Spatial transcriptomic analysis of primary melanomas with extreme clinical outcomes Prachi Bhave, Marie Trussart, Anthony T. Papenfuss, Grant A. McArthur
• 1216 · PDF 利用空间转录组学剖析结肠癌结构识别出具有临床相关性的间质生态型 Profiling colon cancer architecture with spatial transcriptomics identifies clinically relevant stromal ecotypes Antoine Cazelles, Camilla Pilati, Delphine Le Corre, Gadea Cabrejas, Marine Sroussi, Claire Mulot, Claire Gallois, Gilles Manceau, Mehdi Karoui, Isaias Hernández-Verdin, Antoine Bougoüin, Wolf-Herman Fridman, Aurélien de Reyniès, Côme Lepage, Thierry Andre, Jean-François Emile, Théo Z. Hirsch, Julien Taieb, Pierre Laurent-Puig, Sophie Mouillet-Richard
• 1217 · PDF 整合bulk、单细胞和空间转录组学的多组学分析确定头颈部涎腺腺样囊性癌的稳健预后生物标志物 Multi-omics integration of bulk, single-cell, and spatial transcriptomics identifies robust prognostic biomarkers in head and neck salivary adenoid cystic carcinoma Gopikrishnan Bijukumar, Kathryn J. Brayer, David Lee, Scott A. Ness, Jeremy S. Edwards, Viswanathan Palanisamy
• 1218 · PDF 用于空间解析免疫检查点分析的邻近连接-成像质谱流式细胞术平台的开发 Development of a proximity ligation-imaging mass cytometry platform for spatially resolved immune checkpoint analysis Ghazal Lessan Toussi, Lars Muhl, Anna Gorbunova, Austin James Rayford, Amanda Lindberg, Neda Hekmati, Viktoria Thurfjell, Aglaia Schiza, Agata Zieba Wicher, Patrick Micke, Carina Strell
• 1219 · PDF 空间多组学分析捕获HER2异质性FFPE乳腺癌组织中的功能特征 Spatial multi-omic profiling to capture functional signatures in HER2-heterogeneous FFPE breast cancer tissue Dongyoon Shin, Sumin Lee, Young June Jeon, Jeongwoo Hong, Sohyun Yang, Amos Chungwon Lee, Han Suk Ryu, Youngsoo Kim, Sungwoo Cho, Song-A Park, Sihun Cho, Sungho Ko, Junho Park
• 1220 · PDF 空间转录组学揭示戈沙妥珠单抗在转移性乳腺癌中的潜在耐药和应答因素 Spatial transcriptomics revealed potential resistance and response factors of sacituzumab govitecan in metastatic breast cancer Mengni He, Charles J. Robbins, Julia Benanto, Thazin Nwe Aung, Yalai Bai, Ian E. Krop, David L. Rimm
• 1221 · PDF pelareorep治疗的早期乳腺癌样本的成像质谱流式细胞术揭示发育中的三级淋巴结构 Imaging mass cytometry of pelareorep treated early breast cancer samples reveals developing tertiary lymphoid structures Julian P. Olea, Homa Dadrastoussi, Kaijin Wu, Harley Wu, Paniz Zarand, Claudia Villa Celi, Jennifer S. Carew, Steffan T. Nawrocki, Xuelian Chen, Richard Trauger, Thomas C. Heineman, Kevin R. Kelly
• 1222 · PDF 曲妥珠单抗德鲁替康治疗的转移性乳腺癌的空间转录组学识别候选应答和耐药因素 Spatial transcriptomics of trastuzumab deruxtecan-treated metastatic breast cancer identifies candidate response and resistance factors Charles J. Robbins, Mengni He, Julia Benanto, Thazin Nwe Aung, Yalai Bai, Ian E. Krop, David L. Rimm
• 1223 · PDF 空间转录组学识别髓外多发性骨髓瘤中抑制性T细胞排斥的肿瘤微环境 Spatial transcriptomics identifies a suppressive T-cell excluded tumour microenvironment in extramedullary multiple myeloma Nicholas E. Bingham, Julie R. Boiko, Daniel C. Jones, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Kathleen S. Ensbey, Anna E. Elz, Evan W. Newell, Andrew Spencer, Geoffrey R. Hill
• 1224 · PDF 用于全面表征肿瘤及相关微环境的抗体药物偶联物免疫肿瘤学面板 Antibody-drug conjugate immuno-oncology panel for comprehensive characterization of the tumor and associated microenvironment Sandra F. Lam, Kevin Gallagher, Maryam Rohafza, Courtney Todorov, Harry Nunns, Marianne Thio, Flora Sahafi, Kathy Pham, Victoria Gomez, Erinn A. Parnell, Qingyan Au
• 1225 · PDF 卵巢癌组织样本的三维空间多组学表征 3D spatial multiomics characterization of ovarian cancer tissue samples Lena Nolte, Diogo Bessa-Neto, Salpy Baghdo, Bernadett Szabó, Fabio El Yassouri, Emily Neil, Robert Pinard, Werner Müller, Dominik Eckardt, Christoph Herbel, Andreas Bosio

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