Late-Breaking Research: Clinical Research 2

• LB004 LB004 GPER调控微生物肝-肠轴并抑制肝细胞癌 GPER modulates microbial liver gut axis and suppresses hepatocellular carcinoma Shweta Singh, Valerie Ledezma, Sierra Vidaurri, Hossain Ahmed, Anupam Dhasmana, Swati Dhasmana, Murali Mohan Yallapu, Diane Nguyen, Subhash C. Chauhan, Sheema Khan
• LB114 · PDF 利用血浆细胞外囊泡（EV）拉曼光谱的AI驱动液体活检平台的临床可行性研究 Clinical feasibility study of an AI-driven liquid biopsy platform using Raman spectroscopy of plasma extracellular vesicles (EV) Seungwook Kim, Jongwon Kim, Jiyeong Heo, On Shim, Yejin Won, Yong Park, Yeonho Choi, Hyunku Shin
• LB115 · PDF 结直肠癌中ctDNA假阴性反映CMS3表型和DNASE1L3阳性巨噬细胞，识别出易复发亚组 ctDNA false negativity in colorectal cancer reflects CMS3 phenotype and DNASE1L3 positive macrophages, identifying recurrence prone subgroup Hiromichi Ebi, Rui Yamaguchi, Yoshiaki Nakamura, Satoru Kisoda, Jun Watanabe, Osamu Muto, Hiroki Yukami, Saori Mishima, Hideaki Bando, Hiroya Taniguchi, Ichiro Takemasa, Takeshi Kato, Alexey Aleshin, Daisuke Kotani, Issei Imoto, Eiji Oki, Masahiro Aoki, Takayuki Yoshino
• LB116 LB116 用于NSCLC个体化及肿瘤无关微小残留病检测的纠错血浆全基因组测序 Error-corrected plasma whole-genome sequencing for personalised and tumor-agnostic minimal residual disease detection in NSCLC Jonathan Wan, Sophie Ward, Alexander Azizi, Hila Benjamin, Raju Veeriah, Siân Harries, Jeanette Kittel, Nika Iremadze, Itai Rusinek, Gat Kreiger, Ariel Jaimovich, Jacqui Shaw, Allan Hackshaw, Nnennaya Kanu, Elena Helman, Mariam Jamal-Hanjani, Charles Swanton
• LB117 · PDF 基于血清游离DNA的双重MethyLight检测用于基于液体活检的上皮性卵巢癌检测 Serum cell free DNA based duplex methyLight assay for liquid biopsy based detection of epithelial ovarian cancer Deepa Bisht, Manisha Sachan
• LB118 · PDF 晚期癌症中TP53改变的精准分析：将突变类别与基因组不稳定性及共存可靶向驱动因素相联系的真实世界证据 Precision profiling of TP53 alterations in advanced cancers: Real-world evidence linking mutation class to genomic instability and cooccurring actionable drivers Atul Bharde, Devika Deshmukh, Pooja Sant, Hrishita Kothavade, Sandhya Iyer, Sumit Halder, Ajay Pandita, Mohan Uttarwar, Gowhar Shafi, Kumar Prabhash
• LB119 LB119 一种基于DNA甲基化的整合式多维风险因素模型用于预测乳腺癌进展 An integrated DNA methylation-based and multidimensional risk factor model for predicting breast cancer progression Chin-Sheng Hung, Ruo-Kai Lin
• LB120 · PDF 驱动基因特异性MRD策略与接受新辅助治疗的III期驱动基因突变型NSCLC的病理反应及预测复发相关 Driver-specific MRD strategy associated with pathological response and predicted recurrence in stage III driver-mutant NSCLC receiving neoadjuvant treatment Jian Hu, Xiao Teng, Ziming Li, Yu Qi, Feng Li, Qixun Chen, Changbin Zhu, Xing Li, Shun Lu
• LB121 · PDF 通过临床可用的可穿戴细胞因子生物传感器对转移性乳腺癌进行多组学、HER2导向的监测 Multi-omic, HER2-directed monitoring in metastatic breast cancer through a clinic-ready wearable cytokine biosensor Reza Bayat Mokhtari, Elnaz Haghani, Fatemeh Rahimi, Shahak Rozenblat, Soroosh Arshadi, Pedram Torabian, Milad Falahat Chian, Terry Sachlos, Narges Baluch, Razieh Salahandish
• LB122 · PDF 空间组织的肿瘤、基质和免疫细胞生态位的动态相互作用可预测复发或转移性头颈部鳞状细胞癌（RM-HNSCC）对免疫检查点阻断（ICB）的疗效 Dynamic interactions of spatially organized tumor, stromal and immune cellular niches predict outcome to immune checkpoint blockade (ICB) in recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC) Grégoire Marret, Jinsu An, Farnoosh Abbas Aghababazadeh, Kewei Ni, Lucas Penny, Martin Hyrcza, Ben X. Wang, Enrique Sanz-Garcia, Anna Spreafico, Giselle Boukhaled, Simone Stone, Aaron R. Hansen, Troy Ketela, Benjamin Haibe-Kains, Scott V. Bratman, Pinaki Bose, Lillian L. Siu
• LB123 · PDF 单细胞分辨率的空间免疫结构可预测晚期HCC对atezolizumab联合bevacizumab的疗效 Spatial immune architecture at single-cell resolution predicts response to atezolizumab plus bevacizumab in advanced HCC Anna Vila-Escoda, Marta Piqué-Gili, Marta Casado-Pelaez, Roser Pinyol, Ana Hernández de Sande, Verónica Davalos, Albert Gris-Oliver, Carla Montironi, Judit Peix, Daniela Grases, Ezequiel Mauro, Guillem Cano-Segarra, Sarah Cappuyns, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez-Kozlova, Tim Meyer, Anja Lachenmayer, Jens U Marquardt, Helen L Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Sacha Gnjatic, Jean-Frederic Blanc, Richard A Hubner, Matthias Pinter, Tom Luedde, Arndt Vogel, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Jeroen Dekervel, Eduard Porta-Pardo, Josep M Llovet
