PO.TB10.07 · 肿瘤生物学
Spatial Niches and Functional Boundaries within the Tumor Microenvironment 2
- 6187 6187 利用高分辨率空间转录组学提升bulk测序价值：CRC与NSCLC中临床相关空间生态位的配对数据分析 Elevating bulk sequencing with high-resolution spatial transcriptomics: A paired-data analysis of clinically-relevant spatial niches in CRC and NSCLC Yajas Shah, Tianyou Luo, Christine M. Hoeman, Luca Lonini, Stanislaw Szydlo, Eduardo Diaz, Rossin Erbe, Matthew B. Maxwell, Michelle M. Stein, Andrew J. Sedgewick, Nicholas Rachell, Zachary Chelsky, Sonal Khare, Ryan D. Jones, Kate Sasser, Richard A. Klinghoffer, Justin Guinney, Chi-Sing Ho
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- 6189 6189 ERBB2表达与免疫格局塑造肿瘤微环境并影响食管腺癌脑转移的预后 ERBB2 expression and the immune landscape shape the tumor microenvironment and influence prognosis in esophageal adenocarcinoma brain metastases Nora M. Lawson, Inés Martín-Barrio, Lingqun Ye, Bo Zhao, Thomas Mitchell, Mesut Unal, Chae Yun Cho, Andrew Futreal, Kadir C. Akdemir
- 6190 6190 空间架构分析揭示淋巴毒素信号梯度紊乱与高级别浆液性卵巢癌复发相关 Spatial architecture analysis reveals disrupted lymphotoxin signaling gradients associate with recurrence in high-grade serous ovarian cancer Zhewei Zhang, Tat San Lau, Chi Chiu Wang
- 6191 6191 利用流式细胞术和基于微球的多重免疫分析板解码共培养模型中癌细胞与单核细胞来源巨噬细胞之间的相互作用 Decoding the interactions between cancer cells and monocyte-derived macrophages in a co-culture model using flow cytometry and bead-based multiplexing immunoassay panels Amy Zhao, Anugraha Gandhirajan, Michael Hunegnaw, Anil Kumar Jaiswal, Jessie Ni
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- 6195 6195 空间转录组学分析揭示Ewing肉瘤中的肿瘤细胞可塑性和多样化的肿瘤微环境 Spatial transcriptomics analysis reveals tumor cell plasticity and diverse tumor microenvironments in Ewing sarcoma Heng Luo, Clémence Henon, Gleb Rukhovich, Stefanie Kutschmann, Nina Wilhelm, Wolfgang Hartmann, Uta Dirksen, Duncan T. Odom, Thomas G. Grünewald, Moritz Gerstung
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- 6197 6197 空间转录组学揭示胸腺上皮肿瘤新辅助治疗后与临床反应相关的独特肿瘤微环境 Spatial transcriptomics reveal distinct tumor microenvironment associated with clinical response in thymic epithelial tumors after neoadjuvant therapy Hyunsu Kim, Jinyong Kim, Hyun-Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Seong Yong Park, Woong-Yang Park, Yoon-La Choi, Sehhoon Park
- 6198 6198 转化型滤泡性淋巴瘤肿瘤微环境的单细胞空间多组学表征 Single cell spatial multi-omic characterization of the tumor microenvironment in transformed follicular lymphoma Shaocheng Wu, Eric Lee, Anne-Sophie Fratzscher, Andrew Lytle, Spencer D. Martin, David G. Huntsman, David W. Scott, Christian Steidl, Andrew Roth
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- 6201 6201 PaintScape™在完整新鲜冷冻胶质母细胞瘤组织的天然肿瘤微环境中实现单细胞空间3D基因组结构的多组学原位直接可视化 PaintScape TM enables multiomic in-situ direct visualization of spatial 3D genome architecture of single cells in intact fresh frozen Glioblastoma tissue in native tumor microenvironments Matija Snuderl, Yuxiu Wang, Neha Dhasmana, Pamela Flatley, Stacy Elliott, Douglas Werner, Jude Dunne, Huy Nguyen, Shyamtanu Chattoraj
- 6202 6202 胰腺实性假乳头状肿瘤的整合多组学图谱提示腺泡细胞为潜在起源细胞 Integrated multiomic atlas of pancreatic solid pseudopapillary neoplasms suggests acinar cells as a potential cell-of-origin Biren Reddy, Maria Korah, James P. Agolia, Rosyli Reveron-Thornton, Maggie Lam, Deshka Foster, Michael T. Longaker, Daniel Delitto
- 6203 6203 空间转录组图谱揭示内皮细胞无能和CD4⁺ T细胞应激是结直肠癌肝转移免疫逃逸的关键驱动因素 Spatial transcriptome mapping identifies endothelial anergy and CD4⁺ T cell stress as key drivers of immune escape in colorectal cancer liver metastasis Peter Kok-Ting Wan, Ranchu Cheng, Len Seymour, Kerry Fisher, Alex Gordon-Weeks
- 6204 6204 TSC相关血管平滑肌脂肪瘤的空间转录组解析揭示由mTORC1失调驱动的微环境程序 Spatial transcriptomic dissection of TSC-associated angiomyolipoma reveals microenvironmental programs driven by mTORC1 dysregulation Ryuta Watanabe, Kensuke Shishido, Shota Nobumori, Naoya Sugihara, Keigo Nishida, Haruna Arai, Takatora Sawada, Shunsuke Haga, Osuke Arai, Tomoya Onishi, Kenichi Nishimura, Tstsuya Fukumoto, Noriyoshi Miura, Mie Kurara, Riko Kitazawa, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika
