PO.ET02.01 · 实验与分子治疗
Antibody-Drug Conjugates and Linker Engineering 1
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- 1676 1676 HA-00495：一种开发候选ADC，具有新型蛋白质翻译抑制剂载荷，具备广谱疗效和有利的非人灵长类安全性特征 HA-00495: A development candidate ADC featuring a novel protein translation inhibitor payload with broad efficacy and a favorable non human primate safety profile Tara L. Arvedson, Victor Cee, Corey Reeves, Madhura Deshpande, Natacha Le Moan, Kyle Dunbar, Amandeep Gakhal, Chris Kimberlin, Cynthia Bailey, Edres Babacarkhial, Nolan Carney, Xufeng Cao, Yi-Ming Chiang, Amber Cornelius, Natalie Duong, Colin Harvey, Yingxia Hu, Dimitri Kharakovsky, Jose Leighton, Dennis Liu, Luca Lizzardo, Octovia Monteiro, Samuel Oteng-Pabi, Bruno Perlatti, Rajani Marthappa Shenoy, Joseph Spraker, Mélanie Uguen, Jakub Vaith, Sandeep Venkataram, Kendra Wheeler, Shiyan Xu, Danielle Yee, Clarence Yeung, Eva Yuan
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- 1681 1681 RenLite®转基因小鼠为加速全球全人源双特异性抗体或ADC的开发提供高质量平台 RenLite ® transgenic mice provide a high-quality platform for accelerating the development of fully human bispecific antibodies or ADCs worldwide Jade Hsu, Wenjiao Zhang, Jun Du, Zhuolin Li, Yifu Zhang, Yanfei Han, Chengzhang Shang, Yi Yang
- 1682 1682 PNU-159,682的效力减弱类似物与GlycoConnect®和HydraSpace®技术偶联可提供耐受性和疗效改善的ADC Potency-Attenuated analogues of PNU-159,682 in conjugation with GlycoConnect ® and HydraSpace ® technologies provide ADCs with improved tolerability and efficacy Marcel Scheepstra, Remon van Geel, Jorin Hoogenboom, Lianne Lelieveldt, Sorraya Popal, Mick Verhagen, Oleksandr Zagorodko, Finn McSorley, Çağla Koç, Margarida Espadinha, Floris van Delft, Anette Sommer, Sander van Berkel
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- 1685 1685 结合拓扑异构酶I抑制剂和微管抑制剂的HER2靶向双载荷抗体偶联药物在异种移植模型中展现出优异疗效并克服对单载荷ADC的耐药 The HER2-targeting dual-payload antibody-drug conjugate combining a topoisomerase I inhibitor and a microtubule inhibitor demonstrates superior efficacy and overcomes resistance to single-payload ADCs in xenograft models Angela Matcham, Robert Yuan, Brian Vuillemenot, Rhoneil Pena, Young Park, Abigail Yu, Jeffrey Hanson, Cuong Tran, Xiaofan Li, Miao Wen, Daniel Calarese, Werner Rubas, Krishna Bajjuri, Guifen Xu, Alice Yam, Hanspeter Gerber
- 1686 1686 ZW418的研发：一种双互补位PTK7靶向抗体偶联药物，搭载新型pan-RAS抑制剂载荷，用于治疗非小细胞肺癌 Development of ZW418, a biparatopic PTK7-targeting antibody-drug conjugate incorporating a novel pan-RAS inhibitor payload for the treatment of non-small cell lung cancer Luying Yang, Alex Wu, Vincent Fung, Kaylee J. Wu, Sara Weeres, Katina Mak, Taixiang Wang, Victoria Harman-McKenna, Allysha Bissessur, Jesse Leblanc, Vidhi Khanna, Matthew Bonderud, Jodi Wong, Rehan Higgins, Linglan Fu, Dunja Urosev, Raffaele Colombo, Graham A. E. Garnett, Jamie R. Rich, Stuart D. Barnscher
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- 1689 1689 新一代ConjuAll BCMA抗体偶联药物(ADC)LCB14-2524和LCB14-2516在多发性骨髓瘤临床前模型中显示出更高的疗效 Next generation ConjuAll BCMA antibody-drug conjugates (ADCs) LCB14-2524 and LCB14-2516 show increased efficacy in preclinical models of multiple myeloma Matthew Sender, Joe Ponte, Stephen Slocum, Yun-Hee Park, Yunjoo Jung, Chul Woong Chung, Rodrigo Ruiz-Soto, Jeiwook Chae
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- 1693 1693 利用搭载多样化载荷的抗体偶联药物组合靶向MET-LGR5串扰以克服结直肠癌的适应性耐药 Targeting MET-LGR5 crosstalk using an antibody-drug conjugate combination with diverse payloads to overcome adaptive resistance in colorectal cancer Shraddha Subramanian, Peyton Christian High, Zhengdong Liang, Cara Guernsey-Biddle, Adela Aldana, Kendra S. Carmon
- 1694 1694 应用切向流过滤（TFF）实现抗体药物偶联物载荷-连接子生产中的溶剂置换与沉淀工艺 Application of tangential flow-filtration (TFF) to enable solvent exchange and precipitation process for the production of payload-linkers of antibody-drug conjugates Sudhir Patil, Feng Xu, Minglin Wang, Jianwei Bian, Xudong Wei
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- 1697 1697 NW024-1，一种携带拓扑异构酶 1 抑制剂载荷的新型 ALPP/ALPPL2 靶向抗体药物偶联物，展现出强效抗肿瘤疗效 NW024-1, a novel ALPP/ALPPL2-targeting antibody drug conjugate with a topoisomerase 1 inhibitor payload, demonstrates potent antitumor efficacy Juanjuan Li, Wenting Luo, Li Liu, Yiran Wu, Gang Liu, Changcheng Li, Yaolan Dai, Jiabao Liu, Zhijian Li, Lixia Wang, Dan Wang, Dan Mi, Jiaoyi Zhong, Bin Liu, Desi Pan, Zhigang Guo
- 1698 1698 一种新型协同双载荷 FRalpha ADC（CTPH-08），通过改善 MTD 和 MED 有望为低 IHC+ 卵巢癌患者带来获益 A novel synergistic dual-payload FRalpha ADC (CTPH-08) that can potentially offer benefits for low IHC+ ovarian cancer patients by improving MTD and MED Soyeon Lim, Myeong Joo Kim, Junho Ha, Heegoo Jun, Jongchan Lee, So Hee Im, Seo Ha Kim, Young Sang Kim, Seung Chan Kim, Hyo Jin Kang, Chang-Sun Lee
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