Late-Breaking Research: Clinical Research 2

• LB004 LB004 GPER modulates microbial liver gut axis and suppresses hepatocellular carcinoma Shweta Singh, Valerie Ledezma, Sierra Vidaurri, Hossain Ahmed, Anupam Dhasmana, Swati Dhasmana, Murali Mohan Yallapu, Diane Nguyen, Subhash C. Chauhan, Sheema Khan
• LB114 · PDF Clinical feasibility study of an AI-driven liquid biopsy platform using Raman spectroscopy of plasma extracellular vesicles (EV) Seungwook Kim, Jongwon Kim, Jiyeong Heo, On Shim, Yejin Won, Yong Park, Yeonho Choi, Hyunku Shin
• LB115 · PDF ctDNA false negativity in colorectal cancer reflects CMS3 phenotype and DNASE1L3 positive macrophages, identifying recurrence prone subgroup Hiromichi Ebi, Rui Yamaguchi, Yoshiaki Nakamura, Satoru Kisoda, Jun Watanabe, Osamu Muto, Hiroki Yukami, Saori Mishima, Hideaki Bando, Hiroya Taniguchi, Ichiro Takemasa, Takeshi Kato, Alexey Aleshin, Daisuke Kotani, Issei Imoto, Eiji Oki, Masahiro Aoki, Takayuki Yoshino
• LB116 LB116 Error-corrected plasma whole-genome sequencing for personalised and tumor-agnostic minimal residual disease detection in NSCLC Jonathan Wan, Sophie Ward, Alexander Azizi, Hila Benjamin, Raju Veeriah, Siân Harries, Jeanette Kittel, Nika Iremadze, Itai Rusinek, Gat Kreiger, Ariel Jaimovich, Jacqui Shaw, Allan Hackshaw, Nnennaya Kanu, Elena Helman, Mariam Jamal-Hanjani, Charles Swanton
• LB117 · PDF Serum cell free DNA based duplex methyLight assay for liquid biopsy based detection of epithelial ovarian cancer Deepa Bisht, Manisha Sachan
• LB118 · PDF Precision profiling of TP53 alterations in advanced cancers: Real-world evidence linking mutation class to genomic instability and cooccurring actionable drivers Atul Bharde, Devika Deshmukh, Pooja Sant, Hrishita Kothavade, Sandhya Iyer, Sumit Halder, Ajay Pandita, Mohan Uttarwar, Gowhar Shafi, Kumar Prabhash
• LB119 LB119 An integrated DNA methylation-based and multidimensional risk factor model for predicting breast cancer progression Chin-Sheng Hung, Ruo-Kai Lin
• LB120 · PDF Driver-specific MRD strategy associated with pathological response and predicted recurrence in stage III driver-mutant NSCLC receiving neoadjuvant treatment Jian Hu, Xiao Teng, Ziming Li, Yu Qi, Feng Li, Qixun Chen, Changbin Zhu, Xing Li, Shun Lu
• LB121 · PDF Multi-omic, HER2-directed monitoring in metastatic breast cancer through a clinic-ready wearable cytokine biosensor Reza Bayat Mokhtari, Elnaz Haghani, Fatemeh Rahimi, Shahak Rozenblat, Soroosh Arshadi, Pedram Torabian, Milad Falahat Chian, Terry Sachlos, Narges Baluch, Razieh Salahandish
• LB122 · PDF Dynamic interactions of spatially organized tumor, stromal and immune cellular niches predict outcome to immune checkpoint blockade (ICB) in recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC) Grégoire Marret, Jinsu An, Farnoosh Abbas Aghababazadeh, Kewei Ni, Lucas Penny, Martin Hyrcza, Ben X. Wang, Enrique Sanz-Garcia, Anna Spreafico, Giselle Boukhaled, Simone Stone, Aaron R. Hansen, Troy Ketela, Benjamin Haibe-Kains, Scott V. Bratman, Pinaki Bose, Lillian L. Siu
• LB123 · PDF Spatial immune architecture at single-cell resolution predicts response to atezolizumab plus bevacizumab in advanced HCC Anna Vila-Escoda, Marta Piqué-Gili, Marta Casado-Pelaez, Roser Pinyol, Ana Hernández de Sande, Verónica Davalos, Albert Gris-Oliver, Carla Montironi, Judit Peix, Daniela Grases, Ezequiel Mauro, Guillem Cano-Segarra, Sarah Cappuyns, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez-Kozlova, Tim Meyer, Anja Lachenmayer, Jens U Marquardt, Helen L Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Sacha Gnjatic, Jean-Frederic Blanc, Richard A Hubner, Matthias Pinter, Tom Luedde, Arndt Vogel, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Jeroen Dekervel, Eduard Porta-Pardo, Josep M Llovet
