Genomic Drivers of Cancer Pathogenesis

• 1975 · PDF 转化型小细胞肺癌可塑性的基因组驱动因素 Genomic drivers of plasticity in transformed small cell lung cancer Swanand Rakhade, Mamie Wang, Lena Morrill Gavarró, Emmanuel Spanos, Alvaro Quintanal-Villalonga, Amin Sabet, Parvathy Manoj, Rishika Giri, Ronan Chaligné, Xinjun Wang, Helena A. Yu, Esther Redin, Dana Pe'er, Charles M. Rudin, Joseph Chan
• 1976 · PDF 致病性种系KEAP1变异驱动非小细胞肺癌中NRF2的组成型过度激活并增强致癌适应性 Pathogenic germline KEAP1 variants drive constitutive NRF2 hyperactivation and enhanced oncogenic fitness in non small cell lung cancer Laura Eibler, Miika M. Mehine, Rebecca Caeser, Esther Redin, Michael F. Berger, Chaitanya Bandlamudi, Charles M. Rudin
• 1977 · PDF 对超过8,000例TCGA样本的全基因组测序揭示原发性人类癌症中同源重组缺陷的多样化和非典型谱系 Whole-genome sequencing of >8,000 TCGA samples reveals diverse and atypical spectra of homologous recombination deficiency in primary human cancers Joonoh Lim, Chunyang Bao, Hansol Park, Gang-Hee Lee, Ryul Kim, Won-Chul Lee, Jonghoon Lee, Yoonsuh Lee, Beomki Lee, David Lehotzky, Ron Solan, Antonia Kowalewski, Xavi Loinaz, Vasuki Narasimha Swamy, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Andrew D. Cherniack, Luis Antonio Corchete Sanchez, Brian P. Danysh, Zachary Everton, Chip Stewart, Haruna Tomono, Gengchao Wang, Esther Rheinbay, Gad Getz, Young Seok Ju
• 1978 · PDF 对调控区域的拷贝数分析揭示超过8,000例TCGA样本中反复出现的启动子/增强子体细胞拷贝数改变 Copy number analysis of regulatory regions reveal recurrent promoter/enhancer somatic copy number alterations across >8,000 TCGA samples Haruna Tomono, Chunyang Bao, Antonia Kowalewski, David Lehotzky, Ron Solan, Matthew Leventhal, Luis Antonio Corchete Sanchez, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Brian P. Danysh, Chip Stewart, Vasuki Narasimha Swamy, Gengchao Wang, Xavi Loinaz, Zachary Everton, Gang-Hee Lee, Won-Chul Lee, Hansol Park, Ryul Kim, Young Seok Ju, Esther Rheinbay, Gad Getz, Andrew D. Cherniack, Matthew L. Meyerson, Rameen Beroukhim
• 1979 · PDF 对1,104例连续、前瞻性脑膜瘤的基因组分析界定分子改变的人群患病率并阐明潜在的治疗反应生物标志物 Genomic profiling of 1,104 consecutive, prospective meningiomas defines the population prevalence of molecular alterations and elucidates potential biomarkers of treatment response Minh P. Nguyen, Kanish Mirchia, Brooke C. Braman, Ramin A. Morshed, Nancy Ann Oberheim Bush, Javier E. Villanueva-Meyer, William C. Chen, Walter Patrick Devine, Arie Perry, David R. Raleigh
• 1980 · PDF TCGA全基因组序列中的泛癌种LINE-1逆转座图景 Pan-cancer LINE-1 retrotransposition landscapes in TCGA whole-genome sequences Beomki Lee, Ryul Kim, Chunyang Bao, Hansol Park, Gang-Hee Lee, Jonghoon Lee, Yoonsuh Lee, Won-Chul Lee, David Lehotzky, Ron Solan, Antonia Kowalewski, Xavi Loinaz, Vasuki Narasimha Swamy, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Andrew D. Cherniack, Luis Antonio Corchete Sanchez, Brian P. Danysh, Zachary Everton, Chip Stewart, Haruna Tomono, Gengchao Wang, Esther Rheinbay, Gad Getz, Cheng-Zhong Zhang, Young Seok Ju
