Liquid Biopsies: Circulating Nucleic Acids 1

• 1121 · PDF 使用一种新型超灵敏全基因组测序ctDNA检测法检测结直肠癌术后微小残留病灶 Detection of postoperative minimal residual disease in colorectal cancer using a novel ultrasensitive whole-genome sequencing-based ctDNA test Maria Hønholt, Tenna V. Henriksen, Mads H. Rasmussen, Christina Demuth, Thomas Kolbro, Peter Bondeven, Jeppe Kildsig, Per V. Andersen, Anders Tøttrup, Nis H. Schlesinger, Claudia Jaensch, Ole Thorlacius-Ussing, Christensen Peter, Alessio Monti, Yingyu Wang, Tam Berntsen, George Yeung, Paul Tang, Tobias Wittkop, Malek Faham, Li Weng, Lene Hjerrild Iversen, Kåre A. Gotschalck, Claus L. Andersen
• 1122 · PDF 基于甲基化的肿瘤分数监测可识别具有推定分子进展、可能受益于综合基因组分析的患者 Methylation-based tumor fraction monitoring identifies patients with putative molecular progression who may benefit from comprehensive genomic profiling Jun Zhao, Rihao Qu, Katie Quinn, Tingting Jiang, Jack Tung, Carin R. Espenschied, Samantha I. Liang, Vishnu Ramani, Jing Wang, Sean Gordon, Martina Lefterova, Darya Chudova
• 1123 · PDF 通过多特征全基因组cfDNA分析进行癌症类型识别的机器学习分类器 Machine learning classifier for cancer type identification via multi-feature genome-wide cfDNA profiling Yunjian Zhang, Liang Liu, Hua Bao, Haimeng Tang, Ke Xu, Hao Zhang, Song Wang, Shuang Chang, Dongqin Zhu, Zongyao Huang, Zheng Wang, Liu Yang, Bingzhong Zhang, Ji Tao, Wenhua Liang, Jierong Chen, Shanshan Yang, Xue Wu, Yang Shao, Wenquan Wang, Dongyuan Zhu
• 1124 · PDF cfDNA片段组学可实现妇科肿瘤的灵敏早期检测和组织起源预测 cfDNA fragmentomics enables sensitive early detection and tissue-of-origin prediction in gynecologic cancers Jin Li, Xun Zhang, Song Wang, Xiaoying Wu, Jinpeng Zhang, Hua Bao, Shanhui Liang, Xiaotian Han, Jiangchun Wu, Hao Wen, Hairong Bao, Haimeng Tang, Xue Wu, Xiaohua Wu, Zhao Wu, Xiaoqiu Li
• 1125 · PDF 表征肝细胞癌患者的cfDNA片段组 Characterizing the cfDNA fragmentome in patients with hepatocellular carcinoma Hope Orjuela, Carter Norton, Shashikant Koul, Daniel C. Bruhm, Akshaya V. Annapragada, Sarah Short, Keerti Boyapati, Adrianna Bartolomucci, Vilmos Adleff, Nicholas A. Vulpescu, Kauí Lebarbenchon, Jacob Carey, Carter Portwood, Andrei Sorop, Razvan Iacob, Speranta Iacob, Liana Gheorghe, Simoni Dima, Katherine A. McGlynn, Manuel Ramirez-Zea, Jillian Phallen, Robert B. Scharpf, John Groopman, Victor E. Velculescu, Zachariah Foda
• 1126 · PDF 组织配对血浆全基因组揭示胰腺癌普遍存在的早期播散 Pervasive early dissemination in pancreatic cancer uncovered by tissue-paired plasma whole-genomes Yuanchang Fang, Michelle Chan-Seng-Yue, Karen Ng, Amy Zhang, Tuan Hoang, Gun Ho Jang, Sabiq Chaudhary, Catia Gaspar, Eugenia Flores-Figueroa, Daniela Bevacqua, Stephanie Ramotar, Ayelet Borgida, Shawn Hutchinson, Anna Dodd, Barbara Grünwald, Julie Wilson, Robert Grant, Erica Tsang, George Zogopoulos, Masoom Haider, Jennifer Knox, Steven Gallinger, Faiyaz Notta
