Integrative Computational Approaches 2

• 4174 · PDF hla2vec：利用概率性交叉反应组构建HLA嵌入空间 hla2vec: Developing a HLA embedding space using probabilistic cross-reactive groups Isabel Quesada, Jordan Tagle, Kyle Ellrott
• 4175 4175 神经抗原引导的TCR发现流程以提高特异性并降低AML中的脱靶毒性 Neoantigen-guided TCR discovery pipeline to improve specificity and reduce off-target toxicity in AML Pamella Borges, Martiela Freitas, Samee Ullah, Hussein A. Abbas, Dinler Antunes
• 4176 · PDF DAG引导的核学习框架以缓解乳腺癌中的种族差异 DAG-guided kernel learning framework to mitigate racial disparities in breast cancer Min-jeong Baek, Jieqiong Wang, Vimla Band, Shibiao Wan
• 4177 · PDF 整合式元聚类揭示儿童低级别胶质瘤的亚型特异性转录组异质性 Integrated meta-clustering reveals subtype-specific transcriptomic heterogeneity of pediatric low-grade glioma Bulidierxin Tuerhanbayi, Jieqiong Wang, Shibiao Wan
• 4178 · PDF 绘制2,551例NSCLC患者经插补增强的体细胞突变全景，凸显组织学亚型、吸烟状态与遗传血统之间的对比模式 Mapping the imputation-augmented somatic mutation landscape of 2,551 NSCLC patients highlights contrasting patterns across histologic subtype, smoking status, and ancestry Isam Mohd-Ibrahim, Zhuokun Feng, Yu Chen, Lauren Higa, Youping Deng
• 4179 · PDF 胃肿瘤切片的三维空间多组学揭示超越二维分析的隐藏特征 Three-dimensional spatial multi-omics of gastric tumor sections reveal hidden features beyond 2D analyses Inyeop Jang, Soyoung Im, Minji Kim, Seok-Jin Chung, Minsoo Lee, Soonyoung Lee, Jongseong Jang, Tae Hyun Hwang
• 4180 · PDF 特定于方案且基于覆盖度的RNA-seq指标刻画跨队列的RNA完整性特征 Protocol-specific and coverage-based RNA-seq metrics characterize RNA integrity signatures across cohorts Miyeon Yeon, Wonyoung Choi, Jin Young Lee, David Neil Hayes, Hyo Young Choi
• 4181 · PDF 通过Virtual Lab中机制驱动的模拟为靶点降低风险 De-risk targets through mechanism-enabled simulations in the Virtual Lab Krishna Bulusu, Katalin Szégner, László Mérő, Eszter Szarka, Iván Fekete, María Victoria Ruiz Perez, Csilla Hegedűs, Imre Gáspár, Gábor Kovács, Kristóf Szalay, Daniel Veres
• 4182 4182 转移性肿瘤中转录异质性的泛癌全景 Pan-cancer landscapes of transcriptional heterogeneity in metastatic tumors Ramyar Molania, Himisha Beltran
• 4183 · PDF 寻找恰到好处：AI驱动的共价药物发现如何去除"不可成药"中的"不" Finding Goldilocks: How AI-powered covalent drug discovery removes the “un” from “undruggable” Johannes C. Hermann, Robert Everley, Han Wool Yoon, Rohan Varma, Karsten Krug, Daniel Erlanson, Chris Varma, Kevin R. Webster
• 4184 · PDF 用于预测前列腺癌具有临床意义表型的多模态深度学习框架 Multimodal deep learning framework for predicting clinically significant phenotypes in prostate cancer Priyanka Vasanthakumari, Mohamed Omar
• 4185 · PDF 用于跨适应症多组学评估表面蛋白靶点的模块化计算机分诊流程 A modular in silico triage pipeline for multi omic evaluation of surface protein targets across indications Satyajit Rajapurkar, Lena Eismann, Mariana Pereira, Theodore Groth, Mugdha Khaladkar, Kathrin Jansen, Edward Curry, Marica Speranza
• 4186 · PDF 一种整合AI/ML与COSMIC特征谱分析的新方法：将急变期CML的异质性解析为单患者水平的泛癌可干预程序，为复发难治及转移性癌症提供可重定位疗法 A novel integrated AI ML and COSMIC signature profiling approach resolving blast crisis CML heterogeneity into single patient level pan cancer actionable programs enabling repurposable therapies for relapsed refractory and metastasized cancers Zafar Iqbal, Abdulkareem AlGarni, Lubna Alnuaim, Sahrish Khan, Sohail Rao, Yaqob Taleb, Nasser Mohammed AlQahtani, Muhammad Alshuaibi, Essa Al Mansour, Mashael AlShuker, Azfar Athar Ishaqui, Giuseppe Saglio, Kaleem Ahmed, Rizwan Naeem, Masood A. Shammas, Muhammad Farooq Sabar
• 4187 4187 scOncoNet：用于单细胞癌症数据中程序感知型计算基因扰动的双图注意力网络 scOncoNet: Dual-graph attention network for program-aware in-silico gene perturbation in single-cell cancer data Tingyi Li, Yuanyuan Shen, Bin Baek, Xiaoqing Yu, Xuefeng Wang
