PO.BCS01.11 · 生物信息与计算

Liquid Biopsy: Multi-Analyte and Multi-Omic

28 张海报 28 张含资料时间 Apr 19 2026 2:00PM 区域 Section 5

94 · PDF 液体活检分析肿瘤微环境以判定实体瘤对免疫治疗方案的反应 Liquid biopsy profiling of the tumor microenvironment to determine response to immunotherapy regimens across solid tumors Erin L. Brown, Wubing Zhang, Abul Usmani, Noah Earland, Ayesha Hashmi, Chibuzor Olelewe, Anushka Viswanathan, Pradeep S. Chauhan, Minji Kang, Chloé B. Steen, Hyun Soo Jeon, Susanna Avagyan, Irfan Alahi, Nicholas P. Semenkovich, Matteo Bergsagel, Janella C. Schwab, Chloe M. Sachs, Kaushal Parikh, Faridi Qaium, Peter K. Harris, Antonella Bacchiocchi, Qingyuan Cai, Andrew J. Gentles, Rondell P. Graham, Peter C. Lucas, Ryan C. Fields, Jacob J. Orme, Aaron S. Mansfield, Mario Sznol, Ruth Halaban, David Y. Chen, Aaron M. Newman, Aadel A. Chaudhuri
95 · PDF PlasmaCHORD——一种用于在液体活检中识别克隆性造血变异的机器学习方法 PlasmaCHORD- A machine learning method for identifying clonal hematopoiesis variants in liquid biopsies Daniel J. Rabizadeh, Jenna VanLiere Canzoniero, Ilias Ziakas, Jaime Wehr, Archana Balan, Amna Jamali, Blair V. Landon, Susan Combs Scott, Gavin Pereira, Vincent K. Lam, Christine L. Hann, Christine M. Lovly, Jessica Tao, Patrick M. Forde, Joseph C. Murray, Mark Sausen, Gerrit A. Meijer, Geraldine Vink, Remond J. A. Fijneman, Victor E. Velculescu, Jillian Ayn Phallen, Robert Scharpf, Valsamo Anagnostou
96 · PDF 实时多模态ctDNA与影像学评估助力HPV相关口咽癌的适应性治疗 Real time multimodal ctDNA and imaging assessment enables adaptive treatment in HPV related oropharyngeal cancer Bill H. Diplas, David N. Brown, Xin Pei, Yingjie Zhu, Achraf Shamseddine, Chiharu Graybill, W. Michael Korn, Emily Westheimer, Luc GT Morris, Richard J. Wong, Sean M. McBride, Alan L. Ho, Heiko Schoder, Eric Sherman, Robert Daber, Nora Katabi, Jorge Reis-Filho, Britta Weigelt, Nancy Lee, Nadeem Riaz
98 · PDF 使用Oncuria-Monitor（一种基于尿液的多重免疫分析）监测膀胱癌复发 Surveillance for recurrent bladder cancer using Oncuria-Monitor, a urine-based multiplex immunoassay Sunao Tanaka, Charles Rosser, Yair Lotan, Menghan Liu, Takashi Kobayashi, Sima P. Porten, Yuki Kita, Yingye Zheng, Zhen Zhang, Hideki Furuya
99 · PDF 通过在基于DNA的检测中整合复杂基因组重排来增强EML4-ALK融合的检出 Enhanced detection of EML4-ALK fusions through integration of complex genomic rearrangements in DNA-based assays Aidan C. Manning, Sante Gnerre, Jamie Hutchins
100 · PDF 基于血液整合表观基因组图谱、TMB和MSI以预测晚期非小细胞肺癌（aNSCLC）对免疫检查点抑制剂的应答 Blood-based integration of epigenomic profiles, TMB, and MSI to predict immune checkpoint inhibitor response in advanced non-small cell lung cancer (aNSCLC) Sean Gordon, Jing Wang, Shile Zhang, Marisa Juntilla, Tingting Jiang, Matthew Ellis, Vishnu Ramani, Reagan Barnett, Bernard Herrman, Justin Odegaard, Darya Chudova
101 · PDF 基于片段组学对60,000份游离DNA样本进行癌症类型和亚型分类 Fragmentomics-based cancer type and subtype classification in 60,000 cell-free DNA samples Zhenjia Wang, Kevin Cabrera, Yanmei Huang, Daniel S. Lieber, Justin Y. Newberg, Ethan S. Sokol, Zoe Fleischmann
102 · PDF TAPS+实现对CSF来源ctDNA和FFPE中CNS肿瘤的直接5mC/5hmC分辨的基因组和甲基化分析 TAPS+ enables direct 5mC/5hmC-resolved genomic and methylation profiling of CNS tumors in CSF-derived ctDNA and FFPE Johnathan Rafailov, Eloise Freitag, Aditya Deshpande, Kevin Hadi, Camila Fang, Alexa Oviedo, Emma Hanley, August Kolb, Neha Dhasmana, Hannah Weiss, Chanel Schroff, Yiying Yang, Jonathan Serrano, Kazimierz Wrzeszczynski, Stergios Zacharoulis, Daniel Orringer, Alexandra M. Miller, Marcin Imielinski, Matija Snuderl