• 1127 · PDF 头颈鳞状细胞癌中肿瘤指导ctDNA检测的期中分析：PECAN试验 Interim analysis of tumor-informed ctDNA detection in head and neck squamous cell carcinoma: The PECAN trial Paul van der Leest, Joris Elbers, Amy Greer, Sten Cornelissen, Theodora C. Linders, Mirthe Lanfermeijer, Kalpana Ramkisoensing, Ellen Verner, Laura Smit, Mark Sausen, Abrahim Al-Mamgani, Daan van den Broek
• 1128 · PDF TRACERx研究中早期NSCLC的个性化循环游离DNA片段化动态 Personalized cell-free DNA fragmentation dynamics in early-stage NSCLC in TRACERx Jonathan C. M. Wan, Wing Kin Liu, James R. M. Black, Alexander Mark Frankell, Alexander Azizi, Olivia Lucas, Woody Z. Zhang, Chris Bailey, Nnennaya Kanu, Mariam Jamal-Hanjani, Charles Swanton
• 1129 · PDF 可切除癌症新辅助免疫检查点抑制期间肿瘤指导和肿瘤未知ctDNA残留病灶检测的分析和临床灵敏度 Analytical and clinical sensitivity of tumor-informed and tumor-naïve ctDNA residual disease detection during neoadjuvant immune checkpoint inhibition in resectable cancers Paul K. Lee, Blair V. Landon, Ezgi Oner, Jaime Wehr, Qiong Meng, Amna Jamali, Mimi Najjar, Gavin Pereira, Samira Hosseini-Nami, Rachel Keogh, Chen Hu, Ronan J. Kelly, Joshua E. Reuss, Patrick M. Forde, Mark Sausen, Vincent K. Lam, Robert B. Scharpf, Noushin Niknafs, Valsamo (Elsa) Anagnostou
• 1130 · PDF 通过患者来源外植体模型追踪肿瘤特异性EV-miRNA特征以推进非小细胞肺癌的液体活检 Tracing tumor-specific EV-miRNA signatures via patient-derived explant models to advance liquid biopsy in non-small cell lung cancer Miranda Burdiel, Carlos Rodriguez-Antolin, Ana Arauzo-Cabrera, Olga Pernía, Rocio Moreno-Velasco, Laura Gutiérrez-Sainz, Oliver Higuera, Olga Vera, Javier de Castro
• 1131 · PDF 一种针对新兴生物标志物的新型检测策略：利用循环肿瘤DNA（ctDNA）检测MTAP缺失 A novel detection strategy for an emerging biomarker: MTAP loss detection with circulating tumor DNA (ctDNA) Lauren S. Welch, Radhika Gutta, Fawzi Abu Rous, Bindu R. Potugari, Sudha Sadasivan, Shirish M. Gadgeel
• 1132 · PDF 用于cfDNA/RNA基因分型和药物检测的恶性积液：将恶性液体转化为个性化癌症模型 Malignant effusions for cfDNA/RNA genotyping and drug testing: Turning malignant fluids into personalized cancer models Elba Marin, Silvia Garcia-Roman, Cristina Aguado, Marta Vives, Sonia Rodríguez, Susana Muñoz, Noelia Armiger, Alejandro Martínez-Bueno, Maria Gonzalez-Cao, Ana Velasco, Serafin Morales, Reyes Roxana, Ekaterina Meshoulam, Andrés Aguilar, Clara Mayo de las Casas, Miguel Ángel Molina-Vila
• 1133 · PDF 尿液细胞游离RNA捕获膀胱癌中反映肿瘤的长基因间非编码RNA和环状RNA程序 Urine cell-free RNA captures tumor-reflective long intergenic noncoding and circular RNA programs in bladder cancer Pradeep Chauhan, Li Lin, Irfan Alahi, Jessica Linford, Lilli J. Greiner, Ayesha Hashmi, Anushka Viswanathan, Nathan Colon, Faridi Qaium, Peter K. Harris, John Sheng, Jacob J. Orme, Eric H. Kim, Zachary L. Smith, Woodson Smelser, Christopher A. Maher, Aadel A. Chaudhuri
