PO.MCB06.02 · 分子与细胞生物学

DNA Methylation

23 张海报 22 张含资料时间 Apr 20 2026 9:00AM 区域 Section 22

1949 · PDF 携带嵌合染色体改变的白细胞克隆性扩增加速表观遗传衰老并重塑局部DNA甲基化 Clonal expansion of leukocytes harboring mosaic chromosomal alterations accelerates epigenetic aging and reshapes local DNA methylation Corey D. Young, Charles Breeze, Derek W. Brown, Rebecca Lynn Kelly, Kara Marie Barnao, Aubrey K. Hubbard, Amy Hutchinson Hutchinson, BELYNDA HICKS, Aurélie L. Vogt, Wen-Yi Huang, Steven C. Moore, Stephen J. Chanock, Mitchell J. Machiela
1950 · PDF 整合转录组学与表观基因组学分析，研究吸烟诱导的cg05575921低甲基化增加肺癌风险的机制 Integrated transcriptomic and epigenomic analysis to study the mechanism by which smoke-induced hypomethylation of cg05575921 increases lung cancer risk Matthew Gladstone, Khoi Huynh, Chunli Yan, Kimberly D. Siegmund, Aram Modrek, Ite Offringa
1951 · PDF 非破坏性甲基化测序可在FFPE和cfDNA样本中同时检测遗传变异与表观遗传变异 Non-destructive methylation sequencing enables concurrent detection of genetic and epigenetic variation in FFPE and cfDNA samples Max Boeck, Jennifer Pavlica, Craig MARSHALL, Travis Sanders, Kristina Giorda, Martin Ranik, Eduard Casas, Thomas D. Harrison, Kailee Reed, Aaron Garnett, Doug Wendel, Brian Kudlow
1952 · PDF 实现位点特异性DNA甲基化操控的新型小鼠模型 Novel mouse models enabling locus-specific manipulation of DNA methylation Julia M. Salamat, Li Yang, Xiaomin Chen, Eduardo Lopez, Lanlan Shen
1953 1953 通过使用DNA甲基化沉默基因进行筛选获得的FERMT基因新型合成致死组合 A novel synthetic lethal combination of FERMTs obtained by screening using DNA methylation-silenced genes Takahiro Ebata, Ryoma Mashiko, Yumi Furuichi, Qichun Wang, Yui Ohashi, Toshikazu Ushijima
1954 · PDF 原发性乳腺癌的空间及单细胞DNA甲基化分析揭示谱系独立的表观遗传可塑性 Spatial and single-cell DNA methylation analysis of primary breast cancer reveals lineage independent epigenetic plasticity Ruslan Strogantsev, Aysegul Ors, Jamie Endicott, Aaron R. Doe, Hugo Cros, Joseph Hwang, Hisham Mohammed
1955 · PDF 早期生命肠道菌群编程肠道干细胞表观遗传以在晚年防止结肠癌 Early-life gut microbiota programs intestinal stem cell epigenetics to protect against colon cancer later in life Li Yang, Shirui Zhou, Xiaomin Chen, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M. Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen
1956 · PDF DNA甲基转移酶抑制联合免疫检查点/PARP抑制剂在结直肠癌临床前模型中的疗效 Efficacy of DNA methyltransferase inhibition in combination with immune-checkpoint/PARP-inhibitor in colorectal cancer preclinical model Pooja Mittal, Jae Ho Lo, Ben Yi Tew, Goar Smbatyan, Sandra Algaze, Lesly Torres Gonzalez, Unnati Hemant Shah, Michela Bartolini, Yan Yang, Steve Soto Trujillo, Wu Zhang, Josh Millstein, Gangning Liang, Bodour Salhia, Shivani Soni, Heinz Josef Lenz
1957 · PDF DNA甲基化区分具有不同吸烟史和分级的早期肺腺癌起源细胞 DNA methylation differentiates early-stage lung adenocarcinoma cells-of-origin with distinct smoking history and grade Xuan Cindy Li, Diego Almanza, Phuc Huu Hoang, Thi-Van-Trinh Tranh, Nicholas H. Juul, Maximilian Diehn, Tushar J. Desai, Maria Teresa Landi
1958 · PDF 靶向UHRF1-SUV39H1/H2串扰可增强DNMT1抑制剂在结肠癌中的疗效 Targeting UHRF1-SUV39H1/H2 crosstalk enhances DNMT1 inhibitor efficacy in colon cancer Yanqing Liu, Joel A. Hrit, Alison A. Chomiak, Stephanie Stransky, Jordan Hoffman, Rochelle L. Tiedemann, Ashley K. Wiseman, Leena S. Kariapper, Bradley M. Dickson, Evan J. Worden, Christopher J. Fry, Simone Sidoli, Scott B. Rothbart
1959 · PDF 甲基化DNA标志物在准确检测高危HPV阳性宫颈病变中的潜力 The potential of methylated DNA markers for accurate detection of high-risk, HPV-positive cervical lesions Roshni Saravanan, Mary Jo Fackler, Madison Pleas, Wenfei Xia, Tomisin Adebari, Gang Yu, Liqun Zhang, Suzette Jordaan, Eunice Van Den Berg, Pamela Michelow, Reubina Wadee, Maureen Joffe, Wenlong Carl Chen, Youxiang Wang, Leslie Cope, Saraswati Sukumar