103 · PDF 一种基于多组学集成的方法用于在cfDNA液体活检中高特异性检测克隆性造血 A multiomic ensemble-based approach for high-specificity detection of clonal hematopoiesis in cfDNA liquid biopsy Patrick C. Fiaux, Mingyang Cai, Jeffrey L. Werbin, Andrew Gross, Che-Yu Lee, Marisa Juntilla, Tingtin Jiang, Reagan Barnett, Errin Lagow, Shile Zhang, Martina Lefterova, Darya Chudova
104 · PDF 一种用于预测和缓解伪影变异以检测分子残留病灶的机器学习方法 A machine learning approach to predict and mitigate artifact variants for molecular residual disease detection Violeta B. Guthrie, Aamir Shahpurwalla, Daryanaz Dargahi, Onur Sakarya, Spenser Alexander, Tina Wang, Fei Lu, Alexander Hsieh, Ryan Ptashkin, Matthew Rabinowitz, Eser Kirkizlar, Ahmet Zehir
105 · PDF 使用癌症特异性、基于甲基化的无组织检测对患者循环肿瘤DNA（ctDNA）进行定量以检测分子残留病灶（MRD） Quantification of circulating tumor DNA (ctDNA) in patients using cancer-specific, methylation-based, tissue-free tests for the detection of molecular residual disease (MRD) Princy Parsana, Tzu-Chun Chen, Nathan Liang, Amanda Kennedy, Veronica Rodriguez, Jie Zhang, Boris Gutman, Ehsan Haghshenas, Garima Kushwaha, Breeana L. Mitchell, Minetta Liu, Ehsan Tabari, Joshua Babiarz, Trupti Kawli, Johannes G. Reiter, Matthew Rabinowitz, Alexey Aleshin
106 · PDF 整合的血浆多组学分析识别与NSCLC治疗反应相关的循环预测性生物标志物和生物学通路 Integrated plasma multi-omics profiling identifies circulating predictive biomarkers and biological pathways associated with treatment response in NSCLC Laura Heeb, Polina Shichkova, Sandra Schär, Luca Räss, Arthur Viodé, Martin Mehnert, Tobias Treiber, Esther Wortmann, Gordian Adam, Alice Limonciel, Markus Joerger, Jana Musilova, Stefanie Hayoz, Anurag Gupta, Yuehan Feng, Alessandra Curioni-Fontecedro
107 · PDF 一种利用cfDNA基因组和表观基因组分析对可干预突变进行扩展阴性预测的算法 An expanded negative prediction algorithm for actionable mutations utilizing genomic and epigenomic profiling in cfDNA Andrew M. Gross, Hao Wang, Brandy Freschi, Keelia Clemens, Marisa Juntilla, Martina Lefterova, Justin Odegaard, Darya Chudova
108 · PDF 片段组学助力液体活检中体细胞突变分类的改进 Fragmentomics powers improved classification of somatic mutations in liquid biopsy Mouses Stamboulian, Anton Valouev, Tingtin Jiang, Jamie Hutchins
109 · PDF cfDNA片段组与TCR库的整合分析捕捉弥漫性胸膜间皮瘤的化学免疫治疗反应 Integrative analyses of the cfDNA fragmentome and TCR repertoires capture chemo-immunotherapy response in diffuse pleural mesothelioma Jinny Huang, Jennifer Li, James R. White, Shashikant Koul, Gavin Pereira, Nisha Rao, Jennie Yao, Julie R. Brahmer, Robert B. Scharpf, Rachel Karchin, Victor E. Velculescu, Zhouxin Sun, Suresh S. Ramalingam, Patrick M. Forde, Noushin Niknafs, Valsamo (Elsa) K. Anagnostou
110 · PDF 标志性ctDNA分子反应作为肺癌免疫治疗结局早期指标的临床效用 Clinical utility of landmark ctDNA molecular response as an early indicator of immunotherapy outcomes in lung cancer Jaime Wehr, Noushin Niknafs, Lavanya Sivapalan, Archana Balan, Gavin Pereira, Samira Hosseini-Nami, Iiasha Beadles, Aliyah Pabani, Kristen Marrone, Qing K. Li, Joseph Christopher Murray, Mark Sausen, Bryan Chesnick, Lorenzo Rinaldi, Christine L. Hann, Susan Combs Scott, Josephine Feliciano, Vincent K. Lam, Benjamin Levy, Patrick M. Forde, Julie R. Brahmer, Valsamo (Elsa) Anagnostou
111 · PDF 游离DNA中遗传和表观遗传特征的整合式碱基分辨率分析 Integrated, base-resolution profiling of genetic and epigenetic signatures in cell-free DNA Xingyu Yang, Jing Su, Chen Yang, Xiaoling Li, Si Zhang, Xianrong Chen, Zhihong Zhang, Bingsi Li