• 1981 · PDF 非肿瘤性前列腺上皮中缺乏体细胞拷贝数改变 Absence of somatic copy number alterations in non-neoplastic prostate epithelium Ajay Vaghasia, Levent Trabzonlu, Anuj Gupta, Ibrahim Kulac, Busra Ozbek, Jiayu Chen, Qizhi Zheng, Jessica L. Hicks, Tracy Jones, Roy Elias, Alyza Skaist, Jennifer Meyers, Kornel Schuebel, Christopher M. Heaphy, Alan K. Meeker, William G. Nelson, Angelo Michael De Marzo, Srinivasan Yegnasubramanian
• 1982 · PDF 对患者来源异种移植物的基因组分析揭示PDAC的新型分子亚群及其与临床特征的关联 Genomic analyses of patient-derived xenografts reveal novel molecular subsets of PDAC and their association with clinical features Chani Stossel, Rotem Tal, Rouven Hoefflin, Maria Raitses-Gurevich, Dikla Atias, Yulia Glick Gorman, Gali Altman, Tamar Beller, Talia Golan, Itay Tirosh
• 1985 1985 优化精准肿瘤学：对37,898例患者中WES与靶向panel的大规模临床基因组学分析 Optimizing precision oncology: A large scale clinico-genomic analysis of WES versus targeted panels in 37,898 patients Jing Hu, Minghui Wang, Junqiang Yin, Aibo Xia, Zanmei Xu, Shaohua Yuan, Yannan Zhu, Kunxu Xu, Yimin Guan, Haiyin Huang, Kai Wang
• 1986 · PDF Y染色体改变的泛癌种图景 The pan-cancer landscape of chromosome Y alterations Luis Antonio Corchete Sanchez, Chunyang Bao, Saveliy Belkin, Andrew D. Cherniack, Brian P. Danysh, Zachary Everton, David I. Heiman, Ryul Kim, Antonia Kowalewski, Gang-Hee Lee, Won-Chul Lee, David Lehotzky, Xavi Loinaz, Vasuki Narasimha Swamy, Hansol Park, Ron Solan, Chip Stewart, Haruna Tomono, Samantha Van Seters, Gengchao Wang, Sam Wiseman, Young Seok Ju, Gad Getz, Esther Rheinbay
• 1988 · PDF 人类与病毒全基因组测序确定HPV和APOBEC为鼻窦鳞状细胞癌的致癌驱动因素 Human and viral whole genome sequencing identify HPV and APOBEC as oncogenic drivers in sinonasal squamous cell carcinoma Harrison B. Chong, Michael E. Bryan, Maoxuan Lin, Magdy Gohar, William C. Faquin, Lisa J. Mirabello, James S. Lewis, Michael S. Lawrence, Daniel Faden
• 1989 · PDF 跨>8,000例TCGA全基因组的结构变异驱动因素的系统性发现与分类 Systematic discovery and classification of structural variant drivers across >8,000 TCGA whole genomes Antonia Kowalewski, Xavi Loinaz, Hansol Park, Vasuki Narasimha Swamy, David Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Chunyang Bao, Andrew D. Cherniack, Luis A. Corchete Sanchez, Brian P. Danysh, Zachary Everton, Ryul Kim, Gang-Hee Lee, Won-Chul Lee, David Lehotzky, Ron Solan, Chip Stewart, Haruna Tomono, Gengchao Wang, Rameen Beroukhim, Young Seok Ju, Esther Rheinbay, Gad Getz
