Immune Checkpoints

• 2796 · PDF 将联合PD1和LAG3抑制从临床前模型转化至难治性DNA复制修复缺陷（RRD）胶质母细胞瘤患者：一项IRRDC研究 Translating combined PD1 and LAG3 inhibition from preclinical models to patients with refractory, DNA replication repair deficient (RRD) glioblastoma: An IRRDC study Anirban Das, Vienna Mazzoli, Owen Crump, Olha Kos, Nuno M. Nunes, Lucie Stengs, Amanda Li, Adrian Levine, Yoshiko Nakano, Hope Friedman, Katharine O'Flaherty, Alexander Stein, Gadi Abebe-Campino, Annika Bronsema, Vanessa Bianchi, Melissa Edwards, Stergios Zacharoulis, Birgit Ertl-Wagner, Daniel A. Morgenstern, Trevor J. Pugh, Pamela Ohashi, Eric Bouffet, Cynthia E. Hawkins, Peter B. Dirks, Uri Y. Tabori
• 2797 · PDF 一个针对PD-1的巨噬细胞内吞检查点决定持久反应与超进展反应 A macrophage endocytic checkpoint for PD-1 governs durable vs hyperprogressive response Madhubanti Mullick, Ella McLaren, Suchismita Roy, Brandon Biagas, Mahitha Anandachar, Vanessa Castillo, Samuel Williams, Celia Espinoza, Courtney Tindle, Gajanan Katkar, Saptarshi Sinha, Pradipta Ghosh
• 2798 · PDF CD112通过鞘脂代谢依赖性重塑CD8+ T细胞受体格局并导致功能障碍，驱动HER2阳性乳腺癌的肿瘤免疫逃逸 CD112 drives tumor immune evasion in HER2-positive breast cancer through sphingolipid metabolism-dependent remodeling of CD8+T cell receptor landscapeand consequent dysfunction YI ZHANG, Bingqiu Xiu, Jiong Wu, Qi Zhang
• 2799 · PDF 肿瘤IL-33/ST2信号通过减少抗原呈递驱动免疫逃逸 Tumoral IL-33/ST2 signaling drives immune escape through reduced antigen presentation Alyssa Mauri Cornista, Tao Yu, Zhuolong Zhou, Nikša Roki, Alberto Sigler, David M. Suissa, Haniyeh Eyvani, George E. Sandusky, Rimpi Khurana, Yan Guo, Molly Dalzell, Shyamananda Singh Mayengbam, Prasenjit Dey, Christine Rafie, Erietta Stelekati, Jashodeep Datta, Saratchandra S. Khumukcham, Jatin Roper, Nivedh Paluvoi, Sandro Satta, Daniel Bilbao Cortes, Alejandro Villarino, Kevin Van der Jeught
• 2800 · PDF 阐明CD4+ T细胞使间充质型CD73缺陷肿瘤对抗CTLA4免疫检查点阻断治疗敏感的机制 Understanding the mechanism by which CD4 + T cells sensitize mesenchymal CD73-deficient tumors to anti-CTLA4 immune checkpoint blockade therapy Brian Hongtao Feng, Caitie Hanna Sams, Isabel O'Connell, Shiney Chandraganti, Anushka Dongre
• 2801 · PDF SRY介导的PD-L1上调促进肝细胞癌的免疫逃逸并造成免疫治疗反应中的性别特异性差异 SRY-mediated upregulation of PD-L1 promotes immune evasion in hepatocellular carcinoma and contributes to sex-specific disparities in immunotherapy response Bingyi Ren, Kai Sheng, Yichen Yang
• 2802 · PDF 用于免疫调节剂评估的体外抗原特异性T细胞耗竭模型 In vitro antigen-specific T cell exhaustion model for immunomodulators evaluation Emilio Cosimo, Hannah Findlay, Robert Benson, Agapitos Patakas
• 2803 · PDF 用于表征和预测患者特异性免疫治疗药物反应的离体微肿瘤检测平台 Ex vivo micro-tumor testing platform to characterize and predict patient-specific immunotherapy drug responses Felix M. Behr, Esmee Koedoot, Timothy J. P. Sijsenaar, Léa Le Large, Cor D. de Kroon, Anne van Altena, Farbod Khoraminia, Laurie C. Steinbusch, Christi M. Steendam, Dieudonné J. van der Meer, Willemijn Vader, Nelleke Ottevanger, Judith R. Kroep