• LB124 · PDF Patient-derived organoid-immune cell co-cultures and spatial biology support a CD44v9 cancer stem cell-directed therapeutic strategy for adamantinomatous craniopharyngioma Abigail G. Branch, Xi Sun, Arturo A. Lujan, Jia-Ren Lin, Yi-Chien Wu, Jennifer Eschbacher, Beth Hermes, Andrew S. Little, Yoshie Umemura, Sandro Santagata, Yana Zavros
• LB125 · PDF Automated immunohistochemical assay for detection of homozygous methylthioadenosine phosphorylase (MTAP) gene deletion based on absence of MTAP protein staining Lia Caldwell, Adrian Ostertag, P. Daniel Warren, Logan Morales, Leslie Williams, Nathaniel Hart, Julie Cheung, Yu-Chan Chen, Ken Wang, Hui Zhang, YingMei Liu, Zhiming Liao, Lina Liu, Weiwei Cai, Aram B. Cholanians, Hanen A. Alassady, Justyna Gozdz, Andres Mariscal, Ranjitha Veerappan, Deepa Kasuganti, Tsu-Shuen Tsao
• LB126 · PDF Carrier platin coupled with low dose focal SmART+ X-ray irradiation yields better tumor control than either alone Nate Fredette, Yongbin Liu, Yogindra Vedvyas, Yoo-Shin Kim, Yanping Yang, Moonsoo M. Jin
• LB127 · PDF Drivers and patterns of disease progression as a novel schema for risk stratification in metastatic non-small cell lung cancer Gabriela R. Esnaola, Mengru Wang, Jeffrey J. Ishizuka, Benjamin J. Resio, Alexander Pan, Daniel Lee, Aaron Cohen, Madeleine Schmitter, Kelly L. Olino
• LB128 · PDF Mapping genomically classified molecular clusters to therapeutic outcomes in a pan-Indian lung cohort: A strategy for smarter clinical trial randomization Vidya Veldore, Giridharan Periyasamy, Anjali Kulkarni, Chirantan Bose, Kumar Prabhash, Supriya Goud, Akhil Kapoor, Satya Narayan Sarswat, Kaushal Kalra, Rup Jyoti Sarma, Surender Beniwal, Hitesh Goswami, Kshitij Datta Rishi, Prabakar Sampath, Praveen Kumar Jha, Rahul Kumar
• LB129 · PDF Clinical efficacy of computational reasoning for personalized treatment planning in a pan-cancer cohort discussed by a French multidisciplinary tumor board: A real-world experience-based analysis Barbara Vodicska, Eniko Kispeter, Dora Lakatos, Gabor G. Kalmar, Robert Doczi, Dora Gorog-Tihanyi, Anna Dirner, William T. Beck, Ivan Bieche, Edith Borcoman, Nicolas Servant, Kenza Nedara, Sarah Watson, Celia Dupain, Istvan Petak, Christophe Le Tourneau
• LB130 · PDF High adherence to mammography screening before and after MCED testing Charles H. McDonnell, Gretchen M. Stipec, Arushi Chadha, Anuraag R. Kansal, Claire O'Connell, Alice Kate Cummings Joyner, Andrew J. Epstein, Eric T. Fung, A. Mark Fendrick
• LB131 · PDF The communal process through which prostate cancer survivors and their partners affect each other's diets: A qualitative descriptive study Jingle Xu, Lisa H. Ranzinger, Stephanie Sperry, Hung-jui Tan, Lixin Song, Jennifer Leeman, Baiming Zou, Rachel Hirschey
• LB132 · PDF Doxorubicin impairs the blood-brain barrier in a microfluidic model of the human neurovascular unit Kristen McGovern, Elvis Cuevas, Zahra Kolahchi, Traver Wright, Christopher Danesi, Kathleen Randolph, Richard Pyles, Abbey Berenson, Randall Urban, Carrie Maxwell, Aaron Miller, Melinda Sheffield-Moore

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