• 4188 · PDF 癌症免疫循环中的断点与可预测应答的HNSCC免疫微环境表型相关 Breaks in the cancer immunity cycle correlate with response-predictive HNSCC immune microenvironment phenotypes Sarah R. Harrington, Daniel Uralov, Sophia Linguiti, Hannah Kenny, Parvesh Kumar, Janvi J. Shukla, Marianna Nicodemi, Ian Argento, Emma J. Anisman, Eloise Freitag, Adam J. Luginbuhl, Larry Harshyne, Zhao Lin, Alban J. Linnenbach, Ubaldo E. Martinez-Outschoorn, Joseph M. Curry
• 4189 · PDF 利用贝叶斯神经网络量化虚拟空间转录组学中的不确定性 Quantifying uncertainty in virtual spatial transcriptomics using Bayesian neural networks Thanosan Prathifkumar, Nehan Mohamed, Anvith Kakkera, Zarif Azher, Xiaoying Liu, Fred Kolling, Laurent Perreard, Scott Palisoul, Louis J. Vaickus, Joshua Jay Levy
• 4190 · PDF 一个可扩展的、覆盖全蛋白质组的蛋白质分析平台，可对1000种蛋白进行绝对定量，助力肿瘤学药物发现流程 A scalable, proteome-wide protein profiling platform with absolute quantification of 1000 proteins to power oncologic drug discovery pipelines Jerid Robinson, Nathaniel Robichaud, Grant Ongo, Kiran Edwardson, Alyssa Rosenbloom, Narges Rashidi, Arya Tavakoli, Jeff Munzar, Milad Dagher
• 4191 · PDF TP53功能失调通过mTORC1激活与自噬抑制驱动结直肠癌的免疫代谢重塑 TP53 dysfunction drives immunometabolic rewiring via mTORC1 activation and autophagy suppression in colorectal cancer Eunseuk Lee, Dana Al-Assi, Randy Rueda-Rivera
• 4192 · PDF miRNA对前列腺癌中AR-PI3K/MAPK串扰及EMT的协调调控 Coordinated miRNA regulation of AR-PI3K/MAPK crosstalk and EMT in prostate cancer Fabiana Buono, William Lautert-Dutra, Dan Dion, Camila Morais Melo, Cheryl Crozier, Fabiano Pinto Saggioro, Rodolfo Borges dos Reis, Jeremy Andrew Squire, Jane Bayani
• 4193 · PDF 肺癌与结核病转录组数据集的异质图神经网络荟萃分析揭示趋同的宿主反应网络 Heterogeneous graph neural network meta-analysis of lung cancer and tuberculosis transcriptomic datasets reveals convergent host response networks Andrew Triska, Selvakumar Subbian, Natarajan Ganesan
• 4195 · PDF OncoGraphDB：对患者层面多模态图数据库进行快速投影，促进肿瘤亚型的高效探索，并识别患者预后与基因必需性的新型组合生物标志物 OncoGraphDB: Rapid projections of patient-level multimodal graph database facilitates efficient exploration of tumor subtypes and identifies new combinatorial biomarkers of patient outcomes and gene essentiality Jacob Pfeil, Amber Tse, Severiano Villarruel, Emily Rossi, Liqian Ma, Xi Zhao, Josue Samayoa, Kyle Halliwill
• 4196 · PDF 通过对比学习和T细胞表型分析预测源自肿瘤浸润CD8+ T细胞的TCR对自身抗原的识别 Predicting self-antigen recognition of TCRs derived from tumor infiltrating CD8+ T cells via contrastive learning and T cell phenotyping Brinda Vijaykumar, Qiaomu Tian, Jack Prazich, Preet Joshi, Neel Patel, John Abel, Anthony Coyle, Daniel Pregibon
• 4197 · PDF KRAS信号转导的多组学解析揭示了结直肠癌中可靶向的代谢和DNA修复脆弱性 Multiomic dissection of KRAS signaling reveals targetable metabolic and DNA repair vulnerabilities in colorectal cancer Tom Cohen, Ashima Mehta, Adam Richardson, Monil Gandhi, Douglas Guzior, Kevin Cho, Ethan Stancliffe, Gary Patti
• 4198 · PDF 整合单细胞转录组学与计算对接鉴定CCL18为前列腺癌的免疫调节靶点 Integrative single-cell transcriptomics and computational docking identify CCL18 as an immunomodulatory target in prostate cancer Edwige Flore Gouegni, Gebre-Eziagbher Kiros, Renee Reams, Diana J. Wilke, Fredenburg Kristianna, Bodour Salhia
• 4200 · PDF 通过计算机建模和体内研究探讨无限制使用抗生素、肠道微生物组失衡与化学致癌物对肝脏和肾脏的毒性 Exploring unrestricted antibiotic use gut microbiome imbalance and chemical carcinogens in liver and kidneys toxicity through computer modeling and in vivo study Solomon Owumi, Dooshima A. Bagu, Joseph Chimezie, Esther M. Pius, Uche O. Arunsi, Jesutosin O. Babalola, Ayomide P. Akomolafe, Chima Amadi, Chinedum Udekwu, Adegboyega K. Oyelere, E. Oluwabunmi Olapade-Olaopa, Olorunseun O. Ogunwobi
• 4201 · PDF 模拟通过巨胞饮作用的跨内皮纳米颗粒转运 Simulating trans-endothelial nanoparticle transport via macropinocytosis Marvin Skiba, Hae-gyung T. Han, Warren Chan

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