• 2804 · PDF 唾液酸抑制衔接器介导的T细胞活化 Sialic acid inhibits engager-mediated T cell activation Johanna Nimmerfroh, Dinah Heiligensetzer, Michael Sandholzer, Anastasiya Börsch, Heinz Laubli
• 2806 · PDF 肌红蛋白表达增强T细胞代谢和抗肿瘤效应功能 Myoglobin expression boosts T-cell metabolism and antitumor effector function Julia Werner, Haifeng Xu, Georgios Theodorakis, Ichiro Katahira, Mitrajit Ghosh, Michal Gorzkiewicz, Luisa de Sousa Santos, Ann Kathrin Bergmann, Max Anstötz, Anne Busch, Diran Herebian, Sascha Dietrich, Carsten Berndt, Ertan Mayatepek, Aleksandra Pandyra, Dirk Brenner, Philipp Lang
• 2807 2807 SMARCB1缺陷型肾髓质癌中对LAG3阻断的免疫细胞依赖性耐药 Immune cell-dependent resistance to LAG3 blockade in SMARCB1-deficient renal medullary carcinoma Jing Qian, Kai Yu, Deepa Bisht, Melinda Soeung, Pankaj Chauhan, Fei Duan, Menuka Karki, Rong He, Nizar M. Tanir, Hania Khan, Zilong Zhao, Luigi Perelli, Giannicola Genovese, Linghua Wang, Jianjun Gao, Pavlos Msaouel
• 2808 · PDF 一种同类首创的VIP受体拮抗剂作为急性髓系白血病的免疫治疗药物 A first in class VIP receptor antagonist as an immunotherapeutic for acute myeloid leukemia Swapnaa Balaji, Antonio Ward, Yuou Wang, Jian-Ming Li, Srijon Sarkar, Sonia Mecorapaj, Tenzin Kalsang, Shuhua Wang, Cynthia Giver, Edmund Waller
• 2809 · PDF VIP/VPAC信号作为TP53突变型急性髓系白血病中的吞噬检查点 VIP/VPAC signaling as a phagocytosis checkpoint in TP53-mutated acute myeloid leukemia Zihan (Clarence) Chen, Tuisha Gupta, Fanyuan Zeng, Yujie Chen, Jian Ming Li, Cynthia R. Giver, Kiranj Chaudagar, Edmund K. Waller
• 2810 · PDF 抗PD-1疗效与由具有淋巴结归巢能力的慢性效应细胞组成的克隆轨迹相关 Anti-PD-1 efficacy is associated with a clonal trajectory composed of chronic effectors with lymph node homing capacity Mingshuang Wang*, Guanning Wang*, Khushboo Patel, Ajeya Nandi, Timmy Lai, Shira Rosenberg, Zhoumu Xiang, Stella Park, Tara C. Mitchell, Alexander C. Huang#
• 2812 · PDF Bhlhe40塑造对抗PD1和抗CTLA4免疫检查点治疗的不同T细胞反应 Bhlhe40 shapes distinct T cell reponses to anti PD1 and anti CTLA4 immune checkpoint therapy Akata Saha, Tomoyuki Minowa, Alexander S. Shavkunov, Avery J. Salmon, Sunita Keshari, Kristen E. Pauken, Kenneth H. Hu, Ken Chen, Matthew M. Gubin
• 2813 · PDF 靶向AHR可克服三阴性乳腺癌中PD-L1驱动的免疫检查点阻断耐药 Targeting AHR overcomes PD-L1-driven resistance to immune checkpoint blockade in triple-negative breast cancer Minkyoung Choi, Ju Hee Kim, Han-Byoel Lee, Wonshik Han
• 2814 · PDF 响应免疫检查点阻断治疗的免疫生态系统综合单细胞图谱 Comprehensive single-cell atlas of immune ecosystem in response to immune checkpoint blockade therapy Dayoung Lee, Ji Yoon Lee, Jiwon Kim, You Jin Song, Namsung Moon, Juyoung Lee, Harim Koo, Jason K. Sa
• 2815 · PDF 细胞质PD-L1水平与小细胞肺癌的肿瘤进展相关 Cytoplasmic PD-L1 levels are associated with tumor progression in small cell lung cancer Ji Young Lee, Anindita Das, HyeonJoo Cheon
• 2816 · PDF 靶向TIGIT免疫检查点的新型多肽抑制剂的发现与临床前评估 Discovery and preclinical evaluation of novel peptide inhibitors targeting the TIGIT immune checkpoint Haozhe Cui, Xinyi Zhang, Wanding Wang, Francesco Zonta, Eyad Elkord