• 1990 · PDF 泛癌无PCR全基因组测序在单独外显子组测序之外精细刻画体细胞驱动图谱 Pan-cancer PCR-free whole-genome sequencing refines the somatic driver landscape beyond exome sequencing alone Gengchao Wang, David I Heiman, Vasuki Narasimha Swamy, Chip Stewart, Xavi Loinaz, Ron Solan, Chunyang Bao, David Lehotzky, Brian P Danysh, Luis Antonio Corchete Sanchez, Zachary Everton, Sam Wiseman, Antonia Kowalewski, Samantha Van Seters, Saveliy Belkin, Haruna Tomono, Andrew D Cherniack, Ryul Kim, Gang-Hee Lee, Won-Chul Lee, Hansol Park, Rebecca Jang, Young Seok Ju, Gad Getz, Esther Rheinbay
• 1991 · PDF 癌症基因组图谱（TCGA）全基因组测序数据集中的种系易感性 Germline predisposition in The Cancer Genome Atlas (TCGA) whole-genome sequencing datasets Ryul Kim, Owen Hirschi, Matthew Leventhal, Chunyang Bao, Hansol Park, Gang-Hee Lee, Won-Chul Lee, Jonghoon Lee, Yoonsuh Lee, Beomki Lee, David Lehotzky, Ron Solan, Antonia Kowalewski, Xavi Loinaz, Vasuki Narasimha Swamy, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Andrew D. Cherniack, Luis Antonio Corchete Sanchez, Brian P Danysh, Zachary Everton, Chip Stewart, Haruna Tomono, Gengchao Wang, Esther Rheinbay, Gad Getz, Cheng-Zhong Zhang, Matthew L. Meyerson, Young Seok Ju
• 1992 · PDF 通过整体与单细胞全基因组测序描绘乳腺癌中的基因组不稳定性动态 Delineating genomic instability dynamics in breast cancer by bulk and single-cell whole genome sequencing Konstantinos L. Georgiadis, Sen Li, Thomas Hatschek, Theodoros Foukakis, Nicola Crosetto
• 1993 · PDF 血液系统恶性肿瘤中KMT2A和NPM1变异及融合的真实世界图谱（2020-2025） Real-world landscape of KMT2A and NPM1 variants and fusions in hematologic malignancies (2020-2025) Roisin Puentes, Madhuri Paul, Ryan Bender, Amber Chevalier, Nathan Montgomery
• 1994 · PDF 整合性多组学分析揭示染色体外DNA在黑色素瘤中的亚型特异性影响 Integrative multi-omic analysis reveals subtype-specific impact of extrachromosomal DNA in melanoma Sharadha Sakthikumar, Bryce Turner, Jeffrey Trent, ALEKSANDAR SEKULIC
• 1995 · PDF IPMN来源胰腺癌的临床基因组学图谱 Clinicogenomic landscape of IPMN-derived pancreatic cancer Peter Y. Yu, Joseph R. Habib, Jonah Levine, Brock Hewitt, Michael D. Kluger, Katherine A. Morgan, Anirban Maitra, Christopher Wolfgang, Ammar A. Javed, Greg Sacks
• 1996 · PDF 碱基编辑用于对NF1中意义未明变异进行系统性重新分类 Base editing for systematic reclassification of variants of unknown significance in NF1 Sara Galavotti, Elena Endrizzi, Emanuele Bonetti, Gabriele Picco, Gianmaria Frige, Pier Giuseppe Pelicci, Luca Mazzarella
• 1997 · PDF 对原发性和复发性人类胶质母细胞瘤进行整合性单核空间转录组分析，揭示细胞特异性的EGFRvIII表达和ANXA1信号轴 Integrative single-nuclei spatial transcriptomic profiling of primary and recurrent human glioblastoma reveals cell-specific EGFRvIII expression and ANXA1 signaling axis Simon G. Gregory, Lauren Whaley-Powers, Vaibhav Jain, Michael Aksu, Emily Hocke, Alan Smith, Stephanie Arvai, Ellora Haukefrers, Kevin Stevenson, Khooshbu Patel, Diane Satterfield, Elizabeth Thomas, Karen Abramson, Giselle Y. Lopez, Roger E. McLendon, David M. Ashley
