Mathematical Modeling and Statistical Methods

• 6830 · PDF 时间序列单细胞RNA-seq的状态转换模型识别慢性髓系白血病（CML）疾病微状态稳定性的基因层面起源 State-transition model of time-series single-cell RNA-seq identifies gene-level origins of disease microstate stability in chronic myeloid leukemia (CML) David Eugene Frankhouser, Anupam Dey, Jennifer Rangel Ambriz, Ziang Chen, Denis O'Meally, Yu-Hsuan Fu, Jihyun Irizarry, Tiffany Kanesa Ybarra, Ryan Sathianathen, Jeffrey Trent, Stephen J. Forman, Kathleen M. Sakamoto, Ya-Huei Kuo, Bin Zhang, Adam L. MacLean, Guido Marcucci, Russell Rockne
• 6831 · PDF BMP4分化疗法的虚拟临床试验 Virtual clinical trials of BMP4 differentiation therapy Nicholas Harbour, Lee Curtin, Loizos Michaelides, Matthew E. Hubbard, Pamela Jackson, Vinitha Rani, Rajappa Kenchappa, Virginea Farias, Anna Carrano, Markus Owen, Alfredo Quinones-Hinojosa, Kristin Swanson
• 6832 · PDF 迈向个性化轮换多药疗法以克服胰腺癌治疗耐药：一个小鼠虚拟试验框架 Toward personalized rotational multi-agent therapies to overcome treatment resistance in pancreatic cancer: A virtual trial framework in mice Krithik Vishwanath, Hoon Choi, Mamta Gupta, Rong Zhou, Anna G. Sorace, Thomas E. Yankeelov, Ernesto A.B.F. Lima
• 6834 · PDF 稳态T细胞重建在CAR T细胞疗法持久应答中作用的建模研究 Modeling the role of homeostatic T-cell reconstitution in durable response to CAR T-cell therapy Philipp Martin Altrock, Álvaro Martinez-Rubio, María Rosa, Arne Traulsen, Michael D. Jain, Frederick L. Locke
• 6835 · PDF 多组学状态转换框架揭示急性髓系白血病中化疗诱导的代谢重编程 Multiomic state-transition framework reveals chemotherapy-induced metabolic reprogramming in acute myeloid leukemia Jennifer Rangel Ambriz, Ziang Chen, Yu-Hsuan Fu, David Eugene Frankhouser, Denis O'Meally, Lianjun Zhang, Ying-Chieh Chen, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Guido Marcucci, Russell Rockne, Ya-Huei Kuo
• 6836 6836 机制建模平台预测患者应答以指导抗体药物偶联物的临床开发 Mechanistic modeling platform predicts patient response to guide antibody-drug conjugate clinical development NING Wang, Nathan Siemers
• 6837 · PDF 利用空间信息化的癌症微环境主题推断实现可扩展的细胞类型和空间域建模 Scalable cell type and spatial domain modeling using spatially informed topic inference of cancer niches Jeongbin Park, Tingrui Zhang, Cong Ma
• 6838 · PDF 获批联合疗法中最严重的不良事件发生率与独立作用一致 Most severe adverse events in approved combination therapies occur at rates consistent with independent action Kunhee Kim, Rishi Bollapalli, Adam C. Palmer
• 6839 · PDF 乳腺肿瘤引流淋巴结对放疗诱导纤维化和淋巴水肿风险的结构性脆弱性 Structural vulnerabilities of the breast tumor-draining lymph node to radiotherapy-induced fibrosis and lymphedema risk Laia Vancells, Leopold Green, Nan Kong
• 6840 · PDF 开发数据同化框架以预测低级别胶质瘤患者特异性肿瘤负荷 Developing a data assimilation framework to forecast patient-specific tumor burden in low-grade glioma Sophia Ty, Devika Shankar, Bikash Panthi, Mohamad El-Jammal, Victoria White, Holly Langshaw, Eleni Konstantinopoulou, Hannah Green, Ashi Jain Chakresh, Vishantan Kumar, Thomas E. Yankeelov, Caroline Chung, David A. Hormuth
• 6842 · PDF ctDNA先于影像学：一种用于HPV相关肛门鳞状细胞癌实时治疗调整的预测模型 ctDNA precedes imaging: A predictive model for real-time treatment adaptation in HPV-associated anal squamous cell carcinoma Phebe M.A Havor, Brandon M Huffman, James Cleary, Renee Brady-Nicholls
