PO.ET02.09 · 实验与分子治疗
RNA, Gene and Cell Therapies, and Enabling Assay Technologies
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- 462 462 Therapy and malignant progression reshape the splicing landscape to generate shared, tumor-wide neoantigens in IDH-mutant gliomas Tim Wu, Darwin Kwok, Joseph Costello, Hideho Okada
- 463 463 Inflammatory breast cancer patients derived explants: Autologous post-mastectomy wound fluid enhances the expression of adhesome and matrisome genes associated with recurrence and metastasis Mona Mostafa Mohamed, Hossam Taha Mohamed, Alshimaa Tarek, Shrouk Khalaf El-Sayed, Wendy A. Woodward, Jon Mark Hirshon
- 464 464 Assessment of tumor heterogeneity for Integrin beta-6 expression in non-squamous non-small cell lung cancer specimens using an investigational Integrin beta-6 IHC assay Stefanie Nicole Kapucija, Jim Christian, Dana Sprague, Nicole Medina, Laina Quinones, Maggie Hime, Kiera Borgert, Kevin Brown, Jason Berndt, Pauline Cronin, Emin Oroudjev, Juan Gutierrez, Juan Gutierrez
- 465 465 Targeted repression of UBTF inhibits growth and metastatic phenotypes of pancreatic cancer via inhibition of ribosome biogenesis Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Rajasekhar Baru, Ayati Marzieh, Jose L. Gonzalez Hernandez, Genaro R. Corea, Dae Joon Kim, Mohammad Moshahid Khan, Subhash C. Chauhan, Bilal Bin Hafeez
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- 467 467 Profiling the effects of Peroxiredoxin 3 (PRX3) pharmacological inhibition and genetic deletion with the AVITI24™ multi-omic spatial biology platform Victoria Gibson, Seana Lymer, Trevor Wolf, Brian Cunniff
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- 469 469 Quaratusugene ozeplasmid mediated TUSC2 upregulation in EML4-ALK bearing non-small cell lung carcinoma induces apoptosis and is highly effective in preclinical studies Ananya Banerjee, Neeke Busette, Xu Cheng, Kerslee Kohagen, Liwei Bao, Lluis Lopez-Barcons, Mark S. Berger, Matthew B. Soellner, Angel Qin, Sofia Merajver, Nathan Merrill
- 470 470 JZP898, a conditionally activated interferon alpha, generates efficacy and robust TME engagement in syngeneic mouse models Ankur Karmokar, Emanuele Loro, Zhiling Zhang, Rao Mukavilli, Aparna Gupta, Kevin Trouba, Vian Amber, Robin C. Humphreys
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- 472 472 Adapting a TR-FRET platform to decipher G protein-coupled receptor internalization and recycling kinetics Jie Gao, An Ouyang, Spencer Chiang, Yu Sun
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- 476 476 A practical workflow for adaptive immune receptor profiling and screening of antigen-specific clonotypes with applications in cancer Alex Chenchik, Tianbing Liu, Dongfang Hu, Kitt Paraiso, Lester Kobzik, Khadija Ghias, Paul Diehl
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- 479 479 SONNET 5010, a novel proprietary peptide drug conjugate lock and load platform John K. Cini, Susan Dexter, Stephen McAndrew, Arron Hearn, Evert Bokma, Gavin Birch, Grant Harradence, Christopher Sayer, Rosa Gonzalez-Serrano, Joao Nunes
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- 482 482 Development of high-affinity human antibodies targeting POR006: A novel target in squamous cell carcinoma identified by spatial transcriptomics MinKyu Kim, Jinyeong Choi, Jae Eun Lee, Hongyoon Choi, Hyung-Jun Im
- 483 483 Organoids-based high-throughput drug screening identifies selective vulnerability of AR -/lo CRPC to inhibitors of neurotransmission signaling Shan Wu, Ruize Zhao, Xiaozhuo Liu, Wen (Jess) Li, Moyi Wang, Amanda Tracz, Henry Withers, Brian Buckley, Katerina Gurova, Prashant Singh, Eduardo Cortes, Jianmin Wang, Jason S. Kirk, Dean G. Tang
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