• 1134 · PDF 细胞游离DNA片段组捕获转移性非小细胞肺癌对免疫放疗的反应 Cell-free DNA fragmentomes capture response to immuno-radiotherapy in metastatic non-small cell lung cancer Noushin Niknafs, Lavanya Sivapalan, Bahar Alipanahi, Gavin Pereira, Amna Jamali, Jaime Wehr, Daniel Rabizadeh, Christopher Cherry, Bryan Chesnick, Nicholas C. Dracopoli, Jamie Medina, Stephen Cristiano, Willemijn S. Theelen, Robert Scharpf, Lorenzo Rinaldi, Victor E. Velculescu, Valsamo (Elsa) Anagnostou
• 1135 · PDF 利用细胞游离DNA片段组和蛋白生物标志物进行肺癌亚型分型 Lung cancer subtyping using cell-free DNA fragmentomes and protein biomarkers Stephen Cristiano, Paul van der Leest, Jamie Medina, Zachary Skidmore, Milou M. Schuurbiers, Garrett Graham, Alessandro Leal, Bryan Chesnick, Kim Monkhors, Nicholas C. Dracopoli, Robert Scharpf, Peter B. Bach, Daan van den Broek, Amoolya Singh, Victor E. Velculescu, Sian Jones, Michel M. van den Heuvel, Lorenzo Rinaldi
• 1136 · PDF 一种具有高灵敏度和特异性的全基因组肿瘤知情分子残留病检测方法的分析学评估 Analytical evaluation of a whole genome tumor-informed molecular residual disease detection assay with high sensitivity and specificity Weida Gong, Sung Kim, Guidantonio Malagoli Tagliazucchi, Tevfik Umut Dincer, Megha Ghildiyal, Magdalena Gantuz, Grace Kim, Quyen Bui, Yuan Ding, Jacob Gibson, Leland Mencik, Ambrose Vuong, Marcus Valancius, Kimberly Gietzen, Jennifer Becq, Carey Davis, Josh Bernd, Martin Chian, Dan Schmidt, Eileen de Feo
• 1137 · PDF 一种用于生物标志物发现和肿瘤负荷评估的高灵敏度、无组织血液检测的验证 Validation of a sensitive, tissue-free blood test for biomarker discovery and tumor burden assessment Zeliang Deng, Xiaoling Li, Xinyue Kang, Jiayue Xu, Jing Su, Xianrong Chen, Qiancheng You, Xingyu Yang, Zhihong Zhang, Bingsi Li
• 1138 · PDF 临床级循环肿瘤DNA甲基化预测ALK重排NSCLC患者对brigatinib联合局部巩固治疗的疗效——BRIGHTSTAR试验的液体活检相关性分析 Clinical grade circulating tumor DNA methylation predicts outcome to brigatinib plus local consolidative therapy in patients with ALK rearranged NSCLC - Liquid biopsy correlates from the BRIGHTSTAR trial Simon Heeke, Saumil Gandhi, Hai T. Tran, Lauren Averett Byers, Don Gibbons, Carl M. Gay, Mehmet Altan, Mara B. Antonoff, Xiuning Le, Janet Tu, Anne S. Tsao, Tina Cascone, Marcelo V. Negrao, George R. Blumenschein, John V. Heymach, Yasir Y. Elamin
• 1139 1139 利用液体活检和尿液蛋白质组学早期检测BCG治疗的NMIBC的治疗失败与疾病播散 Early detection of treatment failure and disease dissemination inBCG-treated NMIBC using liquid biopsies and urine proteomics Trine Strandgaard, Tine Ginnerup Andreasen, Iver Nordentoft, Nathalie Demuth Fryd, Philippe Lamy, Julie Pedersen Harrits, Boris Oklander, Danielle Afterman, Tal Katz-Ezov, Imane Bourzgui, Jørn Jakobsen, Kristian Juul, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