- 6205 6205 通过多重复验证和跨切片分析建立Xenium空间转录组学的可重复性标准 Establishing reproducibility standards for Xenium spatial transcriptomics through multi-replicate validation and cross-sectional analysis Tommy Tran, JingHao Tian, Elim Cheung, Rikita Gakhar, Vidyodhaya Sundaram
- 6206 6206 CosMx 6K发现面板揭示WHO 4级IDH野生型胶质母细胞瘤中空间分辨的细胞-细胞结构 Spatially resolved cell-cell architecture in WHO grade 4 IDH- wildtype glioblastoma revealed by CosMx 6K discovery panel Dexter Wing Lun Lee, Kaiyan Xu, Parker Li, Joshua Jing Xi Li, Wei Dai, Karrie Kiang, Gilberto Ka-Kit Leung, Aya El Helali
- 6207 6207 Claudin 18.2表达的晚期胃癌中肿瘤浸润B细胞的空间组织预测免疫检查点抑制的反应 Spatial organisation of tumor-infiltrating B cells in Claudin 18.2-expressing advanced gastric cancer predicts response to immune checkpoint inhibition Joseph J. Zhao, Choong-Kun Lee, Allison Si-Yu Chan, Wenyi Luo, Li Chang, Woo Sun Kwon, Sejung Park, Minkyu Jung, Joe P. Yeong, Anand Devaprasath Jeyasekharan, María Rodríguez Martínez, Sun Young Rha, Raghav Sundar
- 6208 6208 使用全转录组空间分子成像面板对转移性结直肠癌小鼠模型进行亚细胞成像 Subcellular imaging of murine models of metastatic colorectal cancer using a whole transcriptome spatial molecular imaging panel Liang Zhang, Isabel Lee, Shanshan He, Martin Shelton, Owen J. Sansom, Joseph M. Beechem
- 6209 6209 超越上皮-间充质转化的妇科癌肉瘤:肿瘤微环境中免疫梯度的形态-转录组学证据 Gynecologic carcinosarcomas beyond epithelial-mesenchymal transition: Morpho-transcriptomic evidence of an immune gradient in the tumor microenvironment Amel Kime, Julie Berthet, Juliette Renard, Antoine Gaudet Chardonnet, Pierre Laurent-Puig, Jerome Alexandre, Bruno Borghese, Guillaume Beinse
- 6210 6210 肿瘤与免疫细胞结构的空间分区界定了前列腺癌中相反的预后作用 Spatial compartmentalization of tumor and immune cellular architecture defines opposing prognostic roles in prostate cancer Ahmed Elsehemy, Xinpei Ci, Magnus Lam, Matthew Ramotar, Alejandro Berlin, Theodorus van der Kwast, Housheng Hansen He
- 6211 6211 AI引导的空间多组学整合揭示前列腺癌人群差异背后的免疫与基质异质性。 AI-guided spatial multi-omics integration reveals immune and stromal heterogeneity underlying population disparities in prostate cancer. Samuel Mwakisha Mwamburi, Jevon Layne, Niki Talebian, Ezra G. Baraban, Ashley Kiemen, Clayton C. Yates
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- 6213 6213 单细胞成像揭示胰腺导管腺癌中具有基因组关联的协同肿瘤-免疫-基质谱 Single cell imaging uncovers a coordinated tumor-immune-stroma spectrum with genomic associations in pancreatic ductal adenocarcinoma Ferris Nowlan, Noor Shakfa, Sibyl Drissler, Tan Tiak Ju, Elizabeth Sunnucks, Edward LY Chen, Cassandra J. Wong, Brendon Seale, Zhen Yuan Lin, Michelle Chan-Seng-Yue, Amy Zhang, Sabiq Chaudhary, Chengxin Yu, Golnaz Abazari, Michael Geuenich, Matthew Watson, Jiaxi Peng, Somaieh Afiuni-Zadeh, Ayelet Borgida, Ricardo Gonzalez, Sheng-Ben Liang, Klaudia Nowak, Miralem Mrkonjic, Anna Dodd, Julie M. Wilson, Kieran Campbell, Jenn Gorman, Barbara Grünwald, Robert C. Grant, Jennifer J. Knox, Anne-Claude Gringas, Faiyaz Notta, Steven Gallinger, Grainne O'Kane, Hartland Jackson
- 6214 6214 绘制肿瘤全景：空间多组学揭示早期和晚期NSCLC中的免疫与基质异质性 Mapping the tumor landscape: spatial multiomics reveals immune and stromal heterogeneity across early and late-stage NSCLC Gaurav N. Joshi, Nicholas Sciascia, Michael Yang, Brenna Fearey, Junya Yoshioka, Fumiki Yanagawa
- 6215 6215 空间生物学工具识别肺腺癌中可预测生存的空间定位不同的成纤维细胞 Spatial biology tools identify distinct spatially localized fibroblasts in adenomacarcinoma lung cancer predictive of survival Calum MacAulay, Paul Gallagher, Martial Daniel Guillaud
- 6216 6216 新型全转录组空间转录组学技术揭示侵袭前沿处CAF/TAM介导的基底膜重塑 Novel whole transcriptome spatial transcriptomics technology reveals CAF/TAM-mediated basement membrane remodeling at the invasive front Amanda Janesick, McKenzi Toh, Syrus Mohabbat, Stephanie Kravitz, 10X Genomics Development Team