• 2817 · PDF 免疫检查点治疗在三阴性乳腺癌小鼠模型中诱导三级淋巴结构 Immune checkpoint therapy induces tertiary lymphoid structures in a murine model of triple-negative breast cancer Zachary D. Schrank, Benjamin G. Vincent, Jonathan S. Serody
• 2818 · PDF ALG-094295的临床前特征研究：一种高效、口服生物利用度良好的小分子PD-1/PD-L1抑制剂，靶向PD-L1的二聚化、内化和降解 Preclinical Characterization of ALG-094295, a highly potent and orally bioavailable small molecule PD-1/PD-L1 inhibitor targeting dimerization, internalization and degradation of PD-L1 Heleen Roose, Kristina Rekstyte-Matiene, Sarah Stevens, Kusum Gupta, Sandra Chang, Nour Fayyad, Cheng Liu, Vladimir Serebryany, Lillian Adame, Kha Le, Antitsa Stoycheva, Dinah Misner, Lawrence M. Blatt, Sushmita Chanda, David B. Smith, Julian A. Symons, Andreas Jekle, Tongfei Wu
• 2819 · PDF ALG-093940的临床前特征研究：一种高效、口服生物利用度良好的小分子PD-1/PD-L1抑制剂，靶向PD-L1的二聚化、内化和降解 Preclinical characterization of ALG-093940, a potent and orally bioavailable small molecule PD-1/PD-L1 inhibitor targeting PD-L1 dimerization, internalization and degradation Heleen Roose, Kristina Rekstyte-Matien, Sarah Stevens, Kusum Gupta, Sandra Chang, Nour Fayyad, Cheng Liu, Vladimir Serebryany, Lillian Adame, Kha Le, Antitsa Stoycheva, Dinah Misner, Lawrence M. Blatt, Leonid Beigelman, Sushmita Chanda, David B. Smith, Julian A. Symons, Andreas Jekle, Tongfei Wu
• 2820 · PDF PD1-PD-L2相互作用的空间图谱提示非小细胞肺癌中存在另一条检查点轴 Spatial mapping of PD1-PD-L2 interactions suggests an additional checkpoint axis in non-small cell lung cancer Anna Gorbunova, Amanda Lindberg, Lars Muhl, Ghazal Lessan Toussi, Hui Yu, Patrick Micke, Carina Strell
• 2821 · PDF TRIB2调控抗雄激素耐药性及神经内分泌前列腺癌中的免疫逃逸 TRIB2 regulates immune evasion in antiandrogen-resistant and neuroendocrine prostate cancer Sharad K. Suthar, Azizur Rahman, Sang-Yoon Lee, Jitender Monga
• 2822 · PDF 连续转录组分析捕捉新辅助免疫检查点抑制在可切除胃食管癌中的效应 Serial transcriptomic analyses capture the effects of neoadjuvant immune checkpoint inhibition in resectable gastroesophageal cancer Blair V. Landon, Christopher Cherry, Rachel Keogh, Jaime Wehr, Gavin Pereira, Noushin Niknafs, Richard J. Battafarano, Stephen C. Yang, Stephen Broderick, Jinny Ha, Russell K. Hales, K. Ranh Voong, Kristen A. Marrone, Chen Hu, Josephine L. Feliciano, Ali H. Zaidi, Ronan J. Kelly, Vincent K. Lam, Valsamo (Elsa) K. Anagnostou
• 2823 · PDF 单细胞RNA-seq揭示免疫检查点抑制剂效应的新见解 Single-cell RNA-seq reveals insights into the effects of immune checkpoint inhibitors Junting Lu, Jinghui Xiu, Ce Zhong, Wentao Li, Wei Yun, Tan Pang, Jingqi Huang
• 2824 2824 基因内重排负荷：预测TMB低癌症中免疫检查点阻断应答的一种新型生物标志物 Intragenic rearrangement burden: A novel biomarker to predict immune checkpoint blockade response in TMB-low cancers Akshat Gupta, Selena Xiao, Hillary Wang, Rohit Bhargava, Adrian V. Lee, Adam M. Brufsky, Xiaosong Wang

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