PO.BCS01.05 · 生物信息与计算
Application of Bioinformatics to Cancer Biology 5
- 5434 5434 基于蛋白质组学的肺癌免疫细胞浸润分析 Immune cell infiltration analysis of lung cancer based on proteomics Ruoxian Zhang, Liangcheng Lyu
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5436 · PDF HER2阳性和转移性乳腺癌中缺氧与常氧休眠热点的空间识别及预测 Spatial identification of hypoxic and normoxic dormancy hotspots predicting in her2-positive and metastatic breast cancer Tzu-Hung Hsiao, Fan Jhen Liu, Yu-Ting Kang, Kuo Yen Huang, Yidong Chen
- 5437 5437 利用分子技术和新型信息学平台灵敏检测罕见cfDNA变异:一种基因组与蛋白质组联合的MRD应用 Sensitive detection of rare cfDNA variants utilizing molecular technologies and a novel informatics platform: A combined genomic and proteomic MRD application Emma Kaitlyn Longshore, Ethan Barnett, Ingrid T. Erazo, Leisa Jackson, Helen Halpin, Reis Pestano, Patricia Schnepp, Adam Corner, Howard I. Scher, Gary A. Pestano
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5438 · PDF 食管鳞状细胞癌中的转录本异构体多样性:对非洲肿瘤异质性和治疗靶点的见解 Transcript isoform diversity in esophageal squamous cell carcinoma: Insights into tumor heterogeneity and therapeutic targets in Africa Sikhumbuzo Z. Mbatha, Mohammed Alaouna, Botle Precious Damane, Tebogo Marutha, Rodney Hulll, Jonathan Featherston, Aristotelis Chatziioannou, Zodwa Dlamini
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5439 · PDF 单细胞分辨率下人远端胆管癌导管细胞的共有与分化转录特征 Shared and divergent transcriptional signatures of ductal cells in distal human cholangiocarcinoma at a single cell resolution Meng Ting Chen, Jon M. Harrison, David R. Ruddy, Michelle Piquette, Jon Chang, Viviana Cremasco, Andrew L. Warshaw, Carlos Fernandez-Del Castillo, Andrew S. Liss, Divyansh Agarwal
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5441 · PDF R361H SMAD4突变对结直肠癌中TGF-β信号传导的结构和动力学影响 Structural and kinetic effects of R361H SMAD4 mutation on TGF-ß signaling in colorectal cancer Evan Boczko, Isaac Silverman, Yisrael Wiener, Sanjay Goel, Radhashree Maitra
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5442 · PDF 在空间转录组学中跨空间尺度识别细胞间相互作用 Identifying cell-cell interactions across spatial scales in spatial transcriptomics Alex C. Soupir, Mitchell T. Hayes, Brandon J. Manley, Lauren Cole Peres, Julia Wrobel, BROOKE FRIDLEY
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5443 · PDF 液体和组织基因组分析中的拷贝数丢失和体细胞杂合性缺失检测 Copy number loss and somatic loss of heterozygosity calling in liquid- and tissue-based genomic profiling Hao Wang, Andrew Gross, Adrian Bubie, Lauren Lawrence, Reagan Barnett, Bernard Herman, Matthew Ellis, Tingting Jiang
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5444 · PDF 液体活检平台中HLA I类等位基因分型的分析验证 Analytical validation of HLA class I allele typing in a liquid biopsy platform Adrian Bubie, Sante Gnerre, Marisa Juntilla, Reagan Barnett, Matthew Ellis, Tingting Jiang
- 5445 5445 通过分层分子分析揭示:巨噬细胞代谢重编程支撑浸润性黏液腺癌独特的免疫学结构 Macrophage metabolic rewiring underpins the distinct immunological architecture of invasive mucinous adenocarcinoma revealed through layered molecular profiling ShinYoung Park, KyungA Kim, Chung Lee, Byungjin Hwang, Hyo Sup Shim
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5446 · PDF BRCA1、RNA结合蛋白与miR-18a:乳腺癌中的分子三重奏(胜利) BRCA1, RNA-binding proteins, and miR-18a, a molecular tri(umph) in breast carcinoma Raiyan Satti, Anjana Saxena, Shaneen M. Singh
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5447 · PDF GSK3alpha的计算机模拟分析以鉴定用于癌症治疗的新型潜在配体 In silico analysis of GSK3alpha to identify novel potential ligands for cancer therapy Neha Sylvia Walter, Sanchit Dora, Jasmeet Kaur
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5448 · PDF 血清素转录轴塑造肺癌的免疫表型和临床结局 A serotonin transcriptional axis shapes immune phenotypes and clinical outcomes in lung cancer Ecem Kalemoglu, Salih Akgun, Ayse Caner
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5449 · PDF 存活模式和生存参数对脊椎动物癌症风险的影响 The effects of survivorship patterns and survival parameters on cancer risk across vertebrates Olivia K. Corrao, Walker Mellon, Zachary Taylor Compton, Harley Richker, Gissel Marquez Alcaraz, Stefania Kapsetaki, Joel Brown, Orsolya Vincze, Mathieu Giraudeau, Michael Lynch, Carlo C. Maley
