Antibody Technologies and Platforms 1

• 1642 · PDF 一种在RAS突变型癌症中具有高活性的泛RASi抗体-药物偶联物平台 A pan-RASi antibody-drug conjugate platform with high activity in RAS-mutant cancers Graham A. E. Garnett, Victoria K. Harman-McKenna, Taixiang Wang, Jodi Wong, Truman Hirkala-Schaefer, Michael G. Brant, Mark E. Petersen, Catalina Suarez, Khushi Lodaya, Rehan Higgins, Jesse H. Leblanc, Linglan Fu, Cathy Fu, Sara Weeres, Manuel Lasalle, Kaylee J. Wu, Vidhi Khanna, Sam Lawn, Kurt Stahl, Vincent Fung, Raffaele Colombo, Stuart D. Barnscher, Jamie R. Rich
• 1643 · PDF 以人源化单克隆抗体靶向LANCL1可抑制肝细胞癌的肿瘤发生 Targeting LANCL1 with a humanized monoclonal antibody suppresses tumorigenesis in hepatocellular carcinoma Chui-Yee Diana O, Yu-Man Tsui, Irene Oi-Lin Ng
• 1646 · PDF 利用完全Fc静默抗体平台实现治疗指数最大化 Maximizing therapeutic index using fully Fc-silent antibody platform Kihwan Chang
• 1647 1647 RenNano平台助力高效发现全人源VHH抗体 RenNano platform enables efficient discovery of fully human VHH antibodies Frank An, Xun Xu, Jun Du, Yiqing Hu, Baihong Liu, Guan Wang, Hao Cai, Lijun Zhang, Huizhen Zhao, Jiawei Yao, Chengzhang Shang, Qiuhong Yu, Xueyuan Jiang, Fengping Yao, Jing Huang, Gao An, Yi Yang
• 1648 · PDF 用于定量评估抗体-药物偶联物内化的实时成像 Real-time imaging for quantitative assessment of antibody-drug conjugate internalization Tian Wang, Yunfei Pu, Ryan Raver, Xiaoyu Zhang, Peifang Ye, Nancy Li
• 1649 · PDF 免疫缺陷背景的FcRn人源化小鼠可用于评估抗体药物的药代动力学同时避免抗药抗体 FcRn humanized mice with an immunodeficient background can be used to evaluate the pharmacokinetics of antibody drugs while avoiding anti-drug antibodies Hannah Horton, Ruili Lv, Suman Zhao, Qingqing Xu, Xiaofei Zhou
• 1650 · PDF MPSA-AB5000：一种基于细胞的高通量膜蛋白筛选阵列，用于精准的早期脱靶评估以加速更安全抗体治疗药物的开发 MPSA-AB5000: A high-throughput cell-based membrane protein screening array for accurate early-stage off-target assessment to accelerate safer antibody therapeutic development Liping Wang, Guoqian Wang, Yao Peng, Jinying Ning, Feng Hao
• 1651 · PDF 基于自动化成像的单细胞克隆单克隆性验证证实，与有限稀释法相比，Pala单细胞分选与分液系统效率更高 Automated imaging-based verification of monoclonality in single-cell cloning confirms higher efficiency of the Pala single cell sorter and dispenser compared to limiting-dilution assays Ahmed Shaaban, Benjamin Werdelmann, Anna Willms, Matthias Pirsch, Sebastian Kollenda, Aleks Guledani, Ankit Vaghasiya, Susanne Sebens, Ryan McComb, Reinhild Geisen
• 1652 · PDF 从结合到桥联：完整的FcgammaR测定工具套件加速抗体治疗药物开发 Binding to bridging: Complete suite of FcgammaR assay tools accelerates antibody therapeutic development Julia K. Gilden, Denise Garvin, Kristin Riching, Brock F. Binkowski, Richard Moravec, Pete Stecha, Rod Flemming, Becky Godat, Kai Hillman, Marjeta Urh, Mei Cong, Jamison Grailer
• 1653 · PDF 用于抗体药物药代动力学评估的FcRn人源化大鼠 FcRn humanized rats for pharmacokinetics assessment of antibody drugs Kelvin Yin, Suman Zhao, Zhi Zhang, Yanling Wang
• 1654 · PDF 用于全面表征抗体药物偶联物作用机制的生物发光和细胞测定 Bioluminescent and cell-based assays for comprehensive characterization of antibody-drug conjugate mechanisms of action Mei Cong, Yitong Li, virginia Kincaid, Morten Seirup, Christopher Eggers, Rod Flemming, Jim Hartnett, Kristin Riching, Jamison Grailer, Julia K. Gilden
• 1655 1655 构建重组因子C测定以实现抗体开发中可持续的内毒素检测 Building a recombinant Factor C assay to enable sustainable endotoxin testing in antibody development Yingjie Liu, Peter Hsueh, An Ouyang, Spencer Chiang, YuehChun Hsieh
• 1656 · PDF 发光测定平台加速兽医免疫肿瘤学中的治疗性抗体开发 Luminescent assay platforms accelerate therapeutic antibody development in veterinary immuno-oncology Jun Wang, Denise Garvin, Ildiko Kasza, Jim Hartnett, Mei Cong, Jamison Grailer
• 1657 · PDF BCG015：一种靶向TM4SF5用于治疗肝细胞癌的首创抗体药物偶联物 BCG015:A first-in-class antibody-drug conjugate targeting TM4SF5 for the treatment of hepatocellular carcinoma Guan Wang, Zhi Qi, Yu Qi, Gao An, Cong Shen, Yanan Guo
