Liquid Biopsies: Circulating Nucleic Acids 4

• 5306 5306 转移性乳腺癌中小细胞外囊泡的转录组学分析 Transcriptomic analysis of small extracellular vesicles in metastatic breast cancer Emmanuel Acheampong, Tumisang Ntereke, Katie Dixon, Karen Page, Shradha Bhagani, Naila Abid, Marc Wadsley, Rebecca Allsopp, Charles Coombes, Jacqui Shaw
• 5307 · PDF 用于分子残留病灶检测的超灵敏全基因组测序检测的分析性能 Analytical performance of an ultrasensitive whole genome sequencing assay for molecular residual disease detection Andrew Georgiadis, Christopher Greco, Cynthia Maddox, Paul McGregor, Cesar Nalvarte, Kaitlin Victor, Amanda Harvey, Shelby Bain, Robert Summersgill, Ana Perez-Lebron, Liam Cox, Stephen Higgings, David Riley, Samuel Angiuoli, Marcia Eisenberg, Brian Caveney, Eric Severson, Taylor J. Jenson, Shakti Ramkissoon, Mark Sausen
• 5308 · PDF 使用mDETECT检测监测转移性乳腺癌患者的治疗应答 Monitoring treatment response in metastatic breast cancer patients using an mDETECT assay Keira Frosst, Brooke E. Wilson, Katarzyna J. Jerzak, Christopher R. Mueller
• 5309 · PDF 基线ctDNA分析可识别EML4-ALK阳性NSCLC对第二代ALK抑制剂耐药的分子预测因子 Baseline ctDNA profiling identifies molecular predictors of resistance to second-generation ALK inhibitors in EML4-ALK-positive NSCLC Emma Roger Sønderbek, Maiken Parm Ulhøi, Peter Meldgaard, Boe Sandahl Sorensen
• 5310 · PDF ctDNA甲基化的动态变化可预测晚期食管癌对免疫治疗的早期应答 Dynamic changes in ctDNA methylation predict early response to immunotherapy in advanced esophageal cancer Hui Zhang#, Yu Lang#, Yaping Dong#, Wei Li#, Jialin Lin, Lu Yang, Jiapeng Kang, Wenqiang Yu*, Changshun Yang*, Jingxun Wu*, Qiyuan Li*, Feng Ye*, Weiwei Tang*
• 5311 · PDF 通过对原发肿瘤和纵向循环肿瘤DNA进行深度全基因组测序追踪前列腺癌进展 Tracking prostate cancer progression by deep whole genome sequencing of primary tumors and longitudinal circulating tumor DNAs Samira Rahimirad, Eleonora Scarlata, Lucie Hamel, Seta Derderian, Ginette McKercher, Fadi Brimo, Fred Saad, Armen Aprikian, Simone Chevalier
• 5312 · PDF 基于数字PCR的血浆DNA甲基化检测用于小细胞肺癌的无创分子分型：一项前瞻性可行性研究 Digital PCR-based plasma DNA methylationassayfor noninvasive molecular subtyping of small cell lung cancer: A prospective feasibility study Jin-Soo Kim, Mi Young Kim, Jeemin Yim, Yun Young Lee, Joon An, Jinil Han, Ji Eun Kim, Youngho Moon
• 5313 · PDF 对调控区域cfDNA WGS的片段组学分析生成基因水平的类表达特征用于乳腺癌亚型分析 Fragmentomic analysis of cfDNA WGS at regulatory regions generates gene-level expression-like traits for subtype analysis in breast cancer Jonathan H. Shepherd, Jeff Burdine, Yoichiro Shibata, Gregory M. Mayhew, Gabe Milburn, Michael V. Milburn, Matthew LaBella, Shalee Killpack, Kirk L. Pappan, James M. Davison, Kirk Beebe
• 5314 · PDF 通过在商业化CGP panel中加入靶向基因调控区域的定制杂交捕获panel，在单次cfDNA检测中结合基因表达与突变谱分析 Combining gene expression and mutation profiling in a single cfDNA assay through the addition of a custom hybrid capture panel targeting gene regulatory regions to a commercial CGP panel Gregory M. Mayhew, Jonathan H. Shepherd, Yoichiro Shibata, Jeff Burdine, Gabriel V. Milburn, Kirk L. Pappan, Nripesh Prasad, Michael V. Milburn, James M. Davison, Kirk Beebe
• 5315 · PDF 用于早期癌症检测的基于cfDNA的全基因组多特征分类器的分析精密度与跨平台可复现性 Analytical precision and cross-platform replicability of cfDNA-based genome-wide multi-feature classifiers for early cancer detection Vishruth Girish, Alice C. Eastman, Adrianna L. Bartolomucci, Akshaya V. Annapragada, Hope Orjuela, Carter Norton, Daniel H. Du, Sarah Short, Christopher M. Cherry, James R. White, Shashikant Koul, Vilmos Adleff, Zachariah H. Foda, Jillian Phallen, Victor E. Velculescu, Robert B. Scharpf
• 5316 · PDF SPIRAL的分析验证：一种整合基因组与表观基因组的液体活检检测 Analytical validation of SPIRAL: An integrated genomic and epigenomic liquid biopsy assay Lei Wang, Peiru Liu, Chaoran Zheng, Shanshan Yu, Yalan Jin, Fujun Qiu, Bo Yang, Yuan Sun, Xiaotian Wang, Shuailai Wu, Zhihong Zhang
• 5317 · PDF 评价循环肿瘤DNA作为高危神经母细胞瘤患者早期复发检测和分子谱分析的生物标志物 Evaluation of circulating tumor DNA as a biomarker for early relapse detection and molecular profiling in patients with high-risk neuroblastoma Natalia Wojciechowska, David Farbo, Tiffany Duque, Angela Brentlinger, Chelsee Greer, Anish Ray
