LBPO.ET01 · 实验与分子治疗 · Late-Breaking
Late-Breaking Research: Experimental and Molecular Therapeutics 1
- LB048 LB048 ARC-401 - a triple payload first-in-class ADC against Nectin-4 designed to overcome cancer resistance and tumor heterogeneity shows broad anti-tumor activity and high tolerability in rats and non-human primates Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Rachael Fay, Lia Kallenberger, Ramona Stark, Patrick Maurhofer, Emma Renard, Roger Santimaria, Bernd Schlereth, Dragan Grabulovski, Philipp Rene Spycher
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- LB051 LB051 BCG048, a novel bispecific dual-payload ADC targeting ITGB6 and B7H3, exhibited potent efficacy in patient-derived tumor xenograft models Benny Yang, Mengran Li, Haipeng Liu, Chengzhang Shang
- LB052 LB052 Unlocking the Full Human Antibody Repertoire: Novel Humanized Antibody Mouse Models with Fully Humanized Lambda Chains and Diversified Genetic Backgrounds Benny Yang, Lili Liu, Lijun Zhang, Yanshuang Li, Huizhen Zhao, Jiawei Yao
- LB053 LB053 A novel CD16A-nanobody platform overcomes Fc polymorphism limitations for potent and broad-spectrum NK cell engager therapeutics Tiong Sun Chia, Jia Liu, Shuming Lin, Wei Dai, Min Wu, Zhihai Wu
- LB054 LB054 Preclinical characterization of HSC00189, a novel bispecific ADC targeting cadherin-6 (CDH6) and folate receptor alpha (FOLR1) for the treatment of ovarian cancer Hongbin Wang, Qingyuan Meng, He Li, Dong Yao, Tao Peng, Lei Chen, Yao Li, Zhijian Yao, Dengfeng Duan, Ruofeng Tang, Senlin Li, Hongjiao Dong, Pingming Tang, Min Xu, Yao Lu, Ju Wang, Pangke Yan
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- LB057 LB057 Repurposing statins for locally advanced esophageal adenocarcinoma: Integrating scRNAseq, organoid based high throughput drug screening, and patient level clinical data Sanjima Pal, Luís Nuno Cruz Santos Castro, Megan Sperry, Qian Qiu, Shuyuan Wang, Mingyan (Iris) Kong, Nicholas Bertos, Betty Giannias, Cedric Julien, Wotan Zeng, Swneke Bailey, Donald E. Ingber, Lorenzo Ferri
- LB058 LB058 Clinically actionable drug synergy drives transcriptomic and metabolic reprogramming to induce ferroptosis and apoptosis in triple negative breast cancer Gokul M. Das, Chetan C. Oturkar, Junhyoung Park, Iqbal Aijaz, Christina Adams, Utpakl K. Mukhopadhyay, Melissa Dolan, Michalis Mastri, Alexan der J. Caradori, Manasori Oshi, Yali Zhang, Jianmin Zhang, Brent Boleslav, Donald Mager, Tagari Samanta, Seung Y. Yabn, Richa Mishra, Richa Mishra, John Ebos, Kazuaki Takabe, Kris Attwood, Beeny A. Kaipparettu
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- LB062 LB062 DEM301, a novel bifunctional ADC with potent immunomodulatory activity for potential use in difficult to treat colorectal malignancies Agnieszka Denslow, Sarah E. Carden, Peter Sandy, Sandeep Kumar, Loise M. Francisco
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- LB067 LB067 A modular Multi-Antigen T Cell Hybridizers (MATCH) platform enables tunable and potent immunotherapy across hematologic and solid tumors Shannuo Li, Yingduo Yang, Joseph Shami, Douglas Sborov, Paul Shami, Jiyuan Yang, Jindřich Kopeček
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