• 1998 · PDF Minerva：利用长读长测序实现高分辨率等位基因特异性拷贝数与复杂结构变异的协调整合 Minerva: High-Resolution Allele-Specific Copy Number and Complex SV Harmonization with Long Reads Ayse G. Keskus, Tanveer Ahmad, Isabel Rodriguez, Anton Goretsky, Ataberk Donmez, Sonam Tulsyan, Nicholas Syracuse, Michael Dean, Mikhail Kolmogorov
• 1999 · PDF 始祖性Wnt改变引导结直肠肿瘤发生的演化轨迹 Founder Wnt alterations guide the evolutionary trajectories of colorectal tumorigenesis Yoshikage Inoue, Nobuyuki Kakiuchi, Satoshi Nagayama, Yutaro Kuwashima, Sekine Shigeki, Kenichi Yoshida, Koichi Watanabe, Satoshi N. Omura, Kazutaka Obama, Toshiro Sato, Seishi Ogawa
• 2000 · PDF 一例原发性卵巢透明细胞癌中自发性CTNNB1驱动突变的回复 A spontaneous CTNNB1 driver mutation reversion in a primary ovarian clear cell carcinoma Rania Bassiouni, Yuxin Jin, Lee D. Gibbs, Jing Qian, Solomon O. Rotimi, Heather Miller, Michelle G. Webb, David W. Craig, Javier Arias-Stella, Lynda Roman, John D. Carpten
• 2001 · PDF 在超过8000个TCGA全基因组中发现编码区和非编码区驱动突变 Discovery of coding and non-coding driver mutations across >8,000 TCGA whole genomes David Lehotzky, Ron Solan, Antonia Kowalewski, Nick Haradhvala, Xavier Loinaz, Hansol Park, Vasuki N. Swamy, David Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Chunyang Bao, Andrew Cherniack, Luis A. Corchete Sanchez, Brian P. Danysh, Zachary Everton, Ryul Kim, Gang-Hee Lee, Won-Chul Lee, Chip Stewart, Haruna Tomono, Gengchao Wang, Young Seok Ju, Esther Rheinbay, Gad Getz
• 2002 · PDF 癌症中X染色体拷贝数改变的全景 The landscape of X chromosome copy number alterations in cancer Matthew Joseph Leventhal, Chunyang Bao, Ron Solan, Haruna Tomono, Andrew D. Cherniack, Luis A. Corchete Sanchez, Rebecca Jang, Jeehee Suh, Antonia Kowalewski, Sam Wiseman, Samantha Van Seters, Saveliy Belkin, David I. Heiman, Chip Stewart, David Lehotzky, Vasuki N. Swamy, Brian P. Danysh, Gengchao Wang, Xavi Loinaz, Zachary Everton, Gang-Hee Lee, Won-Chul Lee, Hansol Park, Ryul Kim, Young Seok Ju, Esther Rheinbay, Gad Getz, Cheng-Zhong Zhang
• 2003 · PDF 血管肉瘤细胞的全面基因组分析揭示RAS通路的广泛激活 Comprehensive genomic profiling of angiosarcoma cells reveals widespread activation of the RAS pathway Donghee Lee, Sun Hee Choi, Md Abdullah, Eslenur Nipa, Jong Hyuk Kim
• 2004 · PDF 沿时间与治疗轴解析免疫系统与癌症的基因组共进化 Interrogating the genomic co-evolution of the immune system and cancer along the time and treatment continuum John Roy Lozada, Christine Luo, Devin Schmeck, Jeffrey S. Miller, Akash Patnaik, Emmanuel S. Antonarakis, Frank Cichocki, Justin Hwang

在会议检索中浏览本分会场