• 1140 · PDF 纵向肿瘤指导的无细胞DNA全基因组测序联合转录组分析捕捉可切除胃食管癌的肿瘤负荷动态 Longitudinal tumor-informed cell-free DNA whole genome sequencing coupled with transcriptomic analysis captures tumor burden dynamics in resectable gastroesophageal cancer Blair V. Landon, Jaime Wehr, Rachel Keogh, Noushin Niknafs, Christopher Cherry, Nisha Rao, Gavin Pereira, Mark Sausen, Richard J. Battafarano, Stephen C. Yang, Stephen Broderick, Jinny Ha, Russell K. Hales, K. Ranh Voong, Kristen A. Marrone, Chen Hu, Josephine L. Feliciano, Ali H. Zaidi, Ronan J. Kelly, Vincent K. Lam, Valsamo (Elsa) K. Anagnostou
• 1141 · PDF 基于液体活检的预测模型识别肌层浸润性膀胱癌新辅助化疗后可保留膀胱的潜在候选者 A liquid biopsy-based predictive model identifies potential candidates for bladder preservation after neoadjuvant chemotherapy in muscle-invasive bladder cancer Randi Istrup Juul, Iver Nordentoft, Sia Viborg Lindskrog, Abhijit Dasgupta, Diana Merino Vega, Gitte Lam, Line Hammer Dohn, Knud Fabrin, Andreas Carus, Astrid C. Petersen, Ulla N. Joensen, Helle Pappot, Per Søndergaard Holt, Niels Viggo Jensen, Boris Oklander, Danielle Afterman, Mads Agerbæk, Jørgen B. Jensen, Lars Dyrskjøt
• 1142 · PDF 胰腺囊液的超灵敏CRISPR基NGS（MUTE-Seq）：KRAS变异等位基因分数作为恶性潜能的早期标志物 Ultra-sensitive CRISPR-based NGS (MUTE-Seq) of pancreatic cyst fluid: KRAS variant allele fraction as an early marker of malignant potential Min Kyu Sung, Jungmin Kim, Yoon-Ho Won, Sung Sun Koo, In Seon Lee, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Dae Wook Hwang, Jin-Soo Kim, Seong Hyeok Ye, Junseok W. Hur, Song Cheol Kim
• 1143 · PDF Enspyre：一种新型富集技术实现超灵敏ctDNA检测并将测序需求降低98% Enspyre: A novel enrichment technology enables ultra-sensitive ctDNA detection with 98% reduction in sequencing requirements Paul Labrousse, Sophie Hackinger, Hugh Russell, Daniel Stetson, David Shera, Paulina Powalowska-Picton, Katarzyna Anton, Maria Litovchenko, Ernesto Lowy-Gallego, Amy Lovell, Magdalena Stolarek-Januszkiewicz, Barnaby Balmforth, James Hadfield
• 1144 · PDF I-IV期子宫癌患者的肿瘤基因组特征与术后ctDNA状态 Tumor genomic features and postsurgical ctDNA status in patients with stage I-IV uterine cancer Tara Berman, Bhakti Dwivedi, Carly B. Scalise, Punashi Dutta, Adam ElNaggar, Minetta Liu, Casey Cosgrove
• 1145 · PDF 来自血液和唾液的全基因组无细胞DNA片段组学实现头颈癌的早期检测 Genome-wide cell-free DNA fragmentomes from blood and saliva enable early detection of head and neck cancers Akshaya Vijaya Annapragada, Shanaya Patel, Sarah Short, Keerti Boyapati, Shashi Koul, Hope Orjuela, Alice Eastman, Aditi Patel, Shreya Lotia, Vaishnavi Patel, Jason Zavras, Adrianna Bartolomucci, Dushyant Mandlik, Kaustubh Patel, Vivek Tanavde, David Sidransky, Mariana Brait, Rob Scharpf, Victor Velculescu, Jillian Phallen

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