Cell Cycle

• 1893 · PDF 抑制CDK9/13可减缓多发性骨髓瘤及骨髓瘤诱导的骨病进展——一项临床前研究 Inhibiting CDK9/13 decreases progression of multiple myeloma and myeloma-induced bone disease in preclinical studies Tiina E. Kähkönen, Gergana Gababova, Ru Yang, Jie Wen, Michael Thormann, Jussi M. Halleen
• 1894 · PDF 利用CETSA®对CDK2抑制剂进行全蛋白质组范围的靶点结合与选择性分析 Proteome-wide target engagement and selectivity profiling of CDK2 inhibitors using CETSA® Tomas Friman, Merve Kacal, Tuomas Tolvanen
• 1895 · PDF 利用微流控质谱平台鉴定ER+乳腺癌对CDK4/6抑制剂耐药的独特代谢适应 Distinct metabolic adaptations to resistance to CDK4/6 inhibitors in ER+ breast cancer identified using microfluidic mass spectrometry platform Gianna A. Slusher, Yuan Gu, Sunil S. Badve, Andrei G. Fedorov, Yesim Gökmen-Polar
• 1896 · PDF 将CDK9抑制剂的效应"转化"用于靶向前列腺癌 ‘Translating' CDK9 inhibitor effects to target prostate cancer Shivani Yalala, Pedro Durao, Agata Carreira, Joyeeta Chatterjee, Muskan Kumari, Antti Sakari Rannikko, Eileen E. Parkes, Fadi Issa, Ian G. Mills, Harri M. Itkonen
• 1897 · PDF 通过AZD8421选择性抑制CDK2靶向RB缺陷型小细胞肺癌 Targeting RB-deficient small cell lung cancer with selective CDK2 inhibition by AZD8421 Rajita Vatapalli, Michael Grondine, Jun Fan, Grace Guo, Zhan Liu, Tam Nguyen, Deepa Bhavsar, Christopher Denz
• 1899 · PDF 胸苷激酶活性作为一种转化生物标志物，用于支持肿瘤药物开发中的剂量优化并作为患者监测工具 Thymidine kinase activity as a translational biomarker to support dose optimization in oncology drug development and a tool for monitoring patients Hanna Ritzén, Mattias Bergqvist
• 1900 · PDF PTEN功能缺失编码了对多靶点小分子CDK4/6-CDK9-AURKA/B抑制剂LCI133及其他CDK9抑制剂的敏感性 PTEN loss of function encodes sensitivity to multitargeted small molecule CDK4/6-CDK9-AURKA/B inhibitor, LCI133, and other CDK9 inhibitors Halle Goodwin, Qi Zhang, Vaidehi Mujumdar, Krishaniah Maddeboina, Cody McHale, Bharath Yada, Hailey Dryden, Robert Wendel Naumann, Yovanni Casablanca, Erin K. Crane, Jubilee Brown, Allison Puechl, Brittany Lees, Donald Durden, Dhananjaya Pal
• 1901 · PDF 对CDK2抑制剂敏感与耐药的机制 Mechanisms of sensitivity and resistance to CDK2 inhibitors Sabrina L. Spencer
• 1902 · PDF 小分子抑制剂对多种哺乳动物物种CDK/Cyclin复合物疗效的生化比较评估 Comparative biochemical evaluation of small-molecule inhibitor efficacy on CDK/Cyclin complexes across diverse mammalian species Andreas Gericke, Frank Totzke, Constance Rademann, Carolin Heidemann-Dinger, Daniel Mueller
• 1903 · PDF 靶向间皮瘤中的自噬和细胞周期 Targeting autophagy and the cell cycle in mesothelioma George Scaria, Marian Kratzke, Stephen Porter, Betsy Kren, Mark A. Klein
• 1904 1904 双重靶向CDK4和CDK2克服HR+乳腺癌对CDK4/6抑制剂的耐药性 Dual-targeting CDK4 and CDK2 overcomes resistance to CDK4/6 inhibitors in HR+ breast cancer Wenqing Cai, Siwen Liu, Lu Su, Quang Fu, Chen Liao
• 1905 · PDF ABK-CDK4的发现：一种选择性且脑穿透性的CDK4抑制剂 Discovery of ABK-CDK4, a selective and brain-penetrant CDK4 inhibitor Weiling Pan, Hui Wang, Fangfei Qi, Zheng Li, Xinming Du, Jie Zhang, Jie Wang, Manqi Zhang, Haibing Deng, Hongping Yu, Yao-chang Xu, Haiyan Ying
• 1906 · PDF 新型治疗：CDK11抑制在肾脏横纹肌样瘤中的应用 Novel treatment: CDK11 inhibition in rhabdoid tumor of the kidney Kamhung Lam, Yuki Murakami, Shinsuke Fukui, Elizabeth Helmke, Noriko Satake
• 1907 · PDF CDK2调控前列腺癌细胞中RIPK2的泛素化和稳定性 CDK2 controls RIPK2 ubiquitination and stability in prostate cancer cells Lili M. Guerra, Ahmed M. Elgehama, Jaceline G. P. Sanches, Leslie Chiu, Wei Yang*
• 1908 · PDF 双重BET和CDK9抑制在胰腺导管腺癌小鼠模型中的活性 Activity of dual BET and CDK9 inhibition in murine models of pancreatic ductal adenocarcinoma Michela Cadarso, Austin Stram, Lucas Koeppel, Robert J. Millikin, Md Shahadat Hossan, Eleanor Riedl, Ron Stewart, Jeremy D. Kratz