• 1658 · PDF 新型双功能抗MICA/B抗体药物偶联物NW008的临床前研究 Preclinical study of NW008, a novel dual-functional anti-MICA/B antibody-drug conjugate Afang Zhou, Juanjuan Li, Changcheng Li, Xueying Zhong, Yiran Wu, Li Liu, Gang Liu, Jiaoyi Zhong, Lijia Yang, Junkui Yang, Dan Mi, Jiabao Liu, Yaolan Dai, Yan Gao, Zhijian Li, Bin Liu, Zhigang Guo, Wenting Luo
• 1659 · PDF 开发一种新型靶向PSCA的抗体偶联药物，具有高效力和高稳定性，用于前列腺癌治疗 Development of a novel PSCA-targeting antibody-drug conjugate with high potency and stability for prostate cancer therapy Yanyang Cao, Evelyn A. Kono, Robert E. Reiter
• 1660 · PDF 设计一种针对GRP的合成非天然抗体（NoNabody）作为小细胞肺癌的新疗法 Design of a synthetic non-natural antibody (NoNabody) against GRP as a new therapy for small cell lung cancer Pablo Garrido Rodriquez, Jahaziel Gasperin Bulbarela, Alexei Fedorovish Licea Navarro, Alfredo Martínez
• 1661 · PDF XB773的临床前表征——一种新型抗DLL3抗体偶联药物 Preclinical characterization of XB773, a novel anti-DLL3 antibody-drug conjugate Marlene Hennessy, Ganapathy Sarma, Yutaka Matsuda, Jenny Chang, Suprit Deol, Zhenzhen Mo, Yan Hu, Maoyin Li, Rajesh Kumar, Hui Zhao, Brian A. Mendelsohn, Minjong Park, Summer Park, Janice Kim, Ragadeepthi Tunduguru, Kathleen R. Gogas, Seema Kantak
• 1662 · PDF GSPT1降解剂抗体偶联物BLB-201用于治疗高危急性髓系白血病 GSPT1 degrader antibody conjugate, BLB-201, for the treatment of high-risk acute myeloid leukemia Rakesh Bam, Wenjian Qian, John Liu, Peipei Zheng, Haoyang Wang, Jinna Yu, Wenfeng Hou, Xiaoying Wei, Dengqi Xue, Wen Zhang, David Yi, Alice Chen
• 1663 · PDF 靶向B细胞受体复合物的单克隆抗体可直接诱导广泛的激酶抑制和B细胞杀伤，用于治疗白血病和淋巴瘤 Monoclonal antibodies targeting the B-cell receptor complex directly induce widespread kinase inhibition and B-cell killing for the treatment of leukemia and lymphoma Rachel Welt, Virginia Raymond, David Kostyal, Sydney Welt
• 1664 · PDF 采用新型载荷或双载荷的新型GPC3靶向抗体偶联药物，用于治疗肝细胞癌和非小细胞肺癌 Novel GPC3-targeting antibody-drug conjugate using novel payload or dual payloads to treat hepatocellular carcinoma and non-small-cell lung cancer Suk Lee, John Liu, Alice Juang, Aastha Jain, Xiaoying Wei, Wen Zhang, David Yi, Alice Chen
• 1665 · PDF IPN60300的临床前表征——一种首创的ITGA2抗体偶联药物用于癌症治疗 Preclinical characterization of IPN60300, a first-in-class ITGA2 antibody-drug conjugate for cancer therapy Aurélie Courtin, Benjamin Beaufils, Karl Brendel, Sophie Colombo, Isabel Esteves, Marie-Odile Galcera, Thierry Guyon, Pei Han, Feng He, Wei Li, Weihong Nian, Vincent Martin, Lou-Amélia Revellin, Sylvain Roqueviere, Pierre Roubert, Yu Song, Amath Thiongane, Catherine CL Wong, Chuanying Xu, Qing Zhou, Mary Jane Hinrichs, Elisabetta Leo
• 1666 · PDF 用一种新型抗体偶联药物靶向肿瘤微环境中的细胞外基质 Targeting the extra-cellular matrix in the tumor microenvironment with a novel antibody-drug conjugate Matthew J. Edwards, Kovilen Sawmynaden, Aurelie Michelet, Edward Long, Rachel Evans, Dhruv Chauhan, Cecilia Pennica, Nafia Guljar, Cherie Akpotor, Luca Frenguelli, Gareth Muirhead, Sam Cooper, Athiva Shankar, TuVinh Luong, Emma Huang, Giuseppe Mazza, Chris Stevenson
• 1667 1667 抗体包封药物：用于多种癌症靶向治疗的Tr-ACT2 Antibody encapsulated drug: Tr-ACT2 for targeted treatments of various cancers C. J. Yu, Linrong Li, leslie Wang, Kinsley Wang, Mengmeng Liu, Faqing Huang, Warren A. Chow, Xiaojiang Cui
• 1668 · PDF MAC-8001：一种在KRAS突变癌症中具有强效抗肿瘤活性的KRAS靶向分子胶-抗体偶联物 MAC-8001: A KRAS-targeting molecular glue-antibody conjugate with robust antitumor activity in KRAS-mutant cancers Feilong Sun, Shuaishuai Chi, Carlos Chai, Yi Chen, Xuan Zhang
• 1669 · PDF S DUAL™：一种兼具实用可制造性和增强治疗疗效的先进双特异性抗体平台 S DUAL™: An Advanced Bispecific Antibody Platform Delivering Practical Manufacturability and Enhanced Therapeutic Efficacy Jina Kim, Wooseok Yang, Kihong Kim, Hyunbum Kim, Siwon Park, Haewon Ahn, Hyebeen Hong, Hyunseung Sun, Soyeon Lee, Gwangsu Shin, Jihoon Kim, Seonkyeong Jeong, Hyunsik Lee, Sungjin Han, Joseph H. Jeong, Yeumin Kim, Brian Hosung Min

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