PO.PS01.07 · 人群科学
Genetic Epidemiology 1: GxE, GWAS, Polygenic Risk Scores, and Post-GWAS
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- 3584 3584 在前瞻性队列中刻画癌症多基因风险评分:考量PRS方法构建、诊断年龄、遗传血统与样本重叠 Characterizing polygenic risk scores for cancer in prospective cohorts: Considering PRS method construction, age of diagnosis, genetic ancestry, and sample overlap Julie-Alexia Dias, Gillian King, David Bogumil, Brian Huang, Fei Chen, David V. Conti
- 3585 3585 身体质量指数多基因风险评分(PRS BMI)与西班牙裔社区健康研究/拉丁裔研究中女性肥胖相关癌症风险 A body mass index polygenic risk score (PRS BMI ) and obesity-related cancer risk among women in the Hispanic Community Health Study/Study of Latinos Humberto Parada, Tamar Sofer, Margaret Pichardo, Krista M. Perreira, Laura Zhou, Frank J. Penedo, Amber Pirzada, Martha Daviglus, Gregory A. Talavera, Linda C. Gallo
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- 3587 3587 多基因风险评分对高风险非裔美国女性总体乳腺癌和三阴性乳腺癌的独立验证 Independent validation of polygenic risk scores for overall and triple-negative breast cancer among high-risk African American women Yijia Sun, Timothy Simmons, James L. Li, Armaan Jamal, Achille V.C. Manirakiza, Dmitry Pruss, Sarah Ratzel, Olufunmilayo I. Olopade, Alexander Gutin, Elisha Hughes, Dezheng Huo
- 3589 3589 血统驱动的乳腺癌基因转录调控:哥伦比亚人群中通过顺式和反式eQTL的调控 Ancestry-driven transcriptional regulation of breast cancer genes through cis- and trans-eQTLs in colombian populations Laura Rey-Vargas, Lina María Bejarano, Patricia López, Diego Felipe Ballen-Lozano, Silvia Juliana Serrano-Gomez
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- 3591 3591 将多基因风险评分与PSA检测相结合用于接受前列腺活检男性的前列腺癌风险分层 Incorporation of polygenic risk scores with PSA testing for prostate cancer risk stratification in men undergoing prostate biopsy Daniel Sabater Minarim, Roshan Karunamuni, Kylie M. Morgan, Tyler Nelson, Craig Teerlink, Julie Lynch, Isla P. Garraway, Anna M. Dornisch, Tyler M. Seibert, Jason L. Vassy, Brent S. Rose
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- 3593 3593 在一个奠基者人群中BRCA1/2突变及多基因风险评分与前列腺癌风险和死亡率的关联 Associations of BRCA1/2 mutations and polygenic risk score with prostate cancer risk and mortality in a founder population Ilir Agalliu, Mykhaylo Usyk, Michael D`Angelo, Victor Kamensky, Robert Burk
- 3594 3594 肾上腺允许型HSD3B1基因型与患者前列腺癌特异性死亡率：来自多民族队列研究的见解 Adrenal-permissive HSD3B1 genotype and prostate cancer-specific mortality among patients: Insights from the multiethnic cohort Study Wei Xiong, Xin Sheng, Peggy Wan, Lynne R. Wilkens, Loïc Le Marchand, David V. Conti, Christopher A. Haiman, Fei Chen
- 3596 3596 喀麦隆乳腺癌患者中BRCA1和BRCA2突变的特征分析：为弥合非洲基因组差距所做的努力 Characterizing BRCA1 and BRCA2 mutations in Cameroonian breast cancer patients: Efforts towards bridging the genomic gap in Africa Kenn Chi Ndi, Berthe Sabine Esson Mapoko, Vanessa Mouaye, Carmen Vanvolkenburgh, Bonaventure Dzekem, Paul Ndom, Dezheng Huo, Olufunmilayo I. Olopade
