PO.BCS01.04 · 生物信息与计算
Application of Bioinformatics to Cancer Biology 4
- 4121 4121 利用SCRIBE（生存切点报告与整合性生物标志物评估）在分子癌症生物标志物的发现与评估中纳入切点稳健性 Incorporation of cut-point robustness in the discovery and evaluation of molecular cancer biomarkers using SCRIBE (Survival Cut-point Reporting and Integrative Biomarker Evaluation) Miguel Lopez de Rodas Gregorio, Barani Kumar Rajendran, Javier Ramos Paradas, Carlos E. de Andrea, David L. Rimm, Hongyu Zhao, Kurt Alex Schalper
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- 4123 4123 通过转录谱解析mNSCLC的基线肿瘤微环境，识别可预测免疫治疗应答的肿瘤微环境条件 Dissecting the baseline tumor microenvironment in mNSCLC by transcriptional profiling identifies tumor microenvironmental conditions predictive for immunotherapy response Lilian van Vlerken-Ysla, Arash Nabbi, Zhou Zhu, Ross Stewart
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- 4125 4125 杯状细胞阑尾腺癌在分子层面上区别于其他组织学亚型：来自大规模基因组、转录组和类器官建模的见解 Goblet cell appendiceal adenocarcinoma is molecularly distinct from other histologic subtypes: Insights from large-scale genomic, transcriptomic, and organoid modeling Saikat Chowdhury, Ichiaki Ito, Samuel Rivero-Hinojosa, Chia-Mei Young, Eleanor A. Fallon, Beth A. Helmink, Taylor Neilson, Vasily Aushev, Sacha El Khoury, Abdelrahman MG Yousef, Mahmoud Mohamad Gamal Yousef, Shruti Sharma, Robert Lentz, Adham Jurdi, Paul F. Mansfield, Keith Fournier, Yuan-Hung Lo, Michael G. White, John Paul Shen
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- 4130 4130 胃肠上皮化生的单细胞多组学表征揭示 GC 进展高风险病变的潜在遗传、表观遗传和异构体特征 Single-cell multi-omic characterization of gastric intestinal metaplasia reveals potential genetic, epigenetic and isoform signatures of lesions at high risk for GC progression Dongin Lee, Xiangqi Bai, Sue Grimes, Kyungtae Lee, Yan Wang, Charlotte Wong, Anuja Sathe, Ignacio Wichmann, Youlim Kim, Rithika Meka, Renee Long, Allison Im, Billy Lau, Robert Huang, Hanlee P. Ji
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- 4132 4132 前列腺癌等位基因特异性表达图谱揭示AR信号通路和耐药通路中反复出现的、分期特异性事件 Landscape of allele-specific expression in prostate cancer reveals recurrent, stage-specific events in AR signaling and resistance pathways Margaret Tsui, Kevin Hu, Hanbing Song, Sarah Hsu, Rebecca Chen, Lorraine Nuniz, Julia Pham, Chih-Hao Chang, Keliana Hui, David Quigley, Jingjing Li, Franklin Huang
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- 4134 4134 用于改进重叠和重复性体细胞结构变异检测及时序推断的长读长测序与系统发育框架 A long-read sequencing and phylogenetic framework for improved detection and timing of overlapping and repetitive somatic structural variations Anton Goretsky, Yuelin Liu, Ayse Keskus, Tanveer Ahmad, Chi-Ping Day, Erin K. Molloy, Mikhail Kolmogorov
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- 4137 4137 酸性肿瘤微环境通过LPL乳酸化介导的巨噬细胞胆固醇代谢重编程促进结直肠癌肝转移 The acidic tumor microenvironment facilitates colorectal cancer liver metastasis through LPL lactylation-mediated reprogramming of macrophage cholesterol metabolism Yifan Zheng, Zhengyu Wei, Zhengran Zhou, Peishan Hu
- 4138 4138 整合计算与实验分析鉴定1,4-苯二胺经PI3K/AKT-MAPK和JAK/STAT信号通路对肝细胞癌的致癌作用 Integrative computational and experimental analysis identifies carcinogenic effects of 1,4-Phenylenediamine in hepatocellular carcinoma via PI3K/AKT-MAPK and JAK/STAT signaling pathway Liuxian Ban, Ran Ding, ZhiQing Long
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- 4141 4141 减瘤性肾切除术联合免疫检查点抑制剂诱导转移性肾细胞癌全身免疫重塑的多模态单细胞分析 Multimodal single-cell analysis of systemic immune remodeling induced by cytoreductive nephrectomy combined with immune checkpoint inhibitors in metastatic renal cell carcinoma Suebin Park, Byungjin Hwang
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