1960 · PDF 癌症中表观遗传细胞身份的稳定性 The stability of epigenetic cell identity in cancer Cameron Cloud, Benjamin Steinberg, Yitzhak Reizel, Wanding Zhou
1961 · PDF 在两个独立队列中鉴定出与早发性结直肠癌肿瘤位置相关的DNA甲基化特征 DNA methylation signatures associated with tumor location in early-onset colorectal cancer identified across two independent cohorts Aniruddha B. Rathod, Sandi L. Pruitt, Amit G. Singal, Caitlin C. Murphy
1962 · PDF BCOR-PRC1.1复合物的表观遗传重塑决定AML对IDH抑制剂的应答与耐药 Epigenetic remodeling of BCOR-PRC1.1 complex dictates response and resistance to IDH inhibitors in AML Sarah Hanache, Xiaoyan Zhang, Satoko Ogata, Hidetaka Uryu, Ken Furudate, Zongrui Li, Abhinav Jain, Erika Thompson, Courtney D. Dinardo, Margaret A. Goodell, Koichi Takahashi
1963 · PDF 印度前列腺癌患者队列中表观遗传改变的全景 The landscape of epigenetic alterations in the prostate cancer patient cohort from India Promit Ganguly, Tanay Biswas, Atin Singhai, Alok Srivastava, Abhishek Chauhan, Manzoor Ahmad, Piyush Tripathi, Sanjeev Mehrotra, Anjali Tewari, Nuzhat Husain, Apul Goel, Bushra Ateeq
1964 · PDF 年龄相关的p16表观突变是Kras突变型肺癌的可靶向驱动因素 Age-related p16 epimutation is a targetable driver of Kras -mutant lung cancer Xiaomin Chen, Li Yang, Eduardo Lopez, Lili Ma, Chao Cheng, Lanjing Zhang, Lanlan Shen
1965 · PDF 结直肠和乳腺肿瘤微环境中保守的内皮细胞特异性DNA甲基化改变 Conserved endothelial cell-specific DNA methylation alterations in colorectal and breast tumor microenvironments Barbara Karakyriakou, Ze Zhang, Lucas A. Salas Diaz, Brock C. Christensen
1966 · PDF 维生素C通过维持衰老相关基因增强子的低甲基化状态延缓小鼠胚胎细胞的永生化 Vitamin C delays mouse embryonic cells immortalization by maintaining enhancer hypomethylation of senescence-related genes Guillermo A. Urrutia, Minmin Liu, Rachel Shereda, Stacey L. Thomas, Gangning Liang, Peter A. Jones
1967 · PDF 在泛癌种临床队列中使用酶法甲基化测序对循环肿瘤DNA进行基于甲基化的分类 Methylation-based classification of circulating tumor DNA using enzymatic methyl-seq in a pan-cancer clinical cohort Kimberly A. Holden, Ashraf Shabaneh, Dennis D. Krutkin, Adib Shafi, Tong Liu, Kerry D. Fitzgerald, Eyad Almasri, Yuanyu Cao, Xiaojun Guan, Graham McLennan, Nathan Faulkner, Shakti Ramkissoon, Marcia Eisenberg, Brian Caveney, Eric Severson, Taylor J. Jensen, Jonathan Williams
1968 · PDF 通过抑制DNMT1进行表观遗传重编程可降低多西他赛耐药前列腺癌的侵袭和迁移 Epigenetic reprogramming via DNMT1 inhibition reduces invasion and migration in docetaxel-resistant prostate cancer Carmen M. Ortiz-Sanchez, Gabriela Castro, Shakira Abad, Solimar Esteves, Valerie Rodriguez, Stephanie Montalvo, Rodniel Aviles, Ralphdy Vergne, Gustavo Alayón, Caleb Santiago, Lenin Godoy, Kosj Yamoah, Gilberto Ruiz-Deya, Jong Y. Park
1969 · PDF zebularine的低甲基化活性抑制多西他赛耐药前列腺癌细胞的迁移 Hypomethylating activity of zebularine suppresses migration in docetaxel-resistant prostate cancer cells Gabriela Castro Morales, Daniela Gonzalez, Gustavo Alayón, Ralphdy Vergne, Lenin Godoy, Jong Y. Park, Gilberto Ruiz-Deya, Carmen M. Ortiz-Sanchez
1970 · PDF 5-氮杂胞苷的表观遗传调控降低多西他赛耐药前列腺癌3D球体模型中的侵袭性表型 Epigenetic modulation with 5-Azacytidine reduces aggressive phenotypes in 3D spheroid models of docetaxel-resistant prostate cancer Alanis Paola Torres Rosado, Gabriela Castro Morales, Lenin J. Godoy, Jong Y. Park, Gilberto Ruiz Deya, Carmen M. Ortiz-Sanchez
1971 · PDF DKC1、TERC和TINF2致病性种系变异导致的独特全基因组DNA甲基化特征 Distinct genome wide DNA methylation signatures due to pathogenic germline variants in DKC1 , TERC , and TINF2 Kelvin César De Andrade, Gina Ney, Tianna Zhao, Shilpa Gaddam, Jia Liu, Kristine Jones, Lisa J. McReynolds, Neelam Giri, Sharon A. Savage

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