112 · PDF 增强型变异（EV）分析流程用于改善低肿瘤负荷样本中循环肿瘤DNA（ctDNA）检测的分析性能 Analytical performance of an enhanced variant (EV) pipeline for improved circulating tumor DNA (ctDNA) detection in samples with low tumor burden Dina Hafez, Bin Dong, Aamir Shahpurwalla, Bharat Sridhar, Alexander Hsieh, Jordan Feeney, Vu Ngo, Noura Tbeileh, Alexey Aleshin, Matthew Rabinowitz, Himanshu Sethi, Chenlu Hou, Ryan Ptashkin, Eser Kirkizlar, Ahmet Zehir
113 · PDF 跨两种全基因组测序平台评估健康血浆样本中的测序错误率 Assessment of sequencing error rates in healthy plasma samples across two whole genome sequencing platforms Aamir Shahpurwalla, Zach Montague, Fei Lu, Spenser Alexander, Garima Goyal, Dina Hafez, Matthew Rabinowitz, Eser Kirkizlar, Ahmet Zehir
114 · PDF 从血浆来源的cfRNA中解析肿瘤特异性和组织特异性基因表达模式 Unraveling tumor- and tissue-specific gene expression patterns from plasma-derived cfRNA Maria Savchenko, Tatiana Nemchaninova, Alexey Dudakov, Aleksandr Serdiukov, Daria Shafranskaya, Artemiy Nikitin, Anastasia Tarabarova, Desiree Schenk, Alexandr Zaitsev, Anastasia Yudina, Michael F. Goldberg, Alexander Bagaev
116 · PDF 全面的ctDNA分析揭示韩国泛癌患者的分子与预后图景 Comprehensive ctDNA profiling reveals molecular and prognostic landscapes in Korean pan-cancer patients Jiwon Kim, Kyong Hwa Park, Soohyeon Lee, Jwa Hoon Kim, Ju Won Kim, Ji Won Lee, Ji Yoon Lee, You Jin Song, Dayoung Lee, Hyeonmin Jeong, Wooseok Lee, Yoon Ji Choi, Jason K. Sa
117 · PDF 单细胞转录组和CNV分析揭示胰腺导管腺癌中独特的循环肿瘤细胞特征 Single-cell transcriptomic and CNV profiling reveal distinct circulating tumor cell signatures in pancreatic ductal adenocarcinoma Se-Eun Choi, Jihyun Lee, Hyunjung Kee, Moon Jae Chung, Jungwon Kim, Semin Lee
118 · PDF 利用纳米孔测序的cfDNA甲基化特征检测早期癌症 Detecting early cancer using cfDNA methylation signatures with nanopore sequencing Yi Yang Hou, Nicholas Cheng, Jared T. Simpson, Philip Awadalla
119 · PDF 一种轻量级自监督深度学习框架用于自动检测循环肿瘤细胞和癌症相关成纤维细胞 A lightweight self-supervised deep learning framework for automated detection of circulating tumor cells and cancer-associated fibroblasts Hyeongjung Woo, Seonghwan Park, Jungmin Lee, Inkyu Moon, Minseok S. Kim
120 · PDF 肝细胞癌的两种整合分子亚型及其预测性治疗潜力：迈向液体活检指导的精准医学 Two integrative molecular subtypes of hepatocellular carcinoma with predictive therapeutic potential: Toward liquid biopsy-guided precision medicine Jiyon Lyu, Woo Young Kwon, Sung Hwan Lee
121 · PDF 单链连接提升 duet evoC 6碱基检测的性能，在包括液体活检在内的低DNA投入量应用中增强价值 Single stranded ligation enhances the performance of the duet evoC 6-base assay, enhancing value in low DNA input applications including liquid biopsy Tom Charlesworth, Audrey Vandomme, Jens Fullgrabe, Ermira Lleshi, Lidia Prieto-Lafuente, Edyta Bocian-Canepa, Elena Pahiti, Rebecca Ellwood, Mengjie Li, Marjana Lila, Robert Crawford, Robert J. Osborne, Brett Evans
122 · PDF 利用6碱基基因组通过联合甲基化与片段组学分析对cfDNA进行完整多组学分析，以增强临床癌症cfDNA样本的分类 Using the 6-base genome for full multiomic analysis of cfDNA through combined methylation and fragmentomic analysis to enhance classification of clinical cancer cfDNA samples Tom Charlesworth, Fabio Puddu, Luke Sarre, Elena Pahiti, Lidia Prieto-Lafuente, Aurelie Modat, Robert Crawford, Simeone Angela, Robert J. Osborne, Steven Ciaramaglia
123 · PDF 5碱基和6碱基检测的高分析灵敏度与特异性对于增强液体活检应用中ctDNA检测的重要性 The importance of high analytical sensitivity and specificity of 5 and 6-base assays to enhance the detection of ctDNA in liquid biopsy applications Tom Charlesworth, Luke Sarre, Cillian Nolan, Fabio Puddu, Annelie Johansson, Aurelie Modat, Ermira Lleshi, Simeone Angela, Robert Crawford, Robert J. Osborne, Thao Huynh

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