PO.CH02.01 · 化学
Proteomics: Biomarker Discovery and Signaling Networks
- 7677 7677 高通量血浆蛋白质组学实现肌少症分层并识别IGFBP轴为癌症患者肌肉损伤的关键介导因子 High-throughput plasma proteomics enables sarcopenia stratification and identifies the IGFBP axis as a key mediator of muscle impairment in cancer patients Filippo Gustavo Dall'Olio, Wael Salem Zrafi, Xinran Song, Littisha Lawrance, Fei Chen, Pierre Busson, Catherine Brenner, Rebecca Ibrahim, Marie Guinhut, Caroline Even, Nathalie Lassau, Diana Cardenas-Braz, Fabrice Barlesi, Yohann Loriot, Fabrice Andre, Mariam Jamal-Hanjani, Antoine Italiano, Yegor Vassetzky, Benjamin Besse
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- 7681 7681 化学蛋白质组学识别出与新一代poly(ADP-ribose)聚合酶抑制剂saruparib相互作用的转录相关蛋白网络 Chemical proteomics identifies a transcription-related network of proteins that interact with the next-generation poly(ADP-ribose) polymerase inhibitor saruparib Rachael H. Martin, Lindsey Nguy, Thales Da Costa Nepomuceno, Ou Deng, John M. Koomen, Uwe Rix, Alvaro N. Monteiro
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- 7683 7683 铂敏感与铂耐药高级别浆液性卵巢癌之间差异蛋白表达的蛋白质组学分析 A proteomic analysis of differential protein expression between platinum-sensitive and platinum-resistant high grade serous ovarian cancer Nujsaubnusi Cassandra Vue, Kyla Frenia, Xi Peng, Eirwen Miller, John Nakayama, Sharon Liang, Sarah Crafton, Alyssa Wield, Christopher Morse, Thomas Krivak, Qiangmin Zheng, Kunhong Xiao
- 7684 7684 使用新型基于NGS的免疫测定法对400种血浆蛋白进行绝对定量：乳腺癌中的分析验证与生物标志物发现 Absolute quantification of 400 plasma proteins using a novel NGS-based immunoassay: Analytical validation and biomarker discovery in breast cancer David Aaron Routenberg, Evan A. Gizzie, Annamaria Szabolics, Lucie Hebert, Somnath Paul, Anthony Williams, Richard J. Cote, Jacob N. Wohlstadter
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- 7688 7688 基于血液的蛋白质组学分析揭示神经内分泌前列腺癌的新型生物标志物 Blood-based proteomic profiling reveals novel biomarkers of neuroendocrine prostate cancer Tatiana Erazo, Ethan S. Barnett, Amanda Weaver, A. Zara Herskovits, Alisa Valentino, Howard I. Scher, Gary A. Pestano
- 7689 7689 靶向蛋白质组学绝对定量在患者来源异种移植物中识别BRCA1亚效等位基因及其他PARP抑制剂耐药机制 Absolute quantification by targeted proteomics identifies BRCA1 hypomorphs and other PARP inhibitor resistance mechanisms in patient-derived xenografts Beom-Jun Kim, Alba Llop-Guevara, Steve M. Sweet, Camille Lombard-Banek, Robert Hanson, Chris Richardson, Violeta Serra, Elizabeth A. Harrington, Josep Forment, Yeoun Jin Kim
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- 7692 7692 通过高精度显微镜引导的光生物素化对免疫突触进行蛋白质组学分析 Proteomic analysis of immune synapses by high-precision microscopy-guided photo-biotinylation Jung-Chi Liao, Chantal Hoi Yin Cheung, Weng-Man Chong, Harry Huang, Hsiao-Jen Chang, Chia-Wen Chung
- 7693 7693 解锁表面蛋白质组：利用Synlight-Rich与Synlight-Pure进行纳米尺度空间蛋白质组学以发现生物标志物和治疗靶点 Unlocking the surfaceome: Nanoscale spatial proteomics for biomarker and target discovery using Synlight-Rich and Synlight-Pure Jung-Chi Liao, Po-Chao Chan, Weng-Man Chong, Hsiao-Jen Chang, Michelli Faria de Oliveira, Elate Huang, Daniel Dlugolenski
- 7694 7694 BRAF-V600E突变型转移性结直肠癌FFPE组织的蛋白质组学分析揭示WEE1表达可能参与治疗耐药 Proteomic analysis of BRAF-V600E mutant metastatic colorectal cancer FFPE tissues reveals potential involvement of WEE1 expression in therapeutic resistance Shotaro Yamaguchi, Satoshi Muraoka, Yosui Nojima, Toshiharu Hirose, Hidekazu Hirano, Natsuko Okita, Atsuo Takashima, Jun Adachi, Hirokazu Shoji, Ken Kato
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- 7698 7698 推进血浆蛋白质组学：一种用于结直肠癌深度定量生物标志物发现的新一代纳米颗粒富集工作流程 Advancing plasma proteomics: A next-generation nanoparticle enrichment workflow for deep and quantitative biomarker discovery in colorectal cancer Cameron Ellis, Katharina Limm, Sandra Schär, Roland Bruderer, Nils Kulak
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- 7704 7704 对小胶质细胞响应肿瘤学化合物的全蛋白质组高通量扰动筛选揭示了不同的免疫调节和毒性特征 Proteome-wide high throughput perturbation screening of microglial response to oncologic compounds reveals distinct immunomodulation and toxicity profiles Alyssa Rosenbloom, Kiran Edwardson, Nathaniel Robichaud, Narges Rashidi, Milad Dagher
- 7705 7705 使用快速、高分辨率精确质谱法检测同时定量和发现血浆中癌症相关蛋白，为精准肿瘤学和药物发现提供见解 Simultaneous quantitation and discovery of cancer-related proteins in plasma using a fast, high-resolution accurate mass spectrometry-based assay provides insight into precision oncology and drug discovery Dominique Figueroa, Qingling Li, Jared Deyarmin, Sophia Steigerwald, Matthew R. Dallas, Stephanie Samra
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