PO.ET02.09 · 实验与分子治疗
RNA, Gene and Cell Therapies, and Enabling Assay Technologies
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- 462 462 治疗和恶性进展重塑剪接图谱，在IDH突变型胶质瘤中产生共享的、肿瘤全域的新抗原 Therapy and malignant progression reshape the splicing landscape to generate shared, tumor-wide neoantigens in IDH-mutant gliomas Tim Wu, Darwin Kwok, Joseph Costello, Hideho Okada
- 463 463 炎性乳腺癌患者来源的外植体：自体乳房切除术后创面液增强与复发和转移相关的黏附组和基质组基因的表达 Inflammatory breast cancer patients derived explants: Autologous post-mastectomy wound fluid enhances the expression of adhesome and matrisome genes associated with recurrence and metastasis Mona Mostafa Mohamed, Hossam Taha Mohamed, Alshimaa Tarek, Shrouk Khalaf El-Sayed, Wendy A. Woodward, Jon Mark Hirshon
- 464 464 使用一种研究性Integrin beta-6 IHC检测评估非鳞状非小细胞肺癌标本中Integrin beta-6表达的肿瘤异质性 Assessment of tumor heterogeneity for Integrin beta-6 expression in non-squamous non-small cell lung cancer specimens using an investigational Integrin beta-6 IHC assay Stefanie Nicole Kapucija, Jim Christian, Dana Sprague, Nicole Medina, Laina Quinones, Maggie Hime, Kiera Borgert, Kevin Brown, Jason Berndt, Pauline Cronin, Emin Oroudjev, Juan Gutierrez, Juan Gutierrez
- 465 465 靶向抑制UBTF通过抑制核糖体生物合成来抑制胰腺癌的生长和转移表型 Targeted repression of UBTF inhibits growth and metastatic phenotypes of pancreatic cancer via inhibition of ribosome biogenesis Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Rajasekhar Baru, Ayati Marzieh, Jose L. Gonzalez Hernandez, Genaro R. Corea, Dae Joon Kim, Mohammad Moshahid Khan, Subhash C. Chauhan, Bilal Bin Hafeez
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- 467 467 利用 AVITI24™ 多组学空间生物学平台剖析过氧化物还原酶 3（PRX3）药理学抑制和基因敲除的效应 Profiling the effects of Peroxiredoxin 3 (PRX3) pharmacological inhibition and genetic deletion with the AVITI24™ multi-omic spatial biology platform Victoria Gibson, Seana Lymer, Trevor Wolf, Brian Cunniff
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- 469 469 Quaratusugene ozeplasmid 介导的 TUSC2 上调在携带 EML4-ALK 的非小细胞肺癌中诱导凋亡，并在临床前研究中高度有效 Quaratusugene ozeplasmid mediated TUSC2 upregulation in EML4-ALK bearing non-small cell lung carcinoma induces apoptosis and is highly effective in preclinical studies Ananya Banerjee, Neeke Busette, Xu Cheng, Kerslee Kohagen, Liwei Bao, Lluis Lopez-Barcons, Mark S. Berger, Matthew B. Soellner, Angel Qin, Sofia Merajver, Nathan Merrill
- 470 470 JZP898，一种条件性激活的干扰素 α，在同基因小鼠模型中产生疗效并实现强劲的 TME 参与 JZP898, a conditionally activated interferon alpha, generates efficacy and robust TME engagement in syngeneic mouse models Ankur Karmokar, Emanuele Loro, Zhiling Zhang, Rao Mukavilli, Aparna Gupta, Kevin Trouba, Vian Amber, Robin C. Humphreys
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- 472 472 改造 TR-FRET 平台以解析 G 蛋白偶联受体的内化与再循环动力学 Adapting a TR-FRET platform to decipher G protein-coupled receptor internalization and recycling kinetics Jie Gao, An Ouyang, Spencer Chiang, Yu Sun
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- 476 476 一种用于适应性免疫受体分析和抗原特异性克隆型筛选并应用于癌症的实用工作流程 A practical workflow for adaptive immune receptor profiling and screening of antigen-specific clonotypes with applications in cancer Alex Chenchik, Tianbing Liu, Dongfang Hu, Kitt Paraiso, Lester Kobzik, Khadija Ghias, Paul Diehl
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- 479 479 SONNET 5010，一种新型专有肽药物偶联物锁定加载平台 SONNET 5010, a novel proprietary peptide drug conjugate lock and load platform John K. Cini, Susan Dexter, Stephen McAndrew, Arron Hearn, Evert Bokma, Gavin Birch, Grant Harradence, Christopher Sayer, Rosa Gonzalez-Serrano, Joao Nunes
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- 482 482 靶向POR006的高亲和力人源抗体开发：一种通过空间转录组学鉴定的鳞状细胞癌新靶点 Development of high-affinity human antibodies targeting POR006: A novel target in squamous cell carcinoma identified by spatial transcriptomics MinKyu Kim, Jinyeong Choi, Jae Eun Lee, Hongyoon Choi, Hyung-Jun Im
- 483 483 基于类器官的高通量药物筛选揭示AR-/lo CRPC对神经递质信号传导抑制剂的选择性易感性 Organoids-based high-throughput drug screening identifies selective vulnerability of AR -/lo CRPC to inhibitors of neurotransmission signaling Shan Wu, Ruize Zhao, Xiaozhuo Liu, Wen (Jess) Li, Moyi Wang, Amanda Tracz, Henry Withers, Brian Buckley, Katerina Gurova, Prashant Singh, Eduardo Cortes, Jianmin Wang, Jason S. Kirk, Dean G. Tang
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