• 5318 · PDF 一种低成本、超快速、低输入量的扩增子NGS工作流程用于快速癌症谱分析 A low-cost, ultra-fast, low-input amplicon NGS workflow for rapid cancer profiling Fang Liu, Kemin Zhou, Pan Du, Binggang Xiang
• 5319 · PDF 基于循环肿瘤DNA（ctDNA）对晚期实体瘤患者中成纤维细胞生长因子受体（FGFR）2/3抑制剂lavengratinib（ABSK061）获得性耐药的谱分析 Circulating tumor DNA (ctDNA)-based profiling of acquired resistance to the fibroblast growth factor receptor (FGFR)2/3 inhibitor lavengratinib(ABSK061) in patient(pt)s with advanced solid tumors Yue Wang, Chunyu Zhou, Liyun Zhao, Chaoze Cheng, Zhixuan Zhu, Zishuo Wang, Peng Zhang, Jing Zhang, Hua Zou, Jing Ji, Hongping Yu, Ji Zhu, Yan Zhao, Dewei Li, Yongsheng Li, Wei Li, Yanru Qin, Shujun Yang, Nannan Zhang
• 5320 · PDF 利用KAPA EvoPrep Boost流程增强的转化效率进行尿液ctDNA检测 Leveraging enhanced conversion efficiency of the KAPA EvoPrep Boost workflow for urine ctDNA detection Angela Apessos, Maria Shin, Yanpeng Xi, Stephanie J. Yaung, Indira Wu
• 5321 · PDF 前列腺癌患者尿液microRNA的全面分析 Comprehensive profiling of urine microRNAs in prostate cancer patients Matias A. Bustos, Yoko Koh, Jaime Moon, Dai Takamatsu, SooMin Kim, Gianna Jimenez, David L. Krasne, Timothy G. Wilson, Dave S. B. Hoon
• 5322 · PDF 通过液体活检非侵入性追踪克隆演化和治疗反应 Non-invasive tracking of clonal evolution and treatment response through liquid biopsies Farhia Kabeer, Matteo Lepur, Branden Lynch, Emilia Hurtado, Janine Senz, Ding Ma, Vinci Au, Caroline Baril, Gavin Ha, Samuel Aparicio, Jessica N. McAlpine, Alexandre Bouchard-Côté, David G. Huntsman, Yvette Drew, Andrew Roth
• 5323 · PDF 循环肿瘤DNA动态可预测PIK3CA突变型乳腺癌对新辅助化疗的反应，但不能预测长期结局 Circulating tumor DNA dynamics predict the response to neoadjuvant chemotherapy but not long-term outcomes in PIK3CA -mutated breast cancer Ayaka Sato, Takayuki Ueno, Shunji Takahashi, Yoshinori Murakami, Masahiko Tanabe
• 5324 · PDF 循环肿瘤DNA检测食管癌食管切除术后的微小残留病灶并预测结局 Circulating tumor DNA detects minimal residual disease and predicts outcomes in esophageal cancer after esophagectomy Qingjiang Hu, Eiji Oki, Yasue Kimura, Hajime Otsu, Yusuke Yonemura, Koshi Mimori
• 5325 · PDF 游离DNA片段组用于转移性结直肠癌患者的治疗反应监测：Dolphin研究 Cell-free DNA fragmentomes for treatment response monitoring in patients with metastatic colorectal cancer: The Dolphin study Denise E. van Steijn, Lorenzo Rinaldi, Adria Closa, Erica Peters, Alissa Konicki, Mariska Bierkens, Haoyue Wang, Marjolein Greuter, Birgit Lissenberg-Witte, Veerle Coupé, Amoolya Singh, Timothy McDaniel, Meike de Wit, Anna Houben, Daan van den Broek, Miriam Koopman, Gerrit Meijer, Max Lahaye, Manon Braat, Victor Velculescu, Jeanine Roodhart, Nicholas Dracopoli, Frederieke van der Baan, Geraldine Vink, Niels Kok, Remond Fijneman
• 5326 · PDF 组织和液体活检样本的高通量基因组分析揭示了印度人群NSCLC患者中的可靶向突变 High throughput genomic profiling of tissue and liquid biopsy samples reveals targetable mutations in NSCLC patients from the Indian population Amit Kumar, Puja Sinha, Rama Chandran, Shobit Gupta, Giulliana Tessarin
• 5327 · PDF 利用尿液游离DNA作为综合基因组分析的信息性生物材料 Utilization of urinary cell-free DNA as an informative biomaterial for comprehensive genomic profiling Robert Summersgill, Jesse Fox, Patrick Horn, LaRonda White, Vito Caropreso, Amy Meltzer, Ana Perez-Lebron, Kenneth Valkenburg, Eric Severson, Taylor J. Jenson, Shakti Ramkissoon, Brian Caveney, Marcia Eisenberg
• 5328 · PDF 基于磁珠的低起始量靶向DNA富集cfDNA提取的分析性能 Analytical performance of magnetic bead-based cfDNA extraction with a low input targeted DNA enrichment Mayer Saidian, Yingmin Wang, Heng Wang, Yun Bao, Jason Saenz, Carlos Hernandez, Cameron Van Dieren, Daniel Cedeno, Nafiseh Jafari
• 5329 · PDF 解锁经肾DNA：稳定和分离尿液中小片段cfDNA的新方法 Unlocking transrenal DNA: New methods for stabilizing and isolating small cfDNA in urine Daniela Mancarella-Langer, Franziska Kaiser, Daniel Groelz, Moritz Rath, Nguyen Van Nhi Le, Eric Provencher, Michelle Walther

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