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- 3599 3599 外周血中MYC外显子3的DNA甲基化与前列腺、肺、结直肠和卵巢癌筛查试验中侵袭性前列腺癌的风险 MYC exon 3 DNA methylation in peripheral blood and the risk of aggressive prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial Patricia A. Erickson, Lauren M. Hurwitz, Søren M. Bentzen, Stella Koutros, Liying Yan, Matthew L. Poulin, Ann Meyer, Allen Burke, Arif Hussain, Sonja I. Berndt, Kathryn Hughes Barry
- 3600 3600 泛癌全基因组研究揭示七种实体癌之间共享的遗传结构和新的多效性变异 Pan-cancer genome-wide study reveals shared genetic architecture and novel pleiotropic variants across seven solid cancers Xunxuan Chen, Gamaliel T. Taengwa, Brandon J. Coombes, Stacey J. Winham
- 3601 3601 多人群GWAS荟萃分析识别新的膀胱癌易感位点并突出吸烟相关风险的遗传调控 Multi-population GWAS meta-analysis identifies novel bladder cancer susceptibility loci and highlights the genetic regulation of smoking-related risk Ludmila Prokunina-Olsson, Oscar Florez-Vargas, Michael G. Levin, Diptavo Dutta, Charles Breeze, Lauren M. Hurwitz, Wusheng Yan, Philippe Lamy, Brenen Papenberg, Kevin Wang, Chia-Han Lee, Roger L. Milne, Jian Gu, Caroline Y. Um, Vijai Joseph, Helena Furberg, Florence Le Calvez-Kelm, Chikashi Terao, Koichi Matsuda, Francisco X. Real, Lambertus A. Kiemeney, Stephen J. Chanock, Núria Malats, Debra T. Silverman, Lars Dyrskjøt, Nathaniel Rothman, Scott M. Damrauer, Stella Koutros, Jeffrey S. Damrauer
- 3602 3602 套细胞淋巴瘤全基因组关联研究发现新的易感位点，提示B细胞染色质阅读器与DNA修复机制发挥关键作用 Genome-wide association study of mantle cell lymphoma identifies novel loci suggesting a critical role for B-cell chromatin readers and DNA repair mechanisms Charles E. Breeze, Alyssa Clay-Gilmour, Hanla A. Park, Ólafur B. Davíðsson, Angelica Macauda, Brenda M. Birmann, Elizabeth E. Brown, Murat Güler, Michelle A. T. Hildebrandt, Alexandra Nieters, Krystle Ong, Jojo Biel-Nielsen Dietz, Karin E. Smedby, Karl Smith-Byrne, Rosalie Griffin, Sophia S. Wang, Susan Slager, James R. Cerhan, Jonathan N. Hofmann, Qing Lan, Nathaniel Rothman, Ingrid Glimelius, Henrik Hjalgrim, James Mckay, Sonja I. Berndt
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- 3604 3604 前列腺癌风险变异通过激活增强子并在前列腺癌不同阶段形成多连接增强子-启动子枢纽来调控癌基因 Prostate cancer risk variants regulate oncogenes by activating enhancers and forming multi-connected enhancer-promoter hubs at different stages of prostate cancer Zexun Wu, Andrew Vu, Matthew Salcedo, Suhn K. Rhie
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- 3607 3607 基于组织的全蛋白质组关联研究鉴定结直肠癌的新型风险蛋白和候选药物靶点 Tissue-based proteome-wide association study identifies novel risk proteins and candidate drug targets for colorectal cancer Qing Li, Timothy Su, Chao Li, Quanhu Sheng, Shuai Xu, Wanqing Wen, Qi Dai, Martha J. Shrubsole, Jirong Long, Qiuyin Cai, Bing Zhang, Xioa-Ou Shu, Bhuminder Singh, Ken S. Lau, You Chen, Yuankai Huo, Zhijun Yin, Stephen B. Gruber, Riki (Ulrike) Peters, Victor R. Moreno, Wei Zheng, Xingyi Guo
- 3608 3608 多血统甲基化组关联分析鉴定乳腺癌的假定风险甲基化标志物 Multi-ancestry methylation-wide association analyses identifies putative risk methylation markers for breast cancer Shuai Xu, Jiajun Shi, Y-Thanh Lu, Guochong Damon Jia, Fei Ye, Qiuyin Cai, Jirong Long
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