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5450 · PDF 利用整合空间转录组学的肿瘤微环境PK模型解析ADC载荷动力学 Decoding ADC payload dynamics with a spatial transcriptomics-integrated tumor microenvironment PK model Sungwoo Bae, Jeongbin Park, Jin Yeong Choi, Daeseung Lee, Hyung-Jun Im, Hongyoon Choi
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5451 · PDF Omicology:一个基于AI/LLM/NLP的综合性网络资源,用于组学文献的本体、系统发生学及实用导航 Omicology: A comprehensive AI/LLM/NLP-based web resource for the ontology, phylogeny, and practical navigation of omics literature James M. Melott, John N. Weinstein
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5452 · PDF 深度学习实现从结直肠癌全外显子组读长中免配对正常样本估算肿瘤突变负荷 Deep learning enables matched-normal free estimation of tumor mutational burden from whole exome reads in colorectal cancer Amrita Chattopadhyay, Liang-Yu Lin, Ching-Tai Chen, Eric Y. Chuang
- 5453 5453 机器学习加速发现协同性PI3K-mTOR组合,用于强效抑制KRAS G12突变患者来源异种移植瘤的肿瘤生长 Machine learning accelerates discovery of synergistic- PI3K-mTOR combinations for robust tumor growth inhibition in KRAS G12 mutant patient-derived xenografts Emily Eastwood, Yuan-Hung Chien, Jose Lopez-Ramos, Paris Offor, Warren Andrews, Long Hoang Do, Raffaella Pippa
- 5454 5454 鉴定microRNA簇作为急性髓系白血病化疗反应的预测因子 Identification of microRNA clusters as predictors of chemotherapy response in acute myeloid leukemia Ziang Chen, Jennifer Rangel Ambriz, Yu-Hsuan Fu, David Eugene Frankhouser, Denis O'Meally, Lianjun Zhang, Ying-Chieh Chen, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Guido Marcucci, Russell Rockne, Ya-Huei Kuo
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5455 · PDF RNA-seq图谱分析鉴定FOX基因作为潜在的CRC生物标志物 RNA-seq profiling identifies FOX genes as potential CRC biomarkers Yakshi Nicole Ortiz-Maldonado, Hilmaris Centeno-Girona, Camille Zenon-Melendez, Sheila Natalie Lopez-Acevedo, Elba V. Caraballo
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5456 · PDF 多平台生物信息学图谱分析鉴定TTK和NEK2为三阴性乳腺癌中与生存相关的驱动因子 Multiplatform bioinformatic profiling identifies TTK and NEK2 as survival-associated drivers in triple-negative breast cancer Alexandra N. Aquino-Acevedo, Esther M. Irizarry-Quintana, Ángel D. Colón-Burgos, Marileana Rodríguez-Ruiz, Joel A. Orengo-Orengo, Elliott Rodriguez-Lopez, Melanie E. Cruz-Robles, Harold I. Saavedra
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5457 · PDF 从肿瘤到模型:来自患者来源结直肠癌类器官的转录组学与治疗学洞见 From tumor to model: Transcriptomic and therapeutic insights from patient-derived colorectal cancer organoids Matthew Graziano, Ajeet Singh, Stephen Friend, Ruby E. Thamert, Utsav Sharma, Abhay Andar, Jonathan Jacobs, Carolina Lucchesi
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5458 · PDF 单细胞代谢通量分析界定肿瘤浸润免疫细胞中不同的代谢程序 Single-cell metabolic flux analysis defines distinct metabolic programs across tumor-infiltrating immune cells Yue Fang, Changlin Wan, Haiqi Zhu, Zheng An, Pengtao Dang, Chi Zhang, Sha Cao
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5460 · PDF 阐明断裂-融合-桥(BFB)介导的EGFR扩增在乐伐替尼耐药性肝细胞癌中的作用 Elucidation of breakage-fusion-bridge (BFB)-mediated EGFR amplification in lenvatinib-resistant hepatocellular carcinoma JungHyun (Jenny) Kim, Ji Young Kim, Hyeonu Yang, Sang Yun Ha, Han-Na Kim, Hoon Kim, Yeup Yoon, Wonseok Kang
- 5461 5461 一例来自非洲血统患者的原发性神经内分泌前列腺癌在患者来源异种移植(PDX)和类器官模型中的分子遗传学分析 Molecular genetic profiling of a de novo neuroendocrine prostate cancer in a patient-derived xenograft (PDX) and organoid model from an African ancestry patient Tej Sharma, Surendra Gulla, Sasikumar Ponnusamy, Abbas Jawadwala, Ephraim Gardner, Roberto Pili, Maddie Aust, John Bodkin, John Tomaszewski, Remi-adelaya Ogala
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6853 · PDF 一种在分子水平上建模高分辨率空间转录组学的无分割方法 A segmentation-free method for modeling high-resolution spatial transcriptomics at the molecule level Xiao Wang, Nan Zhang, Chi Zhang, Sha Cao