• 1909 1909 SY5609对CDK7的抑制通过抑制RNA pol II介导的转录和Hippo/YAP1信号传导抑制胃癌肿瘤生长 CDK7 inhibition by SY5609 suppresses tumor growth in gastric cancer through inhibiting RNA pol II mediated transcription and Hippo/YAP1 signaling Dipti Athavale, Yan-ting Yann Zhang, Mikel Ghelfi, Anthony Pompetti, Junsong Zhao, Xiaodan Yao, Shumei Song
• 1910 · PDF GDC-4198——一种新一代CDK4/2抑制剂，可诱导持久的细胞周期阻滞，并与giredestrant联用显示出协同获益 GDC-4198, a next-generation CDK4/2 inhibitor, induces durable cell cycle arrest and shows combination benefit with giredestrant Marc Hafner, Steffan Vartanian, Luca Gerosa, Nont Kosaisawe, Michael S. Hwang, Eva Lin, Yi-Chang Wang, Jason Oeh, Tianyi Chen, Kazi N. Islam, Alice Zheng, Karen Samy, Udi Segal, John G. Moffat, DANIEL ZINGG, Annie Collier, Ioannis Sanidas, Zhi Xie, Seth A. Wander
• 1911 · PDF 靶向PLK1或WEE1揭示了BRCA1/2野生型、同源重组功能完好的高级别浆液性卵巢癌中的一个治疗弱点 Targeting PLK1 or WEE1 uncovers a therapeutic vulnerability in BRCA1/2 wild-type, homologous recombination-proficient high-grade serous ovarian cancer Akiko Kunita, Qian Xi, Masanori Kawakami, Miho Ogawa, Mirei Ka, Kousuke Watanabe, Tetsuo Ushiku, Hidenori Kage, Kazuhiro Katayama, Katsutoshi Oda
• 1912 · PDF 染色体外DNA（ecDNA）介导的复制应激作为高危髓母细胞瘤中潜在可靶向的弱点 Extrachromosomal DNA (ecDNA)-mediated replication stress as a potential targetable vulnerability in high-risk medulloblastoma Jessica Wang, Hui Hui, Jon D. Larson, Rishaan Kenkre, Owen Chapman, Yan Yuen Lo, Emerald Adeyan, Lukas Chavez
• 1913 · PDF KMT2D缺陷改变子宫内膜癌中Rb的CDK-cyclin调控 KMT2D deficiency alters CDK-cyclin regulation of Rb in endometrial cancer Madelyn Maurer, Swornalata Pukhrambam, Jessica Long, Sanjeev Ganesh, Sophia Agrusa, Maya Paytas, Katherine Gurdziel, Paul Stemmer, Mike R. Wilson
• 1914 · PDF 序贯抑制CDK4/6和有丝分裂激酶TTK作为三阴性乳腺癌细胞系的潜在治疗方法 Sequential inhibition of CDK4/6 and the mitotic kinase TTK as a potential treatment in triple-negative breast cancer cell lines Gretchen M. Albarrán-Acosta, Janangelis López-Ramos, Magda N. Álvarez-Rodríguez, Alexandra N. Aquino-Acevedo, Harold I. Saavedra-Lugo
• 1915 · PDF Serpine2通过调控DDX3X/MITF/p21信号通路促进黑色素瘤进展 Serpine2 promotes melanoma progression through the modulation of the DDX3X/MITF/p21 signaling pathway Qirui Liu, Xin Huang, Xiao Zhang, Xinyu Ye, Yi Lu, Jian Zhang
• 1916 · PDF 鉴定氯倍他索诱导UMSCV-4外阴癌细胞进入静息期过程中细胞周期调控蛋白的变化 Identifying changes in cell cycle regulatory proteins during clobetasol-induced quiescence in UMSCV-4 vulvar cancer cells Claudia M. Marsello, Trinity A. Trojanowski, Jani E. Lewis
• 1918 · PDF 在人iPSC来源的胶质母细胞瘤模型中进行CRISPR筛选揭示与TERT启动子突变相关的RNA结合蛋白依赖性 CRISPR screening in human iPSC-derived glioblastoma models reveals RNA-binding protein dependencies associated with TERT promoter mutation Christopher C. Chie, Daisuke Kawauchi, Shunichiro Miki, Nicholas O. Stevers, Joseph F. Costello, Chun-Yuan Chen, Gene W. Yeo, Frank B. Furnari
• 1919 · PDF 较长的白细胞端粒及端粒维持基因的特定等位基因与结肠癌患者生存期改善独立相关 Longer leukocyte telomeres and specific alleles of telomere maintenance genes are independently associated with improved survival of colon cancer patients Estela M. Cruz Garcia, Gobinda Sarkar, Jun Chen, Shubham Sood, Kim Kossick, Daniel Schupack, Rondell Graham, Brooke Druliner, Zahra Heydari, Lauren Helgeson, Richard G. Cawthon, Lisa A. Boardman
• 1920 · PDF 通过单细胞DNA测序解析乳腺癌演进中的端粒长度动态 Resolving telomere length dynamics in breast cancer evolution through single-cell DNA sequencing Nicolaas Baudoin, Lei Yang, Chenling Tang, Hanghui Ye, Kaile Wang, Jianzhuo Li, Yun Yan, Nicholas E. Navin
• 1921 1921 邻近标记和热蛋白质组分析揭示YWHAZ和YWHAB在CDK4/6抑制剂耐药中的机制作用 Proximity labeling and thermal profiling proteomic analysis unveil mechanistic role of YWHAZ and YWHAB in CDK4/6 inhibitor resistance Min‑Jyun Dong, Wei-Ting Chung, Yi-Ru Tseng, Chun-Yu Liu, Chi-Cheng Huang, Ling-Ming Tseng, Ta-Chung Chao, Jiun-I Lai

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