• 6843 · PDF 整合基于甲基化的连续肿瘤分数与ESR1评估以预测ER+/HER2-转移性乳腺癌患者总生存期的联合模型 A joint model for integrating serial methylation-based tumor fraction and ESR1 assessment to forecast overall survival in patients with ER+/HER2- metastatic breast cancer Christopher Pretz, Matthew Ellis, Mitchell J. Elliott, Caroline Weiport, Amar Das, Carin Espenschied, David Cescon
• 6844 · PDF 应用空间轨迹对空间蛋白成像数据进行功能数据分析及其在卵巢癌中的应用 Functional data analysis of spatial protein imaging data using spatial trajectories with application to ovarian cancer Brooke L. Fridley, Alex C. Soupir, Daisy Liao, Chase Sakitis, Joellen Schildkraut, Andrew B. Lawson, Mary K. Townsend, Shelley Tworoger, Kathryn L. Terry, Julia Wrobel, Lauren Cole Peres
• 6845 · PDF 利用细胞类型特异性核小体模式改进肺癌中游离DNA片段化模型 Using cell-type-specific nucleosome patterns to improve cell-free DNA fragmentation models in lung cancer Brian Sun Liu, Mengran Zhang, Mohammad Shahrokh Esfahani
• 6846 · PDF 应用基于生理的药代动力学-定量系统药理学模型优化肽-药物偶联物的设计 Using physiologically-based pharmacokinetics-quantitative systems pharmacology model to optimize peptide-drug conjugates design Yuezhe Li, Cole Zmurchok, Daniel C. Kirouac
• 6848 · PDF HPlot：一种用于肿瘤微环境免疫异质性空间分析的新型定量框架 HPlot: A novel quantitative framework for spatial profiling of Immune heterogeneity in tumor microenvironments Chao Hui Huang, Jadwiga Renata Bienkowska, Diane Fernandez, Sara Beth Linker, Xinmeng Jasmine Mu, Robbin Nameki, Jennifer Kinong, Michelle Saul, Aakash Sur, Mehmet Tekman, Alexander Trageser, Wenjing Yang, Daniel Chawla, Greg Szeto, Arne Schmidt, Alberto M. Gonzalo, Srishti Munjal Mehta, Rosemarie Krupar, Nina Kozar-Gillan, Sophie Laturnus, Cornelius Böhm, Marija Pezer, Gloria H.Y. Lin, Darlan Conterno Minussi, Keith Ching, Thomas Powles, Craig Davis
• 6849 · PDF 肿瘤微环境基因表达动态：关键细胞类型与非癌细胞驱动基因 Tumor microenvironment gene expression dynamics: Keystone cell types and non-cancer cell driver genes Yongzhong Zhao, Yixiao Cui, Ji Zheng, Cody Stevens, Jenny Bundy, Eranga Wettewa, Christopher Edwards, Victoria Thilker, Donald Carpenter, Zhongqiang Qiu, Zhijiu Zhong, Eric Zhao, Lili Liao, Qiang Xu, Nan Zhang, John Lin
• 6850 6850 利用模拟残留病灶和PDX数据对不可见肿瘤生长进行动态建模 Dynamic modeling of invisible tumor growth with simulated residual disease and PDX data Bryan A. Hawickhorst, Daniel J. McWilliams, Jonathan M. Baker, Amy H. Tang
• 6851 · PDF 用于分析空间单细胞蛋白成像数据的多细胞类型模型及其在卵巢癌中的应用 Multi-cell type model for analyzing spatial single-cell protein imaging data with application to ovarian cancer Chase Sakitis, Jose Laborde, Julia Wrobel, Alex C. Soupir, Christelle M. Colin-Leitzinger, Benjamin G. Bitler, Mary K. Townsend, Andrew B. Lawson, Joellen M. Schildkraut, Shelley S. Tworoger, Kathryn L. Terry, Lauren C. Peres, Brooke L. Fridley
• 6852 · PDF 用于空间蛋白质成像数据分析的三种细胞群共定位测量方法 Measure of three cell population co-localization for spatial protein imaging data analysis Kirill Sabitov, Alex Soupir, Lauren C. Peres, Brooke L. Fridley

在会议检索中浏览本分会场