• LB124 · PDF 患者来源类器官-免疫细胞共培养及空间生物学支持针对成釉细胞瘤型颅咽管瘤的CD44v9癌症干细胞导向治疗策略 Patient-derived organoid-immune cell co-cultures and spatial biology support a CD44v9 cancer stem cell-directed therapeutic strategy for adamantinomatous craniopharyngioma Abigail G. Branch, Xi Sun, Arturo A. Lujan, Jia-Ren Lin, Yi-Chien Wu, Jennifer Eschbacher, Beth Hermes, Andrew S. Little, Yoshie Umemura, Sandro Santagata, Yana Zavros
• LB125 · PDF 基于MTAP蛋白染色缺失检测纯合性甲硫腺苷磷酸化酶（MTAP）基因缺失的自动化免疫组织化学检测 Automated immunohistochemical assay for detection of homozygous methylthioadenosine phosphorylase (MTAP) gene deletion based on absence of MTAP protein staining Lia Caldwell, Adrian Ostertag, P. Daniel Warren, Logan Morales, Leslie Williams, Nathaniel Hart, Julie Cheung, Yu-Chan Chen, Ken Wang, Hui Zhang, YingMei Liu, Zhiming Liao, Lina Liu, Weiwei Cai, Aram B. Cholanians, Hanen A. Alassady, Justyna Gozdz, Andres Mariscal, Ranjitha Veerappan, Deepa Kasuganti, Tsu-Shuen Tsao
• LB126 · PDF 载体铂（Carrier platin）联合低剂量局部SmART+ X射线照射比单独使用任一疗法均能获得更好的肿瘤控制 Carrier platin coupled with low dose focal SmART+ X-ray irradiation yields better tumor control than either alone Nate Fredette, Yongbin Liu, Yogindra Vedvyas, Yoo-Shin Kim, Yanping Yang, Moonsoo M. Jin
• LB127 · PDF 疾病进展的驱动因素和模式作为转移性非小细胞肺癌风险分层的新框架 Drivers and patterns of disease progression as a novel schema for risk stratification in metastatic non-small cell lung cancer Gabriela R. Esnaola, Mengru Wang, Jeffrey J. Ishizuka, Benjamin J. Resio, Alexander Pan, Daniel Lee, Aaron Cohen, Madeleine Schmitter, Kelly L. Olino
• LB128 · PDF 在泛印度肺癌队列中将基因组分类的分子簇映射到治疗结局：一种更明智的临床试验随机化策略 Mapping genomically classified molecular clusters to therapeutic outcomes in a pan-Indian lung cohort: A strategy for smarter clinical trial randomization Vidya Veldore, Giridharan Periyasamy, Anjali Kulkarni, Chirantan Bose, Kumar Prabhash, Supriya Goud, Akhil Kapoor, Satya Narayan Sarswat, Kaushal Kalra, Rup Jyoti Sarma, Surender Beniwal, Hitesh Goswami, Kshitij Datta Rishi, Prabakar Sampath, Praveen Kumar Jha, Rahul Kumar
• LB129 · PDF 计算推理用于泛癌队列个体化治疗方案制定的临床疗效：一项由法国多学科肿瘤委员会讨论的真实世界经验分析 Clinical efficacy of computational reasoning for personalized treatment planning in a pan-cancer cohort discussed by a French multidisciplinary tumor board: A real-world experience-based analysis Barbara Vodicska, Eniko Kispeter, Dora Lakatos, Gabor G. Kalmar, Robert Doczi, Dora Gorog-Tihanyi, Anna Dirner, William T. Beck, Ivan Bieche, Edith Borcoman, Nicolas Servant, Kenza Nedara, Sarah Watson, Celia Dupain, Istvan Petak, Christophe Le Tourneau
• LB130 · PDF MCED检测前后乳腺X线钼靶筛查的高依从性 High adherence to mammography screening before and after MCED testing Charles H. McDonnell, Gretchen M. Stipec, Arushi Chadha, Anuraag R. Kansal, Claire O'Connell, Alice Kate Cummings Joyner, Andrew J. Epstein, Eric T. Fung, A. Mark Fendrick
• LB131 · PDF 前列腺癌幸存者及其伴侣相互影响彼此饮食的共同过程：一项定性描述性研究 The communal process through which prostate cancer survivors and their partners affect each other's diets: A qualitative descriptive study Jingle Xu, Lisa H. Ranzinger, Stephanie Sperry, Hung-jui Tan, Lixin Song, Jennifer Leeman, Baiming Zou, Rachel Hirschey
• LB132 · PDF 多柔比星（Doxorubicin）在人类神经血管单元微流控模型中损害血脑屏障 Doxorubicin impairs the blood-brain barrier in a microfluidic model of the human neurovascular unit Kristen McGovern, Elvis Cuevas, Zahra Kolahchi, Traver Wright, Christopher Danesi, Kathleen Randolph, Richard Pyles, Abbey Berenson, Randall Urban, Carrie Maxwell, Aaron Miller, Melinda Sheffield-Moore

在会议检索中浏览本分会场