PO.CH01.02 · 化学
Screening and Technology Advances for Probe and Drug Discovery
- 6401 6401 一个集成AI的转化筛选平台，用于临床预测性地发现安全有效的巨胞饮依赖性癌症疗法 A translational screening platform with AI integration for clinically predictive discovery of safe and effective macropinocytosis-dependent cancer therapeutics Qiuming Chu, Antonio Bonanno, Yanping Kong
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- 6404 6404 一个用于高通量筛选和药物发现的稳健的类器官平台 A robust organoid-based platform for high-throughput screening and drug discovery Rene Overmeer, Mariana Martins Costa Silva, Gerben ten Hag, Mayke Doorn, Yasmine Abouleila, Ricardo Korporaal, Francisco Morales Rodriguez, Merel Derksen, Carla Verissimo, Robert G. J. Vries, Sylvia F. Boj
- 6405 6405 对HiBiT标记的PAX3::FOXO1横纹肌肉瘤细胞系进行小分子筛选，鉴定出eltanexor作为一种抗融合阳性横纹肌肉瘤的强效治疗药物 Small-molecule screening of HiBiT-tagged PAX3::FOXO1 rhabdomyosarcoma cell lines identifies eltanexor as a potent therapeutic agent against fusion-positive rhabdomyosarcoma Soumili Dey, Yong Y. Kim, Katrina Jia, Mehal Churiwal, Michele Ceribelli, Teresa S. Hawley, Raj Chari, David Milewski, Young K. Song, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Jun S. Wei, Craig Thomas, Robert G. Hawley, Javed Khan
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- 6407 6407 用于追踪核仁形态的深度学习驱动图像分析 Deep learning-driven image analysis for tracking nucleolar morphology Leif E. Lindberg, Katelyn R. Alley, Sylvia M. Kennerly, Ian Reynolds, Ryan W. Holly, Jongtae Yang, Chris L. Vonnegutt, John C. Rogers, Victoria J. DeRose
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- 6410 6410 mtKO:用于线粒体氧化还原生物学研究的专用向导RNA文库 mtKO: A dedicated guide RNA library for mitochondria redox biology research Karambir Kaur, Fengchao Lang, Chunzhang Yang
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- 6413 6413 细胞DNA编码文库(DEL)筛选与MICRO-TAG实时细胞靶点结合相结合,实现新型疗法的发现 Cellular DNA-Encoded Library (DEL) Screening Coupled with MICRO-TAG Real-Time Cellular Target Engagement Enables Discovery of Novel Therapeutics Ivan Babic, Elmar Nurmemmedov
- 6414 6414 利用深度VHH抗体库(IBMET)进行TNBC和胰腺癌的超敏结构生物标志物发现：一个用于组织无关靶点鉴定的转化平台 Ultra-sensitive structural biomarker discovery for TNBC and pancreatic cancer using a deep VHH repertoire (IBMET): A translational platform for tissue-agnostic target identification Akihiro Imura, Ryota Maeda, Hiroyuki Yamazaki, Tsuyoshi Inoue, Sadako Aakashi-Tanaka, Hiroko Tsukada
- 6415 6415 Champions：用于分析患者来源类器官中化学和遗传扰动的可扩展chem-seq和functional-seq平台 Champions: Scalable chem-seq and functional-seq platforms for profiling chemical and genetic perturbations in patient-derived organoids Devin Porter, BanuPriya Sridharan, Gervaise Henry, Kakajan Komurov, Yamini Nallana, Brandon Walling
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