PO.CL12.02 · 临床研究
Translational Biomarkers and Emerging Molecular Approaches
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- 7897 7897 新型Rho-GTP酶调控蛋白基因家族变异在急性髓系白血病（AML）患者（pts）中频发，并与不良生存相关 Novel Rho-GTPase regulatory protein gene family variants are frequent and associate with poor survival in patients (pts) with acute myeloid leukemia (AML) Ethan Hamp, Lorenz Oelschläger, Bailee N. Kain, Deedra Nicolet, Krzysztof Mrozek, Katherine E. Miller, Audrey Bollas, Michael C. Walker, Christopher J. Walker, Jill Buss, Andrea Laganson, Andrew J. Carroll, William G. Blum, Bayard L. Powell, Geoffrey L. Uy, Wendy Stock, Marina Y. Konopleva, Richard M. Stone, John C. Byrd, Martin Carroll, Tanmoy Sarkar, Akmaljon Salimov, Benjamin J. Kelly, Electra D. Paskett, Jesse J. Plascak, Shannon McWeeney, Jeffrey W. Tyner, Jeffery Klco, Nathan Salomonis, H. Leighton Grimes, Elaine R. Mardis, Ann-Kathrin Eisfeld
- 7898 7898 HIF-2alpha抑制剂casdatifan（Cas）在ARC-20临床研究中透明细胞肾细胞癌（ccRCC）患者各分子亚型中的临床获益 Clinical benefit of the HIF-2alpha inhibitor casdatifan (Cas) across molecular subtypes in clear cell renal cell carcinoma (ccRCC) patients from the ARC-20 Clinical Study Benjamin Weeder, Yinghui Guan, Jaskirat Singh, Brian Rini, Toni K. Choueiri, Angelo Kaplan, Omar Kabbarah, Soonweng Cho
- 7899 7899 BGB-21447，一种新一代Bcl-2抑制剂，在临床前研究中于Bcl-2过表达的B细胞非霍奇金淋巴瘤（NHL）中显示出高潜力 BGB-21447, a next generation Bcl-2 inhibitor, shows high potential in Bcl-2 overexpressing B cell non-Hodgkin lymphomas (NHL) cancers in preclinical studies Haitao Wang, Lin Li, Yiwen Wang, Weiwei Song, Shuang Peng, Sijia Zhai, Ziyu Jia, Peng Chi, Teiko Sumiyoshi, Ting Deng, Yang Liu, Wei Jin, Zhirong Shen
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- 7902 7902 OncoMate MSI Dx分析系统在伴随诊断分类为MSS（非MSI-H）的KEYNOTE-775子宫内膜癌亚组中的分析准确性和临床性能 Analytical accuracy and clinical performance of the OncoMate MSI Dx Analysis System in a subset of KEYNOTE-775 endometrial carcinoma classified as MSS (not MSI-H) by the companion diagnostic Sam Sibley, Matthew Marton, Amy Wehn, Yiwei Zhang, Kathryn Oostdik, Ryan Mordini, Gary Tarpley
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- 7905 7905 抑制二氢乳清酸脱氢酶（DHODH）并协同靶向ROR1：一种在小细胞肺癌中具有前景的治疗策略 Dihydroorotate dehydrogenase (DHODH) inhibition as a promising therapeutic strategy with synergistic targeting of ROR1 in small cell lung cancer Bahareh Nourmohammadi, Ola A. Elgamal, Sandip Vibhute, Christopher C. Coss, Thomas E. Goodwin, Erin Hertlein, Joseph M. Amann, Ju Hwan Cho, Chad E. Bennett, John C. Byrd, David P. Carbone
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- 7907 7907 雌激素受体阳性、HER2低表达乳腺癌的基因组、免疫和临床特征：NextGIM试验最新进展 Genomic, immune, and clinical characterization of estrogen receptor-positive, HER2-low breast cancer: The NextGIM trial latest updates Barbara Cardinali, Alice Stella, Chiara Molinelli, Marco Bruzzone, Yanina Lizet Castillo, Francesca Pitto, Barbara Massa, Simona Pigozzi, Andrea Sciutto, Giorgia Anselmi, Maria Dono, Virna Maltoni, Benedetta Conte, Giulia Buzzatti, Davide Soldato, Gaia Griguolo, Valentina Guarneri, Mario Giuliano, Caterina Marchiò, Fabio Puglisi, Lorenzo Gerratana, Francesca Poggio, Lucia Del Mastro
- 7908 7908 极早发结直肠癌中独特的分子和临床侵袭性：30-39岁与40-49岁患者之间的生存和基因组差异 Distinct molecular and clinical aggressiveness in very early-onset colorectal cancer: Survival and genomic divergence between patients aged 30-39 vs 40-49 years Andrea Pretta, Gaia Rebecchi, Giulia Maddalena, Federica Marmorino, Pina Ziranu, Federica Manoni, Maria Caterina De Grandis, Martina Carullo, Clelia Donisi, Giovanni Randon, Eleonora Perissinotto, Ada Taravella, Vincenzo Nasca, Federica Buggin, Paolo Ciracì, Francesca Bergamo, Chiara Cremolini, Sara Lonardi, Mario Scartozzi, Filippo Pietrantonio
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- 7910 7910 用于原位前列腺癌、膀胱癌、肝癌、胰腺癌和脑癌转化治疗研究的先进临床前癌症模型和成像方案 Advanced preclinical cancer models and imaging protocols for translational treatment studies in orthotopic prostate, bladder, liver, pancreatic and brain cancer Celine Christine Jensen, Emilie Garly, Rikke Stagaard, Michala Nordfalk, Sigrid Cold, Mette Munk Wessel, Tea Kirkegaard Nielsen, Margarete Karg, Natalia Łopuszyńska, Marina Simón Martin, Sara Vangsgaard, Sebastian Gnosa, Ingrid Hunter, Emma Papin, Camilla Malec, Anne Hessellund Langhave, Trine Nielsen, Andreas Kjaer, Esben Christensen, Trine Bjoernbo Engel, Lotte Kellemann, Carsten Haagen Nielsen
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- 7919 7919 高LGR5表达的肺鳞状细胞癌的临床、基因组和治疗结局：一项来自LC-SCRUM-Asia数据库的研究 Clinical, genomic, and therapeutic outcomes of lung squamous cell carcinoma with high LGR5 expression : A study from the LC-SCRUM-Asia database Yu Tanaka, Shuji Murakami, Kazumi Nishino, Motoko Tachihara, Ichiro Nakachi, Mayu Kawakami, Satoshi Hara, hitomi Aono, Shoichi Kuyama, Gaku Yamamoto, Eri Sugiyama, Tetsuya Sakai, Hiroki Izumi, Shigeki Umemura, HIBIKI UDAGAWA, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
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